GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Akt1 | increases phosphorylation | EXP | | 6480464 | CTD | Selenium results in increased phosphorylation of AKT1 protein | PMID:29324385 | Akt1 | multiple interactions | EXP | | 6480464 | CTD | Selenium inhibits the reaction [arsenite results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; Selenium inhibits the reaction [Potassium Iodide results in increased phosphorylation of AKT1 protein] | PMID:29324385 PMID:38013145 | Akt1 | decreases phosphorylation | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | Selenium results in decreased phosphorylation of AKT1 protein | PMID:17339365 | Akt1 | increases expression | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | Selenium results in increased expression of AKT1 mRNA | PMID:19244175 | Akt1 | multiple interactions | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | [Selenium results in decreased phosphorylation of AKT1 protein] which results in increased susceptibility to Doxorubicin; AKT1 protein modified form inhibits the reaction [[Doxorubicin co-treated with Selenium] results in increased degradation of PARP1 protein]; Selenium inhibits the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein] | PMID:17339365 | Akt1 | multiple interactions | ISO | Akt1 (Mus musculus) | 6480464 | CTD | Selenium inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of and results in decreased activity of AKT1 protein] | PMID:17997286 | |
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