GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Akt1 | increases phosphorylation | EXP | | 6480464 | CTD | Genistein results in increased phosphorylation of AKT1 protein | PMID:22504913 PMID:24884420 | Akt1 | multiple interactions | EXP | | 6480464 | CTD | bisphenol A inhibits the reaction [Genistein results in increased phosphorylation of AKT1 protein]; Genistein inhibits the reaction [bisphenol A results in increased expression of and results in increased phosphorylation of AKT1 protein]; Genistein inhibits the reaction [lead acetate results in increased phosphorylation of AKT1 protein]; Genistein inhibits the reaction [lipoteichoic acid results in increased phosphorylation of AKT1 protein] | PMID:20685402 PMID:24884420 PMID:26797587 | Akt1 | affects binding | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | Genistein binds to AKT1 protein | PMID:16789737 | Akt1 | decreases expression | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | Genistein results in decreased expression of AKT1 protein | PMID:24299158 | Akt1 | decreases phosphorylation | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | Genistein results in decreased phosphorylation of AKT1 protein | PMID:15829497 PMID:19038232 PMID:21078540 | Akt1 | decreases phosphorylation | ISO | Akt1 (Mus musculus) | 6480464 | CTD | Genistein results in decreased phosphorylation of AKT1 protein | PMID:21078540 | Akt1 | multiple interactions | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | Genistein inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of AKT1 protein]; Genistein inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of AKT1 protein]; Genistein inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]; Genistein inhibits the reaction [Copper Sulfate results in increased phosphorylation of AKT1 protein]; Genistein inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; Genistein inhibits the reaction [Oxygen deficiency results in increased expression of AKT1 mRNA]; Tretinoin inhibits the reaction [Genistein results in decreased phosphorylation of AKT1 protein] | PMID:19038232 PMID:21078540 PMID:23452621 PMID:23933164 PMID:24933099 PMID:33396024 | Akt1 | multiple interactions | ISO | Akt1 (Mus musculus) | 6480464 | CTD | Genistein inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of AKT1 protein]; Genistein inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein] | PMID:21078540 PMID:30734460 | |
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