RGD Reference Report - Alteration of intracellular calcium and its modulator SLC24A6 after experimental intracerebral hemorrhage. - Rat Genome Database

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Alteration of intracellular calcium and its modulator SLC24A6 after experimental intracerebral hemorrhage.

Authors: Zheng, M  Gong, Y  Wang, X  Xie, Q  Tang, H  Wang, D  Chen, X 
Citation: Zheng M, etal., Acta Neurochir Suppl. 2013;118:169-73. doi: 10.1007/978-3-7091-1434-6_31.
RGD ID: 9685494
Pubmed: PMID:23564126   (View Abstract at PubMed)
DOI: DOI:10.1007/978-3-7091-1434-6_31   (Journal Full-text)

Intracerebral hemorrhage (ICH) can lead to tragic disability and mortality. Accumulating evidence has shown that sodium calcium exchanger (NCX) may contribute to the secondary injury of a stroke. Recently, a novel member of NCX, SLC24A6, was discovered with knowledge of its abundant distribution in brain. In the present study, we examined the time course of expression of SLC24A6 and its mediated intracellular calcium concentration ([Ca(2+)]i) to investigate its potential roles in brain damage after ICH. An ICH model was established as previously reported. Real-time PCR and Western blotting were used to test the mRNA and protein levels of SLC24A6 on the hemorrhagic side and on the contralateral side caudate nucleus tissues at 6 h, and on days 1, 3, 5, and 7 after ICH. Immunohistochemistry was used to analyze the morphological changes. Fura-2/AM loaded, dual wavelength spectrophotofluorometry was used to test [Ca(2+)]i. The data presented a remarkable decrease in SLC24A6 early after ICH, along with a comparable increase in [Ca(2+)]i. Our results indicated that SLC24A6 presents specific and remarkable alterations in both mRNA and protein levels after ICH. Decreases in SLC24A6 level were correlated with [Ca(2+)]i elevation. These data suggest that SLC24A6-mediated calcium overload plays an important role in brain damage after ICH.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SLC24A1HumanCerebral Hemorrhage  ISOSlc24a1 (Rattus norvegicus)mRNA and protein:decreased expression:cerebrumRGD 
SLC8B1HumanCerebral Hemorrhage  ISOSlc8b1 (Rattus norvegicus) RGD 
Slc24a1RatCerebral Hemorrhage  IEP mRNA and protein:decreased expression:cerebrumRGD 
Slc24a1MouseCerebral Hemorrhage  ISOSlc24a1 (Rattus norvegicus)mRNA and protein:decreased expression:cerebrumRGD 
Slc8b1MouseCerebral Hemorrhage  ISOSlc8b1 (Rattus norvegicus) RGD 
Slc8b1RatCerebral Hemorrhage  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Slc24a1  (solute carrier family 24 member 1)
Slc8b1  (solute carrier family 8 member B1)

Genes (Mus musculus)
Slc24a1  (solute carrier family 24 (sodium/potassium/calcium exchanger), member 1)
Slc8b1  (solute carrier family 8 (sodium/lithium/calcium exchanger), member B1)

Genes (Homo sapiens)
SLC24A1  (solute carrier family 24 member 1)
SLC8B1  (solute carrier family 8 member B1)


Additional Information