CRH (corticotropin releasing hormone) - Rat Genome Database

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Gene: CRH (corticotropin releasing hormone) Pan paniscus
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Symbol: CRH
Name: corticotropin releasing hormone
RGD ID: 11720441
Description: ENCODES a protein that exhibits corticotropin-releasing hormone receptor 1 binding (ortholog); corticotropin-releasing hormone receptor 2 binding (ortholog); INVOLVED IN adrenal gland development (ortholog); associative learning (ortholog); cellular response to cocaine (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alcohol-Related Disorders (ortholog); alopecia (ortholog); FOUND IN extracellular space (ortholog); neuronal cell body (ortholog); neuronal dense core vesicle lumen (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: corticoliberin; LOC117981419; uncharacterized LOC117981419
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2781,908,836 - 81,919,149 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1857,548,461 - 57,558,776 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0862,714,721 - 62,716,979 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1864,382,912 - 64,385,175 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl864,383,419 - 64,384,009 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (IEA,ISO)
associative learning  (ISO)
cellular response to cocaine  (ISO)
cellular response to dexamethasone stimulus  (ISO)
diterpenoid metabolic process  (ISO)
female pregnancy  (IEA)
glucocorticoid biosynthetic process  (IEA,ISO)
hormone-mediated apoptotic signaling pathway  (ISO)
hypothalamus development  (ISO)
inflammatory response  (IEA,ISO)
learning or memory  (ISO)
locomotory exploration behavior  (IEA,ISO)
long-term synaptic potentiation  (ISO)
lung development  (IEA,ISO)
monoatomic ion homeostasis  (ISO)
negative regulation of epinephrine secretion  (IEA,ISO)
negative regulation of gene expression  (ISO)
negative regulation of glucagon secretion  (IEA,ISO)
negative regulation of luteinizing hormone secretion  (ISO)
negative regulation of norepinephrine secretion  (ISO)
negative regulation of systemic arterial blood pressure  (ISO)
neuron apoptotic process  (ISO)
positive regulation of behavioral fear response  (ISO)
positive regulation of calcium ion import  (ISO)
positive regulation of cAMP/PKA signal transduction  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular process  (ISO)
positive regulation of corticosterone secretion  (ISO)
positive regulation of corticotropin secretion  (IEA,ISO)
positive regulation of cortisol secretion  (IEA)
positive regulation of digestive system process  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of protein phosphorylation  (ISO)
regulation of NMDA receptor activity  (ISO)
regulation of serotonin secretion  (ISO)
response to alcohol  (ISO)
response to aldosterone  (ISO)
response to cocaine  (ISO)
response to corticosterone  (ISO)
response to estrogen  (ISO)
response to ethanol  (ISO)
response to ether  (ISO)
response to immobilization stress  (ISO)
response to pain  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)
steroid metabolic process  (ISO)
synaptic transmission, dopaminergic  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CRH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2781,908,836 - 81,919,149 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1857,548,461 - 57,558,776 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0862,714,721 - 62,716,979 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1864,382,912 - 64,385,175 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl864,383,419 - 64,384,009 (-)Ensemblpanpan1.1panPan2
CRH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38866,176,376 - 66,178,464 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl866,176,376 - 66,178,464 (-)EnsemblGRCh38hg38GRCh38
GRCh37867,088,611 - 67,090,699 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36867,251,173 - 67,253,252 (-)NCBINCBI36Build 36hg18NCBI36
Build 34867,251,172 - 67,253,252NCBI
Celera863,080,325 - 63,082,559 (-)NCBICelera
Cytogenetic Map8q13.1NCBI
HuRef862,578,767 - 62,581,001 (-)NCBIHuRef
CHM1_1867,143,265 - 67,145,499 (-)NCBICHM1_1
T2T-CHM13v2.0866,602,063 - 66,612,357 (-)NCBIT2T-CHM13v2.0
Crh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39319,747,565 - 19,749,560 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl319,747,565 - 19,749,560 (-)EnsemblGRCm39 Ensembl
GRCm38319,693,401 - 19,695,396 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl319,693,401 - 19,695,396 (-)EnsemblGRCm38mm10GRCm38
MGSCv37319,593,401 - 19,595,396 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36319,885,565 - 19,887,480 (-)NCBIMGSCv36mm8
Celera319,686,501 - 19,688,496 (-)NCBICelera
Cytogenetic Map3A2NCBI
cM Map35.75NCBI
Crh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82104,059,184 - 104,061,048 (-)NCBIGRCr8
mRatBN7.22102,143,055 - 102,144,919 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2102,143,055 - 102,144,919 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2108,674,139 - 108,676,025 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02106,795,271 - 106,797,157 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02101,764,428 - 101,766,314 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02104,459,999 - 104,461,863 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2104,459,999 - 104,461,863 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02124,182,919 - 124,184,783 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42104,764,023 - 104,765,887 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12104,708,984 - 104,710,849 (-)NCBI
Celera297,536,796 - 97,538,660 (-)NCBICelera
Cytogenetic Map2q24NCBI
Crh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544412,989,210 - 12,991,300 (+)NCBIChiLan1.0ChiLan1.0
CRH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12915,831,944 - 15,840,560 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2915,831,944 - 15,834,384 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2916,146,733 - 16,149,174 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02915,890,845 - 16,097,836 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2915,910,573 - 15,913,018 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12915,940,159 - 15,942,599 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02916,042,480 - 16,044,918 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02916,298,228 - 16,300,672 (-)NCBIUU_Cfam_GSD_1.0
Crh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530367,023,855 - 67,026,364 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364967,760,532 - 7,761,122 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364967,759,656 - 7,761,555 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl468,484,053 - 68,486,121 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1468,481,696 - 68,486,122 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2474,349,511 - 74,653,689 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CRH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1862,052,155 - 62,056,424 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl862,052,592 - 62,053,182 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603979,456,894 - 79,459,404 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474425,194,495 - 25,196,488 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474425,194,458 - 25,196,658 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000022030   ⟹   ENSPPAP00000004811
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl864,383,419 - 64,384,009 (-)Ensembl
RefSeq Acc Id: XM_003831372   ⟹   XP_003831420
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2781,908,836 - 81,919,149 (-)NCBI
NHGRI_mPanPan1857,548,461 - 57,558,776 (-)NCBI
Mhudiblu_PPA_v0862,714,721 - 62,716,979 (-)NCBI
PanPan1.1864,382,912 - 64,385,175 (-)NCBI
Sequence:
RefSeq Acc Id: XM_055116612   ⟹   XP_054972587
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2781,908,836 - 81,919,149 (-)NCBI
NHGRI_mPanPan1857,548,461 - 57,558,776 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003831420 (Get FASTA)   NCBI Sequence Viewer  
  XP_054972587 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000004811
  ENSPPAP00000004811.1
RefSeq Acc Id: XP_003831420   ⟸   XM_003831372
- UniProtKB: A0A2R8ZPS7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000004811   ⟸   ENSPPAT00000022030
RefSeq Acc Id: XP_054972587   ⟸   XM_055116612
- UniProtKB: A0A2R8ZPS7 (UniProtKB/TrEMBL)
Protein Domains
Corticotropin-releasing factor


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000020093 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000022030.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.250.1920 UniProtKB/TrEMBL
InterPro Corticotropin-releasing_fac_CS UniProtKB/TrEMBL
  CRF UniProtKB/TrEMBL
  Urocortin_CRF UniProtKB/TrEMBL
KEGG Report pps:100992287 UniProtKB/TrEMBL
NCBI Gene CRH ENTREZGENE
PANTHER CORTICOLIBERIN UniProtKB/TrEMBL
  PTHR15035 UniProtKB/TrEMBL
Pfam CRF UniProtKB/TrEMBL
PRINTS CRFFAMILY UniProtKB/TrEMBL
PROSITE CRF UniProtKB/TrEMBL
SMART CRF UniProtKB/TrEMBL
UniProt A0A2R8ZPS7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-04-20 CRH  corticotropin releasing hormone  LOC117981419  uncharacterized LOC117981419  Data merged from RGD:32733048 737654 PROVISIONAL