PRKN (parkin RBR E3 ubiquitin protein ligase) - Rat Genome Database

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Gene: PRKN (parkin RBR E3 ubiquitin protein ligase) Pan paniscus
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Symbol: PRKN
Name: parkin RBR E3 ubiquitin protein ligase
RGD ID: 11686371
Description: ENCODES a protein that exhibits actin binding (ortholog); beta-catenin binding (ortholog); chaperone binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); aggresome assembly (ortholog); autophagy of mitochondrion (ortholog); PARTICIPATES IN altered mitochondrial autophagy pathway; mitochondrial autophagy pathway; Parkinson's disease pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Animal Disease Models (ortholog); autistic disorder (ortholog); FOUND IN aggresome (ortholog); axon (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: E3 ubiquitin-protein ligase parkin; PARK2; parkinson protein 2, E3 ubiquitin protein ligase (parkin)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16164,498,420 - 165,678,904 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6164,314,990 - 165,678,770 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06159,293,016 - 160,679,106 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (ISO)
aggresome assembly  (ISO)
autophagy of mitochondrion  (ISO)
brain development  (ISO)
cellular protein catabolic process  (ISO)
cellular response to hydrogen sulfide  (ISO)
cellular response to L-glutamate  (ISO)
cellular response to L-glutamine  (ISO)
cellular response to manganese ion  (ISO)
cellular response to toxic substance  (ISO)
dopamine metabolic process  (ISO)
dopamine uptake involved in synaptic transmission  (ISO)
free ubiquitin chain polymerization  (ISO)
learning  (ISO)
locomotory behavior  (ISO)
mitochondrial fragmentation involved in apoptotic process  (ISO)
mitochondrion localization  (ISO)
mitochondrion to lysosome transport  (ISO)
mitophagy  (ISO)
modulation of chemical synaptic transmission  (ISO)
negative regulation by host of viral genome replication  (ISO)
negative regulation of actin filament bundle assembly  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell death  (ISO)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
negative regulation of excitatory postsynaptic potential  (ISO)
negative regulation of exosomal secretion  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of glucokinase activity  (ISO)
negative regulation of insulin secretion  (ISO)
negative regulation of intralumenal vesicle formation  (ISO)
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator  (ISO)
negative regulation of mitochondrial fission  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of oxidative stress-induced neuron death  (ISO)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
negative regulation of primary amine oxidase activity  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of reactive oxygen species metabolic process  (ISO)
negative regulation of release of cytochrome c from mitochondria  (ISO)
negative regulation of spontaneous neurotransmitter secretion  (ISO)
negative regulation of synaptic transmission, glutamatergic  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
norepinephrine metabolic process  (ISO)
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of autophagy of mitochondrion  (ISO)
positive regulation of dendrite extension  (ISO)
positive regulation of DNA binding  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of mitochondrial fusion  (ISO)
positive regulation of mitochondrial membrane potential  (ISO)
positive regulation of mitophagy  (ISO)
positive regulation of mitophagy in response to mitochondrial depolarization  (ISO)
positive regulation of neurotransmitter uptake  (ISO)
positive regulation of proteasomal protein catabolic process  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of protein linear polyubiquitination  (ISO)
positive regulation of protein localization to membrane  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
proteasomal protein catabolic process  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO)
protein autoubiquitination  (ISO)
protein destabilization  (ISO)
protein K11-linked ubiquitination  (ISO)
protein K48-linked ubiquitination  (ISO)
protein K6-linked ubiquitination  (ISO)
protein K63-linked ubiquitination  (ISO)
protein localization to mitochondrion  (ISO)
protein metabolic process  (ISO)
protein monoubiquitination  (ISO)
protein polyubiquitination  (ISO)
protein stabilization  (ISO)
protein ubiquitination  (ISO)
regulation of autophagy  (ISO)
regulation of cellular response to oxidative stress  (ISO)
regulation of dopamine metabolic process  (ISO)
regulation of gene expression  (ISO)
regulation of mitochondrial membrane potential  (ISO)
regulation of mitochondrion organization  (ISO)
regulation of neurotransmitter secretion  (ISO)
regulation of protein stability  (ISO)
regulation of protein ubiquitination  (ISO)
regulation of reactive oxygen species metabolic process  (ISO)
response to corticosterone  (ISO)
response to curcumin  (ISO)
response to endoplasmic reticulum stress  (ISO)
response to muscle activity  (ISO)
response to unfolded protein  (ISO)
response to xenobiotic stimulus  (ISO)
startle response  (ISO)
synaptic transmission, dopaminergic  (ISO)
synaptic transmission, glutamatergic  (ISO)
ubiquitin-dependent protein catabolic process  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
PRKN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16164,498,420 - 165,678,904 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6164,314,990 - 165,678,770 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06159,293,016 - 160,679,106 (-)NCBIMhudiblu_PPA_v0panPan3
PRKN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6161,347,417 - 162,727,775 (-)EnsemblGRCh38hg38GRCh38
GRCh386161,347,417 - 162,727,802 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376161,768,449 - 163,148,798 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366161,689,661 - 163,068,793 (-)NCBINCBI36hg18NCBI36
Build 346161,740,081 - 163,119,211NCBI
Celera6162,497,923 - 163,878,436 (-)NCBI
Cytogenetic Map6q26NCBI
HuRef6159,224,034 - 160,600,983 (-)NCBIHuRef
CHM1_16162,031,091 - 163,411,071 (-)NCBICHM1_1
Prkn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391711,059,227 - 12,282,257 (+)NCBIGRCm39mm39
GRCm39 Ensembl1711,059,271 - 12,282,248 (+)Ensembl
GRCm381710,840,359 - 12,063,370 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1710,840,384 - 12,063,361 (+)EnsemblGRCm38mm10GRCm38
MGSCv371711,033,250 - 12,256,227 (+)NCBIGRCm37mm9NCBIm37
MGSCv361710,683,742 - 11,906,719 (+)NCBImm8
Celera1710,880,667 - 12,092,859 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map177.8NCBI
Prkn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2148,688,651 - 49,882,520 (-)NCBImRatBN7.2
Rnor_6.0148,880,015 - 50,069,998 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0149,684,308 - 50,875,397 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4143,151,265 - 44,374,470 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1143,154,209 - 44,377,415 (-)NCBI
Celera144,478,407 - 45,666,902 (-)NCBICelera
Cytogenetic Map1q11NCBI
Prkn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543918,664,379 - 19,951,152 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543918,664,230 - 19,953,358 (+)NCBIChiLan1.0ChiLan1.0
PRKN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1149,886,887 - 51,201,930 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl149,889,005 - 51,201,764 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha150,729,328 - 52,042,064 (-)NCBI
ROS_Cfam_1.0150,071,882 - 51,381,593 (-)NCBI
UMICH_Zoey_3.1149,954,154 - 51,268,026 (-)NCBI
UNSW_CanFamBas_1.0149,824,568 - 51,126,809 (-)NCBI
UU_Cfam_GSD_1.0150,440,798 - 51,751,574 (-)NCBI
Prkn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946144,866,545 - 145,855,394 (-)NCBI
SpeTri2.0NW_00493648912,118,538 - 12,913,664 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15,465,511 - 6,730,881 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115,698,508 - 6,731,132 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.217,649,954 - 8,260,243 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.217,197,051 - 7,562,040 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11388,856,056 - 90,329,379 (-)NCBI
Vero_WHO_p1.0NW_02366604061,183,625 - 62,136,281 (-)NCBI
Prkn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624855430,148 - 1,992,121 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000045826   ⟹   ENSPPAP00000023009
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6164,314,990 - 165,678,770 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000045827   ⟹   ENSPPAP00000023010
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6164,314,990 - 165,678,770 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000045828   ⟹   ENSPPAP00000023011
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6164,314,990 - 165,678,770 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000045830   ⟹   ENSPPAP00000023013
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6164,498,720 - 165,678,770 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000045832   ⟹   ENSPPAP00000023015
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6165,215,810 - 165,216,121 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000045836   ⟹   ENSPPAP00000023018
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6165,215,879 - 165,228,456 (-)Ensembl
RefSeq Acc Id: XM_034963207   ⟹   XP_034819098
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v06159,293,016 - 160,679,106 (-)NCBI
RefSeq Acc Id: XM_034963209   ⟹   XP_034819100
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v06159,293,725 - 160,679,106 (-)NCBI
RefSeq Acc Id: XM_034963210   ⟹   XP_034819101
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v06159,293,016 - 160,679,106 (-)NCBI
RefSeq Acc Id: XM_034963211   ⟹   XP_034819102
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v06159,293,725 - 160,664,526 (-)NCBI
RefSeq Acc Id: XM_034963212   ⟹   XP_034819103
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v06159,293,725 - 160,679,106 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_034819101   ⟸   XM_034963210
- Peptide Label: isoform X3
RefSeq Acc Id: XP_034819098   ⟸   XM_034963207
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034819103   ⟸   XM_034963212
- Peptide Label: isoform X4
RefSeq Acc Id: XP_034819100   ⟸   XM_034963209
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034819102   ⟸   XM_034963211
- Peptide Label: isoform X4
RefSeq Acc Id: ENSPPAP00000023010   ⟸   ENSPPAT00000045827
RefSeq Acc Id: ENSPPAP00000023009   ⟸   ENSPPAT00000045826
RefSeq Acc Id: ENSPPAP00000023011   ⟸   ENSPPAT00000045828
RefSeq Acc Id: ENSPPAP00000023015   ⟸   ENSPPAT00000045832
RefSeq Acc Id: ENSPPAP00000023018   ⟸   ENSPPAT00000045836
RefSeq Acc Id: ENSPPAP00000023013   ⟸   ENSPPAT00000045830


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000034661 Ensembl, ENTREZGENE
NCBI Gene PARK2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-02-24 PRKN  parkin RBR E3 ubiquitin protein ligase  PARK2    Symbol and/or name change 5135510 APPROVED