SLPI (secretory leukocyte peptidase inhibitor) - Rat Genome Database

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Gene: SLPI (secretory leukocyte peptidase inhibitor) Canis lupus familiaris
Analyze
Symbol: SLPI
Name: secretory leukocyte peptidase inhibitor
RGD ID: 12081858
Description: ENCODES a protein that exhibits DNA binding (inferred); endopeptidase inhibitor activity (inferred); enzyme binding (inferred); INVOLVED IN antibacterial humoral response (inferred); immune response (inferred); innate immune response (inferred); ASSOCIATED WITH Acute Lung Injury (ortholog); Chemical and Drug Induced Liver Injury (ortholog); chronic obstructive pulmonary disease (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); Golgi apparatus (inferred)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: antileukoproteinase; ckpi
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12432,566,030 - 32,568,406 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2432,566,026 - 32,568,420 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2432,210,966 - 32,213,346 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02433,276,396 - 33,278,776 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2433,276,396 - 33,278,790 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12432,537,713 - 32,540,093 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02432,653,063 - 32,655,444 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02433,196,545 - 33,198,948 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:17892946   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SLPI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12432,566,030 - 32,568,406 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2432,566,026 - 32,568,420 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2432,210,966 - 32,213,346 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02433,276,396 - 33,278,776 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2433,276,396 - 33,278,790 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12432,537,713 - 32,540,093 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02432,653,063 - 32,655,444 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02433,196,545 - 33,198,948 (-)NCBIUU_Cfam_GSD_1.0
SLPI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382045,252,239 - 45,254,564 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2045,252,239 - 45,254,564 (-)EnsemblGRCh38hg38GRCh38
GRCh372043,880,880 - 43,883,205 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362043,314,293 - 43,316,620 (-)NCBINCBI36Build 36hg18NCBI36
Build 342043,314,292 - 43,316,620NCBI
Celera2040,589,481 - 40,591,808 (-)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2040,622,786 - 40,625,111 (-)NCBIHuRef
CHM1_12043,783,432 - 43,785,757 (-)NCBICHM1_1
T2T-CHM13v2.02046,988,133 - 46,990,454 (-)NCBIT2T-CHM13v2.0
Slpi
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392164,195,990 - 164,231,086 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2164,195,990 - 164,231,015 (-)EnsemblGRCm39 Ensembl
GRCm382164,354,070 - 164,356,507 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2164,354,070 - 164,389,095 (-)EnsemblGRCm38mm10GRCm38
MGSCv372164,179,806 - 164,182,243 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362164,045,511 - 164,064,154 (-)NCBIMGSCv36mm8
Celera2170,287,487 - 170,289,924 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map285.16NCBI
Slpi
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,501,573 - 173,503,822 (-)NCBIGRCr8
mRatBN7.23153,082,208 - 153,084,457 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3153,082,369 - 153,084,453 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3156,892,395 - 156,894,639 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,391,330 - 165,393,574 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03163,136,592 - 163,138,836 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03160,799,979 - 160,802,228 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3160,799,981 - 160,802,433 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03166,981,037 - 166,983,286 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43155,373,825 - 155,376,074 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13155,279,861 - 155,282,110 (-)NCBI
Celera3151,693,623 - 151,695,872 (-)NCBICelera
Cytogenetic Map3q42NCBI
SLPI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22150,985,903 - 51,026,936 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12050,979,011 - 51,020,044 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02041,583,429 - 41,585,773 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12042,673,417 - 42,675,773 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2042,673,417 - 42,675,773 (-)Ensemblpanpan1.1panPan2
LOC101960095
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640192,165,015 - 192,167,144 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365147,618,261 - 7,620,912 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365147,618,382 - 7,620,790 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLPI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1747,595,803 - 47,598,387 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11747,595,804 - 47,598,364 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21753,167,238 - 53,169,798 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLPI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1218,579,549 - 18,581,897 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl218,579,515 - 18,582,076 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605067,222,449 - 67,224,808 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slpi
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247909,235,650 - 9,239,231 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247909,235,830 - 9,238,562 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SLPI
27 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system respiratory system adipose tissue
High
Medium 5 6 1 5
Low 5 7 4 1 4 1 2
Below cutoff 4 7 2 2 3 2 2 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000047225   ⟹   ENSCAFP00000041773
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2432,566,026 - 32,568,420 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845025762   ⟹   ENSCAFP00845020299
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2433,276,396 - 33,278,790 (-)Ensembl
RefSeq Acc Id: NM_001113171   ⟹   NP_001106642
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12432,566,030 - 32,568,406 (-)NCBI
Dog10K_Boxer_Tasha2432,210,966 - 32,213,346 (-)NCBI
ROS_Cfam_1.02433,276,396 - 33,278,776 (-)NCBI
UMICH_Zoey_3.12432,537,713 - 32,540,093 (-)NCBI
UNSW_CanFamBas_1.02432,653,063 - 32,655,444 (-)NCBI
UU_Cfam_GSD_1.02433,196,545 - 33,198,948 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001106642 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABY59249 (Get FASTA)   NCBI Sequence Viewer  
  BAF91495 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000041773.1
  ENSCAFP00030022414.1
  ENSCAFP00040040185.1
  ENSCAFP00845020299
  ENSCAFP00845020299.1
Reference Protein Sequences
RefSeq Acc Id: NP_001106642   ⟸   NM_001113171
- Peptide Label: precursor
- UniProtKB: A8QWU1 (UniProtKB/TrEMBL),   A0A8C0Z6B9 (UniProtKB/TrEMBL),   A0A8C0KMX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000041773   ⟸   ENSCAFT00000047225
RefSeq Acc Id: ENSCAFP00845020299   ⟸   ENSCAFT00845025762
Protein Domains
WAP

Promoters
RGD ID:13687628
Promoter ID:EPDNEW_C5698
Type:single initiation site
Name:SLPI_1
Description:secretory leukocyte peptidase inhibitor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12432,568,405 - 32,568,465EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000028626 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013843 UniProtKB/TrEMBL
  ENSCAFG00040024719 UniProtKB/TrEMBL
  ENSCAFG00845014398 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000047225.3 UniProtKB/TrEMBL
  ENSCAFT00030025666.1 UniProtKB/TrEMBL
  ENSCAFT00040046050.1 UniProtKB/TrEMBL
  ENSCAFT00845025762 ENTREZGENE
  ENSCAFT00845025762.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.75.10 UniProtKB/TrEMBL
InterPro Elafin-like_sf UniProtKB/TrEMBL
  WAP_dom UniProtKB/TrEMBL
KEGG Report cfa:100127207 UniProtKB/TrEMBL
NCBI Gene SLPI ENTREZGENE
PANTHER ANTILEUKOPROTEINASE UniProtKB/TrEMBL
  WHEY ACDIC PROTEIN WAP UniProtKB/TrEMBL
Pfam WAP UniProtKB/TrEMBL
PRINTS 4DISULPHCORE UniProtKB/TrEMBL
PROSITE WAP UniProtKB/TrEMBL
SMART WAP UniProtKB/TrEMBL
Superfamily-SCOP SSF57256 UniProtKB/TrEMBL
UniProt A0A8C0KMX0 ENTREZGENE
  A0A8C0Z6B9 ENTREZGENE, UniProtKB/TrEMBL
  A8QWU1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:49651 ENTREZGENE