GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Akt1 | increases activity | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | arsenic trichloride results in increased activity of AKT1 protein | PMID:22696236 | Akt1 | increases phosphorylation | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | arsenic trichloride results in increased phosphorylation of AKT1 protein | PMID:25944616 | Akt1 | multiple interactions | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | Acetylcysteine inhibits the reaction [arsenic trichloride results in increased phosphorylation of AKT1 protein]; AKT1 mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of FLNA protein]; arsenic trichloride promotes the reaction [AKT1 protein binds to FLNA protein modified form]; arsenic trichloride promotes the reaction [AKT1 protein modified form binds to FLNA protein modified form]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased activity of AKT1 protein] | PMID:22696236 PMID:25944616 | Akt1 | multiple interactions | ISO | Akt1 (Mus musculus) | 6480464 | CTD | MAPK8 gene mutant form inhibits the reaction [arsenic trichloride results in increased activity of AKT1 protein]; MAPK9 gene mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of AKT1 protein] | PMID:22696236 | | ||||||||||||||||||||||
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