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Protective effect of granulocyte colony-stimulating factor on intracerebral hemorrhage in rat.

Authors: Zhang, L  Shu, XJ  Zhou, HY  Liu, W  Chen, Y  Wang, CL  Li, Y  Chen, QX  Liu, LJ  Wang, JZ 
Citation: Zhang L, etal., Neurochem Res. 2009 Jul;34(7):1317-23. doi: 10.1007/s11064-008-9911-6. Epub 2009 Jan 24.
Pubmed: (View Article at PubMed) PMID:19169816
DOI: Full-text: DOI:10.1007/s11064-008-9911-6

Granulocyte colony-stimulating factor (G-CSF) is a member of the cytokine family of growth factors that can protect the neurons from focal cerebral ischemia-induced injuries. The intracerebral hemorrhage (ICH) has been widely observed in the clinic; however, the protective effect of G-CSF on ICH is still elusive. We found in the present study that the intraperitoneal injection of G-CSF for 5 days could improve the ICH-induced neuronal behavioral impairment measured by limb placement assay. We also observed that injection of G-CSF could increase the number of stem cells in the specific zone of the hemorrhagic areas, demonstrated by the enhanced expression of nestin. Additionally, G-CSF could also promote the mobilization of circulating hemopoietic stem cells (HSCs) to the damaged brain areas and activate the astrocytes. Our results reveal that G-CSF is also protective for the ICH with the mechanisms involving proliferation of neural stem cells, the migration of HSCs and the activation of astrocytes.


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RGD Object Information
RGD ID: 11039433
Created: 2016-03-03
Species: All species
Last Modified: 2016-03-03
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.