Gene: TRPM2 (transient receptor potential cation channel subfamily M member 2) Homo sapiens
Symbol: TRPM2
Name: transient receptor potential cation channel subfamily M member 2
Description: The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: EREG1; estrogen-responsive element-associated gene 1 protein; KNP3; long transient receptor potential channel 2; LTrpC-2; LTRPC2; MGC133383; NUDT9H; NUDT9L1; OTTHUMP00000038504; OTTHUMP00000038505; OTTHUMP00000109530; OTTHUMP00000207883; transient receptor potential cation channel, subfamily M, member 2; transient receptor potential channel 7; transient receptor potential melastatin 2; TRPC7
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382144,350,112 - 44,443,081 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372145,770,046 - 45,862,964 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362144,597,912 - 44,687,392 (+)NCBINCBI36hg18NCBI36
Build 342144,597,998 - 44,687,118NCBI
Celera2130,878,659 - 30,971,052 (+)NCBI
Cytogenetic Map21q22.3NCBI
HuRef2131,143,769 - 31,237,293 (+)NCBIHuRef
CHM1_12145,334,322 - 45,423,804 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TRPM2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1323582
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2018-03-13
Status: ACTIVE