Slpi (secretory leukocyte peptidase inhibitor) - Rat Genome Database

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Gene: Slpi (secretory leukocyte peptidase inhibitor) Heterocephalus glaber
Analyze
Symbol: Slpi
Name: secretory leukocyte peptidase inhibitor
RGD ID: 18902605
Description: ENCODES a protein that exhibits DNA binding (ortholog); endopeptidase inhibitor activity (ortholog); enzyme binding (ortholog); INVOLVED IN immune response (ortholog); negative regulation of viral genome replication (ortholog); response to lipopolysaccharide (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); adenosine deaminase deficiency (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN Golgi apparatus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: antileukoproteinase
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247909,235,650 - 9,239,231 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247909,235,830 - 9,238,562 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Slpi
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247909,235,650 - 9,239,231 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247909,235,830 - 9,238,562 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
SLPI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382045,252,239 - 45,254,564 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2045,252,239 - 45,254,564 (-)EnsemblGRCh38hg38GRCh38
GRCh372043,880,880 - 43,883,205 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362043,314,293 - 43,316,620 (-)NCBINCBI36Build 36hg18NCBI36
Build 342043,314,292 - 43,316,620NCBI
Celera2040,589,481 - 40,591,808 (-)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2040,622,786 - 40,625,111 (-)NCBIHuRef
CHM1_12043,783,432 - 43,785,757 (-)NCBICHM1_1
T2T-CHM13v2.02046,988,133 - 46,990,454 (-)NCBIT2T-CHM13v2.0
Slpi
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392164,195,990 - 164,231,086 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2164,195,990 - 164,231,015 (-)EnsemblGRCm39 Ensembl
GRCm382164,354,070 - 164,356,507 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2164,354,070 - 164,389,095 (-)EnsemblGRCm38mm10GRCm38
MGSCv372164,179,806 - 164,182,243 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362164,045,511 - 164,064,154 (-)NCBIMGSCv36mm8
Celera2170,287,487 - 170,289,924 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map285.16NCBI
Slpi
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,501,573 - 173,503,822 (-)NCBIGRCr8
mRatBN7.23153,082,208 - 153,084,457 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3153,082,369 - 153,084,453 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3156,892,395 - 156,894,639 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,391,330 - 165,393,574 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03163,136,592 - 163,138,836 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03160,799,979 - 160,802,228 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3160,799,981 - 160,802,433 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03166,981,037 - 166,983,286 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43155,373,825 - 155,376,074 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13155,279,861 - 155,282,110 (-)NCBI
Celera3151,693,623 - 151,695,872 (-)NCBICelera
Cytogenetic Map3q42NCBI
SLPI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22150,985,903 - 51,026,936 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12050,979,011 - 51,020,044 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02041,583,429 - 41,585,773 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12042,673,417 - 42,675,773 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2042,673,417 - 42,675,773 (-)Ensemblpanpan1.1panPan2
SLPI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12432,566,030 - 32,568,406 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2432,566,026 - 32,568,420 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2432,210,966 - 32,213,346 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02433,276,396 - 33,278,776 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2433,276,396 - 33,278,790 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12432,537,713 - 32,540,093 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02432,653,063 - 32,655,444 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02433,196,545 - 33,198,948 (-)NCBIUU_Cfam_GSD_1.0
LOC101960095
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640192,165,015 - 192,167,144 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365147,618,261 - 7,620,912 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365147,618,382 - 7,620,790 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLPI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1747,595,803 - 47,598,387 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11747,595,804 - 47,598,364 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21753,167,238 - 53,169,798 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLPI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1218,579,549 - 18,581,897 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl218,579,515 - 18,582,076 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605067,222,449 - 67,224,808 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000013001   ⟹   ENSHGLP00000012864
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247909,235,650 - 9,239,231 (+)Ensembl
RefSeq Acc Id: XM_004858171   ⟹   XP_004858228
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247909,235,830 - 9,238,562 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004858228 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000012864
GenBank Protein JAN97406 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004858228   ⟸   XM_004858171
- UniProtKB: A0A0P6J2E3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000012864   ⟸   ENSHGLT00000013001


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000009195 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000013001 ENTREZGENE
Gene3D-CATH 4.10.75.10 UniProtKB/TrEMBL
InterPro Elafin-like_sf UniProtKB/TrEMBL
  WAP_dom UniProtKB/TrEMBL
  WAP_four-disulfide_core UniProtKB/TrEMBL
KEGG Report hgl:101701899 UniProtKB/TrEMBL
NCBI Gene Slpi ENTREZGENE
PANTHER ANTILEUKOPROTEINASE UniProtKB/TrEMBL
  WHEY ACDIC PROTEIN WAP UniProtKB/TrEMBL
Pfam WAP UniProtKB/TrEMBL
PRINTS 4DISULPHCORE UniProtKB/TrEMBL
PROSITE WAP UniProtKB/TrEMBL
SMART WAP UniProtKB/TrEMBL
Superfamily-SCOP SSF57256 UniProtKB/TrEMBL
UniProt A0A0P6J2E3 ENTREZGENE, UniProtKB/TrEMBL