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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:eriodictyol
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Accession:CHEBI:28412 term browser browse the term
Definition:A tetrahydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 7, 3' and 4' respectively.
Synonyms:related_synonym: (2S)-2-(3,4-DIHYDROXYPHENYL)-5,7-DIHYDROXY-2,3-DIHYDRO-4H-CHROMEN-4-ONE;   (S)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4-benzopyrone;   (S)-eriodictyol;   Eriodictiol;   Formula=C15H12O6;   InChI=1S/C15H12O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-5,13,16-19H,6H2/t13-/m0/s1;   InChIKey=SBHXYTNGIZCORC-ZDUSSCGKSA-N;   SMILES=Oc1cc(O)c2C(=O)C[C@H](Oc2c1)c1ccc(O)c(O)c1
 alt_id: CHEBI:23945;   CHEBI:4832;   CHEBI:49606
 xref: Beilstein:92358;   CAS:552-58-9;   KEGG:C05631;   KNApSAcK:C00000960;   LIPID_MAPS_instance:LMPK12140002;   LIPID_MAPS_instance:LMPK12140432
 xref_mesh: MESH:C007619


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eriodictyol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP [ABCB1 protein results in decreased susceptibility to Doxorubicin] affects the reaction [eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]]; eriodictyol inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]] CTD PMID:20438634 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 decreases activity EXP eriodictyol results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
Ensembl chr16:15,949,577...16,143,074
JBrowse link
G BCL2A1 BCL2 related protein A1 multiple interactions EXP eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2A1 mRNA] CTD PMID:20438634 NCBI chr15:79,960,892...79,971,196
Ensembl chr15:79,960,892...79,971,196
JBrowse link
G CAT catalase multiple interactions ISO eriodictyol inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein] CTD PMID:28978146 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA] CTD PMID:20438634 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCND1 cyclin D1 multiple interactions EXP eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND1 mRNA] CTD PMID:20438634 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 multiple interactions ISO eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; eriodictyol inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA] CTD PMID:19426678 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL8 mRNA] CTD PMID:20438634 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO eriodictyol inhibits the reaction [Arsenic Trioxide results in increased expression of GPT protein] CTD PMID:28978146 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G GSTP1 glutathione S-transferase pi 1 decreases activity EXP eriodictyol results in decreased activity of GSTP1 protein CTD PMID:15041478 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G HMOX1 heme oxygenase 1 increases expression
multiple interactions
EXP
ISO
eriodictyol results in increased expression of HMOX1 protein
eriodictyol results in increased expression of HMOX1 mRNA; eriodictyol results in increased expression of HMOX1 protein
eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]
CTD PMID:16799064 PMID:28978146 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G IFNG interferon gamma multiple interactions ISO eriodictyol inhibits the reaction [IFNG protein results in increased abundance of Nitrites] CTD PMID:23942037 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:21544733 PMID:31860763 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions ISO
EXP
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]
CTD PMID:20438634 PMID:21544733 PMID:31860763 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G IRF3 interferon regulatory factor 3 multiple interactions ISO eriodictyol inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA] CTD PMID:19426678 NCBI chr19:49,659,572...49,665,857
Ensembl chr19:49,659,569...49,665,875
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions ISO eriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein] CTD PMID:21544733 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MPO myeloperoxidase multiple interactions ISO eriodictyol inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] CTD PMID:31860763 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 increases expression
multiple interactions
EXP
ISO
eriodictyol results in increased expression of NFE2L2 protein
eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein]
eriodictyol results in increased expression of NFE2L2 mRNA; eriodictyol results in increased expression of NFE2L2 protein
CTD PMID:16799064 PMID:28978146 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO
EXP
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]
CTD PMID:20438634 PMID:21544733 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions ISO eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein] CTD PMID:31860763 NCBI chr 1:247,416,163...247,448,823
Ensembl chr 1:247,416,156...247,449,108
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:31860763 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein] CTD PMID:20438634 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G TBK1 TANK binding kinase 1 decreases activity EXP eriodictyol results in decreased activity of TBK1 protein CTD PMID:19426678 NCBI chr12:64,452,105...64,502,114
Ensembl chr12:64,452,092...64,502,114
Ensembl chr12:64,452,092...64,502,114
JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases activity
ISO eriodictyol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
eriodictyol results in decreased activity of TNF protein
CTD PMID:11123379 PMID:20438634 PMID:21544733 PMID:31860763 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFAIP3 TNF alpha induced protein 3 multiple interactions EXP eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA] CTD PMID:20438634 NCBI chr 6:137,866,317...137,883,312
Ensembl chr 6:137,867,214...137,883,312
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions EXP [ABCB1 protein results in decreased susceptibility to Doxorubicin] affects the reaction [eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]]; eriodictyol affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA] CTD PMID:20438634 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
homoeriodictyol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIFM1 apoptosis inducing factor mitochondria associated 1 multiple interactions EXP homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the localization of AIFM1 protein] CTD PMID:29902531 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2 protein] CTD PMID:29902531 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions EXP homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2L1 protein] CTD PMID:29902531 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G CASP3 caspase 3 multiple interactions EXP homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein] CTD PMID:29902531 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP9 caspase 9 multiple interactions EXP homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein] CTD PMID:29902531 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein] CTD PMID:31850465 NCBI chr10:100,188,300...100,229,610
Ensembl chr10:100,188,300...100,229,596
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases activity EXP homoeriodictyol results in decreased activity of CYP1A1 protein CTD PMID:10781868 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases activity EXP homoeriodictyol results in decreased activity of CYP1B1 protein CTD PMID:10781868 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression EXP homoeriodictyol results in increased expression of GCLM mRNA CTD PMID:29902531 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GHRL ghrelin and obestatin prepropeptide multiple interactions EXP [homoeriodictyol co-treated with Glucose] results in increased secretion of GHRL protein CTD PMID:28834253 NCBI chr 3:10,285,666...10,292,947
Ensembl chr 3:10,285,666...10,292,947
JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein] CTD PMID:31850465 NCBI chr 8:42,270,727...42,332,460
Ensembl chr 8:42,271,302...42,332,653
Ensembl chr 8:42,271,302...42,332,653
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:31850465 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:31850465 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions EXP homoeriodictyol results in increased expression of and results in increased localization of NFE2L2 protein; homoeriodictyol results in increased stability of and results in increased expression of and results in increased activity of NFE2L2 protein; NFE2L2 protein affects the reaction [homoeriodictyol results in increased expression of NQO1 protein] CTD PMID:29902531 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:31850465 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:31850465 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [homoeriodictyol results in increased expression of NQO1 protein]
homoeriodictyol results in increased expression of NQO1 mRNA
CTD PMID:29902531 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of PARP1 protein] CTD PMID:29902531 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:31850465 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased localization of RELA protein] CTD PMID:31850465 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:31850465 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
neoeriocitrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BGLAP bone gamma-carboxyglutamate protein multiple interactions
increases expression
ISO neoeriocitrin inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of BGLAP mRNA]
neoeriocitrin results in increased expression of BGLAP mRNA
CTD PMID:21741227 NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317
JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions
increases expression
ISO neoeriocitrin inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of COL1A1 mRNA]
neoeriocitrin results in increased expression of COL1A1 mRNA
CTD PMID:21741227 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,183,289...50,201,632
Ensembl chr17:50,183,289...50,201,632
JBrowse link
G RUNX2 RUNX family transcription factor 2 increases expression ISO neoeriocitrin results in increased expression of RUNX2 mRNA CTD PMID:21741227 NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24513
    chemical entity 24481
      molecular entity 24446
        polyatomic entity 24374
          heteroatomic molecular entity 23977
            hydroxides 22508
              organic hydroxy compound 20794
                hydroxyflavanone 313
                  tetrahydroxyflavanone 50
                    eriodictyol 43
                      (2S)-2-hydroxyeriodictyol 0
                      (2S)-eriodictoyl-7-O-beta-D-glucopyranosiduronic acid 0
                      (2S)-eriodictyol 7-O-(6''-O-galloyl)-beta-D-glucopyranoside 0
                      diinsininol 0
                      eriocitrin 0
                      eriodictoyl-7-O-sophoroside 0
                      homoeriodictyol + 21
                      neoeriocitrin 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 24513
    subatomic particle 24471
      composite particle 24471
        hadron 24471
          baryon 24471
            nucleon 24471
              atomic nucleus 24471
                atom 24471
                  main group element atom 24329
                    p-block element atom 24329
                      carbon group element atom 24114
                        carbon atom 24076
                          organic molecular entity 24076
                            organic molecule 23957
                              organic cyclic compound 23156
                                organic heterocyclic compound 21323
                                  oxacycle 19584
                                    benzopyran 10783
                                      1-benzopyran 10485
                                        flavonoid 6935
                                          flavans 3269
                                            flavanones 326
                                              hydroxyflavanone 313
                                                tetrahydroxyflavanone 50
                                                  eriodictyol 43
                                                    (2S)-2-hydroxyeriodictyol 0
                                                    (2S)-eriodictoyl-7-O-beta-D-glucopyranosiduronic acid 0
                                                    (2S)-eriodictyol 7-O-(6''-O-galloyl)-beta-D-glucopyranoside 0
                                                    diinsininol 0
                                                    eriocitrin 0
                                                    eriodictoyl-7-O-sophoroside 0
                                                    homoeriodictyol + 21
                                                    neoeriocitrin 3
paths to the root