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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:4357
Term: deguelin
Definition: A rotenone that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted by methoxy groups at positions 9 and 10, and by two methyl groups at position 3 (the 7aS,13aS-stereoisomer). It exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants and reported to exert anti-tumour effects in various cancers.
Chemical ID: MESH:C107676
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1affects phosphorylationISOAKT1 (Homo sapiens)6480464CTDdeguelin affects the phosphorylation of AKT1 proteinPMID:25322282
Akt1decreases expressionISOAKT1 (Homo sapiens)6480464CTDdeguelin metabolite results in decreased expression of AKT1 protein; deguelin results in decreased expression of AKT1 mRNA; deguelin results in decreased expression of AKT1 proteinPMID:19139008 PMID:19336726 PMID:33512557
Akt1decreases phosphorylationISOAKT1 (Homo sapiens)6480464CTDdeguelin results in decreased phosphorylation of AKT1 proteinPMID:18593368 PMID:19336726 PMID:29512685
Akt1decreases phosphorylationISOAkt1 (Mus musculus)6480464CTDdeguelin results in decreased phosphorylation of AKT1 proteinPMID:16288123
Akt1increases phosphorylationISOAkt1 (Mus musculus)6480464CTDdeguelin results in increased phosphorylation of AKT1 proteinPMID:19901985
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTDdeguelin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]PMID:17015749
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