Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:27568
Term: selenium atom
Definition: A chalcogen that has formula Se.
Chemical ID: MESH:D012643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1increases phosphorylationEXP 6480464CTDSelenium results in increased phosphorylation of AKT1 proteinPMID:29324385
Akt1multiple interactionsEXP 6480464CTDSelenium inhibits the reaction [arsenite results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; Selenium inhibits the reaction [Potassium Iodide results in increased phosphorylation of AKT1 protein]PMID:29324385 PMID:38013145
Akt1decreases phosphorylationISOAKT1 (Homo sapiens)6480464CTDSelenium results in decreased phosphorylation of AKT1 proteinPMID:17339365
Akt1increases expressionISOAKT1 (Homo sapiens)6480464CTDSelenium results in increased expression of AKT1 mRNAPMID:19244175
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTD[Selenium results in decreased phosphorylation of AKT1 protein] which results in increased susceptibility to Doxorubicin; AKT1 protein modified form inhibits the reaction [[Doxorubicin co-treated with Selenium] results in increased degradation of PARP1 protein]; Selenium inhibits the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein]PMID:17339365
Akt1multiple interactionsISOAkt1 (Mus musculus)6480464CTDSelenium inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of and results in decreased activity of AKT1 protein]PMID:17997286
Go Back to source page   Continue to Ontology report