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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:50924
Term: sorafenib
Definition: A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 4-chloro-3-trifluorophenyl group while the other is substituted by a phenyl group which, in turn, is substituted at the para position by a [2-(methylcarbamoyl)pyridin-4-yl]oxy group.
Chemical ID: MESH:C471405
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1decreases expressionISOAKT1 (Homo sapiens)6480464CTDSorafenib analog results in decreased expression of AKT1 proteinPMID:36565974
Akt1decreases phosphorylationISOAKT1 (Homo sapiens)6480464CTDsorafenib results in decreased phosphorylation of AKT1 proteinPMID:23036488
Akt1increases phosphorylationISOAKT1 (Homo sapiens)6480464CTDSorafenib results in increased phosphorylation of AKT1 proteinPMID:21858812
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTD2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [Sorafenib results in decreased phosphorylation of AKT1 protein]; [antrocin analog co-treated with Sorafenib] results in decreased expression of AKT1 protein; [Bortezomib co-treated with Sorafenib] results in decreased phosphorylation of AKT1 protein; AKT1 protein inhibits the reaction [[Bortezomib co-treated with Sorafenib] results in increased cleavage of CASP3 protein]; AKT1 protein inhibits the reaction [[Bortezomib co-treated with Sorafenib] results in increased cleavage of CASP9 protein]; AKT1 protein inhibits the reaction [[Bortezomib co-treated with Sorafenib] results in increased cleavage of PARP1 protein]; AKT1 protein results in decreased susceptibility to [Bortezomib co-treated with Sorafenib]; Oxygen deficiency affects the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [Sorafenib results in decreased phosphorylation of AKT1 protein]]PMID:16985072 PMID:23036488 PMID:36565974
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