RGD Reference Report - PI3K/Akt: getting it right matters. - Rat Genome Database

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PI3K/Akt: getting it right matters.

Authors: Franke, TF 
Citation: Franke TF Oncogene. 2008 Oct 27;27(50):6473-88.
RGD ID: 2313763
Pubmed: PMID:18955974   (View Abstract at PubMed)
DOI: DOI:10.1038/onc.2008.313   (Journal Full-text)

The Akt serine/threonine kinase (also called protein kinase B) has emerged as a critical signaling molecule within eukaryotic cells. Significant progress has been made in clarifying its regulation by upstream kinases and identifying downstream mechanisms that mediate its effects in cells and contribute to signaling specificity. Here, we provide an overview of present advances in the field regarding the function of Akt in physiological and pathological cell function within a more generalized framework of Akt signal transduction. An emphasis is placed on the involvement of Akt in human diseases ranging from cancer to metabolic dysfunction and mental disease.

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Objects Annotated

Genes (Rattus norvegicus)
Akt1  (AKT serine/threonine kinase 1)
Akt2  (AKT serine/threonine kinase 2)
Akt3  (AKT serine/threonine kinase 3)
Pik3ca  (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha)
Pten  (phosphatase and tensin homolog)

Genes (Mus musculus)
Akt1  (thymoma viral proto-oncogene 1)
Akt2  (thymoma viral proto-oncogene 2)
Akt3  (thymoma viral proto-oncogene 3)
Pik3ca  (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
Pten  (phosphatase and tensin homolog)

Genes (Homo sapiens)
AKT1  (AKT serine/threonine kinase 1)
AKT2  (AKT serine/threonine kinase 2)
AKT3  (AKT serine/threonine kinase 3)
PIK3CA  (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
PTEN  (phosphatase and tensin homolog)


Additional Information