RGD Reference Report - Intraventricular insulin potentiates the anorexic effect of corticotropin releasing hormone in rats. - Rat Genome Database

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Intraventricular insulin potentiates the anorexic effect of corticotropin releasing hormone in rats.

Authors: Richardson, RD  Omachi, K  Kermani, R  Woods, SC 
Citation: Richardson RD, etal., Am J Physiol Regul Integr Comp Physiol 2002 Dec;283(6):R1321-6.
RGD ID: 704394
Pubmed: PMID:12429558   (View Abstract at PubMed)
DOI: DOI:10.1152/ajpregu.00521.2001   (Journal Full-text)

Intraventricular corticotropin releasing hormone (CRH) suppresses food intake and body weight as a stress response. Insulin, acting within the brain, also suppresses food intake and body weight, and this suppression is related to caloric homeostasis. We determined if increased insulin within the brain potentiates the anorexic effects of intraventricular CRH. Rats were food deprived for 17 h each day and then given 30-min access to Ensure. One-half received continuous third ventricular infusion of synthetic cerebrospinal fluid via osmotic minipumps, and one-half received insulin (0.6 mU/day). During the infusion, rats also received 0, 0.1, 1.0, or 5.0 microg of CRH into the lateral ventricle just before access to Ensure. Insulin alone had no effect on Ensure intake or body weight. CRH dose dependently reduced Ensure intake in both groups, and the reduction was greater in the insulin group. Hence, central insulin potentiated the ability of centrally administered CRH to suppress food intake. These findings suggest that stress-related influences over food intake, particularly those mediated via CRH, interact with relative adiposity as signaled to the brain by central insulin.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Anorexia  ISOCrh (Rattus norvegicus)704394; 704394 RGD 
Anorexia  IDA 704394 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Crh  (corticotropin releasing hormone)

Genes (Mus musculus)
Crh  (corticotropin releasing hormone)

Genes (Homo sapiens)
CRH  (corticotropin releasing hormone)


Additional Information