CRH (corticotropin releasing hormone) - Rat Genome Database

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Gene: CRH (corticotropin releasing hormone) Pan paniscus
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Symbol: CRH
Name: corticotropin releasing hormone
RGD ID: 11720441
Description: ENCODES a protein that exhibits corticotropin-releasing hormone receptor 1 binding (ortholog); corticotropin-releasing hormone receptor 2 binding (ortholog); INVOLVED IN adrenal gland development (ortholog); associative learning (ortholog); cellular response to cocaine (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); alopecia (ortholog); Alzheimer's disease (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: corticoliberin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1864,382,912 - 64,385,175 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl864,383,419 - 64,384,009 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0862,714,721 - 62,716,979 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
associative learning  (ISO)
cellular response to cocaine  (ISO)
cellular response to dexamethasone stimulus  (ISO)
diterpenoid metabolic process  (ISO)
female pregnancy  (ISO)
glucocorticoid biosynthetic process  (ISO)
hormone-mediated apoptotic signaling pathway  (ISO)
hypothalamus development  (ISO)
inflammatory response  (ISO)
ion homeostasis  (ISO)
learning or memory  (ISO)
locomotory exploration behavior  (ISO)
long-term synaptic potentiation  (ISO)
lung development  (ISO)
negative regulation of cell death  (ISO)
negative regulation of epinephrine secretion  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of glucagon secretion  (ISO)
negative regulation of luteinizing hormone secretion  (ISO)
negative regulation of norepinephrine secretion  (ISO)
negative regulation of systemic arterial blood pressure  (ISO)
positive regulation of behavioral fear response  (ISO)
positive regulation of calcium ion import  (ISO)
positive regulation of cAMP-mediated signaling  (ISO)
positive regulation of cell death  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of corticosterone secretion  (ISO)
positive regulation of corticotropin secretion  (ISO)
positive regulation of cortisol secretion  (ISO)
positive regulation of digestive system process  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of protein phosphorylation  (ISO)
regulation of NMDA receptor activity  (ISO)
regulation of serotonin secretion  (ISO)
response to cocaine  (ISO)
response to corticosterone  (ISO)
response to estrogen  (ISO)
response to ethanol  (ISO)
response to ether  (ISO)
response to immobilization stress  (ISO)
response to pain  (ISO)
response to xenobiotic stimulus  (ISO)
steroid metabolic process  (ISO)
synaptic transmission, dopaminergic  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
CRH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1864,382,912 - 64,385,175 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl864,383,419 - 64,384,009 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0862,714,721 - 62,716,979 (-)NCBIMhudiblu_PPA_v0panPan3
CRH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl866,176,376 - 66,178,464 (-)EnsemblGRCh38hg38GRCh38
GRCh38866,176,376 - 66,178,464 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37867,088,611 - 67,090,699 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36867,251,173 - 67,253,252 (-)NCBINCBI36hg18NCBI36
Build 34867,251,172 - 67,253,252NCBI
Celera863,080,325 - 63,082,559 (-)NCBI
Cytogenetic Map8q13.1NCBI
HuRef862,578,767 - 62,581,001 (-)NCBIHuRef
CHM1_1867,143,265 - 67,145,499 (-)NCBICHM1_1
Crh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39319,747,565 - 19,749,560 (-)NCBIGRCm39mm39
GRCm39 Ensembl319,747,565 - 19,749,560 (-)Ensembl
GRCm38319,693,401 - 19,695,396 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl319,693,401 - 19,695,396 (-)EnsemblGRCm38mm10GRCm38
MGSCv37319,593,401 - 19,595,396 (-)NCBIGRCm37mm9NCBIm37
MGSCv36319,885,565 - 19,887,480 (-)NCBImm8
Celera319,686,501 - 19,688,496 (-)NCBICelera
Cytogenetic Map3A2NCBI
cM Map35.75NCBI
Crh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22102,143,055 - 102,144,919 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2102,143,055 - 102,144,919 (-)Ensembl
Rnor_6.02104,459,999 - 104,461,863 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2104,459,999 - 104,461,863 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02124,182,919 - 124,184,783 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42104,764,023 - 104,765,887 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12104,708,984 - 104,710,849 (-)NCBI
Celera297,536,796 - 97,538,660 (-)NCBICelera
Cytogenetic Map2q24NCBI
Crh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544412,989,210 - 12,991,300 (+)NCBIChiLan1.0ChiLan1.0
CRH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12915,831,944 - 15,840,560 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2915,831,944 - 15,834,384 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2916,146,733 - 16,149,174 (-)NCBI
ROS_Cfam_1.02915,890,845 - 16,097,836 (-)NCBI
UMICH_Zoey_3.12915,940,159 - 15,942,599 (-)NCBI
UNSW_CanFamBas_1.02916,042,480 - 16,044,918 (-)NCBI
UU_Cfam_GSD_1.02916,298,228 - 16,300,672 (-)NCBI
Crh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530367,023,855 - 67,026,364 (-)NCBI
SpeTri2.0NW_0049364967,759,656 - 7,761,555 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl468,483,977 - 68,486,118 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1468,481,696 - 68,486,122 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2474,349,511 - 74,653,689 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CRH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1862,052,155 - 62,056,424 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl862,052,592 - 62,053,182 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603979,456,894 - 79,459,404 (+)NCBIVero_WHO_p1.0
Crh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474425,194,458 - 25,196,658 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003831372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide SSBP01000191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000022030   ⟹   ENSPPAP00000004811
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl864,383,419 - 64,384,009 (-)Ensembl
RefSeq Acc Id: XM_003831372   ⟹   XP_003831420
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1864,382,912 - 64,385,175 (-)NCBI
Mhudiblu_PPA_v0862,714,721 - 62,716,979 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003831420 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003831420   ⟸   XM_003831372
- Sequence:
RefSeq Acc Id: ENSPPAP00000004811   ⟸   ENSPPAT00000022030


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000020093 Ensembl, ENTREZGENE
Ensembl Protein ENSPPAP00000004811 ENTREZGENE
NCBI Gene CRH ENTREZGENE