Gclm (glutamate-cysteine ligase modifier subunit) - Rat Genome Database

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Gene: Gclm (glutamate-cysteine ligase modifier subunit) Heterocephalus glaber
Analyze
Symbol: Gclm
Name: glutamate-cysteine ligase modifier subunit
RGD ID: 18935279
Description: ENCODES a protein that exhibits glutamate-cysteine ligase activity (ortholog); glutamate-cysteine ligase catalytic subunit binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN apoptotic mitochondrial changes (ortholog); cellular response to fibroblast growth factor stimulus (ortholog); cellular response to follicle-stimulating hormone stimulus (ortholog); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; cysteine metabolic pathway; glutamic acid/glutamate metabolic pathway; ASSOCIATED WITH berylliosis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); genetic disease (ortholog); FOUND IN glutamate-cysteine ligase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: glutamate--cysteine ligase regulatory subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247423,713,250 - 3,743,290 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247423,713,275 - 3,746,219 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Gclm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247423,713,250 - 3,743,290 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247423,713,275 - 3,746,219 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
GCLM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38193,885,199 - 93,909,430 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl193,885,199 - 93,909,456 (-)EnsemblGRCh38hg38GRCh38
GRCh37194,350,755 - 94,374,986 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,125,178 - 94,147,600 (-)NCBINCBI36Build 36hg18NCBI36
Build 34194,064,610 - 94,087,033NCBI
Celera192,606,277 - 92,628,698 (-)NCBICelera
Cytogenetic Map1p22.1NCBI
HuRef192,473,642 - 92,495,998 (-)NCBIHuRef
CHM1_1194,467,558 - 94,489,979 (-)NCBICHM1_1
T2T-CHM13v2.0193,733,450 - 93,757,695 (-)NCBIT2T-CHM13v2.0
Gclm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393122,039,206 - 122,060,864 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3122,039,206 - 122,064,381 (+)EnsemblGRCm39 Ensembl
GRCm383122,245,487 - 122,267,215 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3122,245,557 - 122,270,732 (+)EnsemblGRCm38mm10GRCm38
MGSCv373121,948,510 - 121,969,566 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363122,237,614 - 122,258,670 (+)NCBIMGSCv36mm8
MGSCv363122,610,732 - 122,631,895 (+)NCBIMGSCv36mm8
Celera3128,652,324 - 128,663,438 (+)NCBICelera
Cytogenetic Map3G1NCBI
cM Map352.94NCBI
Gclm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82213,032,135 - 213,052,192 (+)NCBIGRCr8
mRatBN7.22210,347,482 - 210,367,537 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2210,347,482 - 210,367,535 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2218,020,579 - 218,040,873 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02215,928,345 - 215,948,639 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02210,770,305 - 210,790,599 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02225,827,504 - 225,847,876 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2225,827,504 - 225,847,874 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02243,862,903 - 243,883,275 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42218,895,434 - 218,915,491 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12218,858,495 - 218,878,551 (+)NCBI
Celera2202,777,122 - 202,797,150 (+)NCBICelera
Cytogenetic Map2q42NCBI
Gclm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955423782,468 - 805,384 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955423782,468 - 805,384 (+)NCBIChiLan1.0ChiLan1.0
GCLM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21133,110,998 - 133,133,736 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11132,267,567 - 132,291,710 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0196,548,850 - 96,573,273 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1195,278,665 - 95,298,854 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl195,278,665 - 95,297,893 (-)Ensemblpanpan1.1panPan2
GCLM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1655,204,602 - 55,244,217 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha657,930,482 - 57,952,133 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0655,598,315 - 55,619,977 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl655,598,408 - 55,617,490 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1655,278,061 - 55,299,711 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0655,263,100 - 55,284,829 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0655,715,747 - 55,737,399 (+)NCBIUU_Cfam_GSD_1.0
LOC101977655
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058103,569,105 - 103,591,072 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365375,356,914 - 5,378,998 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GCLM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4123,371,193 - 123,390,131 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14123,371,198 - 123,390,130 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24135,017,027 - 135,035,890 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GCLM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12039,339,948 - 39,359,980 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2039,339,908 - 39,359,430 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603378,685,244 - 78,710,789 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000023309   ⟹   ENSHGLP00000023094
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247423,713,250 - 3,743,290 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000023310   ⟹   ENSHGLP00000023095
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247423,721,739 - 3,742,775 (+)Ensembl
RefSeq Acc Id: XM_004841237   ⟹   XP_004841294
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247423,713,275 - 3,746,219 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004841294 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000023094
  ENSHGLP00000037668
  ENSHGLP00100037326
GenBank Protein JAN98408 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004841294   ⟸   XM_004841237
- UniProtKB: A0A0P6J709 (UniProtKB/TrEMBL),   G5AW25 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000023095   ⟸   ENSHGLT00000023310
RefSeq Acc Id: ENSHGLP00000023094   ⟸   ENSHGLT00000023309


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000016468 Ensembl, ENTREZGENE
  ENSHGLG00000049623 UniProtKB/TrEMBL
  ENSHGLG00100049106 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000023309 ENTREZGENE
  ENSHGLT00000044542 UniProtKB/TrEMBL
  ENSHGLT00100077129 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.100 UniProtKB/TrEMBL
InterPro Gclm UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/TrEMBL
KEGG Report hgl:101703324 UniProtKB/TrEMBL
NCBI Gene Gclm ENTREZGENE
PANTHER GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT UniProtKB/TrEMBL
  PTHR13295 UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/TrEMBL
Superfamily-SCOP SSF51430 UniProtKB/TrEMBL
UniProt A0A0P6J709 ENTREZGENE, UniProtKB/TrEMBL
  G5AW25 ENTREZGENE, UniProtKB/TrEMBL