MDH1 (malate dehydrogenase 1) - Rat Genome Database

Name: MDH1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: MDH1 (malate dehydrogenase 1) Canis lupus familiaris

Analyze

Symbol:

MDH1

Name:

malate dehydrogenase 1

RGD ID:

12400133

Description:

ENCODES a protein that exhibits L-malate dehydrogenase activity (ortholog); malate dehydrogenase activity (ortholog); NAD binding (ortholog); INVOLVED IN malate metabolic process (ortholog); NAD metabolic process (ortholog); NADH metabolic process (ortholog); PARTICIPATES IN Leigh disease pathway; nicotinamide adenine dinucleotide metabolic pathway; primary hyperoxaluria type 2 pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); adult respiratory distress syndrome (ortholog); Bardet-Biedl syndrome (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); cytosol (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

malate dehydrogenase, cytoplasmic

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MDH1 (malate dehydrogenase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Mdh1 (malate dehydrogenase 1, NAD (soluble))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Mdh1 (malate dehydrogenase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mdh1 (malate dehydrogenase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MDH1 (malate dehydrogenase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mdh1 (malate dehydrogenase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MDH1 (malate dehydrogenase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MDH1 (malate dehydrogenase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mdh1 (malate dehydrogenase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	63,316,818 - 63,334,556 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	63,316,831 - 63,361,735 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	63,205,783 - 63,223,532 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	64,325,732 - 64,343,477 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	64,325,748 - 64,393,190 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	64,008,394 - 64,026,100 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	64,316,618 - 64,334,341 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	64,609,207 - 64,626,872 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Liver Failure (ISO)

adult respiratory distress syndrome (ISO)

Bardet-Biedl syndrome (ISO)

Chemical and Drug Induced Liver Injury (ISO)

developmental and epileptic encephalopathy 88 (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

hypertension (ISO)

Liver Injury (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

carboxylic acid metabolic process (IEA)

malate metabolic process (IEA,ISO)

NAD metabolic process (ISO)

NADH metabolic process (IEA,ISO)

NADP metabolic process (ISO)

oxaloacetate metabolic process (IEA,ISO)

tricarboxylic acid cycle (IEA)

Cellular Component

centrosome (ISO)

cytoplasm (ISO)

cytosol (IEA,ISO)

mitochondrion (IEA)

Molecular Function

catalytic activity (IEA)

L-malate dehydrogenase activity (IEA,ISO)

malate dehydrogenase activity (IEA,ISO)

NAD binding (ISO)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Leigh disease pathway (ISO)

nicotinamide adenine dinucleotide metabolic pathway (ISO)

primary hyperoxaluria type 2 pathway (ISO)

pyruvate decarboxylase deficiency pathway (ISO)

pyruvate dehydrogenase E1 deficiency pathway (ISO)

pyruvate kinase deficiency of red cells pathway (ISO)

pyruvate metabolic pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

MDH1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	63,316,818 - 63,334,556 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	63,316,831 - 63,361,735 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	63,205,783 - 63,223,532 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	64,325,732 - 64,343,477 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	64,325,748 - 64,393,190 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	64,008,394 - 64,026,100 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	64,316,618 - 64,334,341 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	64,609,207 - 64,626,872 (+)	NCBI		UU_Cfam_GSD_1.0

MDH1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	63,588,963 - 63,607,197 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	63,588,609 - 63,607,197 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	63,816,097 - 63,834,331 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	63,669,626 - 63,687,832 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	63,727,772 - 63,745,979	NCBI
Celera	2	63,661,163 - 63,679,336 (+)	NCBI		Celera
Cytogenetic Map	2	p15	NCBI
HuRef	2	63,556,773 - 63,575,326 (+)	NCBI		HuRef
CHM1_1	2	63,745,880 - 63,764,431 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	63,596,617 - 63,614,818 (+)	NCBI		T2T-CHM13v2.0

Mdh1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	21,506,692 - 21,521,934 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	21,506,692 - 21,522,367 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	21,556,692 - 21,571,934 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	21,556,692 - 21,572,367 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	21,456,695 - 21,471,937 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	21,456,790 - 21,471,832 (-)	NCBI		MGSCv36	mm8
Celera	11	23,704,959 - 23,720,201 (-)	NCBI		Celera
Cytogenetic Map	11	A3.1	NCBI
cM Map	11	13.89	NCBI

Mdh1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	99,831,934 - 99,847,227 (-)	NCBI		GRCr8
mRatBN7.2	14	95,630,625 - 95,645,920 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	95,630,306 - 95,645,925 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	99,982,791 - 99,997,990 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	101,223,133 - 101,238,332 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	97,696,668 - 97,711,868 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	106,378,349 - 106,393,642 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	106,378,942 - 106,393,670 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	106,449,337 - 106,463,995 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	102,259,130 - 102,273,788 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	102,278,343 - 102,292,999 (-)	NCBI
Celera	14	94,639,971 - 94,655,156 (-)	NCBI		Celera
Cytogenetic Map	14	q22	NCBI

Mdh1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955424	20,706,058 - 20,723,493 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955424	20,707,765 - 20,723,493 (-)	NCBI	ChiLan1.0	ChiLan1.0

MDH1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	62,789,858 - 62,808,152 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	62,793,808 - 62,812,102 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	63,658,933 - 63,677,257 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	64,785,132 - 64,803,631 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	64,785,132 - 64,803,631 (+)	Ensembl	panpan1.1		panPan2

Mdh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	19,984,379 - 20,000,470 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936491	8,570,472 - 8,587,686 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936491	8,570,472 - 8,586,914 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MDH1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	78,244,999 - 78,268,600 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	78,247,229 - 78,263,085 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	82,274,663 - 82,280,460 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MDH1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	43,406,502 - 43,425,525 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	43,406,499 - 43,425,095 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	68,435,625 - 68,454,293 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mdh1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624762	9,881,950 - 9,901,372 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624762	9,884,521 - 9,900,593 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in MDH1
203 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High		5							3			1
Medium	5		22	6	6	6	6	6	9	8	10	5
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_038489433	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038551416	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038615351	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038680739	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_531844	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000101	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000358	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000005036 ⟹ ENSCAFP00000004671

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	10	63,316,973 - 63,334,554 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000036209 ⟹ ENSCAFP00000031562

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	10	63,316,831 - 63,334,516 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000062772 ⟹ ENSCAFP00000064224

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	10	63,316,973 - 63,334,559 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000066360 ⟹ ENSCAFP00000056917

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	10	63,316,831 - 63,361,735 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845033665 ⟹ ENSCAFP00845026356

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	10	64,325,748 - 64,343,332 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845033788 ⟹ ENSCAFP00845026443

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	10	64,325,816 - 64,393,190 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845033899 ⟹ ENSCAFP00845026525

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	10	64,325,816 - 64,393,190 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845034002 ⟹ ENSCAFP00845026609

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	10	64,325,890 - 64,393,190 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845034056 ⟹ ENSCAFP00845026658

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	10	64,325,890 - 64,393,190 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845034097 ⟹ ENSCAFP00845026693

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	10	64,326,204 - 64,393,190 (+)	Ensembl

RefSeq Acc Id:

XM_038489433 ⟹ XP_038345361

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	10	64,008,394 - 64,026,100 (+)	NCBI

RefSeq Acc Id:

XM_038551416 ⟹ XP_038407344

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	10	64,609,207 - 64,626,872 (+)	NCBI

RefSeq Acc Id:

XM_038615351 ⟹ XP_038471279

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	10	64,316,618 - 64,334,341 (+)	NCBI

RefSeq Acc Id:

XM_038680739 ⟹ XP_038536667

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	10	64,325,732 - 64,343,477 (+)	NCBI

RefSeq Acc Id:

XM_531844 ⟹ XP_531844

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	10	63,316,818 - 63,334,556 (+)	NCBI
Dog10K_Boxer_Tasha	10	63,205,783 - 63,223,532 (+)	NCBI

Sequence:

show sequence

GTAAACTACAGTTCCCAGAGGGCGCTGCGGCGGGGAGCCGAGCATTTTCCCATCCAACAGCGCT
CGCCCTCCCCGAGCCAGTTCCGCAGTAAAGGTGACCCGGCTCCGTGAGGCTCGTTTTGCAGGTG
CTGAAATTGTTCGCGCACTTCTTAATCATGTCTGAACCAATCAGAGTCCTCGTGACTGGAGCAG
CTGGTCAAATTGCATATTCACTGCTGTACAGTATTGGAAATGGATCTGTCTTTGGTAAAGACCA
GCCTATAATTCTTGTGCTGTTGGATATCACTCCCATGATGGGTGTCCTAGATGGTGTCCTAATG
GAACTACAAGACTGTGCCCTTCCCCTCCTGAAAGATGTCATCGCAACAGATAAAGAGGATGTTG
CCTTCAAAGACCTGGATGTGGCCATTCTTGTGGGCTCCATGCCAAGAAGGGATGGCATGGAAAG
GAAGGATTTACTCAAAGCAAATGTGAAAATCTTCAAATGCCAGGGTGCAGCCTTGGAGAAATAT
GCCAAGAAGTCAGTTAAGGTTATCGTGGTGGGAAATCCAGCCAATACCAACTGCCTGACTGCCT
CCAAGTCGGCACCGTCCATCCCCAAGGAGAACTTCAGTTGCTTGACTCGTTTGGATCACAACCG
AGCCAAAGCTCAGATTGCTCTTAAACTTGGTGTGACTTCTGATGATGTAAAGAATGTCATTATC
TGGGGAAACCATTCCTCAACTCAGTATCCAGATGTCAGCCATGCCAAGGTGAAACTGCAAGGAA
AGGAAGTTGGTGTTTATGATGCTCTGAAAGATGAAAGCTGGCTCAAGGGAGAGTTCATCACAAC
CGTGCAGCAGCGTGGCGCTGCTGTCATCAAGGCTCGAAAGCTGTCCAGCGCGATGTCTGCTGCA
AAAGCCATCTGTGACCATGTCAGAGACATCTGGTTTGGAACCCCAGAGGGAGAATTTGTGTCCA
TGGGCATTATCTCCGATGGCAACCCCTACGGTGTTCCTGATGATCTGCTGTACTCATTCCCTGT
TACAATCAAGAATAAAACCTGGAAGATTGTTGAAGGTCTCACTATTAATGATTTCTCCCGTGAG
AAGATGGATCTAACTGCAAAGGAACTGGCGGAAGAAAAAGAAACTGCCTTTGAGTTTCTTTCTT
CTGCCTGACTAGCCCATCATTTTGATGTTACTAAAGGCTCCAAAGCTGAAGAATCTAAATGTCG
TCTTTGACTCTAGTACCAAATGACAATATTGCTGTACTTAAATTCCTTGTGAAAAACAACGTTT
GAAAGATTATGTGCTTCTTGGTATAAATTTGTGACAGTTTATCATGCTGTTAGTGCTGCATTCT
AAATAAAATATATATTCAAATGAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_038345361	(Get FASTA)	NCBI Sequence Viewer
	XP_038407344	(Get FASTA)	NCBI Sequence Viewer
	XP_038471279	(Get FASTA)	NCBI Sequence Viewer
	XP_038536667	(Get FASTA)	NCBI Sequence Viewer
	XP_531844	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000004671.4
	ENSCAFP00000031562.3
	ENSCAFP00000056917.2
	ENSCAFP00000064224.1
	ENSCAFP00000070429.1
	ENSCAFP00000072189.1
	ENSCAFP00030028890.1
	ENSCAFP00030028943.1
	ENSCAFP00030029024.1
	ENSCAFP00040007317.1
	ENSCAFP00040007340.1
	ENSCAFP00040007364.1
	ENSCAFP00845026356.1
	ENSCAFP00845026443
	ENSCAFP00845026443.1
	ENSCAFP00845026525.1
	ENSCAFP00845026609.1
	ENSCAFP00845026658.1
	ENSCAFP00845026693.1

RefSeq Acc Id:

XP_531844 ⟸ XM_531844

- UniProtKB:

A0A8C0LN53 (UniProtKB/TrEMBL), A0A8C0Q1T7 (UniProtKB/TrEMBL), A0A8I3P5G6 (UniProtKB/TrEMBL), A0A8I3P822 (UniProtKB/TrEMBL), A0A8P0P687 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPL
LKDVIATDKEDVAFKDLDVAILVGSMPRRDGMERKDLLKANVKIFKCQGAALEKYAKKSVKVIV
VGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTSDDVKNVIIWGNHSSTQY
PDVSHAKVKLQGKEVGVYDALKDESWLKGEFITTVQQRGAAVIKARKLSSAMSAAKAICDHVRD
IWFGTPEGEFVSMGIISDGNPYGVPDDLLYSFPVTIKNKTWKIVEGLTINDFSREKMDLTAKEL
AEEKETAFEFLSSA

hide sequence

RefSeq Acc Id:

ENSCAFP00000004671 ⟸ ENSCAFT00000005036

RefSeq Acc Id:

ENSCAFP00000056917 ⟸ ENSCAFT00000066360

RefSeq Acc Id:

ENSCAFP00000064224 ⟸ ENSCAFT00000062772

RefSeq Acc Id:

ENSCAFP00000031562 ⟸ ENSCAFT00000036209

RefSeq Acc Id:

XP_038345361 ⟸ XM_038489433

RefSeq Acc Id:

XP_038471279 ⟸ XM_038615351

RefSeq Acc Id:	XP_038536667 ⟸ XM_038680739
- UniProtKB:	A0A8C0Q1T7 (UniProtKB/TrEMBL), A0A8C0LN53 (UniProtKB/TrEMBL), A0A8I3P5G6 (UniProtKB/TrEMBL), A0A8I3P822 (UniProtKB/TrEMBL), A0A8P0P687 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038407344 ⟸ XM_038551416
- UniProtKB:	A0A8C0LN53 (UniProtKB/TrEMBL), A0A8C0Q1T7 (UniProtKB/TrEMBL), A0A8I3P5G6 (UniProtKB/TrEMBL), A0A8I3P822 (UniProtKB/TrEMBL), A0A8P0P687 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCAFP00845026609 ⟸ ENSCAFT00845034002

RefSeq Acc Id:

ENSCAFP00845026443 ⟸ ENSCAFT00845033788

RefSeq Acc Id:

ENSCAFP00845026693 ⟸ ENSCAFT00845034097

RefSeq Acc Id:

ENSCAFP00845026356 ⟸ ENSCAFT00845033665

RefSeq Acc Id:

ENSCAFP00845026525 ⟸ ENSCAFT00845033899

RefSeq Acc Id:

ENSCAFP00845026658 ⟸ ENSCAFT00845034056

Protein Domains

Lactate/malate dehydrogenase C-terminal Lactate/malate dehydrogenase N-terminal

Promoters

RGD ID:

13685084

Promoter ID:

EPDNEW_C3152

Type:

single initiation site

Name:

MDH1_1

Description:

malate dehydrogenase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	10	63,322,334 - 63,322,394	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000003129	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030017855	UniProtKB/TrEMBL
	ENSCAFG00040004403	UniProtKB/TrEMBL
	ENSCAFG00845019026	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000005036.5	UniProtKB/TrEMBL
	ENSCAFT00000036209.5	UniProtKB/TrEMBL
	ENSCAFT00000062772.2	UniProtKB/TrEMBL
	ENSCAFT00000066360.2	UniProtKB/TrEMBL
	ENSCAFT00000094258.1	UniProtKB/TrEMBL
	ENSCAFT00000097367.1	UniProtKB/TrEMBL
	ENSCAFT00030033118.1	UniProtKB/TrEMBL
	ENSCAFT00030033177.1	UniProtKB/TrEMBL
	ENSCAFT00030033266.1	UniProtKB/TrEMBL
	ENSCAFT00040008427.1	UniProtKB/TrEMBL
	ENSCAFT00040008452.1	UniProtKB/TrEMBL
	ENSCAFT00040008478.1	UniProtKB/TrEMBL
	ENSCAFT00845033665.1	UniProtKB/TrEMBL
	ENSCAFT00845033788	ENTREZGENE
	ENSCAFT00845033788.1	UniProtKB/TrEMBL
	ENSCAFT00845033899.1	UniProtKB/TrEMBL
	ENSCAFT00845034002.1	UniProtKB/TrEMBL
	ENSCAFT00845034056.1	UniProtKB/TrEMBL
	ENSCAFT00845034097.1	UniProtKB/TrEMBL
Gene3D-CATH	3.90.110.10	UniProtKB/TrEMBL
	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	L-lactate/malate_DH	UniProtKB/TrEMBL
	Lactate/malate_DH_C	UniProtKB/TrEMBL
	Lactate/malate_DH_N	UniProtKB/TrEMBL
	Lactate_DH/Glyco_Ohase_4_C	UniProtKB/TrEMBL
	Malate_DH_AS	UniProtKB/TrEMBL
	Malate_DH_NAD-dep_euk	UniProtKB/TrEMBL
	Malate_DH_type2	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
KEGG Report	cfa:474614	UniProtKB/TrEMBL
NCBI Gene	MDH1	ENTREZGENE
PANTHER	MALATE DEHYDROGENASE, CYTOPLASMIC	UniProtKB/TrEMBL
	PTHR23382	UniProtKB/TrEMBL
Pfam	Ldh_1_C	UniProtKB/TrEMBL
	Ldh_1_N	UniProtKB/TrEMBL
PIRSF	Lac_mal_DH	UniProtKB/TrEMBL
PROSITE	MDH	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51735	UniProtKB/TrEMBL
	SSF56327	UniProtKB/TrEMBL
UniProt	A0A8C0LN53	ENTREZGENE
	A0A8C0NS65_CANLF	UniProtKB/TrEMBL
	A0A8C0Q1T7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0Q5K6_CANLF	UniProtKB/TrEMBL
	A0A8I3NYN6_CANLF	UniProtKB/TrEMBL
	A0A8I3P5G6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3P822	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3P8F4_CANLF	UniProtKB/TrEMBL
	A0A8I3P8L3_CANLF	UniProtKB/TrEMBL
	A0A8I3P8Q1_CANLF	UniProtKB/TrEMBL
	A0A8P0P687	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0PMK0_CANLF	UniProtKB/TrEMBL
	A0A8P0TN51_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:43103	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

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