Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tetrahydroxyflavanone
go back to main search page
Accession:CHEBI:38742 term browser browse the term
Definition:A hydroxyflavanone with at least four hydroxy substituents.
Synonyms:related_synonym: tetrahydroxyflavanones


show annotations for term's descendants           Sort by:
astilbin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1C1 aldo-keto reductase family 1 member C1 multiple interactions EXP [astilbin co-treated with Cisplatin] results in increased expression of AKR1C1 mRNA CTD PMID:29471006 NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in decreased phosphorylation of AKT1 protein] CTD PMID:29471006 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in increased expression of BAX protein] CTD PMID:29471006 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein] CTD PMID:29471006 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G CASP3 caspase 3 multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein] CTD PMID:29471006 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP9 caspase 9 multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein] CTD PMID:29471006 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in decreased activity of CAT protein] CTD PMID:29471006 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA] CTD PMID:29471006 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970 		JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit multiple interactions EXP astilbin promotes the reaction [Cisplatin results in increased expression of GCLM mRNA] CTD PMID:29471006 NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased expression of IL1B protein] CTD PMID:29471006 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased expression of IL6 protein] CTD PMID:29471006 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein] CTD PMID:29471006 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein] CTD PMID:29471006 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP
ISO		 astilbin promotes the reaction [Cisplatin affects the localization of NFE2L2 protein]
astilbin promotes the reaction [Cisplatin results in increased expression of NFE2L2 protein]		 CTD PMID:29471006 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of NFKBIA protein] CTD PMID:29471006 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein] CTD PMID:29471006 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP astilbin promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA] CTD PMID:29471006 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein] CTD PMID:29471006 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein] CTD PMID:29471006 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein] CTD PMID:29471006 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO
EXP		 astilbin inhibits the reaction [Cisplatin results in increased expression of TNF protein]
astilbin promotes the reaction [Cisplatin results in increased expression of TNF mRNA]		 CTD PMID:29471006 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TP53 tumor protein p53 multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in increased expression of TP53 protein] CTD PMID:29471006 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
eriocitrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator increases expression EXP eriocitrin results in increased expression of BAX protein CTD PMID:34724282 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP eriocitrin results in decreased expression of BCL2 protein CTD PMID:34724282 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G CASP7 caspase 7 increases expression EXP eriocitrin results in increased expression of CASP7 protein CTD PMID:34724282 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907 		JBrowse link
G CASP9 caspase 9 increases expression EXP eriocitrin results in increased expression of CASP9 protein CTD PMID:34724282 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CCND1 cyclin D1 decreases expression EXP eriocitrin results in decreased expression of CCND1 protein CTD PMID:34724282 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G JAK2 Janus kinase 2 decreases phosphorylation EXP eriocitrin results in decreased phosphorylation of JAK2 protein CTD PMID:34724282 NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation		 EXP Acetylcysteine inhibits the reaction [eriocitrin results in increased phosphorylation of MAPK8 protein] CTD PMID:34724282 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G PCNA proliferating cell nuclear antigen decreases expression EXP eriocitrin results in decreased expression of PCNA protein CTD PMID:34724282 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase decreases phosphorylation EXP eriocitrin results in decreased phosphorylation of SRC protein CTD PMID:34724282 NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 decreases phosphorylation EXP eriocitrin results in decreased phosphorylation of STAT3 protein CTD PMID:34724282 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
eriodictyol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP [ABCB1 protein results in decreased susceptibility to Doxorubicin] affects the reaction [eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]]; eriodictyol inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]] CTD PMID:20438634 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) decreases activity EXP eriodictyol results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257 		JBrowse link
G BCL2A1 BCL2 related protein A1 multiple interactions EXP eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2A1 mRNA] CTD PMID:20438634 NCBI chr15:79,960,892...79,971,196
Ensembl chr15:79,960,892...79,971,196 		JBrowse link
G CAT catalase multiple interactions ISO eriodictyol inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein] CTD PMID:28978146 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA] CTD PMID:20438634 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCND1 cyclin D1 multiple interactions EXP eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND1 mRNA] CTD PMID:20438634 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 multiple interactions ISO eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; eriodictyol inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA] CTD PMID:19426678 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL8 mRNA] CTD PMID:20438634 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYCS cytochrome c, somatic increases expression EXP eriodictyol results in increased expression of CYCS protein CTD PMID:37020356 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260 		JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO eriodictyol inhibits the reaction [Arsenic Trioxide results in increased expression of GPT protein] CTD PMID:28978146 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G GPX4 glutathione peroxidase 4 decreases expression EXP eriodictyol results in decreased expression of GPX4 protein CTD PMID:37020356 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,982...1,106,791 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 decreases activity EXP eriodictyol results in decreased activity of GSTP1 protein CTD PMID:15041478 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
G HMOX1 heme oxygenase 1 increases expression
decreases expression
multiple interactions		 EXP
ISO		 eriodictyol results in increased expression of HMOX1 protein
eriodictyol results in decreased expression of HMOX1 protein
bardoxolone methyl inhibits the reaction [eriodictyol results in decreased expression of HMOX1 protein]
eriodictyol results in increased expression of HMOX1 mRNA; eriodictyol results in increased expression of HMOX1 protein
eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]		 CTD PMID:16799064 PMID:28978146 PMID:37020356 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G IFNG interferon gamma multiple interactions ISO eriodictyol inhibits the reaction [IFNG protein results in increased abundance of Nitrites] CTD PMID:23942037 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:21544733 PMID:31860763 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO
EXP		 eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]		 CTD PMID:20438634 PMID:21544733 PMID:31860763 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G IRF3 interferon regulatory factor 3 multiple interactions ISO eriodictyol inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA] CTD PMID:19426678 NCBI chr19:49,659,572...49,665,857
Ensembl chr19:49,659,569...49,665,875 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions ISO eriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein] CTD PMID:21544733 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MPO myeloperoxidase multiple interactions ISO eriodictyol inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] CTD PMID:31860763 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 increases expression
decreases expression
decreases phosphorylation
multiple interactions		 EXP
ISO		 eriodictyol results in increased expression of NFE2L2 protein
eriodictyol results in decreased expression of NFE2L2 protein
eriodictyol results in decreased phosphorylation of NFE2L2 protein
bardoxolone methyl inhibits the reaction [eriodictyol results in decreased phosphorylation of NFE2L2 protein]
eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein]
eriodictyol results in increased expression of NFE2L2 mRNA; eriodictyol results in increased expression of NFE2L2 protein		 CTD PMID:16799064 PMID:28978146 PMID:37020356 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO
EXP		 eriodictyol inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]		 CTD PMID:20438634 PMID:21544733 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions ISO eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein] CTD PMID:31860763 NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,416,156...247,449,108 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 decreases expression
multiple interactions		 EXP eriodictyol results in decreased expression of NQO1 protein
bardoxolone methyl inhibits the reaction [eriodictyol results in decreased expression of NQO1 protein]		 CTD PMID:37020356 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:31860763 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein] CTD PMID:20438634 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G SLC7A11 solute carrier family 7 member 11 decreases expression EXP eriodictyol results in decreased expression of SLC7A11 protein CTD PMID:37020356 NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349 		JBrowse link
G TBK1 TANK binding kinase 1 decreases activity EXP eriodictyol results in decreased activity of TBK1 protein CTD PMID:19426678 NCBI chr12:64,452,120...64,502,114
Ensembl chr12:64,452,090...64,502,114 		JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases activity		 ISO eriodictyol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
eriodictyol results in decreased activity of TNF protein		 CTD PMID:11123379 PMID:20438634 PMID:21544733 PMID:31860763 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFAIP3 TNF alpha induced protein 3 multiple interactions EXP eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA] CTD PMID:20438634 NCBI chr 6:137,866,349...137,883,312
Ensembl chr 6:137,867,214...137,883,314 		JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions EXP [ABCB1 protein results in decreased susceptibility to Doxorubicin] affects the reaction [eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]]; eriodictyol affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA] CTD PMID:20438634 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
homoeriodictyol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIFM1 apoptosis inducing factor mitochondria associated 1 multiple interactions EXP homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the localization of AIFM1 protein] CTD PMID:29902531 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2 protein] CTD PMID:29902531 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions EXP homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2L1 protein] CTD PMID:29902531 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G CASP3 caspase 3 multiple interactions EXP homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein] CTD PMID:29902531 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP9 caspase 9 multiple interactions EXP homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein] CTD PMID:29902531 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein] CTD PMID:31850465 NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases activity EXP homoeriodictyol results in decreased activity of CYP1A1 protein CTD PMID:10781868 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases activity EXP homoeriodictyol results in decreased activity of CYP1B1 protein CTD PMID:10781868 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression EXP homoeriodictyol results in increased expression of GCLM mRNA CTD PMID:29902531 NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456 		JBrowse link
G GHRL ghrelin and obestatin prepropeptide multiple interactions EXP [homoeriodictyol co-treated with Glucose] results in increased secretion of GHRL protein CTD PMID:28834253 NCBI chr 3:10,285,666...10,292,947
Ensembl chr 3:10,285,666...10,292,947 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein] CTD PMID:31850465 NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:31850465 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:31850465 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP homoeriodictyol results in increased expression of and results in increased localization of NFE2L2 protein; homoeriodictyol results in increased stability of and results in increased expression of and results in increased activity of NFE2L2 protein; NFE2L2 protein affects the reaction [homoeriodictyol results in increased expression of NQO1 protein] CTD PMID:29902531 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:31850465 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:31850465 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression		 EXP NFE2L2 protein affects the reaction [homoeriodictyol results in increased expression of NQO1 protein]
homoeriodictyol results in increased expression of NQO1 mRNA		 CTD PMID:29902531 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of PARP1 protein] CTD PMID:29902531 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:31850465 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased localization of RELA protein] CTD PMID:31850465 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:31850465 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
neoastilbin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1C1 aldo-keto reductase family 1 member C1 multiple interactions EXP [astilbin co-treated with Cisplatin] results in increased expression of AKR1C1 mRNA CTD PMID:29471006 NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in decreased phosphorylation of AKT1 protein] CTD PMID:29471006 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in increased expression of BAX protein] CTD PMID:29471006 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein] CTD PMID:29471006 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G CASP3 caspase 3 multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein] CTD PMID:29471006 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP9 caspase 9 multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein] CTD PMID:29471006 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in decreased activity of CAT protein] CTD PMID:29471006 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA] CTD PMID:29471006 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970 		JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit multiple interactions EXP astilbin promotes the reaction [Cisplatin results in increased expression of GCLM mRNA] CTD PMID:29471006 NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased expression of IL1B protein] CTD PMID:29471006 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased expression of IL6 protein] CTD PMID:29471006 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein] CTD PMID:29471006 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein] CTD PMID:29471006 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions ISO
EXP		 astilbin promotes the reaction [Cisplatin results in increased expression of NFE2L2 protein]
astilbin promotes the reaction [Cisplatin affects the localization of NFE2L2 protein]		 CTD PMID:29471006 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of NFKBIA protein] CTD PMID:29471006 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein] CTD PMID:29471006 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP astilbin promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA] CTD PMID:29471006 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein] CTD PMID:29471006 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein] CTD PMID:29471006 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein] CTD PMID:29471006 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO
EXP		 astilbin inhibits the reaction [Cisplatin results in increased expression of TNF protein]
astilbin promotes the reaction [Cisplatin results in increased expression of TNF mRNA]		 CTD PMID:29471006 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TP53 tumor protein p53 multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in increased expression of TP53 protein] CTD PMID:29471006 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
neoeriocitrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BGLAP bone gamma-carboxyglutamate protein multiple interactions
increases expression		 ISO neoeriocitrin inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of BGLAP mRNA]
neoeriocitrin results in increased expression of BGLAP mRNA		 CTD PMID:21741227 NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317 		JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions
increases expression		 ISO neoeriocitrin inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of COL1A1 mRNA]
neoeriocitrin results in increased expression of COL1A1 mRNA		 CTD PMID:21741227 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G RUNX2 RUNX family transcription factor 2 increases expression ISO neoeriocitrin results in increased expression of RUNX2 mRNA CTD PMID:21741227 NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26050
    chemical entity 26029
      molecular entity 26007
        polyatomic entity 25892
          heteroatomic molecular entity 25544
            hydroxides 24065
              organic hydroxy compound 22075
                hydroxyflavanone 557
                  tetrahydroxyflavanone 58
                    (+)-dihydrokaempferol + 0
                    (+)-epitaxifolin 3-O-alpha-D-arabinopyranoside 0
                    (+)-taxifolin 3-O-acetate 0
                    (+)-taxifolin 3-O-alpha-D-arabinopyranoside 0
                    (+)-taxifolin 3-O-alpha-L-arabinofuranoside 0
                    (+)-taxifolin 3-O-alpha-L-arabinopyranoside 0
                    (+)-taxifolin 3-O-beta-D-arabinopyranoside 0
                    (+)-taxifolin 3-O-beta-D-xylopyranoside 0
                    (-)-epitaxifolin 3-O-alpha-D-arabinopyranoside 0
                    (-)-taxifolin 3-O-beta-D-xylopyranoside 0
                    (2S)-5,7,3',5'-tetrahydroxy-8-[3'',8''-dimethylocta-2''(E),7''-dienyl]flavonone 0
                    (S)-2-(3,5-dihydroxyphenyl)-5,7-dihydroxy-6,8-bis(3-methylbut-2-enyl)chroman-4-one 0
                    2,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one + 0
                    5,7,3',5'-tetrahydroxyflavanone 0
                    astilbin 22
                    carthamidin + 0
                    dihydroisorhamnetin + 0
                    eriodictyol + 52
                    exiguaflavanone A 0
                    fustin + 0
                    isonymphaeol B 0
                    leachianone G 0
                    lespeflorin B4 0
                    neoastilbin 22
                    nymphaeol A 0
                    nymphaeol B 0
                    nymphaeol C 0
                    plantagoside 0
                    remangiflavanone B 0
                    schizolaenone B 0
                    sigmoidin A 0
                    sigmoidin B 0
                    sophoraflavanone G 0
                    tanariflavanone C 0
                    tanariflavanone D 0
                    taxifolin 4'-methyl ether 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26050
    subatomic particle 26025
      composite particle 26025
        hadron 26025
          baryon 26025
            nucleon 26025
              atomic nucleus 26025
                atom 26025
                  main group element atom 25850
                    p-block element atom 25850
                      carbon group element atom 25447
                        carbon atom 25405
                          organic molecular entity 25405
                            organic molecule 25233
                              organic cyclic compound 24287
                                organic heterocyclic compound 22334
                                  oxacycle 20035
                                    benzopyran 12744
                                      1-benzopyran 12480
                                        flavonoid 7604
                                          flavans 3890
                                            flavanones 570
                                              hydroxyflavanone 557
                                                tetrahydroxyflavanone 58
                                                  (+)-dihydrokaempferol + 0
                                                  (+)-epitaxifolin 3-O-alpha-D-arabinopyranoside 0
                                                  (+)-taxifolin 3-O-acetate 0
                                                  (+)-taxifolin 3-O-alpha-D-arabinopyranoside 0
                                                  (+)-taxifolin 3-O-alpha-L-arabinofuranoside 0
                                                  (+)-taxifolin 3-O-alpha-L-arabinopyranoside 0
                                                  (+)-taxifolin 3-O-beta-D-arabinopyranoside 0
                                                  (+)-taxifolin 3-O-beta-D-xylopyranoside 0
                                                  (-)-epitaxifolin 3-O-alpha-D-arabinopyranoside 0
                                                  (-)-taxifolin 3-O-beta-D-xylopyranoside 0
                                                  (2S)-5,7,3',5'-tetrahydroxy-8-[3'',8''-dimethylocta-2''(E),7''-dienyl]flavonone 0
                                                  (S)-2-(3,5-dihydroxyphenyl)-5,7-dihydroxy-6,8-bis(3-methylbut-2-enyl)chroman-4-one 0
                                                  2,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one + 0
                                                  5,7,3',5'-tetrahydroxyflavanone 0
                                                  astilbin 22
                                                  carthamidin + 0
                                                  dihydroisorhamnetin + 0
                                                  eriodictyol + 52
                                                  exiguaflavanone A 0
                                                  fustin + 0
                                                  isonymphaeol B 0
                                                  leachianone G 0
                                                  lespeflorin B4 0
                                                  neoastilbin 22
                                                  nymphaeol A 0
                                                  nymphaeol B 0
                                                  nymphaeol C 0
                                                  plantagoside 0
                                                  remangiflavanone B 0
                                                  schizolaenone B 0
                                                  sigmoidin A 0
                                                  sigmoidin B 0
                                                  sophoraflavanone G 0
                                                  tanariflavanone C 0
                                                  tanariflavanone D 0
                                                  taxifolin 4'-methyl ether 0
paths to the root