Trpm2 (transient receptor potential cation channel subfamily M member 2) - Rat Genome Database

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Gene: Trpm2 (transient receptor potential cation channel subfamily M member 2) Heterocephalus glaber
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Symbol: Trpm2
Name: transient receptor potential cation channel subfamily M member 2
RGD ID: 18920808
Description: ENCODES a protein that exhibits ADP-ribose diphosphatase activity (ortholog); calcium ion binding (ortholog); hydrolase activity (ortholog); INVOLVED IN calcium ion import across plasma membrane (ortholog); calcium ion transmembrane import into cytosol (ortholog); cellular response to calcium ion (ortholog); ASSOCIATED WITH autistic disorder (ortholog); autoimmune polyendocrine syndrome type 1 (ortholog); bipolar disorder (ortholog); FOUND IN cytoplasmic vesicle membrane (ortholog); lysosomal membrane (ortholog); lysosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474529,757,106 - 29,806,795 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474529,757,267 - 29,809,607 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Trpm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474529,757,106 - 29,806,795 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474529,757,267 - 29,809,607 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TRPM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382144,353,621 - 44,442,644 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2144,350,163 - 44,443,081 (+)EnsemblGRCh38hg38GRCh38
GRCh372145,773,504 - 45,862,527 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362144,597,912 - 44,687,392 (+)NCBINCBI36Build 36hg18NCBI36
Build 342144,597,998 - 44,687,118NCBI
Celera2130,878,659 - 30,971,052 (+)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2131,143,769 - 31,237,293 (+)NCBIHuRef
CHM1_12145,334,322 - 45,423,804 (+)NCBICHM1_1
T2T-CHM13v2.02142,704,215 - 42,803,115 (+)NCBIT2T-CHM13v2.0
Trpm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391077,743,556 - 77,805,746 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1077,743,556 - 77,806,397 (-)EnsemblGRCm39 Ensembl
GRCm381077,907,722 - 77,969,909 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1077,907,722 - 77,970,563 (-)EnsemblGRCm38mm10GRCm38
MGSCv371077,370,467 - 77,432,617 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361077,312,294 - 77,370,586 (-)NCBIMGSCv36mm8
Celera1078,953,541 - 79,008,872 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Trpm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82010,703,190 - 10,752,795 (+)NCBIGRCr8
mRatBN7.22010,703,568 - 10,753,189 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2010,707,014 - 10,753,181 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2011,406,577 - 11,451,886 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,767,533 - 10,812,846 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02011,239,281 - 11,284,590 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02011,434,062 - 11,482,880 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2011,436,267 - 11,482,051 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02013,604,119 - 13,652,782 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42011,053,301 - 11,099,740 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12011,053,527 - 11,099,966 (+)NCBI
Celera2012,212,844 - 12,258,113 (+)NCBICelera
Cytogenetic Map20p12NCBI
Trpm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540741,057,941 - 41,110,668 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540741,062,217 - 41,110,500 (-)NCBIChiLan1.0ChiLan1.0
TRPM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22240,357,169 - 40,490,267 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12135,207,140 - 35,361,705 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02130,606,825 - 30,737,313 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12143,903,811 - 44,034,712 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2143,903,811 - 44,035,298 (+)Ensemblpanpan1.1panPan2
TRPM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13138,201,075 - 38,224,076 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3137,360,169 - 37,408,622 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03137,748,649 - 37,796,450 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3137,748,507 - 37,796,506 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13137,619,618 - 37,667,467 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03137,598,140 - 37,645,957 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03138,095,431 - 38,143,324 (+)NCBIUU_Cfam_GSD_1.0
Trpm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497137,390,730 - 37,445,869 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650021,942 - 77,260 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650021,960 - 76,895 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRPM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13207,212,457 - 207,262,064 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113207,212,339 - 207,263,313 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213217,096,227 - 217,138,676 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRPM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1288,082,391 - 88,170,340 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl288,087,448 - 88,170,344 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605416,206,670 - 16,292,923 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000026637   ⟹   ENSHGLP00000026401
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474529,757,106 - 29,806,795 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000026638   ⟹   ENSHGLP00000026402
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474529,757,753 - 29,806,531 (-)Ensembl
RefSeq Acc Id: XM_013071366   ⟹   XP_012926820
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474529,757,267 - 29,809,607 (-)NCBI
RefSeq Acc Id: XM_013071367   ⟹   XP_012926821
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474529,757,267 - 29,805,602 (-)NCBI
RefSeq Acc Id: XM_021256358   ⟹   XP_021112017
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474529,757,267 - 29,806,426 (-)NCBI
RefSeq Acc Id: XM_021256359   ⟹   XP_021112018
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474529,757,267 - 29,806,426 (-)NCBI
Protein Sequences
Protein RefSeqs XP_012926820 (Get FASTA)   NCBI Sequence Viewer  
  XP_012926821 (Get FASTA)   NCBI Sequence Viewer  
  XP_021112017 (Get FASTA)   NCBI Sequence Viewer  
  XP_021112018 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000026401
  ENSHGLP00000026402
RefSeq Acc Id: XP_012926820   ⟸   XM_013071366
- Peptide Label: isoform X2
- UniProtKB: G5BG11 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112018   ⟸   XM_021256359
- Peptide Label: isoform X3
- UniProtKB: G5BG11 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112017   ⟸   XM_021256358
- Peptide Label: isoform X1
- UniProtKB: G5BG11 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012926821   ⟸   XM_013071367
- Peptide Label: isoform X4
- UniProtKB: G5BG11 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000026402   ⟸   ENSHGLT00000026638
Ensembl Acc Id: ENSHGLP00000026401   ⟸   ENSHGLT00000026637


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000018785 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000026637 ENTREZGENE
  ENSHGLT00000026638 ENTREZGENE
Gene3D-CATH 3.40.50.450 UniProtKB/TrEMBL
  Nucleoside Triphosphate Pyrophosphohydrolase UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/TrEMBL
  NUDIX_hydrolase-like_dom_sf UniProtKB/TrEMBL
  NUDIX_hydrolase_dom UniProtKB/TrEMBL
  TRPM UniProtKB/TrEMBL
  TRPM_SLOG UniProtKB/TrEMBL
NCBI Gene Trpm2 ENTREZGENE
PANTHER TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 2 UniProtKB/TrEMBL
  TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6 UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/TrEMBL
  LSDAT_euk UniProtKB/TrEMBL
PROSITE NUDIX UniProtKB/TrEMBL
Superfamily-SCOP Nudix UniProtKB/TrEMBL
UniProt G5BG11 ENTREZGENE, UniProtKB/TrEMBL