AIF1 (allograft inflammatory factor 1) - Rat Genome Database

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Gene: AIF1 (allograft inflammatory factor 1) Pan paniscus
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Symbol: AIF1
Name: allograft inflammatory factor 1
RGD ID: 11991814
Description: ENCODES a protein that exhibits actin filament binding (inferred); calcium ion binding (inferred); metal ion binding (inferred); INVOLVED IN actin filament bundle assembly (ortholog); cellular response to hormone stimulus (ortholog); cellular response to hydroperoxide (ortholog); ASSOCIATED WITH Alcohol-Induced Disorders, Nervous System (ortholog); Alzheimer's disease (ortholog); Animal Disease Models (ortholog); FOUND IN cell projection (ortholog); lamellipodium (ortholog); perikaryon (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,092,079 - 46,093,913 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,053,651 - 42,055,477 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,276,215 - 31,278,051 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,166,301 - 32,168,125 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,166,301 - 32,168,125 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin crosslink formation  (IEA)
actin filament bundle assembly  (IEA,ISO)
actin filament polymerization  (IEA)
cellular response to hormone stimulus  (ISO)
cellular response to hydroperoxide  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to morphine  (ISO)
cellular response to oxidative stress  (IEA)
cellular response to type II interferon  (IEA)
cerebellum development  (ISO)
inflammatory response  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of smooth muscle cell chemotaxis  (IEA)
negative regulation of smooth muscle cell proliferation  (IEA)
parallel actin filament bundle assembly  (IEA)
phagocytosis, engulfment  (IEA)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cell population proliferation  (IEA)
positive regulation of chemokine production  (IEA)
positive regulation of chemotaxis  (IEA)
positive regulation of fibroblast growth factor production  (IEA)
positive regulation of G1/S transition of mitotic cell cycle  (IEA)
positive regulation of interleukin-6 production  (IEA)
positive regulation of monocyte chemotaxis  (IEA)
positive regulation of mononuclear cell migration  (IEA)
positive regulation of muscle hyperplasia  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of smooth muscle cell chemotaxis  (IEA)
positive regulation of smooth muscle cell proliferation  (IEA,ISO)
positive regulation of T cell migration  (IEA)
positive regulation of T cell proliferation  (IEA)
Rac protein signal transduction  (IEA)
response to axon injury  (ISO)
response to cytokine  (ISO)
response to electrical stimulus  (ISO)
response to glucocorticoid  (ISO)
ruffle assembly  (IEA)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
AIF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,092,079 - 46,093,913 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,053,651 - 42,055,477 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,276,215 - 31,278,051 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,166,301 - 32,168,125 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,166,301 - 32,168,125 (+)Ensemblpanpan1.1panPan2
AIF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,615,234 - 31,617,015 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl631,615,217 - 31,617,021 (+)EnsemblGRCh38hg38GRCh38
GRCh37631,583,011 - 31,584,792 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,691,012 - 31,692,777 (+)NCBINCBI36Build 36hg18NCBI36
Build 34631,691,767 - 31,692,777NCBI
Celera633,181,222 - 33,183,026 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,369,335 - 31,370,975 (+)NCBIHuRef
CHM1_1631,585,130 - 31,586,934 (+)NCBICHM1_1
T2T-CHM13v2.0631,468,284 - 31,470,065 (+)NCBIT2T-CHM13v2.0
Aif1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,389,967 - 35,394,977 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,389,967 - 35,395,044 (-)EnsemblGRCm39 Ensembl
GRCm381735,170,986 - 35,176,083 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,170,991 - 35,176,068 (-)EnsemblGRCm38mm10GRCm38
MGSCv371735,307,937 - 35,312,946 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,779,048 - 34,784,057 (-)NCBIMGSCv36mm8
Celera1738,267,928 - 38,272,936 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.59NCBI
Aif1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,651,435 - 3,657,341 (+)NCBIGRCr8
mRatBN7.2203,646,784 - 3,652,670 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,646,777 - 3,652,668 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,350,088 - 4,351,997 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,712,144 - 3,714,054 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,249,928 - 4,251,828 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,161,350 - 5,167,176 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,161,333 - 5,166,448 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,234,609 - 7,240,454 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,714,428 - 3,716,327 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,714,654 - 3,716,552NCBI
Celera204,373,127 - 4,375,026 (-)NCBICelera
Cytogenetic Map20p12NCBI
Aif1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955437157,509 - 158,919 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955437157,509 - 158,919 (+)NCBIChiLan1.0ChiLan1.0
AIF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,104,350 - 1,106,179 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,104,394 - 1,106,177 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,240,799 - 1,242,629 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,249,600 - 1,251,430 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,249,645 - 1,251,403 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,108,905 - 1,110,735 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,176,225 - 1,178,056 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,243,086 - 1,244,917 (+)NCBIUU_Cfam_GSD_1.0
Aif1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,651,964 - 35,653,851 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367271,907,505 - 1,909,338 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367271,907,493 - 1,909,350 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AIF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,726,787 - 23,731,671 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,711,752 - 23,731,191 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,520,797 - 27,540,237 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AIF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366604431,525,412 - 31,527,245 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aif1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475424,590,071 - 24,591,904 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475424,590,071 - 24,591,913 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Sequence


Ensembl Acc Id: ENSPPAT00000055490   ⟹   ENSPPAP00000032621
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl632,166,301 - 32,168,125 (+)Ensembl
RefSeq Acc Id: XM_003831583   ⟹   XP_003831631
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2546,092,087 - 46,093,913 (+)NCBI
NHGRI_mPanPan1642,053,660 - 42,055,477 (+)NCBI
Mhudiblu_PPA_v0631,276,226 - 31,278,051 (+)NCBI
PanPan1.1632,166,301 - 32,168,125 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008956942   ⟹   XP_008955190
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2546,092,086 - 46,093,398 (+)NCBI
NHGRI_mPanPan1642,053,658 - 42,054,970 (+)NCBI
Mhudiblu_PPA_v0631,276,224 - 31,277,536 (+)NCBI
PanPan1.1632,166,320 - 32,167,614 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008956943   ⟹   XP_008955191
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2546,092,079 - 46,093,913 (+)NCBI
NHGRI_mPanPan1642,053,651 - 42,055,477 (+)NCBI
Mhudiblu_PPA_v0631,276,217 - 31,278,051 (+)NCBI
PanPan1.1632,166,319 - 32,168,125 (+)NCBI
Sequence:
RefSeq Acc Id: XM_014345301   ⟹   XP_014200787
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2546,092,087 - 46,093,398 (+)NCBI
NHGRI_mPanPan1642,053,659 - 42,054,970 (+)NCBI
Mhudiblu_PPA_v0631,276,225 - 31,277,536 (+)NCBI
PanPan1.1632,166,320 - 32,167,614 (+)NCBI
Sequence:
RefSeq Acc Id: XM_014345303   ⟹   XP_014200789
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2546,092,133 - 46,093,913 (+)NCBI
NHGRI_mPanPan1642,053,709 - 42,055,477 (+)NCBI
Mhudiblu_PPA_v0631,276,277 - 31,278,051 (+)NCBI
PanPan1.1632,166,320 - 32,168,125 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063604803   ⟹   XP_063460873
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2546,092,081 - 46,093,398 (+)NCBI
RefSeq Acc Id: XM_063604804   ⟹   XP_063460874
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2546,092,086 - 46,093,398 (+)NCBI
RefSeq Acc Id: XP_003831631   ⟸   XM_003831583
- Peptide Label: isoform X6
- UniProtKB: A0A2R9BT36 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008955191   ⟸   XM_008956943
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_014200789   ⟸   XM_014345303
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_008955190   ⟸   XM_008956942
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_014200787   ⟸   XM_014345301
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSPPAP00000032621   ⟸   ENSPPAT00000055490
RefSeq Acc Id: XP_063460873   ⟸   XM_063604803
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063460874   ⟸   XM_063604804
- Peptide Label: isoform X3
Protein Domains
EF-hand


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000039190 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000055490.1 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro AIF-1_EF_pair UniProtKB/TrEMBL
  AIF1/AIF1L UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
KEGG Report pps:100975536 UniProtKB/TrEMBL
NCBI Gene AIF1 ENTREZGENE
PANTHER ALLOGRAFT INFLAMMATORY FACTOR 1 UniProtKB/TrEMBL
  PTHR10356 UniProtKB/TrEMBL
Pfam AIF-1 UniProtKB/TrEMBL
PROSITE EF_HAND_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A2R9BT36 ENTREZGENE, UniProtKB/TrEMBL