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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:63959
Term: celastrol
Definition: A pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM).
Chemical ID: MESH:C050414
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1increases phosphorylationEXP 6480464CTDcelastrol results in increased phosphorylation of AKT1 proteinPMID:25903958
Akt1multiple interactionsEXP 6480464CTDcelastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; PTEN protein promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]]PMID:24111524
Akt1decreases phosphorylationISOAKT1 (Homo sapiens)6480464CTDcelastrol results in decreased phosphorylation of AKT1 proteinPMID:21466843 PMID:31715269
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [celastrol results in decreased phosphorylation of AKT1 protein]PMID:31715269
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