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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1increases phosphorylationEXP 6480464CTDProgesterone results in increased phosphorylation of AKT1 proteinPMID:28324061
Akt1multiple interactionsEXP 6480464CTD[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased phosphorylation of AKT1 protein; Mifepristone inhibits the reaction [Progesterone results in increased phosphorylation of AKT1 protein]; Pertussis Toxin inhibits the reaction [Progesterone results in increased phosphorylation of AKT1 protein]PMID:22465879 PMID:28324061
Akt1increases phosphorylationISOAKT1 (Homo sapiens)6480464CTDProgesterone results in increased phosphorylation of AKT1 proteinPMID:15358673
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Progesterone results in increased phosphorylation of AKT1 protein]PMID:15358673
Akt1multiple interactionsISOAkt1 (Mus musculus)6480464CTDProgesterone inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]PMID:15845746
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