Keap1 (kelch like ECH associated protein 1) - Rat Genome Database

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Gene: Keap1 (kelch like ECH associated protein 1) Heterocephalus glaber
Analyze
Symbol: Keap1
Name: kelch like ECH associated protein 1
RGD ID: 18935328
Description: ENCODES a protein that exhibits disordered domain specific binding (inferred); identical protein binding (inferred); RNA polymerase II-specific DNA-binding transcription factor binding (inferred); INVOLVED IN cellular response to carbohydrate stimulus (ortholog); cellular response to interleukin-4 (ortholog); cellular response to organic cyclic compound (ortholog); PARTICIPATES IN nuclear factor, erythroid 2 like 2 signaling pathway; ASSOCIATED WITH Alcoholic Liver Diseases (ortholog); amyotrophic lateral sclerosis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN adherens junction (ortholog); focal adhesion (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: kelch-like ECH-associated protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,580,861 - 2,595,275 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,580,812 - 2,595,023 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Keap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,580,861 - 2,595,275 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,580,812 - 2,595,023 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
KEAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,486,125 - 10,503,356 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1910,486,125 - 10,503,558 (-)EnsemblGRCh38hg38GRCh38
GRCh371910,596,801 - 10,614,032 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,457,796 - 10,475,054 (-)NCBINCBI36Build 36hg18NCBI36
Celera1910,491,509 - 10,508,764 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1910,176,101 - 10,192,927 (-)NCBIHuRef
CHM1_11910,597,575 - 10,614,823 (-)NCBICHM1_1
T2T-CHM13v2.01910,612,569 - 10,629,791 (-)NCBIT2T-CHM13v2.0
Keap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,141,026 - 21,150,628 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,141,026 - 21,150,657 (-)EnsemblGRCm39 Ensembl
GRCm38921,229,730 - 21,239,332 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,229,730 - 21,239,361 (-)EnsemblGRCm38mm10GRCm38
MGSCv37921,034,174 - 21,043,776 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36920,980,469 - 20,989,215 (-)NCBIMGSCv36mm8
Celera918,498,845 - 18,508,447 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.74NCBI
Keap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,044,555 - 28,054,042 (-)NCBIGRCr8
mRatBN7.2819,768,375 - 19,777,862 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,768,375 - 19,777,862 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,787,814 - 23,797,272 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,085,659 - 22,095,117 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,998,059 - 20,007,547 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,250,518 - 22,259,868 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,250,518 - 22,259,779 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,305,765 - 22,315,026 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,259,178 - 20,266,351 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1820,259,177 - 20,266,352 (-)NCBI
Celera821,161,976 - 21,171,435 (-)NCBICelera
Cytogenetic Map8q13NCBI
Keap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,704,695 - 1,711,290 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,704,695 - 1,711,339 (-)NCBIChiLan1.0ChiLan1.0
KEAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22015,404,143 - 15,421,611 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11914,402,746 - 14,420,092 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01910,037,544 - 10,055,091 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11910,701,298 - 10,717,664 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,701,303 - 10,717,604 (-)Ensemblpanpan1.1panPan2
KEAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,651,070 - 50,661,178 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,650,711 - 50,658,496 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2050,523,052 - 50,533,206 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02051,174,558 - 51,182,077 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,164,570 - 51,185,490 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,380,711 - 50,390,863 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,808,833 - 50,818,993 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,049,891 - 51,060,051 (+)NCBIUU_Cfam_GSD_1.0
Keap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,560,465 - 209,569,647 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659782,340 - 793,688 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936659785,059 - 793,775 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KEAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,276,336 - 69,294,382 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1269,280,940 - 69,290,267 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,634,153 - 69,643,610 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KEAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,515,789 - 9,526,699 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl69,515,416 - 9,522,797 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607410,471,467 - 10,484,386 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000021507   ⟹   ENSHGLP00000021299
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248282,580,861 - 2,595,275 (-)Ensembl
RefSeq Acc Id: XM_004865501   ⟹   XP_004865558
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248282,580,861 - 2,589,628 (-)NCBI
RefSeq Acc Id: XM_004865502   ⟹   XP_004865559
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248282,580,861 - 2,595,023 (-)NCBI
RefSeq Acc Id: XM_004865503   ⟹   XP_004865560
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248282,580,861 - 2,589,625 (-)NCBI
RefSeq Acc Id: XR_001182393
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248282,580,812 - 2,589,628 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004865558 (Get FASTA)   NCBI Sequence Viewer  
  XP_004865559 (Get FASTA)   NCBI Sequence Viewer  
  XP_004865560 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB12931 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000021299
GenBank Protein JAN98736 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004865559   ⟸   XM_004865502
- Peptide Label: isoform X1
RefSeq Acc Id: XP_004865558   ⟸   XM_004865501
- Peptide Label: isoform X1
RefSeq Acc Id: XP_004865560   ⟸   XM_004865503
- Peptide Label: isoform X2
- UniProtKB: A0A0P6J3F8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000021299   ⟸   ENSHGLT00000021507


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000015222 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000021507 ENTREZGENE
Gene3D-CATH 1.25.40.420 UniProtKB/TrEMBL
  2.120.10.80 UniProtKB/TrEMBL
InterPro BACK UniProtKB/TrEMBL
  BTB-kelch_protein UniProtKB/TrEMBL
  BTB/POZ_dom UniProtKB/TrEMBL
  KEAP1 UniProtKB/TrEMBL
  KEAP1_BACK UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
NCBI Gene Keap1 ENTREZGENE
PANTHER ACTIN-BINDING PROTEIN IPP UniProtKB/TrEMBL
  KELCH PROTEIN UniProtKB/TrEMBL
Pfam BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
PIRSF Kelch-like_protein_gigaxonin UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
SMART BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch UniProtKB/TrEMBL
Superfamily-SCOP SSF117281 UniProtKB/TrEMBL
  SSF54695 UniProtKB/TrEMBL
UniProt A0A0P6J3F8 ENTREZGENE, UniProtKB/TrEMBL