RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Intracranial Hemorrhages
Accession: DOID:9003104
browse the term
Definition: Bleeding within the SKULL, including hemorrhages in the brain and the three membranes of MENINGES. The escape of blood often leads to the formation of HEMATOMA in the cranial epidural, subdural, and subarachnoid spaces.
Synonyms: exact_synonym: Brain Hemorrhage; Brain Hemorrhages; Posterior Fossa Hemorrhage; intracranial hemorrhage; posterior fossa hemorrhages
primary_id: MESH:D020300
xref: EFO:0000551
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COL4A1
collagen type IV alpha 1 chain
ISO
ClinVar Annotator: match by term: Intracranial Hemorrhages
ClinVar
PMID:7695699 PMID:8218237 PMID:9016532 PMID:16598045 PMID:17078022 PMID:17938367 PMID:19344236 PMID:22102590 PMID:25741868 PMID:26362372 PMID:28492532 PMID:31857254 PMID:32033901 More...
NCBI chr13:91,282,617...91,440,187
Ensembl chr13:110,407,009...110,562,529
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F7
coagulation factor VII
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:15595332 PMID:16159073 PMID:18617125 PMID:20172985 PMID:20522813
NCBI chr13:94,246,694...94,261,133
Ensembl chr13:113,315,868...113,329,995
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HSPB1
heat shock protein family B (small) member 1
ISO
protein:increased expression:brain:
RGD
PMID:15472083
RGD:10402769
NCBI chr 7:67,716,021...67,717,762
Ensembl chr 7:82,751,523...82,752,984
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IL6
interleukin 6
susceptibility
ISO
DNA:polymorphism:promoter -174G>C(human)
RGD
PMID:15331795
RGD:12792203
NCBI chr 7:23,415,922...23,420,767
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NOS3
nitric oxide synthase 3
treatment
ISO
RGD
PMID:29203281
RGD:13504724
NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233
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NSD2
nuclear receptor binding SET domain protein 2
ISO
ClinVar Annotator: match by term: Intracranial Hemorrhages
ClinVar
PMID:25741868
NCBI chr 4:2,009,276...2,119,182
Ensembl chr 4:1,945,307...2,027,425
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PLAT
plasminogen activator, tissue type
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:2104561 PMID:3168586 PMID:7902905 PMID:8961984 PMID:11320361 PMID:12230423 PMID:15017018 PMID:15215796 PMID:15557913 PMID:17612434 PMID:17687131 PMID:17903947 PMID:20123226 PMID:20536612 More...
NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779
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PLAU
plasminogen activator, urokinase
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:10392865 PMID:10472989 PMID:10512912 PMID:17308290 PMID:21779364
RGD:6484131
NCBI chr10:70,433,340...70,441,569
Ensembl chr10:73,105,895...73,113,136
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PPP1R1B
protein phosphatase 1 regulatory inhibitor subunit 1B
ISO
RGD
PMID:23543809
RGD:13515075
NCBI chr17:17,652,216...17,662,085
Ensembl chr17:17,868,965...17,878,120
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PSEN1
presenilin 1
ISO
RGD
PMID:9160754
RGD:1302520
NCBI chr14:53,718,299...53,802,684
Ensembl chr14:72,579,024...72,663,876
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SERPING1
serpin family G member 1
treatment
ISO
associated with Stroke
RGD
PMID:21779364
RGD:6484131
NCBI chr11:52,838,502...52,855,781
Ensembl chr11:56,309,686...56,326,639
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SHOC2
SHOC2 leucine rich repeat scaffold protein
ISO
mRNA:decreased expression:brain:
RGD
PMID:34368865
RGD:155804268
NCBI chr10:107,512,795...107,606,627
Ensembl chr10:110,993,556...111,055,312
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SLC23A1
solute carrier family 23 member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11984597
NCBI chr 5:134,737,344...134,756,153
Ensembl chr 5:140,859,984...140,877,214
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TF
transferrin
ISO
associated with Iron-Deficiency Anemia;protein:increased expression:basal ganglia
RGD
PMID:16671451
RGD:1601537
NCBI chr 3:130,799,063...130,830,227
Ensembl chr 3:138,274,159...138,305,476
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TNF
tumor necrosis factor
ISO
RGD
PMID:16322490
RGD:1580310
NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
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UBIAD1
UbiA prenyltransferase domain containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23533172
NCBI chr 1:10,039,415...10,161,005
Ensembl chr 1:11,260,412...11,281,381
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EPO
erythropoietin
treatment
ISO
RGD
PMID:23415790
RGD:10401075
NCBI chr 7:92,747,671...92,750,886
Ensembl chr 7:106,148,062...106,150,974
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F7
coagulation factor VII
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:12503044
NCBI chr13:94,246,694...94,261,133
Ensembl chr13:113,315,868...113,329,995
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KCNN4
potassium calcium-activated channel subfamily N member 4
treatment
ISO
RGD
PMID:15379997
RGD:329969897
NCBI chr19:40,715,621...40,735,025
Ensembl chr19:49,321,403...49,335,900
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APP
amyloid beta precursor protein
ISO
ClinVar Annotator: match by term: AMYLOIDOSIS, CEREBROARTERIAL, APP-RELATED | ClinVar Annotator: match by term: CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, ARCTIC VARIANT | ClinVar Annotator: match by term: CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, FLEMISH VARIANT | ClinVar Annotator: match by term: CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, IOWA VARIANT | ClinVar Annotator: match by term: CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, ITALIAN VARIANT | ClinVar Annotator: match by term: Cerebral amyloid angiopathy, APP-related
OMIM ClinVar
PMID:1303172 PMID:1303239 PMID:1303275 PMID:1415269 PMID:1520398 PMID:1634237 PMID:1671712 PMID:1674311 PMID:1678057 PMID:1678058 PMID:1679288 PMID:1679289 PMID:1908231 PMID:1925564 PMID:2111584 PMID:7611715 PMID:8191290 PMID:8290965 PMID:8410047 PMID:8499923 PMID:8513318 PMID:8577393 PMID:8610157 PMID:8649577 PMID:8863158 PMID:8886002 PMID:9328472 PMID:9754958 PMID:9848098 PMID:10441572 PMID:10631141 PMID:10821838 PMID:11004129 PMID:11311152 PMID:11409420 PMID:11441013 PMID:11487570 PMID:11528419 PMID:11568920 PMID:11978821 PMID:12552037 PMID:12654973 PMID:14623725 PMID:15365148 PMID:15488330 PMID:15502844 PMID:15776278 PMID:16033913 PMID:16178030 PMID:16921174 PMID:16931535 PMID:18413473 PMID:19061884 PMID:19225789 PMID:19281847 PMID:19363265 PMID:20228223 PMID:20301414 PMID:20523046 PMID:20697050 PMID:21193246 PMID:21210284 PMID:22503161 PMID:22514144 PMID:23143229 PMID:23224319 PMID:23919771 PMID:24033266 PMID:24278680 PMID:24524897 PMID:24650794 PMID:24878480 PMID:25138979 PMID:25604855 PMID:25741868 PMID:25948718 PMID:26104569 PMID:26402770 PMID:26467025 PMID:26803359 PMID:27000221 PMID:27838006 PMID:27858710 PMID:28304299 PMID:28350801 PMID:28492532 PMID:29263818 PMID:29459625 PMID:29859640 PMID:30279455 PMID:30868685 PMID:31011484 PMID:31937505 PMID:32087291 PMID:32317127 PMID:32775599 PMID:32908482 PMID:32917274 PMID:34532568 PMID:36133075 PMID:37051054 PMID:37170141 More...
NCBI chr21:12,324,455...12,608,594
Ensembl chr21:25,684,355...25,995,072
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GSN
gelsolin
severity
ISO
protein:decreased expression:blood plasma (human)
RGD
PMID:23142649
RGD:329333032
NCBI chr 9:92,413,819...92,460,483
Ensembl chr 9:120,741,148...120,805,831
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ACE
angiotensin I converting enzyme
ISO
ClinVar Annotator: match by term: Hemorrhage, intracerebral, susceptibility to | ClinVar Annotator: match by term: Stroke, hemorrhagic, susceptibility to
ClinVar
PMID:1313972 PMID:1319114 PMID:1328889 PMID:1386652 PMID:1976655 PMID:2847529 PMID:2849100 PMID:7593601 PMID:7729604 PMID:7783416 PMID:7854377 PMID:7909524 PMID:8131299 PMID:8131300 PMID:8136829 PMID:8170965 PMID:8208911 PMID:8298638 PMID:8314010 PMID:8541160 PMID:8644984 PMID:8675669 PMID:9120002 PMID:9236417 PMID:9259580 PMID:9699903 PMID:9737775 PMID:9916793 PMID:10099885 PMID:10636736 PMID:10643899 PMID:10841123 PMID:11687636 PMID:11956052 PMID:12220450 PMID:12666117 PMID:14657821 PMID:14872014 PMID:15110771 PMID:15277638 PMID:15381116 PMID:15531537 PMID:15534175 PMID:15635071 PMID:19221299 PMID:20093180 PMID:21471972 PMID:22095942 PMID:25741868 PMID:28492532 More...
NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853
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ANXA1
annexin A1
ISO
mRNA:increased expression:brain
RGD
PMID:16034371
RGD:2306905
NCBI chr 9:51,647,404...51,665,990
Ensembl chr 9:71,929,728...71,948,779
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APEX1
apurinic/apyrimidinic endodeoxyribonuclease 1
ISO
RGD
PMID:15344903
RGD:2315676
NCBI chr14:1,329,745...1,332,315
Ensembl chr14:19,381,911...19,384,542
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APOE
apolipoprotein E
ISO
DNA:missense mutations, haplotype:cds:p.C112R (rs7412) (human)
RGD
PMID:19251191
RGD:6904207
NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490
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AQP4
aquaporin 4
ISO
RGD
PMID:25545558
RGD:11541062
NCBI chr18:20,108,607...20,122,381
Ensembl chr18:23,713,146...23,726,919
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ATP6V1A
ATPase H+ transporting V1 subunit A
ISO
protein:decreased expression:brain
RGD
PMID:30307711
RGD:408426007
NCBI chr 3:110,888,504...110,951,750
Ensembl chr 3:117,808,963...117,872,349
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BAX
BCL2 associated X, apoptosis regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12721362
NCBI chr19:45,955,926...45,962,870
Ensembl chr19:54,793,594...54,800,468
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BCL2
BCL2 apoptosis regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12721362
NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100
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BCL2L1
BCL2 like 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12721362
NCBI chr20:27,955,688...28,015,950
Ensembl chr20:29,088,055...29,146,585
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BDNF
brain derived neurotrophic factor
ISO
RGD
PMID:20818776
RGD:4891129
NCBI chr11:27,618,322...27,687,661
Ensembl chr11:27,520,312...27,589,239
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BECN1
beclin 1
ISO
protein:increased expression:basal ganglion
RGD
PMID:23884876
RGD:11561935
NCBI chr17:14,493,619...14,507,809
Ensembl chr17:14,719,781...14,733,286
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BNIP3L
BCL2 interacting protein 3 like
ISO
RGD
PMID:23771482
RGD:7483577
NCBI chr 8:25,661,629...25,685,878
Ensembl chr 8:22,567,428...22,593,004
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C3
complement C3
ISO
RGD
PMID:17114852
RGD:5129540
NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699
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CA2
carbonic anhydrase 2
ISO
protein:increased expression:brain
RGD
PMID:30307711
RGD:408426007
NCBI chr 8:81,991,037...82,009,010
Ensembl chr 8:83,597,440...83,632,580
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CASP3
caspase 3
treatment ameliorates
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:17971790 PMID:28096675 PMID:31376096
RGD:13782306 RGD:329337378
NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185
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CASP8
caspase 8
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:17971790 PMID:28096675
RGD:13782306
NCBI chr2B:88,490,611...88,542,132
Ensembl chr2B:206,669,544...206,696,468
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CASP9
caspase 9
treatment
ISO
RGD
PMID:28096675
RGD:13782306
NCBI chr 1:14,630,659...14,662,865
Ensembl chr 1:15,624,666...15,656,266
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CD14
CD14 molecule
ISO
mRNA:increased expression:lung, intestine:
RGD
PMID:19534684
RGD:7185660
NCBI chr 5:135,996,265...135,997,909
Ensembl chr 5:142,113,082...142,118,966
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CD36
CD36 molecule (CD36 blood group)
ISO
RGD
PMID:19064796
RGD:6893504
NCBI chr 7:72,566,478...72,643,517
Ensembl chr 7:86,265,114...86,305,865
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CFH
complement factor H
severity
ISO
RGD
PMID:21871809
RGD:5684553
NCBI chr 1:172,155,882...172,251,632
Ensembl chr 1:176,455,247...176,525,521
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CNTF
ciliary neurotrophic factor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:11701153
NCBI chr11:53,876,081...53,882,870
Ensembl chr11:57,336,792...57,341,121
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COL4A1
collagen type IV alpha 1 chain
susceptibility
ISO
ClinVar Annotator: match by term: Hemorrhage, intracerebral, susceptibility to | ClinVar Annotator: match by term: Stroke, hemorrhagic, susceptibility to
ClinVar OMIM
PMID:3691802 PMID:7695699 PMID:8218237 PMID:9016532 PMID:9536098 PMID:9724608 PMID:16159887 PMID:16199547 PMID:17078022 PMID:17576681 PMID:19344236 PMID:21625620 PMID:22522439 PMID:22574627 PMID:22914737 PMID:23225343 PMID:24374867 PMID:24628545 PMID:25457163 PMID:25741868 PMID:26310487 PMID:26467025 PMID:28492532 PMID:29770612 PMID:30413629 PMID:30653986 PMID:31051113 PMID:31069529 PMID:31230195 PMID:31719132 PMID:33353976 PMID:33527515 PMID:35711275 More...
NCBI chr13:91,282,617...91,440,187
Ensembl chr13:110,407,009...110,562,529
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COL4A2
collagen type IV alpha 2 chain
susceptibility
ISO
ClinVar Annotator: match by term: COL4A2-Related Disorder | ClinVar Annotator: match by term: Hemorrhage, intracerebral, susceptibility to DNA:SNPs::
ClinVar RGD OMIM
PMID:22209247 PMID:22333902 PMID:22914737 PMID:24390199 PMID:24646874 PMID:25653287 PMID:25741868 PMID:28492532 PMID:28954878 PMID:30413629 More...
RGD:13450933
NCBI chr13:91,440,314...91,650,138
Ensembl chr13:110,563,119...110,767,530
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CSF3
colony stimulating factor 3
treatment
ISO
RGD
PMID:19169816
RGD:11039433
NCBI chr17:17,271,074...17,273,493
Ensembl chr17:17,491,276...17,493,729
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CXCR4
C-X-C motif chemokine receptor 4
treatment
ISO
RGD
PMID:24955809
RGD:11352686
NCBI chr2B:23,744,271...23,748,106
Ensembl chr2B:140,181,829...140,189,647
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DAG1
dystroglycan 1
ISO
RGD
PMID:25545558
RGD:11541062
NCBI chr 3:49,396,180...49,464,689
Ensembl chr 3:50,640,615...50,703,852
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DCX
doublecortin
ISO
protein:increased expression:dentate gyrus
RGD
PMID:24144742
RGD:12904766
NCBI chr X:100,411,871...100,529,833
Ensembl chr X:110,875,032...110,988,582
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F11
coagulation factor XI
ISO
ClinVar Annotator: match by term: Cerebral hemorrhage
ClinVar
PMID:23929304 PMID:27067486 PMID:28492532 PMID:34776502
NCBI chr 4:178,436,865...178,459,568
Ensembl chr 4:190,643,733...190,666,512
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F13A1
coagulation factor XIII A chain
ISO
RGD
PMID:9550516
RGD:1581027
NCBI chr 6:5,978,505...6,156,705
Ensembl chr 6:6,157,926...6,513,961
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F2
coagulation factor II, thrombin
severity
ISO
protein:increased expression:plasma
RGD
PMID:21244583
RGD:5147770
NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157
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F7
coagulation factor VII
treatment
ISO
human protein in a rat model CTD Direct Evidence: therapeutic
RGD CTD
PMID:16671457 PMID:21127298
RGD:11049545
NCBI chr13:94,246,694...94,261,133
Ensembl chr13:113,315,868...113,329,995
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FLT1
fms related receptor tyrosine kinase 1
ISO
CTD Direct Evidence: marker/mechanism mRNA:increased expression:brain:
CTD RGD
PMID:17888890
RGD:10402152
NCBI chr13:9,584,850...9,779,542
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FTO
FTO alpha-ketoglutarate dependent dioxygenase
ISO
protein:increased expression:thalamic complex
RGD
PMID:34102854
RGD:329812008
NCBI chr16:33,939,300...34,343,419
Ensembl chr16:53,023,425...53,490,231
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GDNF
glial cell derived neurotrophic factor
treatment
ISO
RGD
PMID:21311297
RGD:405878068
NCBI chr 5:72,539,374...72,566,918
Ensembl chr 5:77,577,313...77,601,362
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GP6
glycoprotein VI platelet
ameliorates
ISO
associated with hypertension
RGD
PMID:33556561
RGD:401794565
NCBI chr19:52,051,138...52,071,673
Ensembl chr19:60,746,578...60,770,643
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HMOX1
heme oxygenase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12401953
NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063
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HMOX2
heme oxygenase 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16459095
NCBI chr16:3,399,715...3,436,018
Ensembl chr16:4,567,828...4,604,596
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IFNB1
interferon beta 1
exacerbates
ISO
RGD
PMID:29301581
RGD:401854231
NCBI chr 9:20,884,742...20,886,317
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IL1B
interleukin 1 beta
ameliorates
ISO
RGD
PMID:31376096
RGD:329337378
NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424
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IL1RN
interleukin 1 receptor antagonist
treatment
ISO
mRNA:increased expression:striatum (rat) human gene in a rat model
RGD
PMID:14753487 PMID:22707991
RGD:6997504 RGD:8551833
NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839
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IL6
interleukin 6
ameliorates
ISO
RGD
PMID:31376096
RGD:329337378
NCBI chr 7:23,415,922...23,420,767
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ITGA2B
integrin subunit alpha 2b
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9445356
NCBI chr17:13,009,514...13,027,289
Ensembl chr17:13,176,843...13,193,269
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ITGAV
integrin subunit alpha V
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:9445356 PMID:16102435
RGD:1582447
NCBI chr2B:73,880,962...73,972,486
Ensembl chr2B:191,680,655...191,773,028
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ITGB2
integrin subunit beta 2
ISO
RGD
PMID:18615643
RGD:6482197
NCBI chr21:31,181,228...31,216,033
Ensembl chr21:44,470,999...44,505,963
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ITGB3
integrin subunit beta 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9445356
NCBI chr17:10,134,450...10,194,596
Ensembl chr17:10,353,111...10,392,382
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KAT6B
lysine acetyltransferase 6B
ISO
ClinVar Annotator: match by term: Stroke, hemorrhagic, susceptibility to
ClinVar
PMID:25741868
NCBI chr10:71,354,585...71,561,572
Ensembl chr10:74,035,496...74,223,975
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KDR
kinase insert domain receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17888890
NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109
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LCN2
lipocalin 2
ISO
RGD
PMID:23416150
RGD:126790480
NCBI chr 9:99,259,278...99,274,494
Ensembl chr 9:127,940,799...127,944,798
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LOC100986475
metallothionein-2
ISO
mRNA:increased expression:cerebral cortex, striatum (rat)
RGD
PMID:16034371
RGD:2306905
NCBI chr16:36,894,853...36,895,826
Ensembl chr16:56,007,922...56,028,093
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LOC117975672
COL4A2 antisense RNA 2
ISO
ClinVar Annotator: match by term: Hemorrhage, intracerebral, susceptibility to
ClinVar
PMID:28492532
NCBI chr13:91,593,477...91,600,562
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MAP1LC3A
microtubule associated protein 1 light chain 3 alpha
ISO
RGD
PMID:23884876
RGD:11561935
NCBI chr20:30,887,345...30,888,986
Ensembl chr20:32,010,284...32,020,411
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MMP12
matrix metallopeptidase 12
ISO
RGD
PMID:12783419 PMID:15654856
RGD:1582358 RGD:1582362
NCBI chr11:97,809,644...97,822,063
Ensembl chr11:101,294,475...101,306,762
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MMP2
matrix metallopeptidase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10698078
NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279
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MMP3
matrix metallopeptidase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17971790
NCBI chr11:97,776,729...97,784,549
Ensembl chr11:101,267,566...101,275,354
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MMP9
matrix metallopeptidase 9
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
RGD CTD
PMID:14630814 PMID:15488484 PMID:15529013 PMID:16190367 PMID:17021183 PMID:19095969 More...
RGD:1582637
NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129
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MTOR
mechanistic target of rapamycin kinase
treatment
ISO
RGD
PMID:24602288
RGD:10041041
NCBI chr 1:9,871,700...10,028,704
Ensembl chr 1:11,093,765...11,249,841
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NFKB1
nuclear factor kappa B subunit 1
ISO
protein:increased activity:striatum
RGD
PMID:17250675
RGD:2302394
NCBI chr 4:94,925,048...95,040,849
Ensembl chr 4:105,589,062...105,704,098
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NFKB2
nuclear factor kappa B subunit 2
ISO
protein:increased activity:striatum
RGD
PMID:17250675
RGD:2302394
NCBI chr10:98,997,604...99,006,407
Ensembl chr10:102,463,503...102,471,907
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NFKBIA
NFKB inhibitor alpha
ISO
protein:increased phosphorylation:brain
RGD
PMID:20150961
RGD:10413872
NCBI chr14:16,155,331...16,158,588
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NPPB
natriuretic peptide B
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:19803787
NCBI chr 1:10,621,416...10,622,960
Ensembl chr 1:11,838,518...11,839,995
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NPY
neuropeptide Y
ISO
protein:increased expression:plasma (rat)
RGD
PMID:15068713
RGD:1580182
NCBI chr 7:24,963,056...24,970,803
Ensembl chr 7:24,568,041...24,574,657
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NQO1
NAD(P)H quinone dehydrogenase 1
treatment
ISO
RGD
PMID:29050310
RGD:13442476
NCBI chr16:50,090,696...50,106,495
Ensembl chr16:69,470,288...69,489,731
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PLAT
plasminogen activator, tissue type
treatment severity
ISO
CTD Direct Evidence: marker/mechanism human protein in a rat model associated with Brain Injuries
CTD RGD
PMID:1430592 PMID:1579960 PMID:1899364 PMID:7477192 PMID:7723950 PMID:8969996 PMID:9836764 PMID:10501537 PMID:11113218 PMID:11940547 PMID:12220690 PMID:14630814 PMID:16126134 PMID:16190367 PMID:16908730 PMID:17690543 PMID:18346647 PMID:18369171 PMID:18753474 PMID:19095969 PMID:20212195 PMID:21088392 PMID:22436003 PMID:23876515 PMID:25673638 PMID:29651748 More...
RGD:11537477 RGD:11541064
NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779
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PLAU
plasminogen activator, urokinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:1265806 PMID:8025938 PMID:9731615 PMID:15181847 PMID:17702958
NCBI chr10:70,433,340...70,441,569
Ensembl chr10:73,105,895...73,113,136
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PLOD3
procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
ISO
ClinVar Annotator: match by term: Hemorrhage, intracerebral, susceptibility to
ClinVar
PMID:25741868 PMID:28492532
NCBI chr 7:93,347,335...93,358,921
Ensembl chr 7:106,587,858...106,599,605
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POMC
proopiomelanocortin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:6254450
NCBI chr2A:25,161,668...25,165,600
Ensembl chr2A:25,258,768...25,262,706
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PSEN1
presenilin 1
ISO
RGD
PMID:16079160
RGD:1580694
NCBI chr14:53,718,299...53,802,684
Ensembl chr14:72,579,024...72,663,876
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PTGS2
prostaglandin-endoperoxide synthase 2
ISO
protein:increased expression:neuron, astrocyte, blood vessel
RGD
PMID:21385433
RGD:5508223
NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519
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RAD21
RAD21 cohesin complex component
severity
ISO
RGD
PMID:36538854
RGD:243065265
NCBI chr 8:113,520,456...113,549,339
Ensembl chr 8:116,063,503...116,092,421
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RELA
RELA proto-oncogene, NF-kB subunit
ISO
protein:increased activity:striatum
RGD
PMID:17250675
RGD:2302394
NCBI chr11:61,012,839...61,022,225
Ensembl chr11:64,347,859...64,356,868
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RELB
RELB proto-oncogene, NF-kB subunit
ISO
mRNA, protein:increased expression, increased activity:striatum
RGD
PMID:17250675
RGD:2302394
NCBI chr19:41,948,559...41,987,121
Ensembl chr19:50,554,864...50,590,223
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S100B
S100 calcium binding protein B
disease_progression
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:19027832 PMID:19505208
RGD:5508801
NCBI chr21:33,063,845...33,070,073
Ensembl chr21:46,197,750...46,203,953
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SERPINA3
serpin family A member 3
ISO
RGD
PMID:12126519
RGD:1580109
NCBI chr14:75,220,252...75,247,996
Ensembl chr14:94,551,934...94,579,515
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SERPINC1
serpin family C member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:6636041
NCBI chr 1:149,421,737...149,435,301
Ensembl chr 1:153,126,031...153,139,369
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SLC24A1
solute carrier family 24 member 1
ISO
mRNA, protein:decreased expression:cerebrum
RGD
PMID:23564126
RGD:9685494
NCBI chr15:44,552,886...44,597,640
Ensembl chr15:62,831,987...62,882,431
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SLC8B1
solute carrier family 8 member B1
ISO
RGD
PMID:23564126
RGD:9685494
NCBI chr12:110,903,215...110,936,908
Ensembl chr12:114,286,624...114,319,683
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SPP1
secreted phosphoprotein 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:20440599
NCBI chr 4:80,263,711...80,271,466
Ensembl chr 4:90,988,200...90,995,935
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SQSTM1
sequestosome 1
ISO
protein:decreased expression:basal ganglion
RGD
PMID:23884876
RGD:11561935
NCBI chr 5:174,960,727...174,989,946
Ensembl chr 5:182,284,436...182,299,093
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THBS1
thrombospondin 1
ISO
RGD
PMID:20136391
RGD:2317938
NCBI chr15:18,521,802...18,538,172
Ensembl chr15:36,776,756...36,793,170
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THBS2
thrombospondin 2
ISO
RGD
PMID:20136391
RGD:2317938
NCBI chr 6:167,290,482...167,329,319
Ensembl chr 6:172,130,727...172,169,028
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TNF
tumor necrosis factor
ameliorates
ISO
RGD
PMID:31376096
RGD:329337378
NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
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VEGFA
vascular endothelial growth factor A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17888890
NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353
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GP6
glycoprotein VI platelet
exacerbates
ISO
RGD
PMID:21258336
RGD:401824683
NCBI chr19:52,051,138...52,071,673
Ensembl chr19:60,746,578...60,770,643
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MDM2
MDM2 proto-oncogene
treatment
ISO
RGD
PMID:34334113
RGD:155882538
NCBI chr12:66,322,340...66,357,010
Ensembl chr12:69,102,084...69,133,278
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ZEB2
zinc finger E-box binding homeobox 2
treatment
ISO
protein:increased expression:brain (rat)
RGD
PMID:34334113
RGD:155882538
NCBI chr2B:15,325,094...15,460,908
Ensembl chr2B:148,460,904...148,596,500
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BACE1
beta-secretase 1
ISO
protein:increased expression:hippocampus
RGD
PMID:30028260
RGD:13782136
NCBI chr11:112,120,950...112,151,505
Ensembl chr11:116,054,303...116,084,812
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COL4A1
collagen type IV alpha 1 chain
ISO
ClinVar Annotator: match by term: Intraventricular hemorrhage
ClinVar
PMID:7695699 PMID:8218237 PMID:9016532 PMID:16598045 PMID:17078022 PMID:17938367 PMID:19344236 PMID:22102590 PMID:25741868 PMID:26362372 PMID:28492532 PMID:31857254 PMID:32033901 More...
NCBI chr13:91,282,617...91,440,187
Ensembl chr13:110,407,009...110,562,529
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COL4A2
collagen type IV alpha 2 chain
ISO
ClinVar Annotator: match by term: Intraventricular hemorrhage
ClinVar
PMID:25741868 PMID:33527515
NCBI chr13:91,440,314...91,650,138
Ensembl chr13:110,563,119...110,767,530
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IL6
interleukin 6
ISO
associated with Premature Birth;protein:increased expression:serum:
RGD
PMID:22906886
RGD:12792208
NCBI chr 7:23,415,922...23,420,767
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CRH
corticotropin releasing hormone
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12699433 PMID:12699434
NCBI chr 8:62,714,721...62,716,979
Ensembl chr 8:64,383,419...64,384,009
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CNOT1
CCR4-NOT transcription complex subunit 1
ISO
ClinVar Annotator: match by term: Preterm intraventricular hemorrhage
ClinVar
PMID:25741868
NCBI chr16:38,793,212...38,902,686
Ensembl chr16:57,919,283...58,027,472
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GSN
gelsolin
ISO
protein:decreased expression:blood plasma (human)
RGD
PMID:28755273
RGD:329337382
NCBI chr 9:92,413,819...92,460,483
Ensembl chr 9:120,741,148...120,805,831
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SEMA6B
semaphorin 6B
ISO
ClinVar Annotator: match by term: Grade I preterm intraventricular hemorrhage
ClinVar
PMID:31474318
NCBI chr19:3,562,673...3,600,981
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ABCC8
ATP binding cassette subfamily C member 8
treatment
ISO
RGD
PMID:24114458
RGD:10003028
NCBI chr11:17,447,564...17,531,513
Ensembl chr11:17,133,063...17,216,870
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ADIPOQ
adiponectin, C1Q and collagen domain containing
ISO
protein:increased expression:cerebrospinal fluid
RGD
PMID:22230897
RGD:8695949
NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885
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ADORA1
adenosine A1 receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18950269
NCBI chr 1:178,728,751...178,769,066
Ensembl chr 1:183,023,466...183,063,760
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AGER
advanced glycosylation end-product specific receptor
ISO
mRNA, protein:increased expression:brain
RGD
PMID:24291745
RGD:8696000
NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641
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AIF1
allograft inflammatory factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27157545
NCBI chr 6:31,276,215...31,278,051
Ensembl chr 6:32,166,301...32,168,125
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AQP4
aquaporin 4
exacerbates
ISO
mRNA:increased expression:brain:
RGD
PMID:33574749
RGD:127284879
NCBI chr18:20,108,607...20,122,381
Ensembl chr18:23,713,146...23,726,919
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BCL2
BCL2 apoptosis regulator
treatment
ISO
RGD
PMID:26163325
RGD:13782347
NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100
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BECN1
beclin 1
ISO
protein:increased expression:brain
RGD
PMID:22521819
RGD:6483046
NCBI chr17:14,493,619...14,507,809
Ensembl chr17:14,719,781...14,733,286
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BNIP3
BCL2 interacting protein 3
treatment
ISO
RGD
PMID:23850688
RGD:11561986
NCBI chr10:128,671,663...128,685,952
Ensembl chr10:132,858,211...132,871,634
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C3
complement C3
treatment
ISO
RGD
PMID:26518242
RGD:11040780
NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699
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CASP3
caspase 3
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:24602480 PMID:26163325
RGD:13782347
NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185
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CASP9
caspase 9
treatment
ISO
RGD
PMID:26163325
RGD:13782347
NCBI chr 1:14,630,659...14,662,865
Ensembl chr 1:15,624,666...15,656,266
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CCL20
C-C motif chemokine ligand 20
ISO
mRNA:increased expression:cerebral artery
RGD
PMID:17977275
RGD:7488893
NCBI chr2B:115,052,768...115,056,479
Ensembl chr2B:233,862,505...233,866,225
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CYP3A4
cytochrome P450 family 3 subfamily A member 4
ISO
DNA:snp:cds:p.I118V (human)
RGD
PMID:18566305
RGD:5685415
NCBI chr 7:91,797,037...91,824,696
Ensembl chr 7:105,230,666...105,258,401
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DDIT3
DNA damage inducible transcript 3
treatment
ISO
RGD
PMID:30226536
RGD:35316073
NCBI chr12:31,406,332...31,410,293
Ensembl chr12:31,664,743...31,668,701
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EDN1
endothelin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:8587695
NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545
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EDNRB
endothelin receptor type B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:8587695
NCBI chr13:59,112,349...59,136,615
Ensembl chr13:78,153,020...78,177,286
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EPO
erythropoietin
treatment
ISO
RGD
PMID:23907045
RGD:10400909
NCBI chr 7:92,747,671...92,750,886
Ensembl chr 7:106,148,062...106,150,974
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ERBB4
erb-b2 receptor tyrosine kinase 4
treatment
ISO
RGD
PMID:28756200
RGD:151893490
NCBI chr2B:98,625,630...99,795,371
Ensembl chr2B:217,069,644...218,272,006
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ERN1
endoplasmic reticulum to nucleus signaling 1
treatment
ISO
RGD
PMID:29169414 PMID:30226536
RGD:34901873 RGD:35316073
NCBI chr17:58,132,889...58,224,012
Ensembl chr17:63,226,949...63,317,825
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ESR1
estrogen receptor 1
ISO
protein:increased expression:dentate gyrus
RGD
PMID:23465388
RGD:8553242
NCBI chr 6:149,507,599...149,918,523
Ensembl chr 6:154,317,002...154,631,551
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GLI1
GLI family zinc finger 1
ISO
mRNA, protein:increased expression:brain
RGD
PMID:23933201
RGD:12859044
NCBI chr12:31,453,759...31,466,194
Ensembl chr12:31,710,057...31,722,473
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GPX3
glutathione peroxidase 3
ISO
protein:increased expression:plasma
RGD
PMID:32326289
RGD:401827845
NCBI chr 5:146,447,939...146,456,476
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GSK3B
glycogen synthase kinase 3 beta
treatment
ISO
RGD
PMID:27026509
RGD:13792767
NCBI chr 3:116,943,205...117,215,001
Ensembl chr 3:123,861,379...124,126,771
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GSN
gelsolin
severity disease_progression
ISO
protein:decreased expression:blood plasma (human) mRNA, protein:altered expression:cerebral cortex (rat)
RGD
PMID:23880145 PMID:25744577
RGD:11055426 RGD:329333027
NCBI chr 9:92,413,819...92,460,483
Ensembl chr 9:120,741,148...120,805,831
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HCN1
hyperpolarization activated cyclic nucleotide gated potassium channel 1
ISO
mRNA,protein:decreased expression:hippocampus:
RGD
PMID:22378889
RGD:9686397
NCBI chr 5:64,673,392...65,116,259
Ensembl chr 5:69,724,767...70,158,761
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HIF1A
hypoxia inducible factor 1 subunit alpha
ISO
protein:increased expression:brain
RGD
PMID:15703702
RGD:1626323
NCBI chr14:42,295,691...42,348,478
Ensembl chr14:60,552,374...60,604,885
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HMOX1
heme oxygenase 1
ISO
mRNA:increased expression:subarachnoid space
RGD
PMID:14657544 PMID:16543643 PMID:19686725
RGD:1582702 RGD:1598406 RGD:4145300
NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063
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HSPD1
heat shock protein family D (Hsp60) member 1
ISO
mRNA:increased expression:brain stem
RGD
PMID:14753490
RGD:1624246
NCBI chr2B:84,729,615...84,743,352
Ensembl chr2B:202,623,497...202,636,959
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HTR1B
5-hydroxytryptamine receptor 1B
ISO
RGD
PMID:17542534
RGD:1626451
NCBI chr 6:75,309,078...75,313,747
Ensembl chr 6:78,596,408...78,597,580
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ICAM1
intercellular adhesion molecule 1
ISO
mRNA:increased expression:lung (rat)
RGD
PMID:20731855
RGD:4145368
NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605
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IL1B
interleukin 1 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27157545
NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424
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IL1RN
interleukin 1 receptor antagonist
ISO
rat model treated with human protein
RGD
PMID:22679224
RGD:7051590
NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839
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IL6
interleukin 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27157545
NCBI chr 7:23,415,922...23,420,767
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IRF9
interferon regulatory factor 9
ameliorates
ISO
RGD
PMID:29480757
RGD:125093745
NCBI chr14:4,937,068...4,942,870
Ensembl chr14:23,061,990...23,067,824
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KCNJ10
potassium inwardly rectifying channel subfamily J member 10
treatment
ISO
RGD
PMID:22420318
RGD:8662908
NCBI chr 1:135,391,321...135,424,100
G
LCN2
lipocalin 2
ameliorates
ISO
RGD
PMID:26463936
RGD:126781835
NCBI chr 9:99,259,278...99,274,494
Ensembl chr 9:127,940,799...127,944,798
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LOC100976904
growth-regulated alpha protein
ISO
mRNA:increased expression:lung
RGD
PMID:20731855
RGD:4145368
NCBI chr 4:50,325,248...50,327,165
Ensembl chr 4:56,153,899...56,159,474
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LOC100982531
cytochrome b-245 heavy chain
ISO
Protein:increased expression:cerebral cortex mRNA:increased expression:cerebral vessel:
RGD
PMID:12142572 PMID:16671452
RGD:11040582 RGD:1599680
NCBI chr X:30,230,394...30,267,379
Ensembl chr X:37,939,704...37,973,183
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MAP3K5
mitogen-activated protein kinase kinase kinase 5
treatment
ISO
RGD
PMID:30226536
RGD:35316073
NCBI chr 6:134,316,841...134,582,843
Ensembl chr 6:138,406,398...138,641,727
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MAP3K7
mitogen-activated protein kinase kinase kinase 7
treatment
ISO
RGD
PMID:29273596
RGD:155804269
NCBI chr 6:88,398,329...88,470,926
Ensembl chr 6:91,664,263...91,737,468
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MMP1
matrix metallopeptidase 1
no_association
ISO
RGD
PMID:11546917
RGD:1582365
NCBI chr11:97,730,545...97,739,190
Ensembl chr11:101,221,393...101,230,104
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MMP13
matrix metallopeptidase 13
ISO
RGD
PMID:16961140
RGD:1582545
NCBI chr11:97,890,811...97,902,778
Ensembl chr11:101,377,001...101,387,679
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MMP2
matrix metallopeptidase 2
ISO
RGD
PMID:22475348
RGD:8657107
NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279
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MMP9
matrix metallopeptidase 9
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:17410600 PMID:27157545
RGD:1642039
NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129
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NFE2L2
NFE2 like bZIP transcription factor 2
treatment
ISO
RGD
PMID:22304528
RGD:10412722
NCBI chr2B:64,509,446...64,544,600
Ensembl chr2B:182,214,116...182,248,085
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NGB
neuroglobin
ISO
protein:increased expression:cerebral cortex
RGD
PMID:24281943
RGD:9743950
NCBI chr14:57,818,491...57,824,196
Ensembl chr14:77,020,274...77,025,983
G
NLK
nemo like kinase
disease_progression
ISO
RGD
PMID:23325309
RGD:12791279
NCBI chr17:28,586,894...28,740,252
G
NOS2
nitric oxide synthase 2
ISO
mRNA:increased expression:brainstem, basilar artery (mouse) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:17053178 PMID:21915076
RGD:5509046
NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093
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NOS3
nitric oxide synthase 3
ISO
mRNA:increased expression:parietal cortex, arteriole (rat)
RGD
PMID:11273938
RGD:7794687
NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233
G
NQO1
NAD(P)H quinone dehydrogenase 1
ISO
mRNA, protein:increased expression:brain
RGD
PMID:21259333
RGD:5133235
NCBI chr16:50,090,696...50,106,495
Ensembl chr16:69,470,288...69,489,731
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NRG1
neuregulin 1
treatment
ISO
RGD
PMID:28756200
RGD:151893490
NCBI chr 8:30,954,852...32,084,411
Ensembl chr 8:29,050,222...29,263,977
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NTN1
netrin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29162556
NCBI chr17:42,409,797...42,631,930
Ensembl chr17:47,152,225...47,368,134
G
NTRK2
neurotrophic receptor tyrosine kinase 2
ISO
RGD
PMID:21193742
RGD:5684779
NCBI chr 9:39,663,986...40,208,770
Ensembl chr 9:84,021,837...84,372,678
G
PDCD10
programmed cell death 10
ISO
protein:decreased expression:brain, microglial cell (rat)
RGD
PMID:32302649
RGD:401827168
NCBI chr 3:164,703,909...164,755,085
Ensembl chr 3:172,760,923...172,811,430
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PDGFRB
platelet derived growth factor receptor beta
ameliorates
ISO
RGD
PMID:29480757
RGD:125093745
NCBI chr 5:145,538,330...145,580,312
Ensembl chr 5:151,543,891...151,585,530
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PIK3CB
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
treatment
ISO
RGD
PMID:28756200
RGD:151893490
NCBI chr 3:135,685,120...135,867,096
Ensembl chr 3:143,288,563...143,431,314
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PKD1L1
polycystin 1 like 1, transient receptor potential channel interacting
susceptibility
ISO
DNA:polymorphism:cds:p.Gly243Asp(human)
RGD
PMID:16741147
RGD:155630602
NCBI chr 7:48,451,329...48,596,991
Ensembl chr 7:48,545,432...48,701,736
G
PPARG
peroxisome proliferator activated receptor gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29162556
NCBI chr 3:12,215,322...12,361,669
Ensembl chr 3:12,622,397...12,705,060
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PRKN
parkin RBR E3 ubiquitin protein ligase
treatment
ISO
RGD
PMID:28546552
RGD:13432565
NCBI chr 6:159,293,016...160,679,106
Ensembl chr 6:164,314,990...165,678,770
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PTCH1
patched 1
ISO
mRNA, protein:increased expression:brain
RGD
PMID:23933201
RGD:12859044
NCBI chr 9:66,542,675...66,616,820
Ensembl chr 9:94,668,365...94,741,453
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PTGS2
prostaglandin-endoperoxide synthase 2
ISO
RGD
PMID:21725746
RGD:5508204
NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519
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RELA
RELA proto-oncogene, NF-kB subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27157545
NCBI chr11:61,012,839...61,022,225
Ensembl chr11:64,347,859...64,356,868
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SHH
sonic hedgehog signaling molecule
ISO
mRNA, protein:increased expression:brain
RGD
PMID:23933201
RGD:12859044
NCBI chr 7:147,400,112...147,414,036
Ensembl chr 7:159,114,666...159,126,651
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SMO
smoothened, frizzled class receptor
treatment
ISO
RGD
PMID:28149272
RGD:150521623
NCBI chr 7:121,143,968...121,168,873
Ensembl chr 7:133,668,304...133,693,048
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STAT3
signal transducer and activator of transcription 3
ISO
mRNA, protein:increased expression, increased phosphorylation:cerebral artery
RGD
PMID:24517975
RGD:8694356
NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067
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TACR1
tachykinin receptor 1
ISO
RGD
PMID:17542534
RGD:1626451
NCBI chr2A:75,111,339...75,267,320
Ensembl chr2A:76,614,478...76,771,018
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TJP1
tight junction protein 1
ISO
protein:altered localization
RGD
PMID:18854840
RGD:2325137
NCBI chr15:981,198...1,249,292
Ensembl chr15:26,344,878...26,598,878
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TLR4
toll like receptor 4
ISO
mRNA, protein:increased expression:brain
RGD
PMID:19719951
RGD:4144093
NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711
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TMBIM6
transmembrane BAX inhibitor motif containing 6
treatment
ISO
mRNA,protein:decreased expression:brain
RGD
PMID:30226536
RGD:35316073
NCBI chr12:38,986,844...39,010,307
Ensembl chr12:39,879,951...39,902,303
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TNC
tenascin C
ISO
protein:increased expression:basilar artery
RGD
PMID:19589197
RGD:4889600
NCBI chr 9:86,125,672...86,222,804
Ensembl chr 9:114,486,778...114,584,299
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TNF
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:brain
CTD RGD
PMID:19719951 PMID:27157545
RGD:4144093
NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
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TREM1
triggering receptor expressed on myeloid cells 1
treatment severity
ISO
RGD
PMID:30910643 PMID:33727099
RGD:127284863 RGD:127284864
NCBI chr 6:40,861,283...40,874,446
Ensembl chr 6:42,163,337...42,183,091
G
TRPM4
transient receptor potential cation channel subfamily M member 4
ISO
protein:increased expression:entorhinal cortex
RGD
PMID:24114458
RGD:10003028
NCBI chr19:46,168,301...46,224,726
Ensembl chr19:55,095,029...55,150,464
G
UNC5B
unc-5 netrin receptor B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29162556
NCBI chr10:67,682,415...67,772,760
Ensembl chr10:70,207,998...70,298,038
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YAP1
Yes1 associated transcriptional regulator
treatment
ISO
RGD
PMID:28756200
RGD:151893490
NCBI chr11:97,061,367...97,186,961
Ensembl chr11:100,552,424...100,681,301
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PLAT
plasminogen activator, tissue type
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:1899364
NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779
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F7
coagulation factor VII
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:20370756
NCBI chr13:94,246,694...94,261,133
Ensembl chr13:113,315,868...113,329,995
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ABCC8
ATP binding cassette subfamily C member 8
treatment
ISO
RGD
PMID:18854840
RGD:2325137
NCBI chr11:17,447,564...17,531,513
Ensembl chr11:17,133,063...17,216,870
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