Clu (clusterin) - Rat Genome Database

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Gene: Clu (clusterin) Ictidomys tridecemlineatus
Analyze
Symbol: Clu
Name: clusterin
RGD ID: 12508325
Description: ENCODES a protein that exhibits ATP hydrolysis activity (ortholog); INVOLVED IN cellular response to growth factor stimulus (ortholog); endocrine pancreas development (ortholog); estrous cycle (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); Alzheimer's disease (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); FOUND IN aggresome (ortholog); dendrite (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: clusterin, transcript variant X1; clusterin, transcript variant X2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049438,072,565 - 8,086,406 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936675499,199 - 513,836 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936675499,745 - 513,515 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis type 1  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
atherosclerosis  (ISO)
Atrophy  (ISO)
autosomal dominant nocturnal frontal lobe epilepsy  (ISO)
benign familial infantile seizures 6  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Allograft Nephropathy  (ISO)
chronic kidney disease  (ISO)
cicatricial pemphigoid  (ISO)
Cognitive Dysfunction  (ISO)
conjunctival disease  (ISO)
coronary artery disease  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
exfoliation syndrome  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (ISO)
Facial Nerve Injuries  (ISO)
Fuchs' endothelial dystrophy  (ISO)
gelatinous drop-like corneal dystrophy  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
inclusion body myositis  (ISO)
invasive ductal carcinoma  (ISO)
iron metabolism disease  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kawasaki disease  (ISO)
kidney disease  (ISO)
lupus nephritis  (ISO)
Lymphatic Metastasis  (ISO)
macular retinal edema  (ISO)
melanoma  (ISO)
muscular disease  (ISO)
mycosis fungoides  (ISO)
myocardial infarction  (ISO)
nasal cavity adenocarcinoma  (ISO)
Neointima  (ISO)
Neoplasm Metastasis  (ISO)
Neovascularization, Pathologic  (ISO)
Optic Nerve Injuries  (ISO)
osteoarthritis  (ISO)
Pituitary Neoplasms  (ISO)
pre-eclampsia  (ISO)
prostate adenocarcinoma  (ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
psoriasis  (ISO)
pulmonary hypertension  (ISO)
renal fibrosis  (ISO)
Retina Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
skin papilloma  (ISO)
squamous cell carcinoma  (ISO)
Stevens-Johnson syndrome  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
vitiligo  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance  (IEA)
cell morphogenesis  (IEA)
cellular response to growth factor stimulus  (ISO)
central nervous system myelin maintenance  (IEA)
chaperone-mediated protein complex assembly  (IEA)
chaperone-mediated protein folding  (IEA)
endocrine pancreas development  (ISO)
estrous cycle  (ISO)
immune complex clearance  (IEA)
intrinsic apoptotic signaling pathway  (ISO)
microglial cell activation  (IEA)
microglial cell proliferation  (IEA)
negative regulation of amyloid fibril formation  (IEA)
negative regulation of amyloid-beta formation  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  (IEA)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein-containing complex assembly  (IEA)
negative regulation of response to endoplasmic reticulum stress  (IEA)
neuron projection morphogenesis  (ISO)
positive regulation of amyloid-beta formation  (IEA)
positive regulation of apoptotic process  (IEA)
positive regulation of cell differentiation  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of neurofibrillary tangle assembly  (IEA)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of nitric oxide biosynthetic process  (IEA)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA)
positive regulation of protein-containing complex assembly  (IEA)
positive regulation of receptor-mediated endocytosis  (IEA)
positive regulation of tumor necrosis factor production  (IEA)
positive regulation of ubiquitin-dependent protein catabolic process  (IEA)
protein import  (IEA)
protein stabilization  (IEA)
protein targeting to lysosome involved in chaperone-mediated autophagy  (IEA)
regulation of amyloid-beta clearance  (IEA)
regulation of apoptotic process  (IEA)
regulation of cell population proliferation  (IEA)
regulation of neuronal signal transduction  (IEA)
response to axon injury  (ISO)
response to light stimulus  (ISO)
response to misfolded protein  (IEA)
response to potassium ion  (ISO)
response to virus  (IEA)
signal transduction  (IEA)

References

Genomics

Comparative Map Data
Clu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049438,072,565 - 8,086,406 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936675499,199 - 513,836 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936675499,745 - 513,515 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38827,596,917 - 27,614,700 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl827,596,917 - 27,614,700 (-)EnsemblGRCh38hg38GRCh38
GRCh37827,454,434 - 27,472,217 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,510,368 - 27,528,244 (-)NCBINCBI36Build 36hg18NCBI36
Build 34827,510,367 - 27,524,855NCBI
Celera826,414,541 - 26,432,416 (-)NCBICelera
Cytogenetic Map8p21.1NCBI
HuRef825,999,468 - 26,017,387 (-)NCBIHuRef
CHM1_1827,656,307 - 27,674,217 (-)NCBICHM1_1
T2T-CHM13v2.0827,874,264 - 27,892,057 (-)NCBIT2T-CHM13v2.0
Clu
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391466,206,093 - 66,218,992 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1466,205,932 - 66,218,996 (+)EnsemblGRCm39 Ensembl
GRCm381465,968,483 - 65,981,548 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1465,968,483 - 65,981,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv371466,587,320 - 66,600,382 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361464,922,735 - 64,935,658 (+)NCBIMGSCv36mm8
Celera1451,264,543 - 51,272,775 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.36NCBI
Clu
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81544,336,619 - 44,375,861 (+)NCBIGRCr8
mRatBN7.21540,161,068 - 40,200,315 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1540,174,617 - 40,200,315 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1542,026,339 - 42,065,337 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01543,176,537 - 43,215,535 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01541,621,373 - 41,660,612 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01542,626,612 - 42,665,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,640,146 - 42,665,857 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,926,511 - 48,965,757 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,365,779 - 45,405,314 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11545,381,558 - 45,421,094 (+)NCBI
Celera1539,832,711 - 39,871,901 (+)NCBICelera
Cytogenetic Map15p12NCBI
Clu
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540350,160,598 - 50,175,876 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540350,160,598 - 50,175,876 (-)NCBIChiLan1.0ChiLan1.0
CLU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2746,128,456 - 46,145,344 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1821,842,687 - 21,859,551 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0826,867,973 - 26,884,838 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1824,070,053 - 24,086,934 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl824,070,053 - 24,083,523 (-)Ensemblpanpan1.1panPan2
CLU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12529,982,811 - 29,999,565 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2529,982,811 - 29,999,563 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2530,569,577 - 30,586,344 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02530,173,217 - 30,190,014 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2530,173,100 - 30,195,919 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12530,103,442 - 30,120,185 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02529,984,486 - 30,001,273 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02530,150,889 - 30,167,668 (+)NCBIUU_Cfam_GSD_1.0
CLU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1411,336,595 - 11,349,764 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11411,336,585 - 11,352,569 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21412,516,644 - 12,527,851 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLU
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1825,704,441 - 25,721,789 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl825,703,257 - 25,721,789 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605216,420,009 - 16,437,520 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clu
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475822,426,918 - 22,444,357 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475822,431,331 - 22,444,185 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000022458   ⟹   ENSSTOP00000023812
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936675499,199 - 513,836 (-)Ensembl
RefSeq Acc Id: XM_005337212   ⟹   XP_005337269
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049438,072,566 - 8,086,406 (+)NCBI
SpeTri2.0NW_004936675499,745 - 513,515 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005337213   ⟹   XP_005337270
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049438,072,615 - 8,086,406 (+)NCBI
SpeTri2.0NW_004936675499,745 - 513,464 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040292432   ⟹   XP_040148366
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049438,072,565 - 8,085,949 (+)NCBI
Protein Sequences
Protein RefSeqs XP_005337269 (Get FASTA)   NCBI Sequence Viewer  
  XP_005337270 (Get FASTA)   NCBI Sequence Viewer  
  XP_040148366 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000023812.1
GenBank Protein KAG3294317 (Get FASTA)   NCBI Sequence Viewer  
  KAG3294318 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005337269   ⟸   XM_005337212
- Peptide Label: isoform X1
- UniProtKB: I3NHG5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005337270   ⟸   XM_005337213
- Peptide Label: isoform X1
- UniProtKB: I3NHG5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040148366   ⟸   XM_040292432
- Peptide Label: isoform X2
Ensembl Acc Id: ENSSTOP00000023812   ⟸   ENSSTOT00000022458
Protein Domains
Clusterin C-terminal   Clusterin N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000026703 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000022458.2 UniProtKB/TrEMBL
InterPro Clusterin UniProtKB/TrEMBL
  Clusterin-like UniProtKB/TrEMBL
  Clusterin_C UniProtKB/TrEMBL
  Clusterin_CS UniProtKB/TrEMBL
  Clusterin_N UniProtKB/TrEMBL
NCBI Gene Clu ENTREZGENE
PANTHER PTHR10970 UniProtKB/TrEMBL
  PTHR10970:SF1 UniProtKB/TrEMBL
Pfam Clusterin UniProtKB/TrEMBL
PIRSF Clusterin UniProtKB/TrEMBL
PROSITE CLUSTERIN_1 UniProtKB/TrEMBL
SMART CLa UniProtKB/TrEMBL
  CLb UniProtKB/TrEMBL
UniProt I3NHG5 ENTREZGENE, UniProtKB/TrEMBL