GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Akt1 | increases phosphorylation | EXP | | 6480464 | CTD | Estradiol results in increased phosphorylation of AKT1 protein | PMID:15590986 PMID:16951259 | Akt1 | multiple interactions | EXP | | 6480464 | CTD | [Estradiol co-treated with fulvestrant] results in increased phosphorylation of AKT1 protein; [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased phosphorylation of AKT1 protein; [Estradiol co-treated with Testosterone] results in increased expression of AKT1 mRNA | PMID:11375906 PMID:16951259 PMID:22465879 | Akt1 | affects expression | ISO | Akt1 (Mus musculus) | 6480464 | CTD | Estradiol affects the expression of AKT1 mRNA | PMID:15598610 | Akt1 | decreases expression | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | Estradiol results in decreased expression of AKT1 mRNA | PMID:23373633 | Akt1 | increases phosphorylation | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | Estradiol results in increased phosphorylation of AKT1 protein | PMID:16168102 PMID:21632903 PMID:23000059 PMID:23804311 PMID:23933164 PMID:28882636 PMID:30641053 PMID:37080528 | Akt1 | increases phosphorylation | ISO | Akt1 (Mus musculus) | 6480464 | CTD | Estradiol results in increased phosphorylation of AKT1 protein | PMID:15845746 PMID:23684557 PMID:25461906 | Akt1 | multiple interactions | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone promotes the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Estradiol] results in decreased phosphorylation of AKT1 protein; [Estradiol co-treated with bisphenol A] results in decreased expression of AKT1 mRNA; [Estradiol co-treated with ESR1 protein] results in increased phosphorylation of AKT1 protein; [Estradiol co-treated with sodium arsenite] results in increased phosphorylation of AKT1 protein; [Fulvestrant co-treated with 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline] inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; [U 0126 co-treated with Estradiol] results in increased phosphorylation of AKT1 protein; Acetylcysteine inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; AKT1 protein affects the reaction [Estradiol results in increased expression of CCND1 protein]; BRCA1 protein inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased activity of AKT1 protein]; Estradiol promotes the reaction [AKT1 protein modified form binds to IRS1 protein]; Estradiol results in increased phosphorylation of and results in increased activity of AKT1 protein; Estradiol results in increased phosphorylation of and results in increased activity of and results in increased localization of AKT1 protein; Fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; Genistein inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; NVP-AEW541 inhibits the reaction [Estradiol promotes the reaction [AKT1 protein modified form binds to IRS1 protein]]; PTEN protein affects the reaction [Estradiol promotes the reaction [AKT1 protein modified form binds to IRS1 protein]]; RICTOR mutant form inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; Sirolimus inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; TCL1B protein promotes the reaction [Estradiol results in increased phosphorylation of and results in increased activity of and results in increased localization of AKT1 protein] | PMID:16168102 PMID:18767177 PMID:18997820 PMID:19435893 PMID:20228224 PMID:23000059 PMID:23804311 PMID:23933164 PMID:28882636 PMID:29783106 PMID:30641053 PMID:31614463 | Akt1 | multiple interactions | ISO | Akt1 (Mus musculus) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; Progesterone inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein] | PMID:15845746 PMID:25461906 | | ||||||||||||||||||||||
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