RGD Reference Report - Hyperglycemia-induced cerebral hematoma expansion is mediated by plasma kallikrein. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Hyperglycemia-induced cerebral hematoma expansion is mediated by plasma kallikrein.

Authors: Liu, Jia  Gao, Ben-Bo  Clermont, Allen C  Blair, Price  Chilcote, Tamie J  Sinha, Sukanto  Flaumenhaft, Robert  Feener, Edward P 
Citation: Liu J, etal., Nat Med. 2011 Feb;17(2):206-10. doi: 10.1038/nm.2295. Epub 2011 Jan 23.
RGD ID: 401824683
Pubmed: PMID:21258336   (View Abstract at PubMed)
PMCID: PMC3038677   (View Article at PubMed Central)
DOI: DOI:10.1038/nm.2295   (Journal Full-text)

Hyperglycemia is associated with greater hematoma expansion and poor clinical outcomes after intracerebral hemorrhage. We show that cerebral hematoma expansion triggered by intracerebral infusion of autologous blood is greater in diabetic rats and mice compared to nondiabetic controls and that this augmented expansion is ameliorated by plasma kallikrein (PK) inhibition or deficiency. Intracerebral injection of purified PK augmented hematoma expansion in both diabetic and acutely hyperglycemic rats, whereas injection of bradykinin, plasmin or tissue plasminogen activator did not elicit such a response. This response, which occurs rapidly, was prevented by co-injection of the glycoprotein VI agonist convulxin and was mimicked by glycoprotein VI inhibition or deficiency, implicating an effect of PK on inhibiting platelet aggregation. We show that PK inhibits collagen-induced platelet aggregation by binding collagen, a response enhanced by elevated glucose concentrations. The effect of hyperglycemia on hematoma expansion and PK-mediated inhibition of platelet aggregation could be mimicked by infusing mannitol. These findings suggest that hyperglycemia augments cerebral hematoma expansion by PK-mediated osmotic-sensitive inhibition of hemostasis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GP6HumanIntracranial Subdural Hematoma exacerbatesISOGp6 (Mus musculus) RGD 
Gp6RatIntracranial Subdural Hematoma exacerbatesISOGp6 (Mus musculus) RGD 
Gp6MouseIntracranial Subdural Hematoma exacerbatesIMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gp6  (glycoprotein VI)

Genes (Mus musculus)
Gp6  (glycoprotein 6 platelet)

Genes (Homo sapiens)
GP6  (glycoprotein VI platelet)


Additional Information