Mdh1 (malate dehydrogenase 1) - Rat Genome Database

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Gene: Mdh1 (malate dehydrogenase 1) Heterocephalus glaber
Analyze
Symbol: Mdh1
Name: malate dehydrogenase 1
RGD ID: 18921476
Description: ENCODES a protein that exhibits L-malate dehydrogenase (NAD+) activity (ortholog); malate dehydrogenase activity (ortholog); NAD binding (ortholog); INVOLVED IN malate metabolic process (ortholog); NAD+ metabolic process (ortholog); NADH metabolic process (ortholog); PARTICIPATES IN Leigh disease pathway; nicotinamide adenine dinucleotide metabolic pathway; primary hyperoxaluria type 2 pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); adult respiratory distress syndrome (ortholog); Bardet-Biedl syndrome (ortholog); FOUND IN centrosome (inferred); cytoplasm (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: malate dehydrogenase, cytoplasmic
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247629,881,950 - 9,901,372 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247629,884,521 - 9,900,593 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mdh1Naked Mole-RatLiver Injury treatmentISOMdh1 (Rattus norvegicus)9068941 RGDPMID:24919044 and REF_RGD_ID:13703104
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mdh1Naked Mole-RatBardet-Biedl syndrome  ISOMDH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Bardet-Biedl syndromeClinVarPMID:28492532
Mdh1Naked Mole-Ratdevelopmental and epileptic encephalopathy 88  ISOMDH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathy and 88ClinVarPMID:31538237
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mdh1Naked Mole-RatAcute Liver Failure  ISOMDH1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:35172013
Mdh1Naked Mole-Ratadult respiratory distress syndrome  ISOMDH1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:25070658
Mdh1Naked Mole-RatChemical and Drug Induced Liver Injury  ISOMDH1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:16099942
Mdh1Naked Mole-RatExperimental Liver Cirrhosis  ISOMDH1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:25380136
Mdh1Naked Mole-Rathypertension  ISOMDH1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:22228705
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mdh1Naked Mole-Ratdevelopmental and epileptic encephalopathy 88  ISOMDH1 (Homo sapiens)7240710 OMIM 


Biological Process
1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mdh1Naked Mole-Ratcarboxylic acid metabolic process involved_inIEAInterPro:IPR001557150520179 InterProGO_REF:0000002
Mdh1Naked Mole-Ratmalate metabolic process  ISOMdh1 (Rattus norvegicus)9068941 RGDPMID:12351438 more ...
Mdh1Naked Mole-Ratmalate metabolic process involved_inIEAInterPro:IPR001252 more ...150520179 InterProGO_REF:0000002
Mdh1Naked Mole-Ratmalate-aspartate shuttle involved_inIEAUniProtKB:P14152 more ...150520179 EnsemblGO_REF:0000107
Mdh1Naked Mole-RatNAD+ metabolic process  ISOMdh1 (Rattus norvegicus)9068941 RGDPMID:17447164 and REF_RGD_ID:1624966
Mdh1Naked Mole-RatNADH metabolic process involved_inIEAUniProtKB:P40925 and ensembl:ENSP00000233114150520179 EnsemblGO_REF:0000107
Mdh1Naked Mole-RatNADH metabolic process involved_inIEAARBA:ARBA00050069150520179 UniProtGO_REF:0000117
Mdh1Naked Mole-RatNADH metabolic process  ISOMdh1 (Rattus norvegicus)9068941 RGDPMID:12351438 and REF_RGD_ID:2303499
Mdh1Naked Mole-RatNADP+ metabolic process involved_inIEAUniProtKB:P40925 and ensembl:ENSP00000233114150520179 EnsemblGO_REF:0000107
Mdh1Naked Mole-Ratoxaloacetate metabolic process  ISOMdh1 (Rattus norvegicus)9068941 RGDPMID:17447164 and REF_RGD_ID:1624966
Mdh1Naked Mole-Rattricarboxylic acid cycle involved_inIEAUniProtKB-KW:KW-0816150520179 UniProtGO_REF:0000043
1 to 11 of 11 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mdh1Naked Mole-Ratcentrosome located_inIEAUniProtKB:P40925 more ...150520179 EnsemblGO_REF:0000107
Mdh1Naked Mole-Ratcytoplasm located_inIEAUniProtKB:P40925 and ensembl:ENSP00000233114150520179 EnsemblGO_REF:0000107
Mdh1Naked Mole-Ratcytosol located_inIEAUniProtKB:P40925 more ...150520179 EnsemblGO_REF:0000107
Mdh1Naked Mole-Ratcytosol is_active_inIEAUniProtKB:P14152 and ensembl:ENSMUSP00000099938150520179 EnsemblGO_REF:0000107

Molecular Function
1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mdh1Naked Mole-Ratcatalytic activity enablesIEAInterPro:IPR015955150520179 InterProGO_REF:0000002
Mdh1Naked Mole-Rathydroxyphenylpyruvate reductase activity enablesIEARHEA:10780150520179 RHEAGO_REF:0000116
Mdh1Naked Mole-RatL-malate dehydrogenase (NAD+) activity  ISOMdh1 (Rattus norvegicus)9068941 RGDPMID:12351438 more ...
Mdh1Naked Mole-RatL-malate dehydrogenase (NAD+) activity enablesIEAARBA:ARBA00034976150520179 UniProtGO_REF:0000117
Mdh1Naked Mole-RatL-malate dehydrogenase (NAD+) activity enablesIEAEC:1.1.1.37150520179 UniProtGO_REF:0000003
Mdh1Naked Mole-RatL-malate dehydrogenase (NAD+) activity enablesIEAInterPro:IPR011274150520179 InterProGO_REF:0000002
Mdh1Naked Mole-RatL-malate dehydrogenase (NAD+) activity enablesIEARHEA:21432150520179 RHEAGO_REF:0000116
Mdh1Naked Mole-RatL-malate dehydrogenase (NAD+) activity enablesIEAUniProtKB:P14152 and ensembl:ENSMUSP00000099938150520179 EnsemblGO_REF:0000107
Mdh1Naked Mole-Ratmalate dehydrogenase activity  ISOMdh1 (Rattus norvegicus)9068941 RGDPMID:2820961 and REF_RGD_ID:724435
Mdh1Naked Mole-Ratmalate dehydrogenase activity enablesIEAInterPro:IPR001252 and InterPro:IPR010945150520179 InterProGO_REF:0000002
Mdh1Naked Mole-RatNAD binding  ISOMdh1 (Rattus norvegicus)9068941 RGDPMID:17447164 and REF_RGD_ID:1624966
Mdh1Naked Mole-RatNAD binding enablesISOMDH1 (Sus scrofa)9068941 PMID:10075524UniProtPMID:10075524
Mdh1Naked Mole-Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-0560150520179 UniProtGO_REF:0000043
Mdh1Naked Mole-Ratoxidoreductase activity enablesIEAInterPro:IPR001236150520179 InterProGO_REF:0000002
Mdh1Naked Mole-Ratoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor enablesIEAInterPro:IPR001557 more ...150520179 InterProGO_REF:0000002
Mdh1Naked Mole-Ratprotein binding enablesISOUniProtKB:P542749068941 PMID:21044950IntActPMID:21044950
1 to 16 of 16 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mdh1Naked Mole-Ratnicotinamide adenine dinucleotide metabolic pathway   ISOMDH1 (Homo sapiens)9068941 RGDPMID:16368075 more ...

Imported Annotations - SMPDB

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mdh1Naked Mole-RatLeigh disease pathway  ISOMDH1 (Homo sapiens)9068941 SMPDBSMP:00196
Mdh1Naked Mole-Ratprimary hyperoxaluria type 2 pathway  ISOMDH1 (Homo sapiens)9068941 SMPDBSMP:00558
Mdh1Naked Mole-Ratpyruvate decarboxylase deficiency pathway  ISOMDH1 (Homo sapiens)9068941 SMPDBSMP:00212
Mdh1Naked Mole-Ratpyruvate dehydrogenase E1 deficiency pathway  ISOMDH1 (Homo sapiens)9068941 SMPDBSMP:00334
Mdh1Naked Mole-Ratpyruvate kinase deficiency of red cells pathway  ISOMDH1 (Homo sapiens)9068941 SMPDBSMP:00559
Mdh1Naked Mole-Ratpyruvate metabolic pathway   ISOMDH1 (Homo sapiens)9068941 SMPDBSMP:00060
PMID:22301074   PMID:30032202  



Mdh1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247629,881,950 - 9,901,372 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247629,884,521 - 9,900,593 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MDH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38263,588,963 - 63,607,197 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl263,588,609 - 63,607,197 (+)EnsemblGRCh38hg38GRCh38
GRCh37263,816,097 - 63,834,331 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36263,669,626 - 63,687,832 (+)NCBINCBI36Build 36hg18NCBI36
Build 34263,727,772 - 63,745,979NCBI
Celera263,661,163 - 63,679,336 (+)NCBICelera
Cytogenetic Map2p15NCBI
HuRef263,556,773 - 63,575,326 (+)NCBIHuRef
CHM1_1263,745,880 - 63,764,431 (+)NCBICHM1_1
T2T-CHM13v2.0263,596,617 - 63,614,818 (+)NCBIT2T-CHM13v2.0
Mdh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391121,506,692 - 21,521,934 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1121,506,692 - 21,522,367 (-)EnsemblGRCm39 Ensembl
GRCm381121,556,692 - 21,571,934 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1121,556,692 - 21,572,367 (-)EnsemblGRCm38mm10GRCm38
MGSCv371121,456,695 - 21,471,937 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361121,456,790 - 21,471,832 (-)NCBIMGSCv36mm8
Celera1123,704,959 - 23,720,201 (-)NCBICelera
Cytogenetic Map11A3.1NCBI
cM Map1113.89NCBI
Mdh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81499,831,934 - 99,847,227 (-)NCBIGRCr8
mRatBN7.21495,630,625 - 95,645,920 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1495,630,306 - 95,645,925 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1499,982,791 - 99,997,990 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014101,223,133 - 101,238,332 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01497,696,668 - 97,711,868 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014106,378,349 - 106,393,642 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14106,378,942 - 106,393,670 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014106,449,337 - 106,463,995 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414102,259,130 - 102,273,788 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.114102,278,343 - 102,292,999 (-)NCBI
Celera1494,639,971 - 94,655,156 (-)NCBICelera
Cytogenetic Map14q22NCBI
Mdh1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542420,706,058 - 20,723,493 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542420,707,765 - 20,723,493 (-)NCBIChiLan1.0ChiLan1.0
MDH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21262,789,858 - 62,808,152 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A62,793,808 - 62,812,102 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A63,658,933 - 63,677,257 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A64,785,132 - 64,803,631 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A64,785,132 - 64,803,631 (+)Ensemblpanpan1.1panPan2
MDH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11063,316,818 - 63,334,556 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1063,316,831 - 63,361,735 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1063,205,783 - 63,223,532 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01064,325,732 - 64,343,477 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1064,325,748 - 64,393,190 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11064,008,394 - 64,026,100 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01064,316,618 - 64,334,341 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01064,609,207 - 64,626,872 (+)NCBIUU_Cfam_GSD_1.0
Mdh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629219,984,379 - 20,000,470 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364918,570,472 - 8,587,686 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364918,570,472 - 8,586,914 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MDH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl378,244,999 - 78,268,600 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1378,247,229 - 78,263,085 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2382,274,663 - 82,280,460 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MDH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11443,406,502 - 43,425,525 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1443,406,499 - 43,425,095 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604568,435,625 - 68,454,293 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.






Ensembl Acc Id: ENSHGLT00000007763   ⟹   ENSHGLP00000007677
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247629,881,950 - 9,901,372 (-)Ensembl
RefSeq Acc Id: XM_004849985   ⟹   XP_004850042
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247629,884,521 - 9,900,593 (-)NCBI
RefSeq Acc Id: XM_021262551   ⟹   XP_021118210
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247629,884,521 - 9,899,552 (-)NCBI
Protein RefSeqs XP_004850042 (Get FASTA)   NCBI Sequence Viewer  
  XP_021118210 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000007677
GenBank Protein JAN96835 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004850042   ⟸   XM_004849985
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J385 (UniProtKB/TrEMBL),   G5C8M3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021118210   ⟸   XM_021262551
- Peptide Label: isoform X2
- UniProtKB: A0AAX6TEH0 (UniProtKB/TrEMBL),   G5C8M3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000007677   ⟸   ENSHGLT00000007763



1 to 24 of 24 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSHGLG00000005568 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000007763 ENTREZGENE
Gene3D-CATH 3.90.110.10 UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro L-lactate/malate_DH UniProtKB/TrEMBL
  Lactate/malate_DH_C UniProtKB/TrEMBL
  Lactate/malate_DH_N UniProtKB/TrEMBL
  Lactate_DH/Glyco_Ohase_4_C UniProtKB/TrEMBL
  Malate_DH_AS UniProtKB/TrEMBL
  Malate_DH_NAD-dep_euk UniProtKB/TrEMBL
  Malate_DH_type2 UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
KEGG Report hgl:101719728 UniProtKB/TrEMBL
NCBI Gene Mdh1 ENTREZGENE
PANTHER PTHR23382 UniProtKB/TrEMBL
Pfam Ldh_1_C UniProtKB/TrEMBL
  Ldh_1_N UniProtKB/TrEMBL
PIRSF Lac_mal_DH UniProtKB/TrEMBL
PROSITE MDH UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
  SSF56327 UniProtKB/TrEMBL
UniProt A0A0P6J385 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6TEH0 ENTREZGENE, UniProtKB/TrEMBL
  G5C8M3 ENTREZGENE, UniProtKB/TrEMBL
1 to 24 of 24 rows