RGD Reference Report - Stress and glucocorticoids regulated corticotropin releasing factor in rat prefrontal cortex. - Rat Genome Database

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Stress and glucocorticoids regulated corticotropin releasing factor in rat prefrontal cortex.

Authors: Meng, QY  Chen, XN  Tong, DL  Zhou, JN 
Citation: Meng QY, etal., Mol Cell Endocrinol. 2011 Aug 6;342(1-2):54-63. Epub 2011 Jun 1.
RGD ID: 5490546
Pubmed: PMID:21664419   (View Abstract at PubMed)
DOI: DOI:10.1016/j.mce.2011.05.035   (Journal Full-text)

Corticotropin releasing factor (CRF) is considered as the central driving force in the stress response and plays a key role in the pathogenesis of depression. CRF neurons have been identified to locate in most regions of the prefrontal cortex (PFC), a brain region that is highly associated with the control of emotion and cognition. However, little is known on the regulation of CRF in this region. In this study, we aimed to identify the regulatory effect of acute restraint stress and glucocorticoid on PFC CRF and characterize the possible function of CRF in the PFC. We found that acute restraint stress increased and glucocorticoid decreased PFC CRF mRNA expression. The expression of glucocorticoid receptor (GR) was found to colocalize with CRF neurons in the PFC. In addition, recruitment of GR by the CRF promoter was observed in vivo. Specific attention was paid to the effect of CRF on CRF receptor 1 (CRFR1) expression in primary PFC cultures. The results showed that CRF increased CRFR1 expression through the MEK-ERK1/2 pathway. In summary, this study may contribute to the better understanding of CRF functions in the PFC.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CrhRatcellular response to dexamethasone stimulus  IEP  RGD 
CrhRatditerpenoid metabolic process  IEP forskolinRGD 
CrhRatresponse to corticosterone  IEP  RGD 
Crhr1Ratresponse to immobilization stress  IEP  RGD 
CrhRatsteroid metabolic process  IEP RU486RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Nr3c1RatRNA polymerase II transcription regulatory region sequence-specific DNA binding  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Crh  (corticotropin releasing hormone)
Crhr1  (corticotropin releasing hormone receptor 1)
Nr3c1  (nuclear receptor subfamily 3, group C, member 1)


Additional Information