Clu (clusterin) - Rat Genome Database

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Gene: Clu (clusterin) Heterocephalus glaber
Analyze
Symbol: Clu
Name: clusterin
RGD ID: 18909398
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); ATP hydrolysis activity (ortholog); low-density lipoprotein particle receptor binding (ortholog); INVOLVED IN amyloid-beta clearance (ortholog); cell morphogenesis (ortholog); cellular response to growth factor stimulus (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); Alzheimer's disease (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); FOUND IN aggresome (ortholog); apical dendrite (ortholog); cell periphery (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475822,426,918 - 22,444,357 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475822,431,331 - 22,444,185 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis type 1  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
atherosclerosis  (ISO)
Atrophy  (ISO)
autosomal dominant nocturnal frontal lobe epilepsy  (ISO)
benign familial infantile seizures 6  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Allograft Nephropathy  (ISO)
chronic kidney disease  (ISO)
cicatricial pemphigoid  (ISO)
Cognitive Dysfunction  (ISO)
conjunctival disease  (ISO)
coronary artery disease  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
exfoliation syndrome  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (ISO)
Facial Nerve Injuries  (ISO)
Fuchs' endothelial dystrophy  (ISO)
gelatinous drop-like corneal dystrophy  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
inclusion body myositis  (ISO)
invasive ductal carcinoma  (ISO)
iron metabolism disease  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kawasaki disease  (ISO)
kidney disease  (ISO)
lupus nephritis  (ISO)
Lymphatic Metastasis  (ISO)
macular retinal edema  (ISO)
melanoma  (ISO)
muscular disease  (ISO)
mycosis fungoides  (ISO)
myocardial infarction  (ISO)
nasal cavity adenocarcinoma  (ISO)
Neointima  (ISO)
Neoplasm Metastasis  (ISO)
Neovascularization, Pathologic  (ISO)
Optic Nerve Injuries  (ISO)
osteoarthritis  (ISO)
Pituitary Neoplasms  (ISO)
pre-eclampsia  (ISO)
prostate adenocarcinoma  (ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
psoriasis  (ISO)
pulmonary hypertension  (ISO)
renal fibrosis  (ISO)
Retina Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
skin papilloma  (ISO)
squamous cell carcinoma  (ISO)
Stevens-Johnson syndrome  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
vitiligo  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance  (ISO)
cell morphogenesis  (ISO)
cellular response to growth factor stimulus  (ISO)
central nervous system myelin maintenance  (ISO)
chaperone-mediated protein complex assembly  (ISO)
chaperone-mediated protein folding  (ISO)
endocrine pancreas development  (ISO)
estrous cycle  (ISO)
immune complex clearance  (IEA)
intrinsic apoptotic signaling pathway  (ISO)
microglial cell activation  (ISO)
microglial cell proliferation  (ISO)
negative regulation of amyloid fibril formation  (IEA)
negative regulation of amyloid-beta formation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein-containing complex assembly  (ISO)
negative regulation of response to endoplasmic reticulum stress  (ISO)
neuron projection morphogenesis  (ISO)
positive regulation of amyloid-beta formation  (IEA)
positive regulation of apoptotic process  (IEA)
positive regulation of cell differentiation  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of neurofibrillary tangle assembly  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of receptor-mediated endocytosis  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of ubiquitin-dependent protein catabolic process  (ISO)
protein import  (ISO)
protein stabilization  (ISO)
protein targeting to lysosome involved in chaperone-mediated autophagy  (ISO)
regulation of amyloid-beta clearance  (ISO)
regulation of apoptotic process  (IEA)
regulation of cell population proliferation  (ISO)
regulation of neuronal signal transduction  (ISO)
response to axon injury  (ISO)
response to light stimulus  (ISO)
response to misfolded protein  (ISO)
response to potassium ion  (ISO)
response to virus  (ISO)

References

Genomics

Comparative Map Data
Clu
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475822,426,918 - 22,444,357 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475822,431,331 - 22,444,185 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
CLU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38827,596,917 - 27,614,700 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl827,596,917 - 27,614,700 (-)EnsemblGRCh38hg38GRCh38
GRCh37827,454,434 - 27,472,217 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,510,368 - 27,528,244 (-)NCBINCBI36Build 36hg18NCBI36
Build 34827,510,367 - 27,524,855NCBI
Celera826,414,541 - 26,432,416 (-)NCBICelera
Cytogenetic Map8p21.1NCBI
HuRef825,999,468 - 26,017,387 (-)NCBIHuRef
CHM1_1827,656,307 - 27,674,217 (-)NCBICHM1_1
T2T-CHM13v2.0827,874,264 - 27,892,057 (-)NCBIT2T-CHM13v2.0
Clu
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391466,206,093 - 66,218,992 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1466,205,932 - 66,218,996 (+)EnsemblGRCm39 Ensembl
GRCm381465,968,483 - 65,981,548 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1465,968,483 - 65,981,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv371466,587,320 - 66,600,382 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361464,922,735 - 64,935,658 (+)NCBIMGSCv36mm8
Celera1451,264,543 - 51,272,775 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.36NCBI
Clu
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81544,336,619 - 44,375,861 (+)NCBIGRCr8
mRatBN7.21540,161,068 - 40,200,315 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1540,174,617 - 40,200,315 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1542,026,339 - 42,065,337 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01543,176,537 - 43,215,535 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01541,621,373 - 41,660,612 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01542,626,612 - 42,665,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,640,146 - 42,665,857 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,926,511 - 48,965,757 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,365,779 - 45,405,314 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11545,381,558 - 45,421,094 (+)NCBI
Celera1539,832,711 - 39,871,901 (+)NCBICelera
Cytogenetic Map15p12NCBI
Clu
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540350,160,598 - 50,175,876 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540350,160,598 - 50,175,876 (-)NCBIChiLan1.0ChiLan1.0
CLU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2746,128,456 - 46,145,344 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1821,842,687 - 21,859,551 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0826,867,973 - 26,884,838 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1824,070,053 - 24,086,934 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl824,070,053 - 24,083,523 (-)Ensemblpanpan1.1panPan2
CLU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12529,982,811 - 29,999,565 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2529,982,811 - 29,999,563 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2530,569,577 - 30,586,344 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02530,173,217 - 30,190,014 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2530,173,100 - 30,195,919 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12530,103,442 - 30,120,185 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02529,984,486 - 30,001,273 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02530,150,889 - 30,167,668 (+)NCBIUU_Cfam_GSD_1.0
Clu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049438,072,565 - 8,086,406 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936675499,199 - 513,836 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936675499,745 - 513,515 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1411,336,595 - 11,349,764 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11411,336,585 - 11,352,569 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21412,516,644 - 12,527,851 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLU
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1825,704,441 - 25,721,789 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl825,703,257 - 25,721,789 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605216,420,009 - 16,437,520 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000007719   ⟹   ENSHGLP00000007633
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475822,426,918 - 22,444,357 (-)Ensembl
RefSeq Acc Id: NM_001279834   ⟹   NP_001266763
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475822,431,334 - 22,444,185 (-)NCBI
RefSeq Acc Id: XM_013073368   ⟹   XP_012928822
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475822,431,331 - 22,444,181 (-)NCBI
RefSeq Acc Id: XM_021261101   ⟹   XP_021116760
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475822,431,331 - 22,441,712 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001266763 (Get FASTA)   NCBI Sequence Viewer  
  XP_012928822 (Get FASTA)   NCBI Sequence Viewer  
  XP_021116760 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ADP20516 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000007633
  ENSHGLP00000043296
RefSeq Acc Id: XP_012928822   ⟸   XM_013073368
- Peptide Label: isoform X1
- UniProtKB: E3VX48 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021116760   ⟸   XM_021261101
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001266763   ⟸   NM_001279834
- Peptide Label: precursor
- UniProtKB: E3VX48 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000007633   ⟸   ENSHGLT00000007719


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000005538 Ensembl, ENTREZGENE
  ENSHGLG00000033946 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000007719 ENTREZGENE
  ENSHGLT00000067959 UniProtKB/TrEMBL
InterPro Clusterin UniProtKB/TrEMBL
  Clusterin-like UniProtKB/TrEMBL
  Clusterin_C UniProtKB/TrEMBL
  Clusterin_CS UniProtKB/TrEMBL
  Clusterin_N UniProtKB/TrEMBL
KEGG Report hgl:101718107 UniProtKB/TrEMBL
NCBI Gene Clu ENTREZGENE
PANTHER PTHR10970 UniProtKB/TrEMBL
  PTHR10970:SF1 UniProtKB/TrEMBL
Pfam Clusterin UniProtKB/TrEMBL
PIRSF Clusterin UniProtKB/TrEMBL
PROSITE CLUSTERIN_1 UniProtKB/TrEMBL
  CLUSTERIN_2 UniProtKB/TrEMBL
SMART CLa UniProtKB/TrEMBL
  CLb UniProtKB/TrEMBL
UniProt E3VX48 ENTREZGENE, UniProtKB/TrEMBL