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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1increases phosphorylationEXP 6480464CTDGenistein results in increased phosphorylation of AKT1 proteinPMID:22504913 PMID:24884420
Akt1multiple interactionsEXP 6480464CTDbisphenol A inhibits the reaction [Genistein results in increased phosphorylation of AKT1 protein]; Genistein inhibits the reaction [bisphenol A results in increased expression of and results in increased phosphorylation of AKT1 protein]; Genistein inhibits the reaction [lead acetate results in increased phosphorylation of AKT1 protein]; Genistein inhibits the reaction [lipoteichoic acid results in increased phosphorylation of AKT1 protein]PMID:20685402 PMID:24884420 PMID:26797587
Akt1affects bindingISOAKT1 (Homo sapiens)6480464CTDGenistein binds to AKT1 proteinPMID:16789737
Akt1decreases expressionISOAKT1 (Homo sapiens)6480464CTDGenistein results in decreased expression of AKT1 proteinPMID:24299158
Akt1decreases phosphorylationISOAKT1 (Homo sapiens)6480464CTDGenistein results in decreased phosphorylation of AKT1 proteinPMID:15829497 PMID:19038232 PMID:21078540
Akt1decreases phosphorylationISOAkt1 (Mus musculus)6480464CTDGenistein results in decreased phosphorylation of AKT1 proteinPMID:21078540
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTDGenistein inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of AKT1 protein]; Genistein inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of AKT1 protein]; Genistein inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]; Genistein inhibits the reaction [Copper Sulfate results in increased phosphorylation of AKT1 protein]; Genistein inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; Genistein inhibits the reaction [Oxygen deficiency results in increased expression of AKT1 mRNA]; Tretinoin inhibits the reaction [Genistein results in decreased phosphorylation of AKT1 protein]PMID:19038232 PMID:21078540 PMID:23452621 PMID:23933164 PMID:24933099 PMID:33396024
Akt1multiple interactionsISOAkt1 (Mus musculus)6480464CTDGenistein inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of AKT1 protein]; Genistein inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]PMID:21078540 PMID:30734460
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