|
G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
[ABCB1 protein results in decreased susceptibility to Doxorubicin] affects the reaction [eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]]; eriodictyol inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]] |
CTD |
PMID:20438634 |
|
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
|
|
G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
decreases activity |
ISO |
eriodictyol results in decreased activity of ABCC1 protein |
CTD |
PMID:15670588 |
|
NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
|
|
G |
Bcl2a1 |
BCL2-related protein A1 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2A1 mRNA] |
CTD |
PMID:20438634 |
|
NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
|
|
G |
Cat |
catalase |
multiple interactions |
EXP |
eriodictyol inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein] |
CTD |
PMID:28978146 |
|
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA] |
CTD |
PMID:20438634 |
|
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
|
|
G |
Ccnd1 |
cyclin D1 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND1 mRNA] |
CTD |
PMID:20438634 |
|
NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
|
|
G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; eriodictyol inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA] |
CTD |
PMID:19426678 |
|
NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
eriodictyol inhibits the reaction [Arsenic Trioxide results in increased expression of GPT protein] |
CTD |
PMID:28978146 |
|
NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
|
|
G |
Gstp1 |
glutathione S-transferase pi 1 |
decreases activity |
ISO |
eriodictyol results in decreased activity of GSTP1 protein |
CTD |
PMID:15041478 |
|
NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
|
|
G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
ISO EXP |
eriodictyol results in increased expression of HMOX1 protein eriodictyol results in increased expression of HMOX1 mRNA; eriodictyol results in increased expression of HMOX1 protein eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein] |
CTD |
PMID:16799064 PMID:28978146 |
|
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
|
|
G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [IFNG protein results in increased abundance of Nitrites] |
CTD |
PMID:23942037 |
|
NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] |
CTD |
PMID:21544733 PMID:31860763 |
|
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA] |
CTD |
PMID:20438634 PMID:21544733 PMID:31860763 |
|
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
|
|
G |
Irf3 |
interferon regulatory factor 3 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA] |
CTD |
PMID:19426678 |
|
NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:21544733 |
|
NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] |
CTD |
PMID:31860763 |
|
NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
|
|
G |
Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
increases expression multiple interactions |
ISO EXP |
eriodictyol results in increased expression of NFE2L2 protein eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein] eriodictyol results in increased expression of NFE2L2 mRNA; eriodictyol results in increased expression of NFE2L2 protein |
CTD |
PMID:16799064 PMID:28978146 |
|
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein] |
CTD |
PMID:20438634 PMID:21544733 |
|
NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
|
|
G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein] |
CTD |
PMID:31860763 |
|
NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] |
CTD |
PMID:31860763 |
|
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein] |
CTD |
PMID:20438634 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
|
|
G |
Tbk1 |
TANK-binding kinase 1 |
decreases activity |
ISO |
eriodictyol results in decreased activity of TBK1 protein |
CTD |
PMID:19426678 |
|
NCBI chr 7:63,655,247...63,687,978
Ensembl chr 7:63,655,247...63,687,978
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions decreases activity |
ISO |
eriodictyol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] eriodictyol results in decreased activity of TNF protein |
CTD |
PMID:11123379 PMID:20438634 PMID:21544733 PMID:31860763 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
|
|
G |
Tnfaip3 |
TNF alpha induced protein 3 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA] |
CTD |
PMID:20438634 |
|
NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
|
|
G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
[ABCB1 protein results in decreased susceptibility to Doxorubicin] affects the reaction [eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]]; eriodictyol affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA] |
CTD |
PMID:20438634 |
|
NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
|
|
|
G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the localization of AIFM1 protein] |
CTD |
PMID:29902531 |
|
NCBI chr X:135,304,063...135,343,062
Ensembl chr X:135,304,066...135,343,087
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2 protein] |
CTD |
PMID:29902531 |
|
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
|
|
G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2L1 protein] |
CTD |
PMID:29902531 |
|
NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein] |
CTD |
PMID:29902531 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
|
|
G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein] |
CTD |
PMID:29902531 |
|
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
|
|
G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein] |
CTD |
PMID:31850465 |
|
NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases activity |
ISO |
homoeriodictyol results in decreased activity of CYP1A1 protein |
CTD |
PMID:10781868 |
|
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
|
|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity |
ISO |
homoeriodictyol results in decreased activity of CYP1B1 protein |
CTD |
PMID:10781868 |
|
NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
|
|
G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
ISO |
homoeriodictyol results in increased expression of GCLM mRNA |
CTD |
PMID:29902531 |
|
NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
|
|
G |
Ghrl |
ghrelin and obestatin prepropeptide |
multiple interactions |
ISO |
[homoeriodictyol co-treated with Glucose] results in increased secretion of GHRL protein |
CTD |
PMID:28834253 |
|
NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066
|
|
G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein] |
CTD |
PMID:31850465 |
|
NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] |
CTD |
PMID:31850465 |
|
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] |
CTD |
PMID:31850465 |
|
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
|
|
G |
Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
multiple interactions |
ISO |
homoeriodictyol results in increased expression of and results in increased localization of NFE2L2 protein; homoeriodictyol results in increased stability of and results in increased expression of and results in increased activity of NFE2L2 protein; NFE2L2 protein affects the reaction [homoeriodictyol results in increased expression of NQO1 protein] |
CTD |
PMID:29902531 |
|
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:31850465 |
|
NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] |
CTD |
PMID:31850465 |
|
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression multiple interactions |
ISO |
homoeriodictyol results in increased expression of NQO1 mRNA NFE2L2 protein affects the reaction [homoeriodictyol results in increased expression of NQO1 protein] |
CTD |
PMID:29902531 |
|
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of PARP1 protein] |
CTD |
PMID:29902531 |
|
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] |
CTD |
PMID:31850465 |
|
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased localization of RELA protein] |
CTD |
PMID:31850465 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] |
CTD |
PMID:31850465 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
|
|
|
G |
Bglap |
bone gamma-carboxyglutamate protein |
multiple interactions increases expression |
ISO |
neoeriocitrin inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of BGLAP mRNA] neoeriocitrin results in increased expression of BGLAP mRNA |
CTD |
PMID:21741227 |
|
NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
|
|
G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions increases expression |
ISO |
neoeriocitrin inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of COL1A1 mRNA] neoeriocitrin results in increased expression of COL1A1 mRNA |
CTD |
PMID:21741227 |
|
NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
|
|
G |
Runx2 |
RUNX family transcription factor 2 |
increases expression |
ISO |
neoeriocitrin results in increased expression of RUNX2 mRNA |
CTD |
PMID:21741227 |
|
NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
|
|