UNC5B (unc-5 netrin receptor B) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: UNC5B (unc-5 netrin receptor B) Pan paniscus
Analyze
Symbol: UNC5B
Name: unc-5 netrin receptor B
RGD ID: 11776547
Description: ENCODES a protein that exhibits netrin receptor activity (ortholog); INVOLVED IN anterior/posterior axon guidance (ortholog); axon guidance (ortholog); positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); genetic disease (ortholog); Subarachnoid Hemorrhage (ortholog); FOUND IN membrane raft (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: netrin receptor UNC5B; unc-5 homolog B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2883,362,648 - 83,453,001 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11083,367,973 - 83,458,343 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01067,682,415 - 67,772,760 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11070,207,998 - 70,298,038 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1070,207,998 - 70,298,038 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
UNC5B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2883,362,648 - 83,453,001 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11083,367,973 - 83,458,343 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01067,682,415 - 67,772,760 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11070,207,998 - 70,298,038 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1070,207,998 - 70,298,038 (+)Ensemblpanpan1.1panPan2
UNC5B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381071,212,570 - 71,302,864 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1071,212,570 - 71,302,864 (+)EnsemblGRCh38hg38GRCh38
GRCh371072,972,327 - 73,062,621 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361072,642,353 - 72,729,722 (+)NCBINCBI36Build 36hg18NCBI36
Build 341072,642,354 - 72,729,714NCBI
Celera1066,254,788 - 66,343,547 (+)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1066,966,129 - 67,056,670 (+)NCBIHuRef
CHM1_11073,254,992 - 73,345,299 (+)NCBICHM1_1
T2T-CHM13v2.01072,082,200 - 72,172,412 (+)NCBIT2T-CHM13v2.0
Unc5b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391060,598,373 - 60,667,360 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1060,598,372 - 60,667,360 (-)EnsemblGRCm39 Ensembl
GRCm381060,762,594 - 60,831,581 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1060,762,593 - 60,831,581 (-)EnsemblGRCm38mm10GRCm38
MGSCv371060,225,343 - 60,294,329 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361060,157,952 - 60,226,938 (-)NCBIMGSCv36mm8
Celera1061,863,405 - 61,932,538 (-)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1031.52NCBI
Unc5b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82029,240,639 - 29,307,270 (-)NCBIGRCr8
mRatBN7.22028,697,726 - 28,764,474 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2028,697,726 - 28,764,537 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2029,713,216 - 29,779,955 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02029,099,533 - 29,166,268 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02029,842,007 - 29,908,740 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02030,339,680 - 30,406,593 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2030,339,673 - 30,406,295 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02032,148,315 - 32,215,391 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42028,095,243 - 28,162,204 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12028,109,042 - 28,176,004 (-)NCBI
Celera2030,138,282 - 30,201,182 (-)NCBICelera
Cytogenetic Map20q11NCBI
Unc5b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543720,120,946 - 20,199,877 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543720,120,996 - 20,199,877 (-)NCBIChiLan1.0ChiLan1.0
UNC5B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1422,003,131 - 22,084,107 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl422,003,131 - 22,081,744 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha422,139,026 - 22,219,691 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0422,280,582 - 22,358,557 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl422,280,284 - 22,357,950 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1422,178,248 - 22,258,859 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0422,383,898 - 22,464,744 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0422,736,647 - 22,817,352 (+)NCBIUU_Cfam_GSD_1.0
Unc5b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721358,980,118 - 59,055,010 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365217,470,663 - 7,547,793 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365217,472,788 - 7,547,408 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UNC5B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1474,120,050 - 74,205,263 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11474,120,055 - 74,208,055 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21480,011,267 - 80,098,887 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UNC5B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1959,995,997 - 60,086,663 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604820,718,376 - 20,809,131 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Unc5b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247545,204,855 - 5,282,170 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247545,204,875 - 5,280,479 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000047267   ⟹   ENSPPAP00000024442
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1070,207,998 - 70,298,038 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000047271   ⟹   ENSPPAP00000024446
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1070,207,998 - 70,298,038 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000047281   ⟹   ENSPPAP00000024456
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1070,271,899 - 70,294,441 (+)Ensembl
RefSeq Acc Id: XM_003815956   ⟹   XP_003816004
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2883,362,648 - 83,453,001 (+)NCBI
NHGRI_mPanPan11083,367,973 - 83,458,343 (+)NCBI
Mhudiblu_PPA_v01067,682,415 - 67,772,760 (+)NCBI
PanPan1.11070,207,998 - 70,298,038 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003815957   ⟹   XP_003816005
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2883,362,648 - 83,453,001 (+)NCBI
NHGRI_mPanPan11083,367,973 - 83,458,343 (+)NCBI
Mhudiblu_PPA_v01067,682,447 - 67,772,760 (+)NCBI
PanPan1.11070,207,998 - 70,298,038 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003816004 (Get FASTA)   NCBI Sequence Viewer  
  XP_003816005 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000024442.1
  ENSPPAP00000024446.1
  ENSPPAP00000024456.1
Reference Protein Sequences
RefSeq Acc Id: XP_003816004   ⟸   XM_003815956
- Peptide Label: isoform X1
- UniProtKB: A0A2R9B4C2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003816005   ⟸   XM_003815957
- Peptide Label: isoform X2
- UniProtKB: A0A2R9B5X7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000024442   ⟸   ENSPPAT00000047267
RefSeq Acc Id: ENSPPAP00000024446   ⟸   ENSPPAT00000047271
RefSeq Acc Id: ENSPPAP00000024456   ⟸   ENSPPAT00000047281
Protein Domains
Ig-like   ZU5


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000035322 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000047267.1 UniProtKB/TrEMBL
  ENSPPAT00000047271.1 UniProtKB/TrEMBL
  ENSPPAT00000047281.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  2.20.100.10 UniProtKB/TrEMBL
  2.60.220.30 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
InterPro DEATH-like_dom_sf UniProtKB/TrEMBL
  Death_domain UniProtKB/TrEMBL
  Death_UNC5B UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
  UNC5 UniProtKB/TrEMBL
  UPA UniProtKB/TrEMBL
  ZU5_dom UniProtKB/TrEMBL
KEGG Report pps:100982640 UniProtKB/TrEMBL
NCBI Gene UNC5B ENTREZGENE
PANTHER NETRIN RECEPTOR UNC5B UniProtKB/TrEMBL
  PTHR12582 UniProtKB/TrEMBL
Pfam Death UniProtKB/TrEMBL
  I-set UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
  UPA UniProtKB/TrEMBL
  ZU5 UniProtKB/TrEMBL
PRINTS TSP1REPEAT UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
  ZU5 UniProtKB/TrEMBL
SMART DEATH UniProtKB/TrEMBL
  IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
  ZU5 UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
  SSF82895 UniProtKB/TrEMBL
UniProt A0A2R9B4C2 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9B5X7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9B5Y5_PANPA UniProtKB/TrEMBL