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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Dictamnine
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Accession:CHEBI:4512 term browser browse the term
Definition:An alkaloid antibiotic that has formula C12H9NO2.
Synonyms:related_synonym: Formula=C12H9NO2;   InChI=1S/C12H9NO2/c1-14-11-8-4-2-3-5-10(8)13-12-9(11)6-7-15-12/h2-7H,1H3;   InChIKey=WIONIXOBNMDJFJ-UHFFFAOYSA-N;   SMILES=COc1c2ccoc2nc2ccccc12
 xref: CAS:484-29-7;   KEGG:C10660;   KNApSAcK:C00002151;   LINCS:LSM-2642
 xref_mesh: MESH:C026398


show annotations for term's descendants           Sort by:
Dictamnine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO dictamnine inhibits the reaction [FGF protein results in increased phosphorylation of AKT1 protein]
dictamnine results in decreased phosphorylation of AKT1 protein		 CTD PMID:34861243 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bag3 BAG cochaperone 3 decreases expression ISO dictamnine results in decreased expression of BAG3 mRNA CTD PMID:34861243 NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO dictamnine results in increased expression of BAX mRNA CTD PMID:34861243 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO dictamnine results in increased expression of BBC3 protein CTD PMID:34861243 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO dictamnine results in decreased expression of BCL2 mRNA; dictamnine results in decreased expression of BCL2 protein CTD PMID:34861243 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO dictamnine results in decreased expression of BCL2L1 mRNA CTD PMID:34861243 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO dictamnine results in increased expression of BID mRNA CTD PMID:34861243 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases phosphorylation ISO dictamnine results in decreased phosphorylation of BRAF protein CTD PMID:34861243 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO dictamnine results in increased cleavage of CASP3 protein CTD PMID:34861243 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cd44 CD44 molecule decreases expression ISO dictamnine results in decreased expression of CD44 protein CTD PMID:34861243 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression		 ISO [dictamnine co-treated with Oxygen deficiency] results in increased expression of CDH1 protein; dictamnine inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; dictamnine inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; dictamnine promotes the reaction [HIF1A protein affects the expression of CDH1 mRNA]; dictamnine promotes the reaction [HIF1A protein affects the expression of CDH1 protein]; dictamnine promotes the reaction [SNAI2 protein affects the expression of CDH1 mRNA]; dictamnine promotes the reaction [SNAI2 protein affects the expression of CDH1 protein]
dictamnine results in increased expression of CDH1 mRNA; dictamnine results in increased expression of CDH1 protein		 CTD PMID:30266538 PMID:34861243 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 decreases expression
multiple interactions		 ISO dictamnine results in decreased expression of CDH2 mRNA; dictamnine results in decreased expression of CDH2 protein
[dictamnine co-treated with Oxygen deficiency] results in decreased expression of CDH2 protein; dictamnine inhibits the reaction [TGFB1 protein results in increased expression of CDH2 mRNA]; dictamnine inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein]; dictamnine promotes the reaction [HIF1A protein affects the expression of CDH2 mRNA]; dictamnine promotes the reaction [HIF1A protein affects the expression of CDH2 protein]; dictamnine promotes the reaction [SNAI2 protein affects the expression of CDH2 mRNA]; dictamnine promotes the reaction [SNAI2 protein affects the expression of CDH2 protein]		 CTD PMID:30266538 PMID:34861243 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO dictamnine results in decreased expression of CDK1 protein CTD PMID:34861243 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO dictamnine results in decreased expression of CTNNB1 protein CTD PMID:34861243 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO [dictamnine co-treated with Oxygen deficiency] results in decreased phosphorylation of EIF4E protein CTD PMID:30266538 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [dictamnine co-treated with Oxygen deficiency] results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:30266538 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
decreases phosphorylation		 ISO dictamnine inhibits the reaction [FGF protein results in increased phosphorylation of GSK3B protein]; dictamnine inhibits the reaction [Oxygen deficiency results in increased phosphorylation of GSK3B protein]
dictamnine results in decreased phosphorylation of GSK3B protein		 CTD PMID:30266538 PMID:34861243 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO [dictamnine co-treated with HGF protein] results in decreased expression of MMP9 protein; dictamnine inhibits the reaction [HGF protein results in increased expression of MMP2 protein] CTD PMID:34861243 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression		 ISO dictamnine inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; dictamnine inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; dictamnine promotes the reaction [HIF1A protein affects the expression of CDH1 mRNA]; dictamnine promotes the reaction [HIF1A protein affects the expression of CDH1 protein]; dictamnine promotes the reaction [HIF1A protein affects the expression of CDH2 mRNA]; dictamnine promotes the reaction [HIF1A protein affects the expression of CDH2 protein]; dictamnine promotes the reaction [HIF1A protein affects the expression of OCLN mRNA]; dictamnine promotes the reaction [HIF1A protein affects the expression of OCLN protein]; dictamnine promotes the reaction [HIF1A protein affects the expression of VIM mRNA]; dictamnine promotes the reaction [HIF1A protein affects the expression of VIM protein]
dictamnine results in decreased expression of HIF1A protein		 CTD PMID:30266538 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO dictamnine results in increased expression of IL1B protein CTD PMID:34861243 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 decreases expression ISO dictamnine results in decreased expression of IL6 protein CTD PMID:34861243 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO dictamnine results in increased expression of JUN protein CTD PMID:34861243 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation		 ISO dictamnine inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MAPK1 protein]
dictamnine results in decreased phosphorylation of MAPK1 protein		 CTD PMID:30266538 PMID:34861243 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO dictamnine inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MAPK14 protein] CTD PMID:30266538 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO dictamnine inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MAPK3 protein]
dictamnine results in decreased phosphorylation of MAPK3 protein		 CTD PMID:30266538 PMID:34861243 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO dictamnine inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MAPK8 protein] CTD PMID:30266538 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO dictamnine results in decreased expression of MCL1 mRNA CTD PMID:34861243 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression
affects binding
multiple interactions
decreases phosphorylation		 ISO dictamnine results in decreased expression of MET mRNA
dictamnine binds to MET protein
dictamnine inhibits the reaction [FGF protein results in increased phosphorylation of MET protein]
dictamnine results in decreased phosphorylation of MET protein		 CTD PMID:34861243 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO dictamnine results in decreased expression of MKI67 protein CTD PMID:34861243 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO dictamnine inhibits the reaction [HGF protein results in increased expression of MMP2 protein] CTD PMID:34861243 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [dictamnine co-treated with HGF protein] results in decreased expression of MMP9 protein CTD PMID:34861243 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation		 ISO [dictamnine co-treated with Oxygen deficiency] results in decreased phosphorylation of MTOR protein; dictamnine inhibits the reaction [FGF protein results in increased phosphorylation of MTOR protein]
dictamnine results in decreased phosphorylation of MTOR protein		 CTD PMID:30266538 PMID:34861243 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO dictamnine results in decreased expression of MYC protein CTD PMID:34861243 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Ocln occludin multiple interactions ISO [dictamnine co-treated with Oxygen deficiency] results in increased expression of OCLN protein; dictamnine promotes the reaction [HIF1A protein affects the expression of OCLN mRNA]; dictamnine promotes the reaction [HIF1A protein affects the expression of OCLN protein]; dictamnine promotes the reaction [SNAI2 protein affects the expression of OCLN mRNA]; dictamnine promotes the reaction [SNAI2 protein affects the expression of OCLN protein] CTD PMID:30266538 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO dictamnine results in decreased expression of and results in increased cleavage of PARP1 protein CTD PMID:34861243 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO dictamnine results in decreased phosphorylation of PTK2 protein CTD PMID:34861243 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Pxn paxillin decreases phosphorylation ISO dictamnine results in decreased phosphorylation of PXN protein CTD PMID:34861243 NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases phosphorylation ISO dictamnine results in decreased phosphorylation of RAF1 protein CTD PMID:34861243 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO [dictamnine co-treated with Oxygen deficiency] results in decreased phosphorylation of RPS6KB1 protein CTD PMID:30266538 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions
decreases expression		 ISO dictamnine inhibits the reaction [Oxygen deficiency results in increased expression of SNAI2 protein]; dictamnine promotes the reaction [SNAI2 protein affects the expression of CDH1 mRNA]; dictamnine promotes the reaction [SNAI2 protein affects the expression of CDH1 protein]; dictamnine promotes the reaction [SNAI2 protein affects the expression of CDH2 mRNA]; dictamnine promotes the reaction [SNAI2 protein affects the expression of CDH2 protein]; dictamnine promotes the reaction [SNAI2 protein affects the expression of OCLN mRNA]; dictamnine promotes the reaction [SNAI2 protein affects the expression of OCLN protein]; dictamnine promotes the reaction [SNAI2 protein affects the expression of VIM mRNA]; dictamnine promotes the reaction [SNAI2 protein affects the expression of VIM protein]
dictamnine results in decreased expression of SNAI2 protein		 CTD PMID:30266538 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO dictamnine results in decreased phosphorylation of STAT3 protein CTD PMID:34861243 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO dictamnine inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; dictamnine inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; dictamnine inhibits the reaction [TGFB1 protein results in increased expression of CDH2 mRNA]; dictamnine inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein]; dictamnine inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]; dictamnine inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] CTD PMID:34861243 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO dictamnine results in increased expression of TP53 protein CTD PMID:34861243 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vim vimentin multiple interactions
decreases expression		 ISO [dictamnine co-treated with Oxygen deficiency] results in decreased expression of VIM protein; dictamnine inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]; dictamnine inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; dictamnine promotes the reaction [HIF1A protein affects the expression of VIM mRNA]; dictamnine promotes the reaction [HIF1A protein affects the expression of VIM protein]; dictamnine promotes the reaction [SNAI2 protein affects the expression of VIM mRNA]; dictamnine promotes the reaction [SNAI2 protein affects the expression of VIM protein]
dictamnine results in decreased expression of VIM mRNA; dictamnine results in decreased expression of VIM protein		 CTD PMID:30266538 PMID:34861243 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        antimicrobial agent 18141
          alkaloid antibiotic 334
            Dictamnine 44
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic heterocyclic compound 18848
                                  organic heteropolycyclic compound 18278
                                    organic heterotricyclic compound 15623
                                      Dictamnine 44
paths to the root