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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway
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Accession:PW:0000801 term browser browse the term
Definition:The pathway of beta adrenergic drug-target interactions and of the biochemical or physiological responses to drug. The beta-agonists are used to stimulate while the beta-blockers are used to inhibit the action of adrenergic beta receptors, as necessary. Adrenergic beta receptors are G-protein coupled receptors that in response to epinephrine or norepinephrine elicit various sympathetic responses important for proper cardiac function and in the case of beta2 receptor, smooth muscle relaxation and bronchodilation. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00296;   SMP:00297
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adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 ISO SMPDB SMP:00296 NCBI chr 1:105,734,992...105,816,272
Ensembl chr 1:105,734,992...105,815,982 		JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 ISO SMPDB SMP:00296 NCBI chr 4:177,262,848...177,386,837
Ensembl chr 4:177,262,848...177,386,348 		JBrowse link
G Adrb1 adrenoceptor beta 1 ISO SMPDB
RGD		 PMID:19127141 SMP:00296, RGD:4140443 NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:265,766,079...265,849,237 		JBrowse link
G Adrb2 adrenoceptor beta 2 ISO RGD PMID:19127141 PMID:18426615 RGD:4140443, RGD:4140444 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a ISO SMPDB SMP:00296 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 ISO SMPDB SMP:00296 NCBI chr 2:191,709,311...191,737,414
Ensembl chr 2:191,709,311...191,737,425 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 ISO SMPDB SMP:00296 NCBI chr13:87,261,964...87,286,911
Ensembl chr13:87,261,968...87,286,911 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 ISO SMPDB SMP:00296 NCBI chr 1:89,700,645...89,729,782
Ensembl chr 1:89,700,649...89,729,825 		JBrowse link
G Atp1a4 ATPase Na+/K+ transporting subunit alpha 4 ISO SMPDB SMP:00296 NCBI chr13:87,216,139...87,252,155
Ensembl chr13:87,216,139...87,251,724 		JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 ISO SMPDB SMP:00296 NCBI chr13:79,319,708...79,340,226
Ensembl chr13:79,319,706...79,340,549 		JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 ISO SMPDB SMP:00296 NCBI chr10:54,817,473...54,823,708
Ensembl chr10:54,817,476...54,823,708 		JBrowse link
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 ISO SMPDB SMP:00296 NCBI chr 8:105,789,824...105,821,151
Ensembl chr 8:65,253,361...65,254,304
Ensembl chr 8:65,253,361...65,254,304 		JBrowse link
G Atp1b4 ATPase Na+/K+ transporting family member beta 4 ISO SMPDB SMP:00296 NCBI chr  X:121,952,923...121,974,146
Ensembl chr  X:121,923,061...121,973,654 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO SMPDB SMP:00296 NCBI chr12:39,733,519...39,782,942
Ensembl chr12:39,733,458...39,782,934 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO SMPDB SMP:00296 NCBI chr 4:153,431,169...154,051,932
Ensembl chr 4:153,436,427...154,051,762 		JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G ISO SMPDB SMP:00296 NCBI chr10:79,851,886...79,919,926
Ensembl chr10:79,851,896...79,919,634 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H ISO SMPDB SMP:00296 NCBI chr10:14,894,630...14,952,317
Ensembl chr10:14,894,641...14,952,771 		JBrowse link
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 ISO SMPDB SMP:00296 NCBI chr 8:116,950,860...117,082,159
Ensembl chr 8:116,950,907...117,081,759 		JBrowse link
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 ISO SMPDB SMP:00296 NCBI chr10:83,494,509...83,515,164
Ensembl chr10:83,494,509...83,515,146 		JBrowse link
G Calm1 calmodulin 1 ISO SMPDB SMP:00296 NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:125,217,246...125,225,381 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 ISO SMPDB SMP:00296 NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,981,006...66,126,464 		JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 ISO SMPDB SMP:00296 NCBI chr11:82,416,853...82,607,797
Ensembl chr11:82,416,853...82,607,797 		JBrowse link
G Fxyd2 FXYD domain-containing ion transport regulator 2 ISO SMPDB SMP:00296 NCBI chr 8:54,609,658...54,616,788
Ensembl chr 8:54,609,658...54,616,957 		JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 ISO SMPDB SMP:00296 NCBI chr 8:68,118,062...68,155,482
Ensembl chr 8:68,118,062...68,155,495 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 ISO SMPDB SMP:00296 NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:142,743,334...143,066,504 		JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 ISO SMPDB SMP:00296 NCBI chr 4:161,040,853...161,044,311
Ensembl chr 4:160,996,950...161,044,408 		JBrowse link
G Kcnd3 potassium voltage-gated channel subfamily D member 3 ISO SMPDB SMP:00296 NCBI chr 2:195,626,316...195,843,690
Ensembl chr 2:195,626,316...195,843,690 		JBrowse link
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 ISO SMPDB SMP:00296 NCBI chr11:45,066,875...45,080,024
Ensembl chr11:45,064,162...45,081,247 		JBrowse link
G Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 ISO SMPDB SMP:00296 NCBI chr11:45,003,468...45,015,942
Ensembl chr11:45,014,406...45,016,168 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 ISO SMPDB SMP:00296 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421 		JBrowse link
G Kcnip2 potassium voltage-gated channel interacting protein 2 ISO SMPDB SMP:00296 NCBI chr 1:254,590,172...254,614,437
Ensembl chr 1:254,590,175...254,613,898 		JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 ISO SMPDB SMP:00296 NCBI chr 1:105,727,473...105,731,167
Ensembl chr 1:105,727,570...105,731,169 		JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 ISO SMPDB SMP:00296 NCBI chr10:96,560,225...96,570,788
Ensembl chr10:96,565,600...96,570,901 		JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 ISO SMPDB SMP:00296 NCBI chr 3:60,353,990...60,518,110
Ensembl chr 3:60,354,146...60,518,104 		JBrowse link
G Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 ISO SMPDB SMP:00296 NCBI chr 7:112,927,494...112,954,547
Ensembl chr 7:112,922,532...112,954,826 		JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 ISO SMPDB SMP:00296 NCBI chr 8:38,981,598...39,011,197
Ensembl chr 8:38,983,034...39,011,101 		JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 ISO SMPDB SMP:00296 NCBI chr 4:177,240,692...177,246,548
Ensembl chr 4:177,239,908...177,246,531 		JBrowse link
G Kcnk1 potassium two pore domain channel subfamily K member 1 ISO SMPDB SMP:00296 NCBI chr19:70,856,985...70,895,053
Ensembl chr19:70,856,985...70,895,051 		JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 ISO SMPDB SMP:00296 NCBI chr 1:207,721,134...208,054,073
Ensembl chr 1:207,721,131...208,054,072 		JBrowse link
G Mylk myosin light chain kinase ISO SMPDB SMP:00296 NCBI chr11:79,288,243...79,535,450
Ensembl chr11:79,288,243...79,535,659 		JBrowse link
G Plcb1 phospholipase C beta 1 ISO SMPDB SMP:00296 NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:142,513,033...143,225,646 		JBrowse link
G Pln phospholamban ISO SMPDB SMP:00296 NCBI chr20:33,166,512...33,182,241
Ensembl chr20:33,172,494...33,182,241 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha ISO SMPDB SMP:00296 NCBI chr19:41,059,843...41,083,189
Ensembl chr19:41,059,843...41,086,494 		JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha ISO SMPDB SMP:00296 NCBI chr10:95,120,537...95,139,028
Ensembl chr10:95,120,487...95,139,025 		JBrowse link
G Ryr2 ryanodine receptor 2 ISO SMPDB SMP:00296 NCBI chr17:63,081,527...63,667,141
Ensembl chr17:63,081,527...63,666,705 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO SMPDB SMP:00296 NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:128,098,613...128,196,470 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 ISO SMPDB SMP:00296 NCBI chr 6:18,975,498...19,299,704
Ensembl chr 6:18,946,798...19,287,964 		JBrowse link
G Snta1 syntrophin, alpha 1 ISO SMPDB SMP:00296 NCBI chr 3:163,336,509...163,366,954
Ensembl chr 3:163,336,516...163,366,927 		JBrowse link
G Sntb1 syntrophin, beta 1 ISO SMPDB SMP:00296 NCBI chr 7:88,950,642...89,219,017
Ensembl chr 7:88,950,642...89,219,017 		JBrowse link
G Sntb2 syntrophin, beta 2 ISO SMPDB SMP:00296 NCBI chr19:51,739,492...51,832,083
Ensembl chr19:51,741,183...51,823,872 		JBrowse link
G Tnnc1 troponin C1, slow skeletal and cardiac type ISO SMPDB SMP:00296 NCBI chr16:6,408,607...6,412,070
Ensembl chr16:6,408,607...6,412,070 		JBrowse link
G Tnnc2 troponin C2, fast skeletal type ISO SMPDB SMP:00296 NCBI chr 3:173,932,611...173,935,339
Ensembl chr 3:173,932,611...173,935,339 		JBrowse link
G Tnni1 troponin I1, slow skeletal type ISO SMPDB SMP:00296 NCBI chr13:49,781,529...49,793,385
Ensembl chr13:49,780,951...49,793,390 		JBrowse link
G Tnni2 troponin I2, fast skeletal type ISO SMPDB SMP:00296 NCBI chr 1:206,882,358...207,027,034
Ensembl chr 1:207,024,416...207,027,038 		JBrowse link
G Tnni3 troponin I3, cardiac type ISO SMPDB SMP:00296 NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:78,342,592...78,346,253 		JBrowse link
G Tnnt1 troponin T1, slow skeletal type ISO SMPDB SMP:00296 NCBI chr 1:78,349,035...78,359,394
Ensembl chr 1:78,349,035...78,359,394 		JBrowse link
G Tnnt2 troponin T2, cardiac type ISO SMPDB SMP:00296 NCBI chr13:49,819,123...49,837,125
Ensembl chr13:49,822,304...49,837,125 		JBrowse link
G Tnnt3 troponin T3, fast skeletal type ISO SMPDB SMP:00296 NCBI chr 1:207,082,014...207,099,014
Ensembl chr 1:207,081,812...207,099,423 		JBrowse link
G Tpm1 tropomyosin 1 ISO SMPDB SMP:00296 NCBI chr 8:76,516,654...76,543,661
Ensembl chr 8:76,511,871...76,543,468 		JBrowse link
G Tpm2 tropomyosin 2 ISO SMPDB SMP:00296 NCBI chr 5:62,566,712...62,576,066
Ensembl chr 5:62,566,652...62,575,726 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    drug pathway 397
      respiratory system drug pathway 80
        adrenergic beta receptor drug pathway - beta-agonist and beta-blocker 60
          adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway 60
paths to the root