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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1affects phosphorylationEXP 6480464CTDHydrogen Peroxide affects the phosphorylation of AKT1 proteinPMID:19222219
Akt1decreases phosphorylationEXP 6480464CTDHydrogen Peroxide results in decreased phosphorylation of AKT1 proteinPMID:16249675 PMID:17045724 PMID:23178681 PMID:25065601
Akt1increases expressionEXP 6480464CTDHydrogen Peroxide results in increased expression of AKT1 mRNAPMID:36518482
Akt1increases phosphorylationEXP 6480464CTDHydrogen Peroxide results in increased phosphorylation of AKT1 proteinPMID:12472888 PMID:17302912 PMID:23159718
Akt1multiple interactionsEXP 6480464CTD1-Butanol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[5-aminoisoquinolinone co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]; 3-methylquercetin affects the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]; [5-aminoisoquinolinone co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein; [Hydrogen Peroxide co-treated with RLN2 protein] results in increased phosphorylation of AKT1 protein; [Hydrogen Peroxide co-treated with sodium arsenite] results in increased phosphorylation of AKT1 protein; [Hydrogen Peroxide co-treated with Tretinoin] results in increased phosphorylation of AKT1 protein; [Luteolin co-treated with Hydrogen Peroxide] results in increased expression of AKT1 protein; bellidifolin inhibits the reaction [Hydrogen Peroxide results in increased expression of AKT1 mRNA]; bellidifolin inhibits the reaction [Hydrogen Peroxide results in increased expression of and results in increased phosphorylation of AKT1 protein]; Cycloheximide inhibits the reaction [[Hydrogen Peroxide co-treated with sodium arsenite] results in increased phosphorylation of AKT1 protein]; hesperetin affects the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]; Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]; Hydrogen Peroxide results in increased expression of and results in increased phosphorylation of AKT1 protein; Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of AKT1 protein; isosakuranetin affects the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]; Pertussis Toxin inhibits the reaction [[Hydrogen Peroxide co-treated with RLN2 protein] results in increased phosphorylation of AKT1 protein]; PLD2 protein affects the reaction [Hydrogen Peroxide results in increased activity of and results in increased phosphorylation of AKT1 protein]; PTK2B protein affects the reaction [Hydrogen Peroxide results in increased activity of and results in increased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [[Hydrogen Peroxide co-treated with Tretinoin] results in increased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]PMID:12472888 PMID:15705590 PMID:17045724 PMID:17204550 PMID:19222219 PMID:23178681 PMID:23352507 PMID:25203460 PMID:27525270 PMID:36518482
Akt1affects expressionISOAKT1 (Homo sapiens)6480464CTDHydrogen Peroxide affects the expression of AKT1 proteinPMID:21179406
Akt1affects response to substanceISOAKT1 (Homo sapiens)6480464CTDAKT1 protein affects the susceptibility to Hydrogen PeroxidePMID:12361705
Akt1decreases phosphorylationISOAKT1 (Homo sapiens)6480464CTDHydrogen Peroxide results in decreased phosphorylation of AKT1 proteinPMID:19451193 PMID:26164594 PMID:27049278 PMID:29061316 PMID:31173752 PMID:32043704 PMID:36880193 PMID:37648050
Akt1increases phosphorylationISOAKT1 (Homo sapiens)6480464CTDHydrogen Peroxide results in increased phosphorylation of AKT1 proteinPMID:22020565 PMID:24933099 PMID:25944616 PMID:27451028 PMID:29486183 PMID:30265530 PMID:30296409 PMID:34077701
Akt1increases phosphorylationISOAkt1 (Mus musculus)6480464CTDHydrogen Peroxide results in increased phosphorylation of AKT1 proteinPMID:15123721 PMID:27494022
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phosphocreatine inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]; [[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein; [Acetylcysteine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein; [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]; [Hydrogen Peroxide co-treated with loliolide] results in increased phosphorylation of AKT1 protein; [Hydrogen Peroxide co-treated with N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride] promotes the reaction [ATM protein modified form binds to AKT1 protein binds to MTOR protein binds to IKBKG protein]; [Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of AKT1 protein; [Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein; [luteolin-7-glucoside co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein; [nobiletin co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein; AKT1 mutant form inhibits the reaction [Hydrogen Peroxide results in increased expression of MMP9 mRNA]; AKT1 protein modified form affects the reaction [ATM protein affects the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of GSK3B protein]]]; ATM protein affects the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; CDKN1A protein affects the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]; formononetin promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]; gingerol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]; Ginkgo biloba extract affects the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of AKT1 protein]; Hydrogen Peroxide promotes the reaction [Metribolone results in increased phosphorylation of AKT1 protein]; Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of AKT1 protein; IKBKG protein affects the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]]; KISS1 protein affects the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]; kukoamine B inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]; Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]; MTOR protein affects the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]; Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]; olaparib promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]; PARP1 protein affects the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]; Phosphocreatine inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]; resorcinol inhibits the reaction [[[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]; SHC1 protein modified form inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]; Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of AKT1 protein]; swietenine inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]; veliparib promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [[[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]]PMID:17325745 PMID:19414004 PMID:20562903 PMID:22020565 PMID:26164594 PMID:26262998 PMID:26514923 PMID:27049278 PMID:27451028 PMID:29061316 PMID:29486183 PMID:29687528 PMID:30231594 PMID:30296409 PMID:31157476 PMID:31173752 PMID:32043704 PMID:34077701 PMID:36880193 PMID:37648050
Akt1multiple interactionsISOAkt1 (Mus musculus)6480464CTD[PI103 co-treated with Hydrogen Peroxide] results in decreased expression of AKT1 protein; [Quercetin co-treated with Hydrogen Peroxide] results in decreased expression of AKT1 protein; AXL protein promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]; Hydrogen Peroxide results in decreased phosphorylation of and results in decreased activity of AKT1 protein; PI103 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]; Selenium inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of and results in decreased activity of AKT1 protein]PMID:15123721 PMID:17997286 PMID:27494022
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