IFNB1 (interferon beta 1) - Rat Genome Database

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Gene: IFNB1 (interferon beta 1) Pan paniscus
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Symbol: IFNB1
Name: interferon beta 1
RGD ID: 11853352
Description: ENCODES a protein that exhibits chloramphenicol O-acetyltransferase activity (ortholog); cytokine activity (ortholog); cytokine receptor binding (ortholog); INVOLVED IN adaptive immune response (ortholog); B cell activation involved in immune response (ortholog); B cell proliferation (ortholog); ASSOCIATED WITH amelanotic melanoma (ortholog); anus benign neoplasm (ortholog); Aortic Remodeling (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: interferon beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211103,458,347 - 103,470,724 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19103,466,363 - 103,476,669 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0920,884,742 - 20,886,317 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1921,540,849 - 21,541,695 (-)NCBIpanpan1.1PanPan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (ISO)
B cell activation involved in immune response  (ISO)
B cell proliferation  (ISO)
cell surface receptor signaling pathway via JAK-STAT  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to dsDNA  (ISO)
cellular response to dsRNA  (ISO)
cellular response to exogenous dsRNA  (ISO)
cellular response to interferon-beta  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to virus  (ISO)
cytokine-mediated signaling pathway  (ISO)
defense response to bacterium  (ISO)
defense response to virus  (ISO)
endoplasmic reticulum unfolded protein response  (ISO)
humoral immune response  (ISO)
innate immune response  (ISO)
macrophage activation involved in immune response  (ISO)
negative regulation of blood-brain barrier permeability  (ISO)
negative regulation of cell adhesion molecule production  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of immunoglobulin production  (ISO)
negative regulation of Lewy body formation  (ISO)
negative regulation of matrix metallopeptidase secretion  (ISO)
negative regulation of mononuclear cell migration  (ISO)
negative regulation of neuroinflammatory response  (ISO)
negative regulation of osteoclast differentiation  (ISO)
negative regulation of T cell differentiation  (ISO)
negative regulation of T-helper 2 cell cytokine production  (ISO)
negative regulation of type II interferon production  (ISO)
negative regulation of viral genome replication  (ISO)
neuron cellular homeostasis  (ISO)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of peptidyl-serine phosphorylation of STAT protein  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transforming growth factor beta production  (ISO)
response to exogenous dsRNA  (ISO)
type I interferon-mediated signaling pathway  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
IFNB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211103,458,347 - 103,470,724 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19103,466,363 - 103,476,669 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0920,884,742 - 20,886,317 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1921,540,849 - 21,541,695 (-)NCBIpanpan1.1PanPan1.1panPan2
IFNB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38921,077,104 - 21,077,942 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl921,077,104 - 21,077,942 (-)EnsemblGRCh38hg38GRCh38
GRCh37921,077,103 - 21,077,941 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36921,067,104 - 21,067,943 (-)NCBINCBI36Build 36hg18NCBI36
Build 34921,067,103 - 21,067,943NCBI
Celera921,015,373 - 21,016,212 (-)NCBICelera
Cytogenetic Map9p21.3NCBI
HuRef921,040,313 - 21,041,152 (-)NCBIHuRef
CHM1_1921,076,893 - 21,077,732 (-)NCBICHM1_1
T2T-CHM13v2.0921,090,986 - 21,091,824 (-)NCBIT2T-CHM13v2.0
Ifnb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39488,440,253 - 88,441,083 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl488,440,262 - 88,441,011 (-)EnsemblGRCm39 Ensembl
GRCm38488,522,025 - 88,522,794 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl488,522,025 - 88,522,774 (-)EnsemblGRCm38mm10GRCm38
MGSCv37488,167,929 - 88,168,698 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36487,993,256 - 87,994,025 (-)NCBIMGSCv36mm8
Celera487,037,706 - 87,038,475 (-)NCBICelera
Cytogenetic Map4C4NCBI
cM Map441.91NCBI
Ifnb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85108,066,650 - 108,067,487 (-)NCBIGRCr8
mRatBN7.25103,020,758 - 103,021,595 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5103,020,969 - 103,021,523 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5105,375,610 - 105,376,164 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05107,166,057 - 107,166,611 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05107,226,739 - 107,227,293 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05106,865,192 - 106,865,746 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5106,865,192 - 106,865,746 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05110,843,902 - 110,844,456 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45107,837,628 - 107,838,182 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15107,842,853 - 107,843,408 (-)NCBI
Celera5100,095,218 - 100,095,772 (+)NCBICelera
RH 3.4 Map5746.3RGD
Cytogenetic Map5q32NCBI
Ifnb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543423,301,623 - 23,302,304 (-)NCBIChiLan1.0ChiLan1.0
IFNB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11140,668,295 - 40,668,855 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1140,668,295 - 40,668,855 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1139,330,806 - 39,331,366 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01141,610,249 - 41,610,809 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1141,610,249 - 41,610,809 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11140,302,366 - 40,302,926 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01140,090,657 - 40,091,217 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01140,726,193 - 40,726,753 (-)NCBIUU_Cfam_GSD_1.0
Ifnb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947155,066,763 - 155,067,326 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366522,736,270 - 2,736,833 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IFNB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1201,850,935 - 201,851,495 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11201,850,935 - 201,851,495 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21225,469,554 - 225,470,114 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q23-q27NCBI
Ifnb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473625,099,061 - 25,099,746 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_055092090   ⟹   XP_054948065
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v211103,458,347 - 103,470,724 (+)NCBI
NHGRI_mPanPan19103,466,363 - 103,476,669 (+)NCBI
Protein Sequences
Protein RefSeqs XP_054948065 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_054948065   ⟸   XM_055092090


Additional Information

Database Acc Id Source(s)
NCBI Gene IFNB1 ENTREZGENE