RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Chemical and Drug Induced Liver Injury
Accession: DOID:9007383
browse the term
Definition: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
Synonyms: exact_synonym: Chemically Induced Liver Toxicity; Drug Induced Acute Liver Injury; Drug Induced Liver Disease; Drug Induced Liver Injury; Drug-Induced Liver Diseases; Drug-Induced Liver Injuries; Toxic Hepatitis; chemically-induced liver toxicities; hepatotoxicity; toxic hepatitides
narrow_synonym: Drug-induced liver injury due to flucloxacillin
primary_id: MESH:D056486
alt_id: RDO:0007742
xref: EFO:0004228 ; EFO:0011052 ; NCI:C84427
GViewer not supported for the selected species.
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Aass
aminoadipate-semialdehyde synthase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624783:13,831,220...13,904,806
Ensembl chrNW_004624783:13,831,150...13,902,082
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Abcb11
ATP binding cassette subfamily B member 11
severity
ISO
DNA:SNP: :rs2287616(human)
RGD
PMID:27293027
RGD:14402413
NCBI chrNW_004624787:6,653,849...6,733,058
Ensembl chrNW_004624787:6,650,772...6,733,195
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Abcc1
ATP binding cassette subfamily C member 1 (ABCC1 blood group)
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18466103
NCBI chrNW_004624782:449,217...590,306
Ensembl chrNW_004624782:449,288...591,310
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Abcc2
ATP binding cassette subfamily C member 2
susceptibility
ISO
DNA:polymorphism:promoter:-24C>T(human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:17241877 PMID:18381794 PMID:18466103 PMID:25196354
RGD:14700812 RGD:14700814
NCBI chrNW_004624737:11,593,701...11,686,790
Ensembl chrNW_004624737:11,593,864...11,688,460
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Abi1
abl interactor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624796:2,312,005...2,431,284
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Ace
angiotensin I converting enzyme
ISO
mRNA:increased expression:liver (rat)
RGD
PMID:25143335
RGD:25671447
NCBI chrNW_004624849:998,262...1,019,305
Ensembl chrNW_004624849:998,277...1,019,521
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Acox3
acyl-CoA oxidase 3, pristanoyl
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624755:23,995,256...24,026,581
Ensembl chrNW_004624755:23,995,089...24,024,083
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Acsl1
acyl-CoA synthetase long chain family member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624769:15,503,757...15,584,741
Ensembl chrNW_004624769:15,503,757...15,584,777
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Actb
actin beta
ISO
CTD Direct Evidence: marker/mechanism mRNA:increased expression:liver
CTD RGD
PMID:22563491 PMID:25231249
RGD:9587759
NCBI chrNW_004624740:28,087,051...28,090,359
Ensembl chrNW_004624740:28,087,736...28,090,512
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Actn4
actinin alpha 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624794:12,042,627...12,113,762
Ensembl chrNW_004624794:12,042,533...12,113,886
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Actr3
actin related protein 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624732:31,360,804...31,427,885
Ensembl chrNW_004624732:31,361,147...31,427,811
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Ada
adenosine deaminase
ISO
protein:increased expression:liver
RGD
PMID:21161045
RGD:5128859
NCBI chrNW_004624790:9,809,550...9,829,199
Ensembl chrNW_004624790:9,809,492...9,829,883
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Adam8
ADAM metallopeptidase domain 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24646716
NCBI chrNW_004624737:13,459,274...13,474,686
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Adipoq
adiponectin, C1Q and collagen domain containing
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:20709802
NCBI chrNW_004624730:69,941,963...69,959,266
Ensembl chrNW_004624730:69,941,001...69,957,012
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Adipor2
adiponectin receptor 2
severity
ISO
associated with obesity, LPS;mRNA:decreased expression:liver (rat)
RGD
PMID:23838384
RGD:8695926
NCBI chrNW_004624735:11,103,082...11,174,277
Ensembl chrNW_004624735:11,103,076...11,174,337
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Adora2b
adenosine A2b receptor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:35292334
NCBI chrNW_004624877:4,421,307...4,447,574
Ensembl chrNW_004624877:4,422,022...4,447,460
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Agt
angiotensinogen
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29499335
NCBI chrNW_004624775:18,846,222...18,856,093
Ensembl chrNW_004624775:18,849,118...18,855,577
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Ahr
aryl hydrocarbon receptor
ISO
CTD Direct Evidence: marker/mechanism|therapeutic mRNA:decreased expression:liver (rat)
CTD RGD
PMID:21890736 PMID:28959666 PMID:34848246
RGD:401794432
NCBI chrNW_004624739:12,939,183...12,987,574
Ensembl chrNW_004624739:12,942,165...12,987,973
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Aifm1
apoptosis inducing factor mitochondria associated 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25743375
NCBI chrNW_004624797:9,346,620...9,384,531
Ensembl chrNW_004624797:9,345,726...9,384,645
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Ak4
adenylate kinase 4
ISO
protein:increased expression:liver (rat)
RGD
PMID:16538043
RGD:2301096
NCBI chrNW_004624742:29,547,237...29,574,160
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Akr1a1
aldo-keto reductase family 1 member A1
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:29763686 PMID:32805337
RGD:27226688
NCBI chrNW_004624906:1,463,201...1,474,001
Ensembl chrNW_004624906:1,462,693...1,474,214
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Alb
albumin
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:18779383 PMID:22310181 PMID:27567545
RGD:14694844
NCBI chrNW_004624735:34,105,237...34,123,479
Ensembl chrNW_004624735:34,104,537...34,123,624
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Aldh1l2
aldehyde dehydrogenase 1 family member L2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624750:3,912,030...4,054,170
Ensembl chrNW_004624750:3,912,002...3,961,963
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Aldh2
aldehyde dehydrogenase 2 family member
severity susceptibility
ISO
DNA:deletion:exon 3 (mouse) protein:increased expression:liver
RGD
PMID:21138988 PMID:24492981 PMID:30121625
RGD:14975148 RGD:15036810 RGD:7241599
NCBI chrNW_004624747:20,407,190...20,438,605
Ensembl chrNW_004624747:20,403,717...20,438,690
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Aldh9a1
aldehyde dehydrogenase 9 family member A1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624826:3,994,188...4,026,437
Ensembl chrNW_004624826:3,994,183...4,026,696
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Aldob
aldolase, fructose-bisphosphate B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16115720
NCBI chrNW_004624758:9,868,223...9,880,205
Ensembl chrNW_004624758:9,868,260...9,880,205
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Ambp
alpha-1-microglobulin/bikunin precursor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18779383
NCBI chrNW_004624760:21,047,576...21,064,698
Ensembl chrNW_004624760:21,047,303...21,068,076
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Anxa2
annexin A2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624781:11,781,893...11,820,440
Ensembl chrNW_004624781:11,781,886...11,821,816
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Anxa6
annexin A6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624733:41,024,503...41,071,390
Ensembl chrNW_004624733:41,024,514...41,071,353
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Apoa1
apolipoprotein A1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942
NCBI chrNW_004624784:12,249,283...12,251,215
Ensembl chrNW_004624784:12,249,283...12,251,136
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Apoe
apolipoprotein E
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942
NCBI chrNW_004624907:1,752,322...1,755,308
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Apoh
apolipoprotein H
ISO
CTD Direct Evidence: marker/mechanism mRNA:increased expression:plasma:
CTD RGD
PMID:16099942 PMID:23288050
RGD:10054107
NCBI chrNW_004624870:2,082,050...2,096,220
Ensembl chrNW_004624870:2,081,968...2,099,517
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Arg1
arginase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22872058
NCBI chrNW_004624753:5,737,720...5,749,313
Ensembl chrNW_004624753:5,737,237...5,752,966
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Arnt
aryl hydrocarbon receptor nuclear translocator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20935161
NCBI chrNW_004624772:18,949,221...19,016,672
Ensembl chrNW_004624772:18,949,108...19,015,504
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Atg5
autophagy related 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22491424
NCBI chrNW_004624780:15,987,483...16,124,158
Ensembl chrNW_004624780:15,987,397...16,124,151
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Atoh8
atonal bHLH transcription factor 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624749:17,397,332...17,428,980
Ensembl chrNW_004624749:17,399,111...17,428,893
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Atp6v1d
ATPase H+ transporting V1 subunit D
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624734:33,640,842...33,669,471
Ensembl chrNW_004624734:33,640,839...33,657,745
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Avp
arginine vasopressin
ISO
DNA:SNP:intron: (rs2282018)
RGD
PMID:28462386
RGD:408364979
NCBI chrNW_004624741:4,208,305...4,210,097
Ensembl chrNW_004624741:4,208,329...4,210,071
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Bad
BCL2 associated agonist of cell death
treatment
ISO
RGD
PMID:25447754
RGD:10053709
NCBI chrNW_004624767:22,025,721...22,037,283
Ensembl chrNW_004624767:22,026,133...22,037,277
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Bax
BCL2 associated X, apoptosis regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17906064
NCBI chrNW_004624832:5,050,222...5,068,565
Ensembl chrNW_004624832:5,050,222...5,055,506
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Bdh1
3-hydroxybutyrate dehydrogenase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624730:62,397,242...62,466,172
Ensembl chrNW_004624730:62,397,245...62,424,924
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Bdkrb2
bradykinin receptor B2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30685357
NCBI chrNW_004624734:8,513,601...8,538,838
Ensembl chrNW_004624734:8,513,814...8,539,036
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Blvrb
biliverdin reductase B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624925:432,137...452,946
Ensembl chrNW_004624925:432,137...452,903
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Bmal1
basic helix-loop-helix ARNT like 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:36602574
NCBI chrNW_004624766:5,295,120...5,391,645
Ensembl chrNW_004624766:5,317,635...5,391,645
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Bpnt1
3'(2'), 5'-bisphosphate nucleotidase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624835:3,704,455...3,722,825
Ensembl chrNW_004624835:3,704,664...3,718,129
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Brd4
bromodomain containing 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624901:2,348,218...2,434,429
Ensembl chrNW_004624901:2,346,734...2,380,852
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Btd
biotinidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15469856
NCBI chrNW_004624821:926,159...948,331
Ensembl chrNW_004624821:926,310...949,065
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C3
complement C3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942
NCBI chrNW_004624828:3,773,816...3,798,077
Ensembl chrNW_004624828:3,770,221...3,797,946
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Ca3
carbonic anhydrase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513 PMID:25231249
NCBI chrNW_004624744:6,202,151...6,211,662
Ensembl chrNW_004624744:6,199,382...6,212,163
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Cabp1
calcium binding protein 1
ISO
protein:increased expression:liver
RGD
PMID:21138988
RGD:7241599
NCBI chrNW_004624747:13,027,839...13,050,262
Ensembl chrNW_004624747:13,027,844...13,050,165
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Cadps2
calcium dependent secretion activator 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chrNW_004624783:13,142,036...13,701,430
Ensembl chrNW_004624783:13,142,198...13,700,683
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Canx
calnexin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624733:42,588,680...42,616,624
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Cap1
cyclase associated actin cytoskeleton regulatory protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624764:22,517,254...22,542,356
Ensembl chrNW_004624764:22,517,315...22,542,351
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Casp8
caspase 8
treatment
ISO
RGD
PMID:25447754
RGD:10053709
NCBI chrNW_004624899:427,064...450,931
Ensembl chrNW_004624899:424,363...451,087
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Cast
calpastatin
ISO
RGD
PMID:16871587
RGD:5683869
NCBI chrNW_004624743:15,265,930...15,405,904
Ensembl chrNW_004624743:15,346,837...15,403,150
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Cat
catalase
ISO
CTD Direct Evidence: marker/mechanism protein:decreased expression:liver
CTD RGD
PMID:20623750 PMID:21138988 PMID:25231249
RGD:7241599
NCBI chrNW_004624767:12,680,940...12,715,468
Ensembl chrNW_004624767:12,680,953...12,715,739
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Ccdc80
coiled-coil domain containing 80
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624731:35,891,180...35,928,497
Ensembl chrNW_004624731:35,891,184...35,929,936
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Cct3
chaperonin containing TCP1 subunit 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624885:1,575,560...1,592,540
Ensembl chrNW_004624885:1,575,562...1,592,594
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Cct5
chaperonin containing TCP1 subunit 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624751:7,615,098...7,628,985
Ensembl chrNW_004624751:7,615,007...7,630,606
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Cdc25b
cell division cycle 25B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624741:4,871,275...4,892,730
Ensembl chrNW_004624741:4,882,516...4,892,925
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Cds1
CDP-diacylglycerol synthase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624900:1,701,507...1,765,791
Ensembl chrNW_004624900:1,701,522...1,766,768
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Cela1
chymotrypsin like elastase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624816:906,103...939,252
Ensembl chrNW_004624816:906,121...939,696
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Cfap20
cilia and flagella associated protein 20
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624746:28,071,502...28,085,040
Ensembl chrNW_004624746:28,071,519...28,085,231
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Cfh
complement factor H
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624798:3,332,549...3,414,435
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Chrm3
cholinergic receptor muscarinic 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20197374
NCBI chrNW_004624775:10,948,075...11,427,898
Ensembl chrNW_004624775:10,949,983...10,951,755
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Ckb
creatine kinase B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624734:1,346,056...1,349,383
Ensembl chrNW_004624734:1,346,510...1,349,383
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Clu
clusterin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20623750
NCBI chrNW_004624758:22,431,331...22,444,185
Ensembl chrNW_004624758:22,426,918...22,444,357
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Col14a1
collagen type XIV alpha 1 chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624763:17,982,646...18,172,742
Ensembl chrNW_004624763:17,982,646...18,172,904
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Col3a1
collagen type III alpha 1 chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16679477
NCBI chrNW_004624899:1,192,078...1,230,528
Ensembl chrNW_004624899:1,192,360...1,230,404
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Comt
catechol-O-methyltransferase
ISO
protein:decreased expression:liver
RGD
PMID:21138988
RGD:7241599
NCBI chrNW_004624747:569,127...588,479
Ensembl chrNW_004624747:581,832...588,333
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Coq9
coenzyme Q9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624746:28,614,589...28,630,774
Ensembl chrNW_004624746:28,615,215...28,630,667
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Cp
ceruloplasmin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624730:26,458,554...26,510,796
Ensembl chrNW_004624730:26,462,550...26,511,078
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Cpb2
carboxypeptidase B2
ISO
mRNA,protein:increased expression,increased activity:liver,plasma
RGD
PMID:19386599
RGD:7243112
NCBI chrNW_004624748:8,850,128...8,927,986
Ensembl chrNW_004624748:8,849,900...8,928,853
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Cps1
carbamoyl-phosphate synthase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624765:5,527,029...5,652,343
Ensembl chrNW_004624765:5,528,112...5,651,415
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Cpt1a
carnitine palmitoyltransferase 1A
ISO
mRNA:decreased expression:liver (rat)
RGD
PMID:28959666
RGD:401794432
NCBI chrNW_004624767:18,109,011...18,161,378
Ensembl chrNW_004624767:18,109,008...18,161,639
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Crp
C-reactive protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624794:1,531,555...1,533,804
Ensembl chrNW_004624794:1,531,571...1,533,804
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Csf3
colony stimulating factor 3
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:20005281 PMID:33882750
NCBI chrNW_004624795:3,162,999...3,167,248
Ensembl chrNW_004624795:3,163,009...3,166,594
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Ctnnb1
catenin beta 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:19679878
NCBI chrNW_004624730:77,876,361...77,887,228
Ensembl chrNW_004624730:77,875,257...77,887,234
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Ctse
cathepsin E
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624807:5,291,993...5,306,507
Ensembl chrNW_004624807:5,291,736...5,305,104
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Cxcl10
C-X-C motif chemokine ligand 10
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:11739529
NCBI chrNW_004624757:14,989,241...14,991,650
Ensembl chrNW_004624757:14,989,084...14,991,910
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Cxcl14
C-X-C motif chemokine ligand 14
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:38614205
NCBI chrNW_004624733:11,455,166...11,463,086
Ensembl chrNW_004624733:11,455,047...11,463,176
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Dbt
dihydrolipoamide branched chain transacylase E2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624857:3,056,799...3,138,430
Ensembl chrNW_004624857:3,056,781...3,138,396
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Ddb1
damage specific DNA binding protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624926:871,003...893,902
Ensembl chrNW_004624926:871,000...897,777
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Dgat2
diacylglycerol O-acyltransferase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17984051
NCBI chrNW_004624817:1,386,876...1,418,129
Ensembl chrNW_004624817:1,386,764...1,418,300
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Dhfr
dihydrofolate reductase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19648163
NCBI chrNW_004624743:1,446,643...1,462,319
Ensembl chrNW_004624743:1,446,643...1,461,863
G
Dhrs7
dehydrogenase/reductase 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624734:40,994,786...41,006,001
Ensembl chrNW_004624734:40,993,587...41,006,074
G
Dlat
dihydrolipoamide S-acetyltransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624784:7,181,550...7,216,779
Ensembl chrNW_004624784:7,181,671...7,214,751
G
Dnajb9
DnaJ heat shock protein family (Hsp40) member B9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chrNW_004624739:21,187,581...21,193,345
Ensembl chrNW_004624739:21,187,581...21,193,337
G
Dnajc12
DnaJ heat shock protein family (Hsp40) member C12
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chrNW_004624754:2,175,204...2,227,405
Ensembl chrNW_004624754:2,172,942...2,227,529
G
Dsc2
desmocollin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624770:1,748,561...1,778,566
Ensembl chrNW_004624770:1,748,276...1,781,117
G
E2f1
E2F transcription factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30515189
NCBI chrNW_004624842:5,602,432...5,612,951
Ensembl chrNW_004624842:5,602,432...5,612,951
G
Echdc1
ethylmalonyl-CoA decarboxylase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624753:1,707,116...1,750,708
Ensembl chrNW_004624753:1,708,153...1,740,824
G
Echs1
enoyl-CoA hydratase, short chain 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624737:13,329,052...13,338,358
Ensembl chrNW_004624737:13,328,904...13,338,366
G
Edem1
ER degradation enhancing alpha-mannosidase like protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624773:15,846,347...15,878,312
Ensembl chrNW_004624773:15,846,553...15,878,803
G
Eif2ak1
eukaryotic translation initiation factor 2 alpha kinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25411909
NCBI chrNW_004624740:31,223,583...31,306,749
Ensembl chrNW_004624740:31,274,483...31,306,430
G
Eif4ebp2
eukaryotic translation initiation factor 4E binding protein 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624754:4,523,616...4,553,994
Ensembl chrNW_004624754:4,523,661...4,549,936
G
Endog
endonuclease G
ISO
protein:decreased expression:mitochondrion:
RGD
PMID:22509279
RGD:9685364
NCBI chrNW_004624760:6,193,168...6,196,209
Ensembl chrNW_004624760:6,193,173...6,196,374
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Eng
endoglin
ISO
protein:increased expression:liver (rat)
RGD
PMID:21146604
RGD:7257529
NCBI chrNW_004624760:7,703,979...7,735,636
Ensembl chrNW_004624760:7,703,820...7,734,457
G
Eno1
enolase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942 PMID:25231249
NCBI chrNW_004624818:3,223,384...3,235,128
Ensembl chrNW_004624818:3,223,308...3,238,419
G
Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
ISO
protein:increased activity:serum:
RGD
PMID:17850827
RGD:9685426
NCBI chrNW_004624763:17,677,825...17,775,284
Ensembl chrNW_004624763:17,677,722...17,765,292
G
Ephx1
epoxide hydrolase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624835:6,161,930...6,181,016
Ensembl chrNW_004624835:6,162,111...6,168,714
G
Erlec1
endoplasmic reticulum lectin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chrNW_004624833:7,964,815...7,992,277
Ensembl chrNW_004624833:7,964,810...7,992,582
G
Ern1
endoplasmic reticulum to nucleus signaling 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30538632
NCBI chrNW_004624849:1,521,996...1,625,878
Ensembl chrNW_004624849:1,525,235...1,625,893
G
F13a1
coagulation factor XIII A chain
ISO
RGD
PMID:22019897
RGD:11041813
NCBI chrNW_004624756:19,103,064...19,259,632
Ensembl chrNW_004624756:19,103,327...19,259,964
G
F2rl3
F2R like thrombin or trypsin receptor 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20974703
NCBI chrNW_004624908:761,067...764,562
Ensembl chrNW_004624908:762,356...766,563
G
F3
coagulation factor III, tissue factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22407844
NCBI chrNW_004624742:3,112,827...3,123,424
Ensembl chrNW_004624742:3,112,801...3,124,301
G
Fadd
Fas associated via death domain
treatment
ISO
RGD
PMID:25447754 PMID:26062544
RGD:10053709 RGD:11341803
NCBI chrNW_004624767:17,050,929...17,059,648
Ensembl chrNW_004624767:17,055,509...17,059,705
G
Fads1
fatty acid desaturase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624926:594,421...607,654
Ensembl chrNW_004624926:598,922...606,611
G
Fads2
fatty acid desaturase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624926:529,456...548,800
Ensembl chrNW_004624926:528,791...548,854
G
Fas
Fas cell surface death receptor
ISO
protein:increased expression:liver (rat)
RGD
PMID:16831245
RGD:8662853
NCBI chrNW_004624791:15,290,022...15,315,848
Ensembl chrNW_004624791:15,289,348...15,315,848
G
Fasn
fatty acid synthase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624801:10,910,022...10,926,505
Ensembl chrNW_004624801:10,909,647...10,927,547
G
Fcmr
Fc mu receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624807:4,567,240...4,581,406
G
Fga
fibrinogen alpha chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20974703
NCBI chrNW_004624858:5,848,817...5,856,448
G
Fgf21
fibroblast growth factor 21
severity
ISO
mRNA:increased expression:liver (rat)
RGD
PMID:29883717
RGD:15045603
NCBI chrNW_004624832:5,165,195...5,166,865
Ensembl chrNW_004624832:5,164,856...5,167,370
G
Flt1
fms related receptor tyrosine kinase 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:21135413
NCBI chrNW_004624776:10,043,113...10,218,598
Ensembl chrNW_004624776:10,043,258...10,219,104
G
Ftl
ferritin light chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624832:5,046,207...5,047,828
Ensembl chrNW_004624832:5,046,208...5,047,828
G
G6pc1
glucose-6-phosphatase catalytic subunit 1
ISO
mRNA:decreased expression:liver (mouse)
RGD
PMID:28189721
RGD:14695531
NCBI chrNW_004624795:1,331,592...1,339,575
Ensembl chrNW_004624795:1,331,601...1,339,580
G
G6pd
glucose-6-phosphate dehydrogenase
treatment
ISO
RGD
PMID:21864513
RGD:10449168
NCBI chrNW_004624946:989,376...1,001,787
Ensembl chrNW_004624946:986,107...1,001,955
G
Gadd45a
growth arrest and DNA damage inducible alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20623750
NCBI chrNW_004624742:27,727,801...27,730,252
Ensembl chrNW_004624742:27,727,660...27,730,316
G
Ganab
glucosidase II alpha subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624926:1,147,470...1,160,901
Ensembl chrNW_004624926:1,146,886...1,160,876
G
Gc
GC vitamin D binding protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942
NCBI chrNW_004624890:3,274,239...3,318,281
Ensembl chrNW_004624890:3,226,900...3,318,316
G
Gclc
glutamate-cysteine ligase catalytic subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:17573345 PMID:19481141
RGD:10402383
NCBI chrNW_004624850:749,046...793,654
Ensembl chrNW_004624850:749,050...793,959
G
Gclm
glutamate-cysteine ligase modifier subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624742:3,713,275...3,746,219
Ensembl chrNW_004624742:3,713,250...3,743,290
G
Gda
guanine deaminase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624736:836,283...914,616
Ensembl chrNW_004624736:836,286...914,409
G
Gdi1
GDP dissociation inhibitor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624946:902,831...908,815
Ensembl chrNW_004624946:902,461...909,613
G
Gfer
growth factor, augmenter of liver regeneration
treatment
ISO
RGD
PMID:15968720 PMID:22033404
RGD:9685722 RGD:9685727
NCBI chrNW_004624913:273,126...276,353
Ensembl chrNW_004624913:273,705...275,693
G
Ggh
gamma-glutamyl hydrolase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21219404
NCBI chrNW_004624744:28,752,785...28,786,293
Ensembl chrNW_004624744:28,752,909...28,785,661
G
Ggt1
gamma-glutamyltransferase 1
ISO
RGD
PMID:10934156
RGD:14701049
NCBI chrNW_004624747:10,030,034...10,048,554
G
Ghrl
ghrelin and obestatin prepropeptide
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:34151639
NCBI chrNW_004624731:5,257,813...5,262,878
Ensembl chrNW_004624731:5,257,830...5,262,473
G
Glud1
glutamate dehydrogenase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33483742
NCBI chrNW_004624841:133,267...171,324
G
Got1
glutamic-oxaloacetic transaminase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624737:11,114,818...11,153,209
Ensembl chrNW_004624737:11,115,066...11,153,211
G
Gpd1
glycerol-3-phosphate dehydrogenase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624816:2,203,731...2,211,006
Ensembl chrNW_004624816:2,203,731...2,210,509
G
Gpt
glutamic--pyruvic transaminase
treatment
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression, activity:serum:
RGD CTD
PMID:145039 PMID:19085960 PMID:19481104 PMID:21772750 PMID:27293452 PMID:28487901 More...
RGD:14975162 RGD:14975166 RGD:14975168 RGD:14975249
NCBI chrNW_004624735:12,355,476...12,359,910
Ensembl chrNW_004624735:12,355,476...12,360,028
G
Gpt2
glutamic--pyruvic transaminase 2
ISO
protein:increased expression, activity:serum:
RGD
PMID:19085960
RGD:14975249
NCBI chrNW_004624914:460,240...501,087
Ensembl chrNW_004624914:459,701...501,765
G
Grk4
G protein-coupled receptor kinase 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624755:24,741,985...24,789,972
Ensembl chrNW_004624755:24,742,073...24,830,314
G
Gsn
gelsolin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942
NCBI chrNW_004624760:13,943,680...14,004,660
Ensembl chrNW_004624760:13,943,888...13,969,905
G
Gsr
glutathione-disulfide reductase
treatment
ISO
mRNA, protein:increased expression:liver CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:23554813 PMID:24154663 PMID:25226513 PMID:28069987
RGD:10401878 RGD:7257532
NCBI chrNW_004624780:13,440,269...13,497,435
Ensembl chrNW_004624780:13,440,235...13,496,535
G
Gsta4
glutathione S-transferase alpha 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624850:201,119...217,302
Ensembl chrNW_004624850:201,592...216,680
G
Gstm3
glutathione S-transferase mu 3
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:25743375
NCBI chrNW_004624772:5,495,452...5,498,714
Ensembl chrNW_004624772:5,495,452...5,498,652
G
Gsto1
glutathione S-transferase omega 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624831:3,342,539...3,351,766
Ensembl chrNW_004624831:3,342,584...3,352,467
G
Hacl1
2-hydroxyacyl-CoA lyase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chrNW_004624822:5,078,925...5,189,253
Ensembl chrNW_004624822:5,079,634...5,145,503
G
Hadha
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624738:8,338,250...8,384,701
Ensembl chrNW_004624738:8,338,250...8,384,704
G
Hamp
hepcidin antimicrobial peptide
ISO
mRNA:increased expression:hepatocyte
RGD
PMID:24373749
RGD:11041724
NCBI chrNW_004624794:8,257,760...8,259,243
Ensembl chrNW_004624794:8,257,760...8,259,264
G
Hao2
hydroxyacid oxidase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624772:14,981,777...15,022,699
Ensembl chrNW_004624772:14,981,666...15,023,173
G
Havcr1
hepatitis A virus cellular receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20623750
NCBI chrNW_004624733:32,284,793...32,310,980
G
Hmgb1
high mobility group box 1
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:19783637 PMID:29091898
RGD:15090820
NCBI chrNW_004624776:7,858,400...7,862,716
Ensembl chrNW_004624776:7,793,259...7,863,184
G
Hmox1
heme oxygenase 1
treatment
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD RGD
PMID:18227147 PMID:22688006 PMID:22886620 PMID:29091898
RGD:10762620 RGD:15090820
NCBI chrNW_004624750:341,699...346,005
Ensembl chrNW_004624750:342,146...345,887
G
Hpd
4-hydroxyphenylpyruvate dioxygenase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942 PMID:22872058
NCBI chrNW_004624747:22,209,191...22,217,665
Ensembl chrNW_004624747:22,209,009...22,217,841
G
Hprt1
hypoxanthine phosphoribosyltransferase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624797:14,148,580...14,184,471
G
Hpx
hemopexin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942
NCBI chrNW_004624817:7,947,554...7,957,553
Ensembl chrNW_004624817:7,947,639...7,957,462
G
Hrh2
histamine receptor H2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22926047
NCBI chrNW_004624733:14,261,799...14,308,320
Ensembl chrNW_004624733:14,260,720...14,308,217
G
Hspa5
heat shock protein family A (Hsp70) member 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624760:9,986,529...9,991,261
Ensembl chrNW_004624760:9,986,656...9,995,252
G
Hspa8
heat shock protein family A (Hsp70) member 8
ISO
protein:altered localization:liver (rat)
RGD
PMID:12376827
RGD:10059389
NCBI chrNW_004624880:2,070,410...2,075,069
Ensembl chrNW_004624880:2,070,523...2,079,421
G
Icam1
intercellular adhesion molecule 1
treatment
ISO
RGD
PMID:29091898
RGD:15090820
NCBI chrNW_004624828:2,432,584...2,451,997
Ensembl chrNW_004624828:2,432,550...2,453,071
G
Idh2
isocitrate dehydrogenase (NADP(+)) 2
severity
ISO
RGD
PMID:31121248
RGD:14985250
NCBI chrNW_004624768:17,094,649...17,111,333
Ensembl chrNW_004624768:17,094,655...17,111,397
G
Ido2
indoleamine 2,3-dioxygenase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32289347
NCBI chrNW_004624780:3,620,899...3,668,351
Ensembl chrNW_004624780:3,621,623...3,668,177
G
Ifng
interferon gamma
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:12153990 PMID:21245496 PMID:30013034
RGD:14975100
NCBI chrNW_004624802:163,261...166,534
Ensembl chrNW_004624802:163,261...166,534
G
Igf1
insulin like growth factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23639586 PMID:25226513
NCBI chrNW_004624750:5,881,065...5,954,799
Ensembl chrNW_004624750:5,881,091...5,952,300
G
Il11
interleukin 11
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:11421492
NCBI chrNW_004624832:1,932,959...1,936,937
Ensembl chrNW_004624832:1,933,179...1,935,971
G
Il12b
interleukin 12B
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:36520315
NCBI chrNW_004624733:30,146,050...30,156,144
Ensembl chrNW_004624733:30,146,050...30,154,589
G
Il17a
interleukin 17A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19633216 PMID:24949944
NCBI chrNW_004624855:3,911,349...3,914,214
Ensembl chrNW_004624855:3,911,349...3,913,136
G
Il18
interleukin 18
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19164858
NCBI chrNW_004624784:7,294,286...7,312,959
Ensembl chrNW_004624784:7,294,183...7,304,687
G
Il1a
interleukin 1 alpha
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:8218930
NCBI chrNW_004624749:12,795,967...12,805,658
Ensembl chrNW_004624749:12,795,946...12,805,154
G
Il1b
interleukin 1 beta
treatment
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
RGD CTD
PMID:19164858 PMID:23102243 PMID:28138970 PMID:29091898 PMID:29278859 PMID:31077717 PMID:31342809 More...
RGD:13793380 RGD:14975281 RGD:15036799 RGD:15090820 RGD:7204421
NCBI chrNW_004624749:12,852,128...12,858,478
Ensembl chrNW_004624749:12,852,021...12,858,760
G
Il1r2
interleukin 1 receptor type 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17984051
NCBI chrNW_004624749:6,549,112...6,586,409
Ensembl chrNW_004624749:6,511,584...6,586,511
G
Il22
interleukin 22
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:15122762 PMID:16212920 PMID:23375450
NCBI chrNW_004624802:46,585...51,095
Ensembl chrNW_004624802:46,585...51,095
G
Il4
interleukin 4
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:21094227 PMID:21735453 PMID:22107450
NCBI chrNW_004624733:39,412,800...39,420,079
G
Il6
interleukin 6
treatment
ISO
CTD Direct Evidence: therapeutic
CTD RGD
PMID:7532385 PMID:15763341 PMID:29091898
RGD:15090820
NCBI chrNW_004624739:7,957,709...7,963,414
Ensembl chrNW_004624739:7,957,674...7,962,318
G
Immt
inner membrane mitochondrial protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624749:17,060,809...17,103,919
Ensembl chrNW_004624749:17,060,790...17,103,919
G
Irak1
interleukin 1 receptor associated kinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624946:613,392...618,459
Ensembl chrNW_004624946:613,890...618,445
G
Itpr1
inositol 1,4,5-trisphosphate receptor type 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624773:14,856,803...15,193,173
Ensembl chrNW_004624773:14,856,804...15,193,168
G
Jund
JunD proto-oncogene, AP-1 transcription factor subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30515189
NCBI chrNW_004624908:1,572,628...1,574,205
Ensembl chrNW_004624908:1,573,174...1,574,113
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Keap1
kelch like ECH associated protein 1
ISO
RGD
PMID:18417483
RGD:6893370
NCBI chrNW_004624828:2,580,812...2,595,023
Ensembl chrNW_004624828:2,580,861...2,595,275
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Kitlg
KIT ligand
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:12594235
NCBI chrNW_004624837:7,456,116...7,541,764
Ensembl chrNW_004624837:7,456,120...7,541,730
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Kng1
kininogen 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20362651 PMID:30685357
NCBI chrNW_004624730:70,022,449...70,065,115
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Krt18
keratin 18
ISO
mRNA, protein:increased expression:liver (mouse) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:17340120 PMID:19783637 PMID:33483742 PMID:38521541
RGD:18337498
NCBI chrNW_004624904:1,011,675...1,015,319
Ensembl chrNW_004624904:1,011,755...1,015,416
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Krt8
keratin 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624904:970,136...978,211
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Lap3
leucine aminopeptidase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624755:14,241,178...14,266,337
Ensembl chrNW_004624755:14,241,178...14,266,280
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Lbp
lipopolysaccharide binding protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624842:1,306,299...1,332,269
Ensembl chrNW_004624842:1,301,831...1,332,346
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Lcat
lecithin-cholesterol acyltransferase
ISO
mRNA:decreased expression:liver (rat)
RGD
PMID:28959666
RGD:401794432
NCBI chrNW_004624746:18,438,308...18,441,650
Ensembl chrNW_004624746:18,437,429...18,441,806
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Ldlr
low density lipoprotein receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:36108984
NCBI chrNW_004624828:2,999,122...3,021,893
Ensembl chrNW_004624828:2,999,169...3,021,987
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Lgals3
galectin 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22461450
NCBI chrNW_004624731:14,300,138...14,307,843
Ensembl chrNW_004624731:14,298,201...14,304,637
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Lipc
lipase C, hepatic type
ISO
mRNA:decreased expression:liver (rat)
RGD
PMID:28959666
RGD:401794432
NCBI chrNW_004624781:13,342,469...13,468,120
Ensembl chrNW_004624781:13,342,357...13,455,055
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LOC101700851
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
ISO
mRNA, protein:decreased expression:kidney (mouse)
RGD
PMID:26476181
RGD:25671412
NCBI chrNW_004624802:10,176,865...10,181,725
Ensembl chrNW_004624802:10,176,919...10,181,657
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LOC101701066
cytochrome P450 1B1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33814510
NCBI chrNW_004624738:19,639,215...19,647,807
Ensembl chrNW_004624738:19,638,456...19,647,497
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LOC101701891
histone H2AX
treatment
ISO
RGD
PMID:23265463
RGD:8693741
NCBI chrNW_004624784:14,475,813...14,477,269
Ensembl chrNW_004624784:14,476,730...14,477,161
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LOC101703821
HLA class II histocompatibility antigen, DQ beta 1 chain
susceptibility
ISO
DNA:polymorphism, haplotype CTD Direct Evidence: marker/mechanism DNA:polymorphism: :HLA-DQB1*05(human)
RGD CTD
PMID:21570397 PMID:25250564 PMID:26959717
RGD:11573514 RGD:36174016
NCBI chrNW_004624754:23,895,509...23,902,487
Ensembl chrNW_004624754:23,895,607...23,906,713
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LOC101707509
cytochrome P450 1A1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33814510
NCBI chrNW_004627988:7...1,323
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LOC101715424
tubulin alpha-1B chain-like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624816:3,001,252...3,006,166
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LOC101719398
serotransferrin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942
NCBI chrNW_004624730:10,078,165...10,109,349
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LOC101722366
cytochrome P450 2E1
treatment
ISO
CTD Direct Evidence: marker/mechanism associated with Endotoxemia DNA:hypermethylation:promoter
CTD RGD
PMID:12668988 PMID:16770646 PMID:21741958 PMID:25681370 PMID:27324775 PMID:27490558 PMID:27960551 PMID:28762043 PMID:29404441 More...
RGD:14700872 RGD:14700873 RGD:14700878 RGD:14700879 RGD:14700901
NCBI chrNW_004624737:12,335,733...12,345,278
Ensembl chrNW_004624737:12,335,681...12,345,514
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Lpl
lipoprotein lipase
treatment
ISO
RGD
PMID:27071702
RGD:13794380
NCBI chrNW_004624758:15,652,553...15,680,107
Ensembl chrNW_004624758:15,651,992...15,680,762
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Lrat
lecithin retinol acyltransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624853:2,936,426...2,941,993
Ensembl chrNW_004624853:2,936,109...2,945,101
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Ltb4r
leukotriene B4 receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28487374
NCBI chrNW_004624820:8,187,496...8,196,381
Ensembl chrNW_004624820:8,187,496...8,189,562
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Ltf
lactotransferrin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16141546
NCBI chrNW_004624730:74,636,554...74,656,817
Ensembl chrNW_004624730:74,636,522...74,656,886
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Map1lc3b
microtubule associated protein 1 light chain 3 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624746:3,084,418...3,094,250
Ensembl chrNW_004624746:3,084,392...3,094,250
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Map3k5
mitogen-activated protein kinase kinase kinase 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18700144
NCBI chrNW_004624886:970,415...1,189,595
Ensembl chrNW_004624886:969,623...1,190,709
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Mat1a
methionine adenosyltransferase 1A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624841:6,843,725...6,864,700
Ensembl chrNW_004624841:6,843,741...6,862,683
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Mccc1
methylcrotonyl-CoA carboxylase subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624730:60,749,678...60,803,091
Ensembl chrNW_004624730:60,749,896...60,803,235
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Mdh1
malate dehydrogenase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942
NCBI chrNW_004624762:9,884,521...9,900,593
Ensembl chrNW_004624762:9,881,950...9,901,372
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Me1
malic enzyme 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624799:11,166,398...11,382,662
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Med1
mediator complex subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16109766
NCBI chrNW_004624795:3,572,025...3,605,675
Ensembl chrNW_004624795:3,572,266...3,607,126
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Mmp2
matrix metallopeptidase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15763341
NCBI chrNW_004624757:1,450,680...1,479,160
Ensembl chrNW_004624757:1,448,698...1,479,255
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Mmp9
matrix metallopeptidase 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22507835
NCBI chrNW_004624790:8,584,399...8,591,763
Ensembl chrNW_004624790:8,583,457...8,591,713
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Mst1
macrophage stimulating 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624730:3,612,467...3,617,257
Ensembl chrNW_004624730:3,610,241...3,617,530
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Mst1r
macrophage stimulating 1 receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22575169
NCBI chrNW_004624730:3,802,452...3,818,593
Ensembl chrNW_004624730:3,800,749...3,822,389
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Mthfr
methylenetetrahydrofolate reductase
treatment
ISO
CTD Direct Evidence: marker/mechanism associated with precursor lymphoblastic lymphoma/leukemia; DNA:SNP: :677C>T(human)
CTD RGD
PMID:18551038 PMID:19648163 PMID:30545275
RGD:14696733
NCBI chrNW_004624818:1,184,736...1,202,708
Ensembl chrNW_004624818:1,187,869...1,199,168
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Mtpn
myotrophin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624765:16,182,691...16,218,634
Ensembl chrNW_004624765:16,181,809...16,218,720
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Myd88
MYD88 innate immune signal transduction adaptor
ameliorates
ISO
RGD
PMID:17615358
RGD:150521532
NCBI chrNW_004624731:2,677,259...2,681,408
Ensembl chrNW_004624731:2,677,290...2,681,489
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Ndufs3
NADH:ubiquinone oxidoreductase core subunit S3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624767:1,238,953...1,243,945
Ensembl chrNW_004624767:1,237,261...1,244,031
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Nfatc4
nuclear factor of activated T cells 4
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:34192554
NCBI chrNW_004624820:8,136,231...8,145,395
Ensembl chrNW_004624820:8,136,156...8,146,312
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Nfe2l2
NFE2 like bZIP transcription factor 2
treatment
ISO
CTD Direct Evidence: therapeutic induced by methotrexate (CHEBI:44185), treated by ferulic acid (CHEBI:17620)
RGD CTD
PMID:18417483 PMID:22491424 PMID:22627062 PMID:24813929 PMID:26958860 PMID:29091898 PMID:30215777 PMID:31889292 PMID:31927046 PMID:31972209 PMID:32066295 More...
RGD:15090820 RGD:21201280 RGD:21201283 RGD:21201305 RGD:21201308 RGD:6893370
NCBI chrNW_004624787:14,355,330...14,381,353
Ensembl chrNW_004624787:14,355,791...14,381,251
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Nfkb1
nuclear factor kappa B subunit 1
treatment susceptibility
ISO
associated with tuberculosis ;DNA:SNPs,haplotypes: 3'utr,5'utr: (rs78872571,rs4647992) (human)
RGD
PMID:29091898 PMID:31490979
RGD:15090820 RGD:40902984
NCBI chrNW_004624830:5,334,273...5,430,887
Ensembl chrNW_004624830:5,333,616...5,408,723
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Nfxl1
nuclear transcription factor, X-box binding like 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chrNW_004624761:19,029,537...19,084,156
Ensembl chrNW_004624761:19,029,434...19,084,307
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Notch1
notch receptor 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:30394310
NCBI chrNW_004624760:1,636,331...1,676,398
Ensembl chrNW_004624760:1,634,702...1,676,531
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Nox4
NADPH oxidase 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624845:669,880...829,471
Ensembl chrNW_004624845:669,902...827,834
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Nqo1
NAD(P)H quinone dehydrogenase 1
treatment
ISO
RGD
PMID:28472605 PMID:28522909 PMID:29091898
RGD:13439737 RGD:13439739 RGD:15090820
NCBI chrNW_004624746:16,684,620...16,698,194
Ensembl chrNW_004624746:16,684,407...16,697,479
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Nr0b2
nuclear receptor subfamily 0 group B member 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29943110
NCBI chrNW_004624764:10,896,728...10,899,898
Ensembl chrNW_004624764:10,892,481...10,899,215
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Nr1d1
nuclear receptor subfamily 1 group D member 1
treatment
ISO
RGD
PMID:24497272
RGD:10448995
NCBI chrNW_004624795:3,102,424...3,109,497
Ensembl chrNW_004624795:3,102,439...3,109,497
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Nr1h3
nuclear receptor subfamily 1 group H member 3
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:17256725
NCBI chrNW_004624767:1,459,601...1,473,224
Ensembl chrNW_004624767:1,459,601...1,467,795
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Nr1h4
nuclear receptor subfamily 1 group H member 4
treatment severity
ISO
mRNA:decreased expression:liver (rat) protein:decreased expression:liver (rat) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:12875239 PMID:20573685 PMID:22711662 PMID:28827769 PMID:29091898 PMID:30068870 More...
RGD:14701035 RGD:14701036 RGD:15042870 RGD:15045609 RGD:15090820
NCBI chrNW_004624750:7,222,306...7,303,809
Ensembl chrNW_004624750:7,219,251...7,303,834
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Nr1i2
nuclear receptor subfamily 1 group I member 2
susceptibility
ISO
CTD Direct Evidence: marker/mechanism|therapeutic associated with tuberculosis ;DNA:SNP,haplotypes:promoter: (rs3814055) (human)
CTD RGD
PMID:19797606 PMID:28058446 PMID:31490979
RGD:40902984
NCBI chrNW_004624731:28,371,707...28,405,327
Ensembl chrNW_004624731:28,371,707...28,381,357
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Nr1i3
nuclear receptor subfamily 1 group I member 3
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:14742670 PMID:25656644 PMID:28058446
NCBI chrNW_004624794:141,316...158,059
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Nr2f2
nuclear receptor subfamily 2 group F member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624768:7,713,771...7,728,102
Ensembl chrNW_004624768:7,701,674...7,728,408
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Nr5a2
nuclear receptor subfamily 5 group A member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29515023
NCBI chrNW_004624798:356,953...494,877
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Nrep
neuronal regeneration related protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624743:29,529,356...29,557,620
Ensembl chrNW_004624743:29,529,356...29,557,414
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Ntn1
netrin 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:35292334
NCBI chrNW_004624786:11,508,643...11,707,060
Ensembl chrNW_004624786:11,526,050...11,703,258
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Nus1
NUS1 dehydrodolichyl diphosphate synthase subunit
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:33812996
NCBI chrNW_004624798:12,132,570...12,154,252
Ensembl chrNW_004624798:12,130,569...12,154,314
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Ociad1
OCIA domain containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624761:18,144,270...18,171,205
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Ogdh
oxoglutarate dehydrogenase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624740:7,481,719...7,549,809
Ensembl chrNW_004624740:7,482,314...7,549,417
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P4hb
prolyl 4-hydroxylase subunit beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624801:10,700,301...10,712,889
Ensembl chrNW_004624801:10,699,161...10,712,896
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Pah
phenylalanine hydroxylase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624750:5,527,720...5,598,173
Ensembl chrNW_004624750:5,527,638...5,601,964
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Pan2
poly(A) specific ribonuclease subunit PAN2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chrNW_004624802:11,668,977...11,686,840
Ensembl chrNW_004624802:11,669,908...11,686,122
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Panx1
pannexin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29246445
NCBI chrNW_004624735:38,766,973...38,823,284
Ensembl chrNW_004624735:38,766,981...38,819,092
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Park7
Parkinsonism associated deglycase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624818:3,900,917...3,915,457
Ensembl chrNW_004624818:3,900,917...3,911,042
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Pc
pyruvate carboxylase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624767:19,481,158...19,601,036
Ensembl chrNW_004624767:19,480,522...19,614,051
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Pcolce
procollagen C-endopeptidase enhancer
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624740:16,476,004...16,480,818
Ensembl chrNW_004624740:16,475,058...16,480,807
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Pcyt1a
phosphate cytidylyltransferase 1A, choline
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624730:61,417,030...61,466,028
Ensembl chrNW_004624730:61,418,013...61,466,016
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Pdk4
pyruvate dehydrogenase kinase 4
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:21182459 PMID:31809757
NCBI chrNW_004624813:2,258,279...2,270,540
Ensembl chrNW_004624813:2,258,279...2,270,824
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Pdlim5
PDZ and LIM domain 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624757:22,332,479...22,597,312
Ensembl chrNW_004624757:22,332,505...22,597,586
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Pex11a
peroxisomal biogenesis factor 11 alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624768:16,751,366...16,759,829
Ensembl chrNW_004624768:16,751,366...16,760,326
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Pgm1
phosphoglucomutase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624742:30,543,161...30,592,117
Ensembl chrNW_004624742:30,542,448...30,592,162
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Plat
plasminogen activator, tissue type
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22507835
NCBI chrNW_004624780:1,014,429...1,063,636
Ensembl chrNW_004624780:1,028,085...1,063,649
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Plg
plasminogen
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22507835
NCBI chrNW_004624855:2,362,793...2,401,519
Ensembl chrNW_004624855:2,360,229...2,402,079
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Pls3
plastin 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624940:120,073...216,522
Ensembl chrNW_004624940:120,073...216,622
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Pnp
purine nucleoside phosphorylase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942
NCBI chrNW_004624825:4,688,662...4,699,912
Ensembl chrNW_004624825:4,690,831...4,700,717
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Pnrc1
proline rich nuclear receptor coactivator 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624799:5,097,175...5,100,692
Ensembl chrNW_004624799:5,097,809...5,100,507
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Polg
DNA polymerase gamma, catalytic subunit
susceptibility no_association
ISO
DNA:missense mutation:cds:p.W748S, p.E1143G (2243G>C, 3428A>G) (human) DNA:missense mutations:cds:p.Q1236H, p.E1143G (33708G>T, 3428A>G) (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:18208989 PMID:20138553 PMID:25065347 PMID:30255931
RGD:15039297 RGD:15039302
NCBI chrNW_004624768:16,493,123...16,509,747
Ensembl chrNW_004624768:16,491,555...16,509,900
G
Polr2g
RNA polymerase II subunit G
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624926:1,228,590...1,230,943
Ensembl chrNW_004624926:1,228,602...1,230,943
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Pon1
paraoxonase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942
NCBI chrNW_004624813:1,953,796...1,979,846
Ensembl chrNW_004624813:1,949,614...1,979,882
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Ppara
peroxisome proliferator activated receptor alpha
ISO
LPS-induced acute liver damage CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:21262334 PMID:24385052 PMID:38181850
RGD:5509941
NCBI chrNW_004624752:3,646,499...3,702,553
Ensembl chrNW_004624752:3,650,922...3,701,672
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Pparg
peroxisome proliferator activated receptor gamma
ISO
mRNA, protein:decreased expression:liver
RGD
PMID:26599535
RGD:11554658
NCBI chrNW_004624956:84,673...207,176
Ensembl chrNW_004624956:83,842...149,481
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Pptc7
protein phosphatase targeting COQ7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624747:21,320,525...21,358,830
Ensembl chrNW_004624747:21,320,617...21,358,904
G
Prkaa1
protein kinase AMP-activated catalytic subunit alpha 1
treatment
ISO
RGD
PMID:29091898
RGD:15090820
NCBI chrNW_004624759:14,143,439...14,174,971
Ensembl chrNW_004624759:14,142,956...14,171,718
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Prkcd
protein kinase C delta
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:30393195
NCBI chrNW_004624822:4,035,819...4,062,907
Ensembl chrNW_004624822:4,033,130...4,059,555
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Prkdc
protein kinase, DNA-activated, catalytic subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21224054
NCBI chrNW_004624735:7,534,483...7,702,079
Ensembl chrNW_004624735:7,534,506...7,700,305
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Ptf1a
pancreas associated transcription factor 1a
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:21182459
NCBI chrNW_004624796:5,548,982...5,550,563
Ensembl chrNW_004624796:5,549,184...5,550,439
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Ptges2
prostaglandin E synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31444509
NCBI chrNW_004624760:7,501,902...7,506,221
Ensembl chrNW_004624760:7,501,939...7,507,093
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Ptgs2
prostaglandin-endoperoxide synthase 2
treatment
ISO
CTD Direct Evidence: therapeutic
RGD CTD
PMID:11743745 PMID:29091898
RGD:15090820
NCBI chrNW_004624814:6,897,818...6,904,890
Ensembl chrNW_004624814:6,897,857...6,903,728
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Pum1
pumilio RNA binding family member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624764:14,361,376...14,486,460
Ensembl chrNW_004624764:14,361,012...14,486,542
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Pygl
glycogen phosphorylase L
ISO
protein:increased expression:serum (rat) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:25231249 PMID:25336395
RGD:21079733
NCBI chrNW_004624731:17,990,877...18,028,351
Ensembl chrNW_004624731:17,990,977...18,028,186
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Rasa1
RAS p21 protein activator 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624743:6,750,476...6,882,556
Ensembl chrNW_004624743:6,788,108...6,882,223
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Rbp1
retinol binding protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942
NCBI chrNW_004624730:16,091,863...16,119,591
Ensembl chrNW_004624730:16,091,863...16,119,591
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Rdh13
retinol dehydrogenase 13
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27865848
NCBI chrNW_004624832:2,141,906...2,159,009
Ensembl chrNW_004624832:2,141,902...2,159,009
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Reep5
receptor accessory protein 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chrNW_004624743:30,690,339...30,729,229
Ensembl chrNW_004624743:30,690,350...30,729,785
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Rgn
regucalcin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624887:3,881,624...3,900,144
Ensembl chrNW_004624887:3,883,213...3,899,277
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Ripk3
receptor interacting serine/threonine kinase 3
ISO
protein:increased expression:liver (mouse) CTD Direct Evidence: therapeutic
RGD CTD
PMID:26769846 PMID:28205631
RGD:127229945
NCBI chrNW_004624820:8,165,546...8,169,172
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S100a11
S100 calcium binding protein A11
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624772:19,563,871...19,568,413
Ensembl chrNW_004624772:19,563,889...19,568,766
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Scarb1
scavenger receptor class B member 1
ISO
mRNA:increased expression:liver (rat)
RGD
PMID:28959666
RGD:401794432
NCBI chrNW_004624747:23,970,782...24,010,683
Ensembl chrNW_004624747:23,973,648...24,010,820
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Selenbp1
selenium binding protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20623750
NCBI chrNW_004624772:18,496,479...18,505,706
Ensembl chrNW_004624772:18,496,495...18,505,706
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Sema3a
semaphorin 3A
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:33290778
NCBI chrNW_004624739:32,104,014...32,426,980
Ensembl chrNW_004624739:32,105,824...32,309,271
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Sema4a
semaphorin 4A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33290778
NCBI chrNW_004624885:1,470,666...1,493,634
Ensembl chrNW_004624885:1,470,525...1,495,369
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Senp2
SUMO specific peptidase 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29535048
NCBI chrNW_004624730:71,068,112...71,100,121
Ensembl chrNW_004624730:71,068,112...71,100,225
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Serpina6
serpin family A member 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624734:10,638,031...10,650,297
Ensembl chrNW_004624734:10,637,515...10,651,033
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Serpine1
serpin family E member 1
treatment
ISO
associated with precursor lymphoblastic lymphoma/leukemia;DNA:SNPs: :DNA:SNPs: :677C>T, 1298A>C(human)
RGD
PMID:23183238
RGD:14696750
NCBI chrNW_004624740:16,128,145...16,136,696
Ensembl chrNW_004624740:16,128,059...16,137,337
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Serping1
serpin family G member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624864:3,091,397...3,103,084
Ensembl chrNW_004624864:3,091,083...3,103,090
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Sesn2
sestrin 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:28209544
NCBI chrNW_004624764:12,087,901...12,135,145
Ensembl chrNW_004624764:12,087,858...12,120,914
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Sgf29
SAGA complex associated factor 29
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624782:13,054,643...13,076,640
Ensembl chrNW_004624782:13,054,343...13,072,515
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Shc1
SHC adaptor protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249 PMID:32659284
NCBI chrNW_004624885:2,511,039...2,520,883
Ensembl chrNW_004624885:2,511,240...2,521,155
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Slc10a1
solute carrier family 10 member 1
ISO
mRNA:decreased expression:liver (rat)
RGD
PMID:28827769
RGD:15045609
NCBI chrNW_004624734:31,287,539...31,307,339
Ensembl chrNW_004624734:31,287,394...31,311,357
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Slc10a7
solute carrier family 10 member 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chrNW_004624853:5,110,729...5,365,312
Ensembl chrNW_004624853:5,113,153...5,365,339
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Slc13a4
solute carrier family 13 member 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624765:15,960,269...16,001,700
Ensembl chrNW_004624765:15,963,047...16,000,929
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Slc22a8
solute carrier family 22 member 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624926:1,373,804...1,390,248
Ensembl chrNW_004624926:1,374,103...1,388,586
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Slc25a29
solute carrier family 25 member 29
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624734:3,830,624...3,839,970
Ensembl chrNW_004624734:3,830,743...3,839,098
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Slc7a5
solute carrier family 7 member 5
treatment
ISO
RGD
PMID:9200186
RGD:151357001
NCBI chrNW_004624746:1,325,368...1,349,616
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Slpi
secretory leukocyte peptidase inhibitor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17984051
NCBI chrNW_004624790:9,235,830...9,238,562
Ensembl chrNW_004624790:9,235,650...9,239,231
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Snx18
sorting nexin 18
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17984051
NCBI chrNW_004624759:4,851,014...4,879,365
Ensembl chrNW_004624759:4,850,555...4,879,478
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Sod1
superoxide dismutase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20623750 PMID:27349771
NCBI chrNW_004624745:20,032,003...20,037,958
Ensembl chrNW_004624745:20,032,011...20,037,958
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Sod2
superoxide dismutase 2
susceptibility severity treatment
ISO
CTD Direct Evidence: marker/mechanism DNA:SNP:cds:p.Val16Ala(human) associated with acute lymphoblastic leukemia;DNA:SNP: :(rs4880)(human)
RGD CTD
PMID:19332662 PMID:19647030 PMID:20578157 PMID:25226513 PMID:27019981
RGD:11060605 RGD:26923957 RGD:26923959 RGD:26923961
NCBI chrNW_004624855:3,260,800...3,271,864
Ensembl chrNW_004624855:3,260,809...3,271,367
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Sod3
superoxide dismutase 3
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:11529661
NCBI chrNW_004624755:7,535,044...7,541,298
Ensembl chrNW_004624755:7,535,044...7,541,221
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Sord
sorbitol dehydrogenase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12763371
NCBI chrNW_004624731:14,159,439...14,185,960
Ensembl chrNW_004624731:14,156,522...14,185,989
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Sorl1
sortilin related receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chrNW_004624880:3,579,783...3,749,958
Ensembl chrNW_004624880:3,583,838...3,749,930
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Spp1
secreted phosphoprotein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20623750
NCBI chrNW_004624872:4,505,796...4,513,247
Ensembl chrNW_004624872:4,505,522...4,513,742
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Srp72
signal recognition particle 72
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chrNW_004624761:12,917,855...12,949,423
Ensembl chrNW_004624761:12,917,855...12,949,457
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Stat3
signal transducer and activator of transcription 3
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:38460807
NCBI chrNW_004624795:1,648,235...1,680,788
Ensembl chrNW_004624795:1,648,080...1,681,200
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Stat4
signal transducer and activator of transcription 4
severity
ISO
protein:increased phosphorylation:liver, inflammatory cell (mouse) mRNA:increased expression:liver, macrophage (mouse)
RGD
PMID:23876342 PMID:24731448
RGD:25671417 RGD:25671422
NCBI chrNW_004624854:4,975,724...5,056,940
Ensembl chrNW_004624854:4,976,507...5,057,391
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Sting1
stimulator of interferon response cGAMP interactor 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:36520315
NCBI chrNW_004624743:32,277,197...32,283,346
Ensembl chrNW_004624743:32,273,385...32,283,235
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Sult2b1
sulfotransferase family 2B member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27052460
NCBI chrNW_004624832:5,268,000...5,290,888
Ensembl chrNW_004624832:5,267,900...5,290,991
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Suox
sulfite oxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624802:12,049,787...12,054,810
Ensembl chrNW_004624802:12,047,270...12,054,523
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Tagln2
transgelin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624794:1,331,075...1,338,445
G
Taldo1
transaldolase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19436114
NCBI chrNW_004624766:21,758,821...21,766,052
Ensembl chrNW_004624766:21,758,821...21,766,027
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Tbxa2r
thromboxane A2 receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22206755
NCBI chrNW_004624828:6,291,010...6,312,438
Ensembl chrNW_004624828:6,291,167...6,309,482
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Tctn1
tectonic family member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17984051
NCBI chrNW_004624747:21,259,515...21,300,180
Ensembl chrNW_004624747:21,265,197...21,300,149
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Tgfb1
transforming growth factor beta 1
treatment
ISO
RGD
PMID:27516150
RGD:14995464
NCBI chrNW_004624907:162,567...175,696
Ensembl chrNW_004624907:161,569...176,605
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Tgfbr1
transforming growth factor beta receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28560358
NCBI chrNW_004624825:1,773,158...1,899,120
Ensembl chrNW_004624825:1,839,178...1,899,156
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Thbs1
thrombospondin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:35357534
NCBI chrNW_004624804:6,849,660...6,866,164
Ensembl chrNW_004624804:6,849,670...6,867,684
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Thpo
thrombopoietin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:33122006
NCBI chrNW_004624730:72,210,880...72,218,615
Ensembl chrNW_004624730:72,212,423...72,219,485
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Tlr4
toll like receptor 4
disease_progression
ISO
RGD
PMID:17504260
RGD:14697733
NCBI chrNW_004624760:17,596,516...17,608,955
Ensembl chrNW_004624760:17,598,630...17,609,120
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Tlr5
toll like receptor 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30508503
NCBI chrNW_004624835:5,495,723...5,503,462
Ensembl chrNW_004624835:5,500,461...5,503,034
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Tmem117
transmembrane protein 117
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chrNW_004624816:8,150,836...8,739,599
Ensembl chrNW_004624816:8,151,171...8,730,823
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Tmem164
transmembrane protein 164
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624803:5,744,576...5,914,749
Ensembl chrNW_004624803:5,744,703...5,914,327
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Tmem38b
transmembrane protein 38B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624758:5,664,287...5,720,061
Ensembl chrNW_004624758:5,662,661...5,719,865
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Tnf
tumor necrosis factor
severity treatment
ISO
protein:increased expression:serum (rat) CTD Direct Evidence: marker/mechanism|therapeutic
RGD CTD
PMID:7532385 PMID:9309314 PMID:9696492 PMID:10801287 PMID:10801288 PMID:11124822 PMID:14686721 PMID:15830285 PMID:17070847 PMID:17709330 PMID:19638433 PMID:20623750 PMID:21984482 PMID:29091898 PMID:31077717 PMID:31342809 PMID:37866487 More...
RGD:10450531 RGD:14696804 RGD:14975281 RGD:14995429 RGD:14995432 RGD:14995435 RGD:14995437 RGD:14995485 RGD:15036799 RGD:15090820
NCBI chrNW_004624754:24,623,059...24,625,647
Ensembl chrNW_004624754:24,623,425...24,625,531
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Trpm2
transient receptor potential cation channel subfamily M member 2
ISO
RGD
PMID:24569808
RGD:9999438
NCBI chrNW_004624745:29,757,267...29,809,607
Ensembl chrNW_004624745:29,757,106...29,806,795
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Ttr
transthyretin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942
NCBI chrNW_004624770:1,255,401...1,262,019
Ensembl chrNW_004624770:1,251,716...1,262,213
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Tubb4b
tubulin beta 4B class IVb
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624760:715,013...717,462
Ensembl chrNW_004624760:712,987...717,951
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Uba5
ubiquitin like modifier activating enzyme 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chrNW_004624730:8,791,691...8,819,957
Ensembl chrNW_004624730:8,792,854...8,867,707
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Unc93b1
unc-93 homolog B1, TLR signaling regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624767:18,859,990...18,869,083
Ensembl chrNW_004624767:18,860,017...18,868,581
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Usp5
ubiquitin specific peptidase 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624860:3,519,106...3,532,690
Ensembl chrNW_004624860:3,519,113...3,532,687
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Vegfa
vascular endothelial growth factor A
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:17784864 PMID:25231249
RGD:15003197
NCBI chrNW_004624754:15,929,414...15,943,637
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Vim
vimentin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624796:10,624,672...10,632,300
Ensembl chrNW_004624796:10,623,929...10,632,600
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Vwf
von Willebrand factor
ISO
protein:increased expression:liver: CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:7531171 PMID:28527913
RGD:11079232
NCBI chrNW_004624860:2,843,268...2,973,888
Ensembl chrNW_004624860:2,858,088...2,973,052
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Wasl
WASP like actin nucleation promoting factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624783:12,239,467...12,322,403
Ensembl chrNW_004624783:12,254,715...12,323,232
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Xrcc1
X-ray repair cross complementing 1
susceptibility
ISO
DNA:haploinsufficiency: : (mouse)
RGD
PMID:21737425
RGD:15036796
NCBI chrNW_004624907:1,087,611...1,113,275
Ensembl chrNW_004624907:1,087,611...1,113,266
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Xylb
xylulokinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chrNW_004624731:2,616,924...2,658,675
Ensembl chrNW_004624731:2,619,334...2,658,967
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Zdhhc23
zinc finger DHHC-type palmitoyltransferase 23
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chrNW_004624731:34,544,476...34,561,284
Ensembl chrNW_004624731:34,544,250...34,560,790
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Abcc2
ATP binding cassette subfamily C member 2
no_association susceptibility
ISO
DNA:SNPs:multiple: DNA:polymorphisms,haplotype:promoter:g.-1774delG,g.-1549G>A(human)
RGD
PMID:17502832 PMID:22178260
RGD:14700816 RGD:14700817
NCBI chrNW_004624737:11,593,701...11,686,790
Ensembl chrNW_004624737:11,593,864...11,688,460
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Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
ISO
RGD
PMID:16140414
RGD:2316848
NCBI chrNW_004624951:681,559...711,476
Ensembl chrNW_004624951:682,178...711,474
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LOC101722366
cytochrome P450 2E1
ISO
DNA:hypermethylation:promoter
RGD
PMID:23619520
RGD:14700910
NCBI chrNW_004624737:12,335,733...12,345,278
Ensembl chrNW_004624737:12,335,681...12,345,514
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Lpar1
lysophosphatidic acid receptor 1
ISO
protein:increased expression:liver (mouse)
RGD
PMID:12201952
RGD:10054288
NCBI chrNW_004624758:518,070...668,915
Ensembl chrNW_004624758:519,249...669,471
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Gpt
glutamic--pyruvic transaminase
treatment
ISO
RGD
PMID:28921207
RGD:14975164
NCBI chrNW_004624735:12,355,476...12,359,910
Ensembl chrNW_004624735:12,355,476...12,360,028
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all