Mccc1 (methylcrotonyl-CoA carboxylase subunit 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Mccc1 (methylcrotonyl-CoA carboxylase subunit 1) Heterocephalus glaber
Analyze
Symbol: Mccc1
Name: methylcrotonyl-CoA carboxylase subunit 1 (Ensembl:methylcrotonoyl-CoA carboxylase 1)
RGD ID: 18919683
Description: ENCODES a protein that exhibits methylcrotonoyl-CoA carboxylase activity (ortholog); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; ASSOCIATED WITH 3-methylcrotonyl-CoA carboxylase 1 deficiency (ortholog); 3-methylcrotonyl-CoA carboxylase deficiency (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN methylcrotonoyl-CoA carboxylase complex (ortholog); mitochondrial matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: methylcrotonoyl-CoA carboxylase 1; methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473060,749,896 - 60,803,235 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473060,749,678 - 60,803,091 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mccc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473060,749,896 - 60,803,235 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473060,749,678 - 60,803,091 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MCCC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383183,015,218 - 183,116,196 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3183,015,218 - 183,116,075 (-)EnsemblGRCh38hg38GRCh38
GRCh373182,733,006 - 182,817,375 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363184,215,700 - 184,300,059 (-)NCBINCBI36Build 36hg18NCBI36
Build 343184,215,709 - 184,300,062NCBI
Celera3181,167,501 - 181,251,735 (-)NCBICelera
Cytogenetic Map3q27.1NCBI
HuRef3180,137,627 - 180,222,143 (-)NCBIHuRef
CHM1_13182,695,925 - 182,780,289 (-)NCBICHM1_1
T2T-CHM13v2.03185,820,313 - 185,922,411 (-)NCBIT2T-CHM13v2.0
Mccc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39336,009,584 - 36,054,843 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl336,013,461 - 36,054,827 (-)EnsemblGRCm39 Ensembl
GRCm38335,956,292 - 36,000,694 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl335,959,312 - 36,000,678 (-)EnsemblGRCm38mm10GRCm38
MGSCv37335,858,218 - 35,899,600 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36336,151,385 - 36,192,188 (-)NCBIMGSCv36mm8
MGSCv36335,827,354 - 35,868,158 (-)NCBIMGSCv36mm8
Celera335,846,334 - 35,883,101 (-)NCBICelera
Cytogenetic Map3BNCBI
cM Map317.41NCBI
Mccc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82120,727,313 - 120,779,334 (-)NCBIGRCr8
mRatBN7.22118,799,147 - 118,851,181 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2118,799,150 - 118,851,222 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2125,352,210 - 125,404,078 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02123,464,896 - 123,516,764 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02118,093,657 - 118,145,531 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02122,550,777 - 122,690,540 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2122,550,775 - 122,690,617 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02142,300,575 - 142,317,803 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02142,186,426 - 142,203,853 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42122,416,660 - 122,469,557 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12122,361,622 - 122,414,519 (-)NCBI
Celera2113,761,210 - 113,811,967 (-)NCBICelera
Cytogenetic Map2q25NCBI
Mccc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542011,781,104 - 11,820,338 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542011,781,662 - 11,828,060 (-)NCBIChiLan1.0ChiLan1.0
MCCC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22180,881,195 - 180,965,639 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13180,885,910 - 180,970,354 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03180,045,592 - 180,129,988 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13188,217,186 - 188,300,284 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3188,217,186 - 188,300,284 (-)Ensemblpanpan1.1panPan2
MCCC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13416,022,493 - 16,084,346 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3416,022,499 - 16,084,387 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3420,111,194 - 20,173,075 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03415,929,888 - 15,991,791 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3415,929,684 - 15,991,778 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13415,970,787 - 16,032,643 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03415,951,431 - 16,016,266 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03416,194,344 - 16,256,270 (-)NCBIUU_Cfam_GSD_1.0
Mccc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602112,751,848 - 112,811,180 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936566409,462 - 469,225 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936566409,558 - 468,898 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCCC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13120,915,730 - 121,106,395 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113120,983,226 - 121,070,695 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213130,222,439 - 130,308,733 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MCCC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1156,318,788 - 6,400,539 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl156,318,791 - 6,401,849 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606315,121,745 - 15,202,856 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000020698   ⟹   ENSHGLP00000020496
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473060,749,896 - 60,803,235 (-)Ensembl
RefSeq Acc Id: XM_021254852   ⟹   XP_021110511
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473060,749,678 - 60,803,091 (-)NCBI
RefSeq Acc Id: XR_002393385
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473060,749,922 - 60,803,091 (-)NCBI
Protein Sequences
Protein RefSeqs XP_021110511 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000020496
GenBank Protein JAN97820 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021110511   ⟸   XM_021254852
- UniProtKB: A0A0P6J0G2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000020496   ⟸   ENSHGLT00000020698


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000014650 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000020698 ENTREZGENE
Gene3D-CATH 2.40.50.100 UniProtKB/TrEMBL
  3.30.1490.20 UniProtKB/TrEMBL
  3.30.700.40 UniProtKB/TrEMBL
  3.40.50.20 UniProtKB/TrEMBL
  ATP-grasp fold, B domain UniProtKB/TrEMBL
InterPro ATP-grasp UniProtKB/TrEMBL
  ATP_grasp_subdomain_1 UniProtKB/TrEMBL
  BC-like_N UniProtKB/TrEMBL
  Biotin_BS UniProtKB/TrEMBL
  Biotin_carboxylase_complex UniProtKB/TrEMBL
  Biotin_carboxylation_dom UniProtKB/TrEMBL
  Biotin_COase_C UniProtKB/TrEMBL
  Biotin_lipoyl UniProtKB/TrEMBL
  CbamoylP_synth_lsu-like_ATP-bd UniProtKB/TrEMBL
  PreATP-grasp_dom_sf UniProtKB/TrEMBL
  Rudment_hybrid_motif UniProtKB/TrEMBL
  Single_hybrid_motif UniProtKB/TrEMBL
NCBI Gene Mccc1 ENTREZGENE
PANTHER CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE UniProtKB/TrEMBL
  METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED UniProtKB/TrEMBL
Pfam Biotin_carb_C UniProtKB/TrEMBL
  Biotin_carb_N UniProtKB/TrEMBL
  Biotin_lipoyl UniProtKB/TrEMBL
  CPSase_L_D2 UniProtKB/TrEMBL
PROSITE ATP_GRASP UniProtKB/TrEMBL
  BIOTIN UniProtKB/TrEMBL
  BIOTINYL_LIPOYL UniProtKB/TrEMBL
  CPSASE_2 UniProtKB/TrEMBL
  PS50979 UniProtKB/TrEMBL
SMART Biotin_carb_C UniProtKB/TrEMBL
Superfamily-SCOP Glutathione synthetase ATP-binding domain-like UniProtKB/TrEMBL
  SSF51230 UniProtKB/TrEMBL
  SSF51246 UniProtKB/TrEMBL
  SSF52440 UniProtKB/TrEMBL
UniProt A0A0P6J0G2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-23 Mccc1  methylcrotonyl-CoA carboxylase subunit 1  Mccc1  methylcrotonoyl-CoA carboxylase 1  Symbol and/or name change 5135510 APPROVED