Mapk3 (mitogen activated protein kinase 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Mapk3 (mitogen activated protein kinase 3) Rattus norvegicus
Analyze
Symbol: Mapk3
Name: mitogen activated protein kinase 3
RGD ID: 3046
Description: Enables ATP binding activity; MAP kinase activity; and scaffold protein binding activity. Involved in several processes, including MAPK cascade; arachidonate metabolic process; and decidualization. Located in caveola; cytoplasm; and nucleoplasm. Part of protein-containing complex. Used to study several diseases, including alcohol dependence; cocaine abuse; drug dependence (multiple); gastric ulcer; and middle cerebral artery infarction. Biomarker of alcohol use disorder. Human ortholog(s) of this gene implicated in Parkinson's disease; carcinoma (multiple); and pulmonary hypertension. Orthologous to human MAPK3 (mitogen-activated protein kinase 3); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; ceramide signaling pathway; endothelin signaling pathway; INTERACTS WITH (+)-catechin; (+)-dihydromyricetin; (+)-pilocarpine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Erk-1; ERK1; ERT2; Esrk1; extracellular signal-regulated kinase 1; extracellular-signal-regulated kinase 1; insulin-stimulated MAP2 kinase; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; MAPK 1; MAPK 3; MAPK1; microtubule-associated protein 2 kinase; mitogen activated kinase 3; mitogen-activated 3; mitogen-activated 3 (MAP kinase 3, p44); mitogen-activated protein kinase 1; mitogen-activated protein kinase 3; MNK1; p44; p44-ERK1; p44-MAPK; p44erk1; p44mapk; Prkm3; Protein kinase mitogen activated 3 (extracellular-signal-regulated kinase 1 ERK1); Protein kinase, mitogen activated 3 (extracellular-signal-regulated kinase 1, ERK1)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,797,189 - 190,803,411 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1190,797,185 - 190,803,411 (+)EnsemblGRCr8
mRatBN7.21181,366,646 - 181,372,863 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,366,637 - 181,372,863 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1189,717,952 - 189,724,168 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01196,904,026 - 196,910,242 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,571,369 - 189,577,596 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01198,192,773 - 198,198,975 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,192,773 - 198,198,975 (+)Ensemblrn6Rnor6.0
Rnor_5.01205,172,641 - 205,178,843 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41185,935,044 - 185,941,245 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1179,022,318 - 179,028,386 (+)NCBICelera
RGSC_v3.11186,084,924 - 186,091,127 (+)NCBI
Cytogenetic Map1q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (ISO)
alcohol dependence  (IDA)
alcohol use disorder  (IEP)
Alzheimer's disease  (ISO)
Animal Disease Models  (ISO)
Atrophy  (ISO)
autistic disorder  (ISO)
brain ischemia  (ISO)
cardiomyopathy  (ISO)
cocaine abuse  (IDA)
cocaine dependence  (IDA)
Cocaine-Related Disorders  (ISO)
colon adenocarcinoma  (ISO)
colorectal adenocarcinoma  (ISO)
Colorectal Neoplasms  (ISO)
Coronavirus infectious disease  (ISO)
Developmental Disabilities  (ISO)
Diabetic Cardiomyopathies  (IDA)
endometrial adenocarcinoma  (ISO)
endometrial carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
Experimental Colitis  (IDA)
Experimental Diabetes Mellitus  (IDA)
Experimental Liver Cirrhosis  (IEP)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (IDA)
Experimental Radiation Injuries  (ISO)
extrahepatic cholestasis  (ISO)
Female Infertility  (ISO)
gastric ulcer  (IDA)
Gliosis  (ISO)
Head and Neck Neoplasms  (ISO)
high grade glioma  (ISO)
Hyperalgesia  (ISO)
Hypertrophy  (ISO)
Insulin Resistance  (IDA)
Kidney Neoplasms  (ISO)
Lung Neoplasms  (ISO)
Memory Disorders  (IDA,ISO)
middle cerebral artery infarction  (IDA)
morphine dependence  (IDA,ISO)
Myocardial Reperfusion Injury  (IDA,IEP)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
neuronal ceroid lipofuscinosis 6A  (ISO)
obesity  (ISO)
Osteoarthritis, Experimental  (IEP)
Ovarian Neoplasms  (ISO)
pancreatic ductal carcinoma  (ISO)
Parkinson's disease  (ISO)
Pneumococcal Pneumonia  (ISO)
Postoperative Cognitive Dysfunction  (IDA,ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Shock  (IDA)
spondylocostal dysostosis 5  (ISO)
squamous cell carcinoma  (ISO)
Stomach Neoplasms  (ISO)
Testis Reperfusion Injury  (IMP)
trigeminal neuralgia  (ISO)
type 2 diabetes mellitus  (IDA,ISO)
ureteral obstruction  (IDA)
withdrawal disorder  (IDA,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (ISO)
(+)-catechin  (EXP,ISO)
(+)-dihydromyricetin  (EXP)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (EXP,ISO)
(+)-Pimaric acid  (ISO)
(+)-schisandrin B  (ISO)
(+)-Tetrandrine  (EXP,ISO)
(-)-anisomycin  (EXP,ISO)
(-)-Arctigenin  (ISO)
(-)-citrinin  (EXP,ISO)
(-)-cotinine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-lobeline  (ISO)
(-)-matairesinol  (ISO)
(-)-selegiline  (EXP,ISO)
(-)-trans-epsilon-viniferin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(1S)-bornane-2,3-dione  (ISO)
(20R)-protopanaxadiol  (ISO)
(20S)-ginsenoside Rh2  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(9R)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione  (EXP)
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (ISO)
(R)-adrenaline  (EXP,ISO)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP,ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-(-)-perillyl alcohol  (ISO)
(S)-3,5-dihydroxyphenylglycine  (EXP,ISO)
(S)-AMPA  (EXP)
(S)-amphetamine  (EXP,ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
(S)-timolol (anhydrous)  (EXP,ISO)
(Z)-ligustilide  (EXP)
1'-acetoxychavicol acetate  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,2-naphthoquinone  (ISO)
1,3-dichloropropan-2-ol  (EXP,ISO)
1,3-dinitrobenzene  (ISO)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (ISO)
1,4-naphthoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP)
1-bromopropane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-hydroxy-2-naphthoic acid  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (EXP)
1-octadec-9-enoylglycero-3-phosphate  (EXP,ISO)
10-DEBC hydrochloride  (EXP)
14,15-EET  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17-hydroxyjolkinolide B  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2''-galloylhyperin  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2,2',3,3',6,6'-hexachlorobiphenyl  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',4,4'-tetrachlorobiphenyl  (EXP,ISO)
2,2',4,5-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3',5-trichlorobiphenyl  (EXP)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (ISO)
2,3,3',4,4',5-Hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP,ISO)
2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4,6-tribromophenol  (ISO)
2,4-D  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-aminobiphenyl  (ISO)
2-aminopurine  (ISO)
2-arachidonoylglycerol  (EXP,ISO)
2-chloroethanol  (EXP)
2-deoxy-D-glucose  (EXP,ISO)
2-methoxyethanol  (EXP)
2-methyl-6-(phenylethynyl)pyridine  (EXP,ISO)
2-methylcholine  (ISO)
2-tert-butylhydroquinone  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
26-hydroxycholesterol  (ISO)
3',4'-dimethoxyflavone  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3'-O-(4-Benzoyl)benzoyl ATP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5,5'-tetraiodothyroacetic acid  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
3,5-dichlorobiphenyl  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-bromopyruvic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-Methoxynobiletin  (ISO)
3-methyladenine  (ISO)
3-Nitrobenzanthrone  (ISO)
3-Nitrofluoranthene  (ISO)
3-nitropropanoic acid  (EXP)
3-O-Caffeoyl-1-O-methylquinic acid  (ISO)
3-phenylprop-2-enal  (EXP,ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4,4'-thiodiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (EXP)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside  (ISO)
4-aminopyridine  (EXP,ISO)
4-chlorobiphenyl  (EXP)
4-ethylphenol  (EXP,ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-Hydroxy-N-desmethyltamoxifen  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methoxy-TEMPO  (ISO)
4-nonylphenol  (EXP,ISO)
4-octylphenol  (EXP,ISO)
4-phenylbutyric acid  (EXP,ISO)
4-Propylphenol  (EXP,ISO)
4-tert-Octylphenol  (ISO)
5,6alpha-epoxy-5alpha-cholestan-3beta-ol  (EXP)
5,7-dihydroxy-4'-methoxyflavone  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
5-aminolevulinic acid  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
5-methoxypsoralen  (ISO)
6,7-dimethoxy-2-phenylquinoxaline  (ISO)
6-aminohexanoate  (ISO)
6-aminohexanoic acid  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-Cyano-7-nitroquinoxaline-2,3-dione  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7,8-dihydroxycoumarin  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
7-ketocholesterol  (EXP,ISO)
7alpha-hydroxycholesterol  (ISO)
8-Br-cAMP  (EXP,ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
9,10-phenanthroquinone  (ISO)
9-cis-retinoic acid  (EXP,ISO)
[6]-Shogaol  (ISO)
AACOCF3  (ISO)
Abemaciclib  (ISO)
acadesine  (EXP)
acamprosate  (ISO)
acebutolol  (ISO)
acetaldehyde  (EXP,ISO)
acetamiprid  (EXP)
acetic acid  (EXP)
acetochlor  (ISO)
acetylsalicylic acid  (ISO)
aconitine  (EXP)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
Actein  (ISO)
acteoside  (ISO)
actinomycin D  (EXP,ISO)
adenine  (ISO)
adenosine  (ISO)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (EXP)
ADP  (ISO)
afimoxifene  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
AH23848  (ISO)
AICA ribonucleotide  (EXP,ISO)
AL 8810  (ISO)
albuterol  (EXP,ISO)
alcohol  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (ISO)
aldrithiol  (EXP)
alendronic acid  (ISO)
Alisol B  (ISO)
alizarin  (ISO)
all-trans-acitretin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
allethrin  (EXP)
allicin  (ISO)
allopurinol  (ISO)
alloxan  (EXP)
allyl isothiocyanate  (ISO)
Allylamine  (EXP)
alpha-D-galactose  (EXP)
alpha-mangostin  (ISO)
alpha-melanocyte stimulating hormone  (ISO)
alpha-naphthoflavone  (ISO)
alpha-Zearalanol  (ISO)
alprenolol  (ISO)
aluminium atom  (EXP)
aluminium hydroxide  (ISO)
aluminium sulfate (anhydrous)  (ISO)
aluminium(0)  (EXP)
alvocidib  (ISO)
AM-251  (ISO)
AM6545  (ISO)
amentoflavone  (ISO)
amidotrizoic acid  (ISO)
amiloride  (ISO)
amino acid  (ISO)
aminoguanidine  (EXP)
amiodarone  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
amodiaquine  (ISO)
amosite asbestos  (EXP,ISO)
amosulalol  (EXP)
amoxicillin  (ISO)
amphetamine  (EXP,ISO)
amphibole asbestos  (EXP,ISO)
ampicillin  (EXP)
amsacrine  (ISO)
anandamide  (EXP,ISO)
andrographolide  (ISO)
Anemoside B4  (ISO)
anethole  (ISO)
aniline  (EXP)
aniracetam  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antigen  (ISO)
antimonite  (ISO)
antimony trichloride  (ISO)
antimony(0)  (EXP)
antimycin A  (ISO)
Antrocin  (ISO)
antroquinonol  (ISO)
apigenin  (EXP,ISO)
apocynin  (EXP,ISO)
arachidonic acid  (EXP,ISO)
arachidonyl-2'-chloroethylamide  (EXP,ISO)
Arctiin  (ISO)
arecoline  (EXP,ISO)
Arg-Gly-Asp  (EXP,ISO)
aristolochic acid A  (ISO)
aristolochic acids  (ISO)
arjunolic acid  (EXP)
Aroclor 1254  (EXP)
ARS-1620  (ISO)
arsane  (EXP,ISO)
arsenic acid  (ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
ascofuranone  (ISO)
asoxime chloride  (EXP)
aspalathin  (ISO)
aspartame  (ISO)
astaxanthin  (ISO)
astilbin  (ISO)
astragaloside IV  (ISO)
astressin  (EXP)
atenolol  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (EXP,ISO)
atrasentan  (EXP)
atrazine  (EXP,ISO)
atropine  (EXP)
aucubin  (ISO)
auranofin  (ISO)
aureusidin  (EXP)
Auriculasin  (ISO)
avermectin  (ISO)
avobenzone  (ISO)
axitinib  (ISO)
azadirachtin A  (ISO)
azathioprine  (ISO)
AZD4547  (ISO)
azetidine  (ISO)
Azoxymethane  (ISO)
baclofen  (EXP)
bafilomycin A1  (ISO)
baicalein  (ISO)
baicalin  (EXP)
BAPTA  (ISO)
bathocuproine disulfonic acid  (EXP,ISO)
batimastat  (ISO)
BAY 60-6583  (ISO)
beauvericin  (EXP)
benzamide  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[a]pyrene-7,8-dione  (ISO)
benzo[e]pyrene  (ISO)
benzofurans  (ISO)
benzyl isothiocyanate  (ISO)
berberine  (EXP,ISO)
Bergenin  (ISO)
beryllium difluoride  (ISO)
beta-carotene  (EXP,ISO)
beta-cyclodextrin  (ISO)
beta-D-fructofuranose 1,6-bisphosphate  (ISO)
beta-D-glucosamine  (ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-endorphin  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-ionone  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
betulin  (EXP,ISO)
betulinic acid  (ISO)
Betulonic acid  (ISO)
bezafibrate  (EXP)
bicalutamide  (ISO)
bicuculline  (EXP,ISO)
bifenthrin  (ISO)
bilirubin IXalpha  (ISO)
bilobalide  (EXP)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
bortezomib  (ISO)
Botulinum toxin type A  (EXP)
brefeldin A  (EXP)
bromocriptine  (EXP)
Bruceantinol  (ISO)
bucladesine  (ISO)
bufalin  (ISO)
bupivacaine  (ISO)
buprenorphine  (ISO)
busulfan  (ISO)
butan-1-ol  (EXP,ISO)
butane-2,3-dione  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cadmium acetate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
cadmium sulfate  (EXP,ISO)
cadmium telluride  (ISO)
caffeine  (ISO)
calcidiol  (ISO)
Calcimycin  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium dichloride  (EXP,ISO)
calcium silicate  (ISO)
calcium(0)  (EXP,ISO)
Calphostin C  (EXP,ISO)
calycosin  (ISO)
camostat  (ISO)
camptothecin  (ISO)
candesartan  (EXP)
canertinib  (ISO)
cannabidiol  (ISO)
cantharidic acid  (ISO)
cantharidin  (ISO)
capsaicin  (EXP,ISO)
capsanthin  (EXP)
capsazepine  (EXP,ISO)
captan  (ISO)
carbachol  (EXP,ISO)
carbendazim  (ISO)
CARBENOXOLONE  (ISO)
carbon dioxide  (EXP)
carbon nanotube  (ISO)
Carnosol  (ISO)
carrageenan  (ISO)
carteolol  (ISO)
carvedilol  (EXP,ISO)
Cassine  (ISO)
cefaloridine  (EXP)
celastrol  (EXP)
celecoxib  (EXP,ISO)
ceric oxide  (ISO)
ceritinib  (ISO)
cetrorelix  (ISO)
CGP 12177  (ISO)
chaetocin  (ISO)
chaetoglobosin A  (EXP,ISO)
chalcone  (ISO)
chelerythrine  (EXP,ISO)
chenodeoxycholic acid  (ISO)
chitosan  (EXP,ISO)
chlorogenic acid  (ISO)
chlorohydrocarbon  (ISO)
chlorophyllin  (ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorothalonil  (ISO)
chlorpromazine  (EXP,ISO)
chlorpyrifos  (EXP,ISO)
cholic acid  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP,ISO)
chrysin  (ISO)
chrysophanol  (ISO)
ciclopirox  (ISO)
ciglitazone  (EXP,ISO)
ciprofloxacin  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
clopidogrel  (ISO)
clothianidin  (ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cobimetinib  (ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP,ISO)
compound 48/80  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP)
copper(II) sulfate  (ISO)
cordycepin  (EXP,ISO)
corn oil  (ISO)
corosolic acid  (ISO)
corticosterone  (EXP,ISO)
cortisone  (ISO)
coumestrol  (EXP)
crizotinib  (ISO)
crocidolite asbestos  (EXP,ISO)
crocin-1  (EXP,ISO)
CU-O LINKAGE  (ISO)
cucurbitacin E  (EXP)
cudraflavone B  (ISO)
cudratricusxanthone A  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
Cyclosporin H  (ISO)
cyfluthrin  (ISO)
cyhalothrin  (EXP)
cypermethrin  (ISO)
cyproconazole  (ISO)
cyprodinil  (ISO)
cytochalasin B  (ISO)
D-aspartic acid  (EXP,ISO)
D-cycloserine  (EXP)
D-fructofuranose 1,6-bisphosphate  (ISO)
D-glucose  (EXP,ISO)
dabrafenib  (ISO)
dacarbazine  (ISO)
dactolisib  (ISO)
daidzein  (EXP,ISO)
dapsone  (ISO)
daunorubicin  (EXP,ISO)
DDE  (EXP,ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
Decursin  (ISO)
deferiprone  (EXP,ISO)
deguelin  (ISO)
dehydroacetic acid  (EXP)
delphinidin  (ISO)
Delta(9)-tetrahydrocannabinolic acid  (ISO)
demethoxycurcumin  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
Deoxyschizandrin  (ISO)
Deoxyshikonin  (ISO)
desferrioxamine B  (EXP,ISO)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
dextromethorphan  (ISO)
Di-n-hexyl phthalate  (EXP)
Di-n-octyl phthalate  (EXP,ISO)
diallyl disulfide  (EXP,ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazepam  (EXP,ISO)
diazinon  (EXP,ISO)
dibenziodolium  (EXP,ISO)
dibenzo[a,l]pyrene  (EXP,ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diclofenac  (ISO)
dicoumarol  (ISO)
Dictamnine  (ISO)
Dicyclohexyl phthalate  (EXP)
Didymin  (ISO)
dieckol  (ISO)
dieldrin  (EXP,ISO)
diepoxybutane  (ISO)
diethyl malate  (ISO)
diethyl phthalate  (ISO)
diethyldithiocarbamic acid  (EXP)
diethylstilbestrol  (EXP,ISO)
digitoxin  (ISO)
digoxin  (EXP)
dihydroartemisinin  (ISO)
dihydrocapsaicin  (ISO)
dihydrolipoic acid  (EXP)
Dihydrotanshinone I  (ISO)
dihydroxyacetone  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (ISO)
diltiazem  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP,ISO)
diminazene diaceturate  (ISO)
dinaciclib  (ISO)
Dinitramine  (ISO)
dinitrogen  (ISO)
dioscin  (EXP,ISO)
diosmetin  (ISO)
dioxygen  (EXP,ISO)
diphenyl diselenide  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP,ISO)
diquat  (ISO)
disodium cromoglycate  (EXP,ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
divanadium pentaoxide  (ISO)
dizocilpine maleate  (EXP,ISO)
dobutamine  (EXP,ISO)
donepezil hydrochloride  (EXP)
dopamine  (EXP,ISO)
dorsomorphin  (EXP,ISO)
doxazosin  (EXP)
doxorubicin  (EXP,ISO)
DPCPX  (EXP)
ebselen  (EXP,ISO)
eckol  (ISO)
elemental selenium  (EXP,ISO)
ellagic acid  (EXP,ISO)
ellipticine  (ISO)
emetine  (ISO)
emodin  (EXP,ISO)
endosulfan  (EXP,ISO)
enzacamene  (ISO)
enzyme inhibitor  (ISO)
eplerenone  (ISO)
equol  (ISO)
erastin  (ISO)
erdosteine  (EXP)
erlotinib hydrochloride  (EXP,ISO)
Erucin  (ISO)
esculetin  (EXP,ISO)
estragole  (EXP)
estriol  (EXP,ISO)
estrogen  (EXP)
estrone  (EXP,ISO)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ether  (EXP)
Ethyl pyruvate  (EXP,ISO)
ethyl trans-caffeate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
eticlopride(1+)  (ISO)
etoposide  (ISO)
etoxazole  (ISO)
EUK-134  (ISO)
EUK-8  (EXP)
euscaphic acid  (ISO)
Evodiamine  (EXP,ISO)
excitatory amino acid agonist  (EXP,ISO)
famotidine  (ISO)
farnesyl diphosphate  (ISO)
farrerol  (EXP,ISO)
fenbuconazole  (ISO)
fenoterol  (ISO)
fentanyl  (ISO)
fenthion  (ISO)
fenvalerate  (EXP,ISO)
ferric ammonium citrate  (ISO)
ferric oxide  (EXP,ISO)
ferroheme b  (ISO)
ferrosoferric oxide  (ISO)
ferulic acid  (EXP,ISO)
Fexofenadine hydrochloride  (ISO)
Fidarestat  (ISO)
filipin III  (EXP)
fingolimod hydrochloride  (ISO)
fipronil  (ISO)
fisetin  (EXP,ISO)
flavanones  (ISO)
flavonol  (ISO)
flavonols  (ISO)
flufenoxuron  (ISO)
fluoranthene  (ISO)
fluorescein 5-isothiocyanate  (ISO)
fluoxetine  (EXP,ISO)
fluprostenol  (ISO)
flurbiprofen  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
folpet  (ISO)
fomepizole  (ISO)
formaldehyde  (ISO)
formononetin  (ISO)
formoterol fumarate  (ISO)
FR900359  (ISO)
fructose  (EXP)
fucoxanthin  (ISO)
fulvestrant  (EXP,ISO)
Fulvic acid  (ISO)
furan  (EXP,ISO)
gadodiamide hydrate  (ISO)
gadolinium atom  (EXP)
gadolinium trichloride  (EXP,ISO)
galactose  (EXP)
galangin  (EXP)
gallein  (EXP)
gallic acid  (EXP,ISO)
gamma-hexachlorocyclohexane  (EXP,ISO)
gamma-linolenic acid  (ISO)
Garcinol  (ISO)
gefitinib  (EXP,ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
Genipin  (ISO)
Geniposide pentaacetate  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
Gentiopicrin  (ISO)
Geraniin  (ISO)
geraniol  (EXP,ISO)
GGTI-2133  (EXP)
Gingerenone A  (EXP,ISO)
ginkgolide B  (ISO)
ginsenoside Rd  (ISO)
ginsenoside Re  (ISO)
ginsenoside Rg1  (ISO)
Ginsenoside Rh4  (EXP)
Glabrene  (ISO)
glabridin  (ISO)
gliclazide  (EXP)
gliotoxin  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
Glutathione ethyl ester  (ISO)
glyburide  (EXP)
glycine  (EXP)
glycitein  (ISO)
glycochenodeoxycholic acid  (EXP,ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (EXP,ISO)
Goe 6976  (EXP,ISO)
gossypol  (ISO)
guanosine  (ISO)
GW 1929  (ISO)
haloperidol  (ISO)
halothane  (ISO)
harmine  (ISO)
Harpagoside  (ISO)
helioxanthin  (ISO)
heme b  (ISO)
hemin  (ISO)
heparan sulfate  (ISO)
heparin  (EXP,ISO)
heptachlor  (EXP,ISO)
herbicide  (EXP)
herbimycin  (ISO)
hesperetin  (ISO)
hexachlorobenzene  (EXP,ISO)
hexadecanoic acid  (EXP,ISO)
Hexamethonium  (ISO)
hexamethylene diisocyanate  (ISO)
high-density lipoprotein cholesterol  (ISO)
hinokiflavone  (ISO)
hispidulin  (EXP,ISO)
histamine  (EXP,ISO)
homocysteine  (ISO)
Honokiol  (ISO)
hyaluronic acid  (ISO)
hydralazine  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
hydroxyflutamide  (EXP,ISO)
hydroxytyrosol  (ISO)
hydroxyurea  (EXP)
hyperforin  (ISO)
hypochlorous acid  (ISO)
ibuprofen  (ISO)
IC-87114  (ISO)
icariin  (EXP,ISO)
icariside II  (ISO)
icatibant  (ISO)
ICI 118551  (EXP,ISO)
ICI-164384  (ISO)
icosanoid  (ISO)
Ilimaquinone  (ISO)
iloprost  (ISO)
imidacloprid  (ISO)
imipramine  (EXP)
imiquimod  (ISO)
imperatorin  (ISO)
indapamide  (EXP)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
indoprofen  (ISO)
indoxyl sulfate  (ISO)
Inotodiol  (ISO)
iohexol  (ISO)
ionomycin  (EXP,ISO)
iopromide  (ISO)
Ioversol  (ISO)
ioxynil  (EXP)
irinotecan  (ISO)
iron atom  (EXP,ISO)
iron dextran  (EXP,ISO)
iron dichloride  (ISO)
iron trichloride  (EXP)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP)
isocarbophos  (ISO)
isoeugenol  (ISO)
isoflurane  (EXP)
isoliquiritigenin  (ISO)
isoniazide  (ISO)
isoorientin  (ISO)
isoprenaline  (EXP,ISO)
isoprene  (ISO)
isorhapontigenin  (EXP)
isothiocyanate  (ISO)
ivermectin  (ISO)
JTE-013  (ISO)
juglone  (ISO)
Jujuboside A  (ISO)
kaempferol  (EXP,ISO)
kahweol  (ISO)
kainic acid  (ISO)
ketamine  (EXP,ISO)
ketanserin  (ISO)
keto-D-fructose 1,6-bisphosphate  (ISO)
KN-93  (EXP,ISO)
kojic acid  (ISO)
KT 5720  (ISO)
KT 5823  (EXP,ISO)
Kukoamine B  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (EXP)
L-cystine  (ISO)
L-glutamic acid  (EXP,ISO)
L-methionine  (EXP,ISO)
labetalol  (ISO)
lactacystin  (ISO)
lactucin  (ISO)
lansoprazole  (EXP)
lapatinib  (ISO)
latrunculin B  (EXP)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (EXP,ISO)
leflunomide  (ISO)
lentinan  (ISO)
leptomycin B  (ISO)
lercanidipine  (EXP,ISO)
letrozole  (EXP,ISO)
leukotriene B4  (ISO)
leukotriene C4  (ISO)
leukotriene D4  (ISO)
levofloxacin  (ISO)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
lidocaine  (EXP)
Liensinine  (ISO)
linagliptin  (EXP)
linalool  (ISO)
linderalactone  (EXP,ISO)
linoleic acid  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP,ISO)
lipoxin A4  (ISO)
lithium atom  (EXP,ISO)
lithium chloride  (EXP)
lithium hydride  (EXP,ISO)
lithocholic acid  (ISO)
LM-1685  (ISO)
loliolide  (ISO)
lonidamine  (ISO)
loperamide  (ISO)
losartan  (EXP,ISO)
lovastatin  (EXP,ISO)
loxoprofen  (ISO)
Lupalbigenin  (ISO)
luteolin  (EXP,ISO)
luteolin 7-O-beta-D-glucoside  (ISO)
LY 117018  (ISO)
LY 379268  (EXP)
LY294002  (EXP,ISO)
lycopene  (ISO)
lysophosphatidylcholine  (EXP)
Maduramicin  (EXP)
Magnolol  (EXP,ISO)
Malonoben  (ISO)
malvidin  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP,ISO)
manumycin A  (EXP)
Maprotiline  (ISO)
marimastat  (EXP)
masoprocol  (ISO)
mebendazole  (ISO)
Mecamylamine  (ISO)
mechlorethamine  (ISO)
medroxyprogesterone acetate  (ISO)
melamine  (ISO)
melatonin  (EXP,ISO)
melittin  (EXP,ISO)
meloxicam  (ISO)
melphalan  (ISO)
memantine  (EXP)
menadione  (EXP,ISO)
mepyramine  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
mesalamine  (ISO)
metacetamol  (ISO)
metam  (ISO)
metformin  (EXP,ISO)
methadone  (ISO)
methamphetamine  (ISO)
Methanandamide  (EXP,ISO)
methapyrilene  (EXP,ISO)
methimazole  (EXP,ISO)
methoctramine tetrahydrochloride  (EXP)
methohexital  (ISO)
methotrexate  (EXP)
methoxyacetic acid  (ISO)
methoxychlor  (EXP,ISO)
methyl beta-cyclodextrin  (ISO)
methyl caffeate  (ISO)
methyl tert-butyl ether  (EXP)
methylglyoxal  (ISO)
methyllycaconitine  (ISO)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
Methylthiouracil  (ISO)
metronidazole  (EXP)
mevalonic acid  (EXP,ISO)
microcystin-LR  (ISO)
midazolam  (ISO)
midostaurin  (ISO)
mifepristone  (EXP,ISO)
minocycline  (ISO)
mitomycin C  (ISO)
MitoTEMPO  (ISO)
MK 571  (ISO)
MK-2206  (ISO)
ML-7  (ISO)
mocetinostat  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotaline  (EXP)
monodansylcadaverine  (ISO)
montelukast  (ISO)
morin  (EXP)
morphine  (EXP,ISO)
Morroniside  (EXP)
morusin  (ISO)
moxifloxacin  (ISO)
Muconic dialdehyde  (EXP)
muscimol  (EXP)
mycophenolic acid  (ISO)
myo-inositol hexakisphosphate  (EXP,ISO)
myricetin  (ISO)
myricitrin  (ISO)
N(6)-butyryl-cAMP  (ISO)
N,N'-diphenyl-1,4-phenylenediamine  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N,N-dimethylformamide  (ISO)
N,O-dimethyltyramine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (EXP)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (EXP)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-D-aspartic acid  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-methylnicotinate  (ISO)
N-Nitroso-N-methylurethane  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-phenylthiourea  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naloxone  (EXP,ISO)
naringin  (EXP,ISO)
NCX-4040  (ISO)
nectandrin B  (ISO)
nefazodone  (ISO)
Neferine  (ISO)
neoastilbin  (ISO)
neocuproine  (EXP)
neohesperidin  (EXP,ISO)
neomycin  (EXP,ISO)
nerolidol  (EXP)
nicardipine  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (EXP)
nickel sulfate  (EXP,ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nifedipine  (ISO)
nimesulide  (ISO)
nimodipine  (ISO)
nimustine  (ISO)
nintedanib  (ISO)
nitrates  (ISO)
nitric oxide  (EXP)
nitroprusside  (EXP,ISO)
Nivalenol  (ISO)
NMN zwitterion  (ISO)
nocodazole  (EXP,ISO)
Nodularin  (EXP)
nonanedioic acid  (ISO)
Nonylphenol  (EXP,ISO)
Nookatone  (EXP)
norathyriol  (ISO)
Norbinaltorphimine  (ISO)
NORCANTHARIDIN  (ISO)
notoginsenoside R1  (EXP,ISO)
NS-398  (EXP,ISO)
nystatin  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (EXP,ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
oleuropein  (ISO)
oligopeptide  (ISO)
olmesartan  (ISO)
omacetaxine mepesuccinate  (ISO)
omipalisib  (ISO)
organoselenium compound  (EXP)
orlistat  (ISO)
oroxylin A  (ISO)
Ortho-topolin riboside  (ISO)
osimertinib  (ISO)
osthole  (ISO)
ouabain  (EXP,ISO)
oxaliplatin  (EXP,ISO)
oxidopamine  (EXP,ISO)
oxycodone  (EXP)
oxytocin  (EXP)
ozone  (EXP,ISO)
p-tert-Amylphenol  (ISO)
p-tolualdehyde  (ISO)
paclitaxel  (EXP,ISO)
paeoniflorin  (ISO)
palmatine  (EXP)
palytoxin  (ISO)
pamoic acid  (ISO)
Panaxynol  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parecoxib  (ISO)
paroxetine  (ISO)
Parthenin  (ISO)
patchouli alcohol  (ISO)
patulin  (EXP,ISO)
pazopanib  (ISO)
PCB138  (ISO)
PD 0325901  (EXP,ISO)
PD 168393  (ISO)
PD123319  (ISO)
PD173074  (EXP,ISO)
pelargonidin  (ISO)
pentachlorophenol  (ISO)
pentobarbital  (EXP,ISO)
Pentoxifylline  (ISO)
peptidoglycan  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluoroheptanoic acid  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (EXP)
perifosine  (ISO)
perillyl alcohol  (ISO)
permethrin  (EXP,ISO)
peroxides  (EXP)
peroxynitrous acid  (EXP)
PF-3758309  (ISO)
PHA-665752  (ISO)
phenanthrolines  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenols  (ISO)
phentolamine  (ISO)
phenylarsine oxide  (EXP,ISO)
phenylephrine  (EXP,ISO)
phenytoin  (ISO)
PhIP  (ISO)
phloretin  (EXP)
phlorizin  (ISO)
phlorizin chalcone  (ISO)
phorbol 12,13-dibutanoate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (EXP)
phosphatidic acid  (ISO)
phosphoramidon  (ISO)
phylloquinone  (ISO)
phytol  (ISO)
phytosphingosine  (ISO)
picoxystrobin  (ISO)
picropodophyllotoxin  (ISO)
Picroside ii  (ISO)
picrotoxin  (EXP)
picrotoxinin  (ISO)
pifithrin-alpha hydrobromide  (EXP,ISO)
pindolol  (ISO)
pinocembrin  (ISO)
pioglitazone  (EXP,ISO)
piperine  (ISO)
pipoxolan  (ISO)
pirarubicin  (EXP)
pirinixic acid  (ISO)
platinum  (ISO)
platinum(0)  (ISO)
platycodin D  (EXP,ISO)
plumbagin  (ISO)
PNU-282987  (EXP)
poly(I:C)  (ISO)
poly(vinylpyrrolidone)  (ISO)
Polygodial  (EXP)
polymyxin B2  (ISO)
polyphosphates  (ISO)
ponatinib  (ISO)
potassium atom  (EXP)
potassium bromate  (ISO)
potassium chloride  (EXP)
potassium dichromate  (EXP,ISO)
practolol  (ISO)
Praeruptorin A  (ISO)
prazosin  (EXP,ISO)
prednisolone  (EXP)
prednisone  (ISO)
probenecid  (EXP)
procaine  (ISO)
prochloraz  (ISO)
procyanidin B2  (ISO)
prodigiosin  (ISO)
progesterone  (EXP,ISO)
promegestone  (EXP,ISO)
propacetamol  (ISO)
propane-1,2-diol  (ISO)
propazine  (ISO)
propiconazole  (ISO)
propofol  (EXP,ISO)
propranolol  (EXP,ISO)
propylparaben  (ISO)
prostaglandin D2  (ISO)
prostaglandin E2  (EXP,ISO)
prostaglandin F2alpha  (EXP,ISO)
prostaglandin I2  (ISO)
protein kinase inhibitor  (ISO)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
pyocyanine  (ISO)
pyrazines  (ISO)
pyridazines  (ISO)
Pyridostigmine bromide  (EXP)
pyrithione  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
pyrroloquinoline quinone  (ISO)
quercetagetin  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinacrine  (ISO)
quinazolines  (ISO)
quinpirole  (ISO)
quizartinib  (ISO)
raloxifene  (EXP,ISO)
ranitidine  (ISO)
razoxane  (EXP)
reactive oxygen species  (EXP,ISO)
Rebamipide  (ISO)
regorafenib  (ISO)
reparixin  (ISO)
resiniferatoxin  (ISO)
resveratrol  (EXP,ISO)
RGFP966  (ISO)
rimonabant  (EXP,ISO)
Risedronate sodium  (ISO)
Ro 31-8220  (EXP,ISO)
roflumilast  (ISO)
rolipram  (EXP)
romidepsin  (ISO)
ropinirole  (ISO)
rosmarinic acid  (EXP)
rotenone  (EXP,ISO)
rottlerin  (EXP,ISO)
Ruscogenin  (ISO)
ruthenium red  (EXP,ISO)
rutin  (EXP,ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
saccharin  (EXP)
Salidroside  (EXP,ISO)
Salinomycin  (ISO)
Salmeterol xinafoate  (ISO)
salubrinal  (EXP,ISO)
Salvianolic acid A  (ISO)
salvianolic acid B  (ISO)
Sanggenon C  (ISO)
sanguinarine  (ISO)
sapanisertib  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SB-239063  (EXP)
SCH 23390  (ISO)
SCH772984  (EXP,ISO)
sclareol  (ISO)
scopoletin  (EXP)
secobarbital  (ISO)
selenic acid  (ISO)
selenium atom  (EXP,ISO)
selenocystine  (ISO)
selenomethionine  (ISO)
selumetinib  (ISO)
semilicoisoflavone B  (ISO)
sepantronium  (ISO)
serotonin  (ISO)
serpentine asbestos  (EXP,ISO)
sertraline  (EXP,ISO)
sevoflurane  (EXP,ISO)
Shikonin  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silmitasertib  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
simazine  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sirtinol  (ISO)
SKF-96365 hydrochloride  (ISO)
SL-327  (EXP,ISO)
sodium acetate trihydrate  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium benzoate  (ISO)
sodium chlorate  (ISO)
sodium chloride  (EXP,ISO)
sodium cholate  (ISO)
sodium chromate  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP,ISO)
Sodium salicylate  (EXP,ISO)
Soman  (EXP)
sorafenib  (EXP,ISO)
sorbinil  (ISO)
sotorasib  (ISO)
sotrastaurin  (ISO)
sphingosine 1-phosphate  (EXP,ISO)
SR 144528  (ISO)
staurosporine  (EXP,ISO)
StemRegenin 1  (ISO)
stilbenoid  (ISO)
streptozocin  (EXP,ISO)
SU6656  (ISO)
sucrose  (EXP,ISO)
sulfadimethoxine  (EXP)
sulfasalazine  (EXP,ISO)
sulfonyldimethane  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sunitinib  (ISO)
superoxide  (EXP,ISO)
suramin  (EXP,ISO)
surfactin  (ISO)
surfactin C  (ISO)
suvorexant  (ISO)
swainsonine  (ISO)
Swertiamarin  (ISO)
syringic acid  (ISO)
tadalafil  (ISO)
taiwanin C  (ISO)
tamibarotene  (EXP,ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (EXP,ISO)
Tanshinone I  (ISO)
taurine  (EXP,ISO)
taurocholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
tazarotene  (ISO)
tebufenpyrad  (ISO)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
Temsirolimus  (ISO)
tephrosin  (ISO)
terbinafine  (ISO)
terbutaline  (EXP,ISO)
terbutylazine  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
tetracaine  (EXP)
Tetrachlorobisphenol A  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetraethylammonium  (EXP)
tetramethylpyrazine  (ISO)
tetrathiomolybdate(2-)  (EXP,ISO)
tetrodotoxin  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
Theaflavin 3,3'-digallate  (EXP,ISO)
theophylline  (ISO)
thiamylal  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP,ISO)
Thiorphan  (ISO)
thiostrepton  (ISO)
Thrombin  (ISO)
thymoquinone  (EXP,ISO)
thyroxine  (EXP,ISO)
tibolone  (ISO)
tipifarnib  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
toluene 2,4-diisocyanate  (ISO)
tomatidine  (ISO)
Tomentosin  (ISO)
toosendanin  (ISO)
Tormentic acid  (ISO)
trametinib  (ISO)
trans-anethole  (ISO)
trans-caffeic acid  (ISO)
trans-chalcone  (ISO)
trans-isoeugenol  (ISO)
trans-piceid  (ISO)
triadimefon  (EXP)
tributylstannane  (EXP,ISO)
tributyrin  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trifluoperazine  (EXP,ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (EXP)
Triptolide  (EXP)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
trovafloxacin  (ISO)
tubocurarine  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (EXP,ISO)
Typhaneoside  (EXP)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (EXP,ISO)
U0126  (EXP)
U69593  (ISO)
UDP  (ISO)
umbelliferone  (EXP)
urethane  (EXP,ISO)
ursodeoxycholic acid  (ISO)
ursolic acid  (EXP)
Ursonic acid  (ISO)
usnic acid  (ISO)
UTP  (EXP,ISO)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vanadium atom  (EXP,ISO)
vanadium(0)  (EXP,ISO)
vanadyl sulfate  (ISO)
vancomycin  (EXP)
varenicline  (ISO)
vecuronium bromide  (ISO)
vemurafenib  (ISO)
venetoclax  (ISO)
venlafaxine hydrochloride  (EXP)
verapamil  (ISO)
Vernodalin  (ISO)
Vernodalol  (ISO)
vildagliptin  (ISO)
vinclozolin  (EXP)
vitamin D  (EXP)
vitamin E  (ISO)
Vitisin A  (EXP,ISO)
vorinostat  (ISO)
warfarin  (ISO)
WIN 55212-2  (EXP,ISO)
withaferin A  (ISO)
Withanone  (ISO)
wogonin  (ISO)
wortmannin  (EXP,ISO)
WP1066  (ISO)
Xamoterol  (ISO)
xanthohumol  (ISO)
xanthones  (ISO)
xenon atom  (EXP)
xenon(0)  (EXP)
xestospongin C  (ISO)
XMU-MP-1  (ISO)
Y-27632  (EXP,ISO)
YM-254890  (ISO)
zearalenone  (EXP,ISO)
zebularine  (ISO)
zerumbone  (ISO)
zileuton  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)
zingerone  (EXP)
ziram  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
apoptotic process  (IEA)
arachidonate metabolic process  (IEP)
Bergmann glial cell differentiation  (ISO)
BMP signaling pathway  (ISO)
cardiac neural crest cell development involved in heart development  (ISO)
cartilage development  (ISO)
caveolin-mediated endocytosis  (IEA,TAS)
cell surface receptor signaling pathway  (IBA)
cellular response to amino acid starvation  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to toxic substance  (IDA)
cellular response to tumor necrosis factor  (ISO)
decidualization  (IDA,IEA)
DNA damage response  (ISO)
epidermal growth factor receptor signaling pathway  (ISO)
ERBB2-ERBB3 signaling pathway  (ISO)
ERK1 and ERK2 cascade  (ISO)
face development  (ISO)
insulin receptor signaling pathway  (ISO)
insulin-like growth factor receptor signaling pathway  (ISO)
interleukin-1-mediated signaling pathway  (ISO)
interleukin-34-mediated signaling pathway  (ISO)
intracellular signal transduction  (IBA,IDA,TAS)
lipopolysaccharide-mediated signaling pathway  (ISO)
lung morphogenesis  (ISO)
MAPK cascade  (IEA,IMP,ISO)
modulation of chemical synaptic transmission  (ISO)
myelination  (ISO)
negative regulation of cholesterol efflux  (ISO)
negative regulation of T cell mediated immune response to tumor cell  (ISO)
negative regulation of TORC1 signaling  (ISO)
neural crest cell development  (ISO)
outer ear morphogenesis  (ISO)
peptidyl-serine phosphorylation  (IMP)
peptidyl-tyrosine autophosphorylation  (ISO)
phosphorylation  (ISO)
positive regulation of cyclase activity  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of macrophage chemotaxis  (ISO)
positive regulation of macrophage proliferation  (ISO)
positive regulation of neuroinflammatory response  (ISO)
positive regulation of telomere maintenance  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of translation  (IEA,IMP)
positive regulation of xenophagy  (ISO)
protein phosphorylation  (IDA,ISO,TAS)
regulation of cellular pH  (ISO)
regulation of cytoskeleton organization  (IEA,TAS)
regulation of early endosome to late endosome transport  (IEA,TAS)
regulation of Golgi inheritance  (IEA,TAS)
regulation of ossification  (ISO)
regulation of stress-activated MAPK cascade  (IEA,TAS)
response to epidermal growth factor  (ISO,ISS)
response to exogenous dsRNA  (ISO)
response to lipopolysaccharide  (ISO)
response to toxic substance  (IDA)
Schwann cell development  (ISO)
sensory perception of pain  (ISO)
signal transduction in response to DNA damage  (ISO)
stress-activated MAPK cascade  (ISO)
thymus development  (ISO)
thyroid gland development  (ISO)
trachea formation  (ISO)

Cellular Component
caveola  (IDA,IEA,TAS)
cytoplasm  (IBA,IDA,IEA,ISO)
cytoskeleton  (IEA,TAS)
cytosol  (ISO,TAS)
early endosome  (IEA,TAS)
focal adhesion  (IEA,TAS)
glutamatergic synapse  (ISO)
Golgi apparatus  (IEA,TAS)
late endosome  (IEA,TAS)
mitochondrion  (IEA,TAS)
nuclear envelope  (ISO)
nucleoplasm  (IDA,IEA,ISO)
nucleus  (IBA,IEA,ISO,TAS)
plasma membrane  (IDA)
protein-containing complex  (IDA)
pseudopodium  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway   (IEA)
aldosterone signaling pathway   (IEA)
Alzheimer's disease pathway  (IEA)
B cell receptor signaling pathway  (IEA)
ceramide signaling pathway  (IEA,ISO)
Chagas disease pathway  (IEA)
chemokine mediated signaling pathway  (IEA)
chronic myeloid leukemia pathway   (IEA)
colorectal cancer pathway   (IEA)
endometrial cancer pathway  (IEA)
endothelin signaling pathway  (ISO)
ephrin - ephrin receptor bidirectional signaling axis   (ISO)
epidermal growth factor/neuregulin signaling pathway  (IEA,ISO)
Fc epsilon receptor mediated signaling pathway  (IEA)
Fc gamma receptor mediated signaling pathway  (IEA)
fibroblast growth factor signaling pathway  (ISO)
glioma pathway  (IEA)
glutamate signaling pathway  (IEA)
gonadotropin-releasing hormone signaling pathway  (IEA)
granulocyte-macrophage colony-stimulating factor signaling pathway  (ISO)
hepatitis C pathway  (IEA)
influenza A pathway   (IEA)
insulin signaling pathway  (IEA)
interleukin-2 signaling pathway  (ISO)
Leishmaniasis pathway  (IEA)
long term depression  (IEA)
long term potentiation   (IEA)
lung non-small cell carcinoma pathway  (IEA)
melanoma pathway   (IEA)
mitogen activated protein kinase signaling pathway   (IEA)
mTOR signaling pathway  (IEA,ISO)
neurotrophic factor signaling pathway  (IEA)
NOD-like receptor signaling pathway   (IEA)
pancreatic cancer pathway  (IEA)
platelet-derived growth factor signaling pathway  (ISO)
prion disease pathway   (IEA)
prostate cancer pathway   (IEA)
renal cell carcinoma pathway  (IEA)
sphingosine 1-phosphate signaling pathway  (ISO)
syndecan signaling pathway  (ISO)
T cell receptor signaling pathway   (IEA)
the extracellular signal-regulated Raf/Mek/Erk signaling pathway  (IDA,IMP,ISO)
thyroid cancer pathway   (IEA)
Toll-like receptor signaling pathway  (IEA)
toxoplasmosis pathway   (IEA)
Trail mediated signaling pathway  (ISO)
transforming growth factor-beta superfamily mediated signaling pathway  (IEA)
tuberculosis pathway   (IEA)
type 2 diabetes mellitus pathway  (IEA)
type II interferon signaling pathway  (ISO)
urinary bladder cancer pathway   (IEA)
vascular endothelial growth factor signaling pathway  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Cyclic changes in estradiol regulate synaptic plasticity through the MAP kinase pathway. Bi R, etal., Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13391-5.
2. P2X7 receptors activate protein kinase D and p42/p44 mitogen-activated protein kinase (MAPK) downstream of protein kinase C. Bradford MD and Soltoff SP, Biochem J 2002 Sep 15;366(Pt 3):745-55.
3. Bradykinin reduces growth factor-induced glomerular ERK1/2 phosphorylation. Cellier E, etal., Am J Physiol Renal Physiol 2003 Feb;284(2):F282-92.
4. Anti-tumorigenic action of 2-[piperidinoethoxyphenyl]-3-[4-hydroxyphenyl]-2H-benzo(b)pyran: evidence for involvement of GPR30/EGFR signaling pathway. Chandra V, etal., Gynecol Oncol. 2013 May;129(2):433-42. doi: 10.1016/j.ygyno.2013.02.005. Epub 2013 Feb 8.
5. Systemic dexmedetomidine attenuates mechanical allodynia through extracellular sign db type 2 diabetic mice. Chen H, etal., Neurosci Lett. 2017 Sep 14;657:126-133. doi: 10.1016/j.neulet.2017.07.048. Epub 2017 Jul 28.
6. Dopamine promotes striatal neuronal apoptotic death via ERK signaling cascades. Chen J, etal., Eur J Neurosci. 2009 Jan;29(2):287-306.
7. Alterations in mammalian target of rapamycin signaling pathways after traumatic brain injury. Chen S, etal., J Cereb Blood Flow Metab. 2007 May;27(5):939-49. Epub 2006 Aug 30.
8. Pfaffia paniculata (Brazilian ginseng) extract modulates Mapk and mucin pathways in intestinal inflammation. Costa CARA, etal., J Ethnopharmacol. 2018 Mar 1;213:21-25. doi: 10.1016/j.jep.2017.10.009. Epub 2017 Oct 14.
9. SRC kinase and mitogen-activated protein kinases in the progression from normal to malignant endometrium. Desouki MM and Rowan BG, Clin Cancer Res. 2004 Jan 15;10(2):546-55.
10. Nanoproteomic analysis of extracellular receptor kinase-1/2 post-translational activation in microdissected human hyperplastic colon lesions. Drew DA, etal., Proteomics. 2013 May;13(9):1428-36. doi: 10.1002/pmic.201200430. Epub 2013 Apr 4.
11. Deregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7ß-Aurora A pathway. Duhamel S, etal., Cell Cycle. 2016 Jun 17;15(12):1631-42. doi: 10.1080/15384101.2016.1183851. Epub 2016 May 6.
12. Expression and activity of mitogen activated protein kinases in human colorectal carcinoma. Eggstein S, etal., Gut. 1999 Jun;44(6):834-8.
13. Effect of suvorexant on morphine tolerance and dependence in mice: Role of NMDA, AMPA, ERK and CREB proteins. Esmaili-Shahzade-Ali-Akbari P, etal., Neurotoxicology. 2021 May;84:64-72. doi: 10.1016/j.neuro.2021.02.005. Epub 2021 Feb 18.
14. Agomelatine attenuates alcohol craving and withdrawal symptoms by modulating the Notch1 signaling pathway in rats. Fathi D, etal., Life Sci. 2021 Nov 1;284:119904. doi: 10.1016/j.lfs.2021.119904. Epub 2021 Aug 25.
15. Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia. Föcking M, etal., Mol Psychiatry. 2015 Apr;20(4):424-32. doi: 10.1038/mp.2014.63. Epub 2014 Jul 22.
16. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. Gille H, etal., EMBO J. 1995 Mar 1;14(5):951-62.
18. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
19. Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells. Gorin Y, etal., Biochem J. 2004 Jul 1;381(Pt 1):231-9.
20. Intranasal Lactoferrin Enhances a-Secretase-Dependent Amyloid Precursor Protein Processing via the ERK1/2-CREB and HIF-1a Pathways in an Alzheimer's Disease Mouse Model. Guo C, etal., Neuropsychopharmacology. 2017 Dec;42(13):2504-2515. doi: 10.1038/npp.2017.8. Epub 2017 Jan 12.
21. The role of microRNA-1 targeting of MAPK3 in myocardial ischemia-reperfusion injury in rats undergoing sevoflurane preconditioning via the PI3K/Akt pathway. Hao YL, etal., Am J Physiol Cell Physiol. 2018 Sep 1;315(3):C380-C388. doi: 10.1152/ajpcell.00310.2017. Epub 2018 May 9.
22. ERK1/2 antagonizes glycogen synthase kinase-3beta-induced apoptosis in cortical neurons. Hetman M, etal., J Biol Chem 2002 Dec 20;277(51):49577-84.
23. Paridis Rhizoma Sapoinins attenuates liver fibrosis in rats by regulating the expression of RASAL1/ERK1/2 signal pathway. Hong Y, etal., J Ethnopharmacol. 2016 Nov 4;192:114-122. doi: 10.1016/j.jep.2016.07.010. Epub 2016 Jul 7.
24. Endothelin-1 activates mesangial cell ERK1/2 via EGF-receptor transactivation and caveolin-1 interaction. Hua H, etal., Am J Physiol Renal Physiol 2003 Feb;284(2):F303-12.
25. CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner. Huising MO, etal., Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):912-7. Epub 2009 Dec 22.
26. Crosstalk from cAMP to ERK1/2 emerges during postnatal maturation of nociceptive neurons and is maintained during aging. Isensee J, etal., J Cell Sci. 2017 Jul 1;130(13):2134-2146. doi: 10.1242/jcs.197327. Epub 2017 May 17.
27. Growth hormone-induced differential desensitization of STAT5, ERK, and Akt phosphorylation. Ji S, etal., J Biol Chem 2002 Aug 9;277(32):28384-93.
28. Melatonin regulates the circadian rhythm to ameliorate postoperative sleep disorder and neurobehavioral abnormalities in aged mice. Jia X, etal., CNS Neurosci Ther. 2023 Sep 22. doi: 10.1111/cns.14436.
29. Electrical vs manual acupuncture stimulation in a rat model of polycystic ovary syndrome: different effects on muscle and fat tissue insulin signaling. Johansson J, etal., PLoS One. 2013;8(1):e54357. doi: 10.1371/journal.pone.0054357. Epub 2013 Jan 18.
30. Estrogen-induced activation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor expression, and edema in the uterus are mediated by the phosphatidylinositol 3-kinase/Akt pathway. Kazi AA and Koos RD, Endocrinology. 2007 May;148(5):2363-74. doi: 10.1210/en.2006-1394. Epub 2007 Feb 1.
31. Caveolin-2 regulation of the cell cycle in response to insulin in Hirc-B fibroblast cells. Kim S and Pak Y, Biochem Biophys Res Commun. 2005 Apr 29;330(1):88-96.
32. Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart. Kim SO, etal., J Cell Biochem 1998 Nov 1;71(2):286-301.
33. ERK1 as a Therapeutic Target for Dendritic Cell Vaccination against High-Grade Gliomas. Ku MC, etal., Mol Cancer Ther. 2016 Aug;15(8):1975-87. doi: 10.1158/1535-7163.MCT-15-0850. Epub 2016 Jun 2.
34. 7,8-Dihydroxycoumarin exerts antitumor potential on DMBA-induced mammary carcinogenesis by inhibiting ERa, PR, EGFR, and IGF1R: involvement of MAPK1/2-JNK1/2-Akt pathway. Kumar A, etal., J Physiol Biochem. 2018 May;74(2):223-234. doi: 10.1007/s13105-018-0608-2. Epub 2018 Feb 12.
35. STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson's disease. Kurup PK, etal., Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1202-7. doi: 10.1073/pnas.1417423112. Epub 2015 Jan 12.
36. Growth suppression of colorectal cancer by plant-derived multiple mAb CO17-1A × BR55 via inhibition of ERK1/2 phosphorylation. Kwak DH, etal., Int J Mol Sci. 2014 Nov 14;15(11):21105-19. doi: 10.3390/ijms151121105.
37. A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2. Kwon H, etal., J Cell Mol Med. 2011 Apr;15(4):888-908. doi: 10.1111/j.1582-4934.2010.01079.x.
38. Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer. Li C, etal., J Clin Invest. 2014 May;124(5):2172-87. Epub 2014 Apr 1.
39. [Effects of hydrogen sulfide on myocardial fibrosis and MAPK1/3 and MMP-8 expression in diabetic rats]. Li F, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2015 Apr;35(4):549-52.
40. Neuroprotective Effects of Hydrogen Sulfide Against Early Brain Injury and Secondary Cognitive Deficits Following Subarachnoid Hemorrhage. Li T, etal., Brain Pathol. 2017 Jan;27(1):51-63. doi: 10.1111/bpa.12361. Epub 2016 Mar 28.
41. ERK1/2-mediated phosphorylation of myometrial caldesmon during pregnancy and labor. Li Y, etal., Am J Physiol Regul Integr Comp Physiol 2003 Jan;284(1):R192-9.
42. Central amygdala extracellular signal-regulated kinase signaling pathway is critical to incubation of opiate craving. Li YQ, etal., J Neurosci. 2008 Dec 3;28(49):13248-57. doi: 10.1523/JNEUROSCI.3027-08.2008.
43. EphB receptor signaling in mouse spinal cord contributes to physical dependence on morphine. Liu WT, etal., FASEB J. 2009 Jan;23(1):90-8. doi: 10.1096/fj.08-114462. Epub 2008 Sep 4.
44. MicroRNA-15b deteriorates hypoxia/reoxygenation-induced cardiomyocyte apoptosis by downregulating Bcl-2 and MAPK3. Liu Y, etal., J Investig Med. 2018 Jan;66(1):39-45. doi: 10.1136/jim-2017-000485. Epub 2017 Aug 16.
45. The Impact of Small RNA Interference Against Homer1 on Rats with Type 2 Diabetes and ERK Phosphorylation. Lu J, etal., Cell Biochem Biophys. 2015 Dec;73(3):597-601. doi: 10.1007/s12013-015-0657-x.
46. The expression of ER, PR in endometrial cancer and analysis of their correlation with ERK signaling pathway. Luo L, etal., Cancer Biomark. 2017 Dec 12;21(1):145-149. doi: 10.3233/CBM-170457.
47. Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. Maisonpierre PC, etal., Genomics 1991 Jul;10(3):558-68.
48. MAPK-ERK activation in kidney of male rats chronically fed ochratoxin A at a dose causing a significant incidence of renal carcinoma. Marin-Kuan M, etal., Toxicol Appl Pharmacol. 2007 Oct 15;224(2):174-81. Epub 2007 Jul 3.
49. Vessel-specific stimulation of protein synthesis by nitric oxide synthase inhibition: role of extracellular signal-regulated kinases 1/2. Martens FM, etal., Hypertension 2002 Jan;39(1):16-21.
50. Eicosapentaenoic acid improves imbalance between vasodilator and vasoconstrictor actions of endothelium-derived factors in mesenteric arteries from rats at chronic stage of type 2 diabetes. Matsumoto T, etal., J Pharmacol Exp Ther. 2009 Apr;329(1):324-34. doi: 10.1124/jpet.108.148718. Epub 2009 Jan 22.
51. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
52. Evidence for a role of mitogen-activated protein kinase 3/mitogen-activated protein kinase in the development of testicular ischemia-reperfusion injury. Minutoli L, etal., Biol Reprod. 2005 Oct;73(4):730-6. doi: 10.1095/biolreprod.105.040741. Epub 2005 Jun 8.
53. Effects of metformin on endometrial cancer cell growth in vivo: a preoperative prospective trial. Mitsuhashi A, etal., Cancer. 2014 Oct 1;120(19):2986-95. doi: 10.1002/cncr.28853. Epub 2014 Jun 10.
54. Molecular Understanding of the Activation of CB1 and Blockade of TRPV1 Receptors: Implications for Novel Treatment Strategies in Osteoarthritis. Mlost J, etal., Int J Mol Sci. 2018 Jan 24;19(2). pii: ijms19020342. doi: 10.3390/ijms19020342.
55. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
56. Sexually dimorphic intracellular responses after cocaine-induced conditioned place preference expression. Nygard SK, etal., Brain Res. 2013 Jul 3;1520:121-33. doi: 10.1016/j.brainres.2013.04.060. Epub 2013 May 9.
57. Region and context-specific intracellular responses associated with cocaine-induced conditioned place preference expression. Nygard SK, etal., Neuroscience. 2015 Feb 26;287:1-8. doi: 10.1016/j.neuroscience.2014.12.010. Epub 2014 Dec 15.
58. MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by a1-adrenergic receptors. Ogata T, etal., Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3811-6. doi: 10.1073/pnas.1315359111. Epub 2014 Feb 24.
59. Targeting the ERK signaling pathway as a potential treatment for insulin resistance and type 2 diabetes. Ozaki KI, etal., Am J Physiol Endocrinol Metab. 2016 Apr 15;310(8):E643-E651. doi: 10.1152/ajpendo.00445.2015. Epub 2016 Feb 9.
60. Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Pages G, etal., Science 1999 Nov 12;286(5443):1374-7.
61. Neurobiological Correlates of Pain Avoidance-Like Behavior in Morphine-Dependent and Non-Dependent Rats. Pahng AR, etal., Neuroscience. 2017 Dec 16;366:1-14. doi: 10.1016/j.neuroscience.2017.09.055. Epub 2017 Oct 9.
62. Vitis labruscana leaf extract ameliorates scopolamine-induced impairments with activation of Akt, ERK and CREB in mice. Pariyar R, etal., Phytomedicine. 2017 Dec 1;36:8-17. doi: 10.1016/j.phymed.2017.09.008. Epub 2017 Sep 23.
63. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
64. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
65. Acrolein activates mitogen-activated protein kinase signal transduction pathways in rat vascular smooth muscle cells. Ranganna K, etal., Mol Cell Biochem. 2002 Nov;240(1-2):83-98.
66. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
67. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
68. The role of extracellular regulated kinases I/II in late-phase long-term potentiation. Rosenblum K, etal., J Neurosci 2002 Jul 1;22(13):5432-41.
69. Protection by mTOR Inhibition on Zymosan-Induced Systemic Inflammatory Response and Oxidative/Nitrosative Stress: Contribution of mTOR/MEK1/ERK1/2/IKKß/I¿B-a/NF-¿B Signalling Pathway. Sahan-Firat S, etal., Inflammation. 2018 Feb;41(1):276-298. doi: 10.1007/s10753-017-0686-2.
70. Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Santos SD, etal., Nat Cell Biol. 2007 Mar;9(3):324-30. Epub 2007 Feb 18.
71. 1alpha,25-dihydroxyvitamin D(3) and 24R,25-dihydroxyvitamin D(3) modulate growth plate chondrocyte physiology via protein kinase C-dependent phosphorylation of extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase. Schwartz Z, etal., Endocrinology 2002 Jul;143(7):2775-86.
72. Protein kinase Ciota is required for pancreatic cancer cell transformed growth and tumorigenesis. Scotti ML, etal., Cancer Res. 2010 Mar 1;70(5):2064-74. doi: 10.1158/0008-5472.CAN-09-2684. Epub 2010 Feb 23.
73. Independence of angiotensin II-induced MAP kinase activation from angiotensin type 1 receptor internalization in clone 9 hepatocytes. Shah BH, etal., Mol Endocrinol 2002 Mar;16(3):610-20.
74. Interactions of beta and gamma ENaC with Nedd4 can be facilitated by an ERK-mediated phosphorylation. Shi H, etal., J Biol Chem 2002 Apr 19;277(16):13539-47.
75. Binge Alcohol Is More Injurious to Liver in Female than in Male Rats: Histopathological, Pharmacologic, and Epigenetic Profiles. Shukla SD, etal., J Pharmacol Exp Ther. 2019 Sep;370(3):390-398. doi: 10.1124/jpet.119.258871. Epub 2019 Jul 1.
76. Decrease of phosphorylated CREB and ERK in nucleus accumbens is associated with the incubation of heroin seeking induced by cues after withdrawal. Sun A, etal., Neurosci Lett. 2015 Mar 30;591:166-170. doi: 10.1016/j.neulet.2015.02.048. Epub 2015 Feb 21.
77. Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet. Syed I, etal., Diabetes. 2011 Nov;60(11):2843-52. doi: 10.2337/db11-0809. Epub 2011 Sep 12.
78. Calcium-sensing receptor stimulates PTHrP release by pathways dependent on PKC, p38 MAPK, JNK, and ERK1/2 in H-500 cells. Tfelt-Hansen J, etal., Am J Physiol Endocrinol Metab 2003 Aug;285(2):E329-37. Epub 2003 Apr 15.
79. Signal-transducing function of Na+-K+-ATPase is essential for ouabain's effect on [Ca2+]i in rat cardiac myocytes. Tian J, etal., Am J Physiol Heart Circ Physiol 2001 Nov;281(5):H1899-907.
80. Role of c-SRC and ERK in acid-induced activation of NHE3. Tsuganezawa H, etal., Kidney Int 2002 Jul;62(1):41-50.
81. Ovarian steroid receptors and activated MAPK in the regional decidualization in rats. Vallejo G, etal., Biol Reprod. 2011 May;84(5):1063-71. doi: 10.1095/biolreprod.110.085928. Epub 2011 Jan 19.
82. The effect of overweight and obesity on proliferation and activation of AKT and ERK in human endometria. Villavicencio A, etal., Gynecol Oncol. 2010 Apr;117(1):96-102. doi: 10.1016/j.ygyno.2009.12.022. Epub 2010 Jan 13.
83. Inhibition of ERK/CREB signaling contributes to postoperative learning and memory dysfunction in neonatal rats. Wang H, etal., J Mol Med (Berl). 2023 Mar;101(3):265-278. doi: 10.1007/s00109-023-02285-9. Epub 2023 Jan 23.
84. Extinction of aversive memories associated with morphine withdrawal requires ERK-mediated epigenetic regulation of brain-derived neurotrophic factor transcription in the rat ventromedial prefrontal cortex. Wang WS, etal., J Neurosci. 2012 Oct 3;32(40):13763-75. doi: 10.1523/JNEUROSCI.1991-12.2012.
85. Insulin promotes proliferation, survival, and invasion in endometrial carcinoma by activating the MEK/ERK pathway. Wang Y, etal., Cancer Lett. 2012 Sep 28;322(2):223-31. doi: 10.1016/j.canlet.2012.03.026. Epub 2012 Mar 27.
86. Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons. Watson PM, etal., Mol Cell Neurosci. 2007 Feb;34(2):147-54. Epub 2006 Dec 5.
87. Rat thy-1 antigens from thymus and brain: their tissue distribution, purification, and chemical composition. Williams AF, etal., Cold Spring Harb Symp Quant Biol 1977;41 Pt 1:51-61.
88. Rac GTPase activity is essential for lipopolysaccharide signaling to extracellular signal-regulated kinase and p38 MAP kinase activation in rat-2 fibroblasts. Woo CH and Kim JH, Mol Cells 2002 Jun 30;13(3):470-5.
89. Leukotriene B(4) stimulates Rac-ERK cascade to generate reactive oxygen species that mediates chemotaxis. Woo CH, etal., J Biol Chem 2002 Mar 8;277(10):8572-8. Epub 2001 Dec 27.
90. Sevoflurane post-conditioning protects isolated rat hearts against ischemia-reperfusion injury via activation of the ERK1/2 pathway. Xie H, etal., Acta Pharmacol Sin. 2014 Dec;35(12):1504-13. doi: 10.1038/aps.2014.78. Epub 2014 Oct 27.
91. Impaired Epithelial Wound Healing and EGFR Signaling Pathways in the Corneas of Diabetic Rats. Xu K and Yu FS, Invest Ophthalmol Vis Sci. 2011 Feb 17.
92. The ERK signaling cascade--views from different subcellular compartments. Yao Z and Seger R, Biofactors. 2009 Sep-Oct;35(5):407-16. doi: 10.1002/biof.52.
93. [Effect of moxibustion intervention on expression of gastric epidermal growth factor receptor and extracellular signal regulated kinase 1/2 expression in rats with gastric ulcer]. Zhang H, etal., Zhen Ci Yan Jiu. 2014 Oct;39(5):351-7.
94. Blockade of Cannabinoid CB1 receptor attenuates the acquisition of morphine-induced conditioned place preference along with a downregulation of ERK, CREB phosphorylation, and BDNF expression in the nucleus accumbens and hippocampus. Zhang J, etal., Neurosci Lett. 2016 Sep 6;630:70-76. doi: 10.1016/j.neulet.2016.07.047. Epub 2016 Jul 25.
95. [Effect of manual acupuncture on expression of BDNF/TrkB/ERK/CREB signaling in infarcted tissue of cerebral ischemia rats]. Zhong LY, etal., Zhen Ci Yan Jiu. 2022 Feb 25;47(2):135-40. doi: 10.13702/j.1000-0607.20210048.
96. Brd4 inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-ß-mediated Nox4 expression. Zhou B, etal., Redox Biol. 2017 Apr;11:390-402. doi: 10.1016/j.redox.2016.12.031. Epub 2016 Dec 30.
Additional References at PubMed
PMID:1327976   PMID:1712480   PMID:1716439   PMID:1846291   PMID:2164259   PMID:7687743   PMID:7939721   PMID:8388392   PMID:9535927   PMID:9857190   PMID:11096076   PMID:11254359  
PMID:11356865   PMID:11684667   PMID:11726647   PMID:11756441   PMID:11832339   PMID:11841548   PMID:11844932   PMID:11994045   PMID:11994544   PMID:12006386   PMID:12121979   PMID:12213812  
PMID:12223545   PMID:12349907   PMID:12435482   PMID:12535947   PMID:12623863   PMID:12645629   PMID:12663469   PMID:12699904   PMID:12730054   PMID:12783880   PMID:12800247   PMID:12810726  
PMID:12821670   PMID:12849998   PMID:12854829   PMID:12871576   PMID:12872135   PMID:12930843   PMID:12935895   PMID:12952860   PMID:12971962   PMID:14501944   PMID:14552884   PMID:14575703  
PMID:14580718   PMID:14593093   PMID:14605008   PMID:14636584   PMID:14741046   PMID:14769808   PMID:14963006   PMID:14984009   PMID:14988413   PMID:15026121   PMID:15030400   PMID:15030409  
PMID:15051723   PMID:15052686   PMID:15059773   PMID:15072963   PMID:15143154   PMID:15158083   PMID:15201339   PMID:15203192   PMID:15229233   PMID:15242988   PMID:15249196   PMID:15257182  
PMID:15262203   PMID:15297310   PMID:15314156   PMID:15322069   PMID:15365619   PMID:15371543   PMID:15383658   PMID:15489642   PMID:15498890   PMID:15537896   PMID:15569628   PMID:15573401  
PMID:15574735   PMID:15617763   PMID:15650391   PMID:15721216   PMID:15731359   PMID:15737734   PMID:15748847   PMID:15778391   PMID:15811423   PMID:15829913   PMID:15845362   PMID:15851690  
PMID:15899886   PMID:15917991   PMID:15921682   PMID:15922485   PMID:15950189   PMID:15964695   PMID:15964902   PMID:15975921   PMID:15975997   PMID:15991247   PMID:16004581   PMID:16024175  
PMID:16044092   PMID:16106045   PMID:16126724   PMID:16126730   PMID:16139272   PMID:16272159   PMID:16283431   PMID:16326014   PMID:16343798   PMID:16482086   PMID:16510265   PMID:16535835  
PMID:16595703   PMID:16611738   PMID:16627622   PMID:16641100   PMID:16641227   PMID:16707097   PMID:16714296   PMID:16737746   PMID:16795048   PMID:16820947   PMID:16831126   PMID:16837555  
PMID:16871540   PMID:16873684   PMID:16877348   PMID:16888810   PMID:16893669   PMID:16897752   PMID:16934944   PMID:16944316   PMID:16944453   PMID:16966488   PMID:16978658   PMID:17005865  
PMID:17029782   PMID:17072965   PMID:17074386   PMID:17088403   PMID:17107949   PMID:17113581   PMID:17161379   PMID:17183546   PMID:17239373   PMID:17265428   PMID:17285312   PMID:17308007  
PMID:17309799   PMID:17333127   PMID:17363453   PMID:17371162   PMID:17396111   PMID:17447135   PMID:17490811   PMID:17502994   PMID:17504975   PMID:17505812   PMID:17512932   PMID:17548467  
PMID:17550972   PMID:17560175   PMID:17583725   PMID:17600551   PMID:17616751   PMID:17620366   PMID:17628608   PMID:17630987   PMID:17644565   PMID:17644814   PMID:17646929   PMID:17647269  
PMID:17654493   PMID:17674030   PMID:17675293   PMID:17687004   PMID:17697861   PMID:17698050   PMID:17705195   PMID:17720772   PMID:17767702   PMID:17890845   PMID:17906102   PMID:17928626  
PMID:17936747   PMID:17942284   PMID:17945186   PMID:17960568   PMID:17965278   PMID:17984113   PMID:17991709   PMID:17996850   PMID:17996937   PMID:18003837   PMID:18006605   PMID:18037394  
PMID:18039182   PMID:18068691   PMID:18077694   PMID:18096574   PMID:18163378   PMID:18163394   PMID:18177419   PMID:18187539   PMID:18195168   PMID:18208547   PMID:18210138   PMID:18243549  
PMID:18243629   PMID:18267113   PMID:18280691   PMID:18306298   PMID:18311544   PMID:18330685   PMID:18338254   PMID:18339311   PMID:18357518   PMID:18367547   PMID:18373519   PMID:18392730  
PMID:18407464   PMID:18411006   PMID:18414498   PMID:18449171   PMID:18460465   PMID:18460826   PMID:18463245   PMID:18471812   PMID:18498041   PMID:18499741   PMID:18535289   PMID:18536752  
PMID:18565507   PMID:18566118   PMID:18573356   PMID:18574076   PMID:18586506   PMID:18615585   PMID:18631385   PMID:18632735   PMID:18635668   PMID:18650426   PMID:18651976   PMID:18664382  
PMID:18665890   PMID:18667434   PMID:18723771   PMID:18725270   PMID:18757484   PMID:18768926   PMID:18769070   PMID:18775851   PMID:18783396   PMID:18785628   PMID:18793415   PMID:18794356  
PMID:18798794   PMID:18804898   PMID:18822274   PMID:18824646   PMID:18832099   PMID:18952607   PMID:18952847   PMID:18959821   PMID:18975057   PMID:18977218   PMID:18982462   PMID:19047410  
PMID:19063870   PMID:19103258   PMID:19111554   PMID:19111870   PMID:19151362   PMID:19176891   PMID:19177593   PMID:19179479   PMID:19194552   PMID:19206164   PMID:19211028   PMID:19211730  
PMID:19238810   PMID:19249096   PMID:19249349   PMID:19257802   PMID:19286949   PMID:19295173   PMID:19298845   PMID:19327173   PMID:19362079   PMID:19396876   PMID:19403379   PMID:19404732  
PMID:19427362   PMID:19437547   PMID:19438724   PMID:19447520   PMID:19471096   PMID:19474322   PMID:19477272   PMID:19494114   PMID:19496172   PMID:19501068   PMID:19505325   PMID:19505457  
PMID:19524666   PMID:19527712   PMID:19531642   PMID:19533291   PMID:19539699   PMID:19544110   PMID:19560459   PMID:19570883   PMID:19593445   PMID:19631649   PMID:19633425   PMID:19638304  
PMID:19650110   PMID:19664780   PMID:19684181   PMID:19728154   PMID:19735699   PMID:19755487   PMID:19787459   PMID:19787807   PMID:19804648   PMID:19816767   PMID:19834610   PMID:19885844  
PMID:19885954   PMID:19901158   PMID:19910580   PMID:19941816   PMID:19948989   PMID:19965664   PMID:19996110   PMID:20018936   PMID:20021662   PMID:20037141   PMID:20039534   PMID:20044047  
PMID:20053668   PMID:20056918   PMID:20074256   PMID:20083167   PMID:20105174   PMID:20139360   PMID:20180400   PMID:20181831   PMID:20202085   PMID:20333648   PMID:20368814   PMID:20369692  
PMID:20383279   PMID:20383584   PMID:20398468   PMID:20401736   PMID:20404059   PMID:20497490   PMID:20518702   PMID:20536329   PMID:20558133   PMID:20568456   PMID:20568963   PMID:20649843  
PMID:20669351   PMID:20714296   PMID:20725141   PMID:20807796   PMID:20808940   PMID:20821260   PMID:20822476   PMID:20840753   PMID:20851839   PMID:21075822   PMID:21084714   PMID:21090343  
PMID:21104457   PMID:21106911   PMID:21134288   PMID:21151572   PMID:21162283   PMID:21166678   PMID:21168220   PMID:21178121   PMID:21179843   PMID:21192431   PMID:21195128   PMID:21196724  
PMID:21246051   PMID:21251262   PMID:21302440   PMID:21354100   PMID:21367774   PMID:21368416   PMID:21408155   PMID:21465566   PMID:21468590   PMID:21474451   PMID:21487005   PMID:21531765  
PMID:21558470   PMID:21605499   PMID:21660462   PMID:21660950   PMID:21666544   PMID:21677150   PMID:21701583   PMID:21722369   PMID:21761118   PMID:21764057   PMID:21771966   PMID:21777515  
PMID:21790671   PMID:21819443   PMID:21822733   PMID:21863308   PMID:21871514   PMID:21909393   PMID:21917714   PMID:21929693   PMID:21943492   PMID:21968647   PMID:22027397   PMID:22033934  
PMID:22116522   PMID:22198514   PMID:22227582   PMID:22280975   PMID:22304864   PMID:22307056   PMID:22349022   PMID:22363435   PMID:22366512   PMID:22407386   PMID:22451653   PMID:22454534  
PMID:22465949   PMID:22479579   PMID:22493236   PMID:22508518   PMID:22521290   PMID:22521762   PMID:22542793   PMID:22543102   PMID:22659623   PMID:22702339   PMID:22705154   PMID:22718885  
PMID:22784206   PMID:22797318   PMID:22811014   PMID:22827283   PMID:22851861   PMID:22878563   PMID:22886408   PMID:22890232   PMID:22913624   PMID:22960015   PMID:23055268   PMID:23109389  
PMID:23209658   PMID:23219970   PMID:23242737   PMID:23328768   PMID:23359369   PMID:23374450   PMID:23376485   PMID:23408424   PMID:23438934   PMID:23450427   PMID:23484128   PMID:23500014  
PMID:23518767   PMID:23526217   PMID:23546948   PMID:23564451   PMID:23576434   PMID:23611777   PMID:23611784   PMID:23680829   PMID:23686869   PMID:23712012   PMID:23715865   PMID:23720316  
PMID:23847209   PMID:23880531   PMID:23987506   PMID:24001592   PMID:24049436   PMID:24117073   PMID:24126801   PMID:24136195   PMID:24185830   PMID:24225419   PMID:24292370   PMID:24349514  
PMID:24431450   PMID:24467360   PMID:24498195   PMID:24553818   PMID:24555431   PMID:24562313   PMID:24634418   PMID:24761931   PMID:24835217   PMID:24907397   PMID:24908085   PMID:25008120  
PMID:25100655   PMID:25107837   PMID:25118288   PMID:25142507   PMID:25162639   PMID:25170617   PMID:25195697   PMID:25204493   PMID:25245272   PMID:25246357   PMID:25281485   PMID:25352744  
PMID:25450615   PMID:25497384   PMID:25517116   PMID:25542256   PMID:25601753   PMID:25624461   PMID:25636810   PMID:25695672   PMID:25697003   PMID:25736434   PMID:25800444   PMID:26006040  
PMID:26022182   PMID:26075533   PMID:26088607   PMID:26116232   PMID:26138882   PMID:26165845   PMID:26303491   PMID:26363522   PMID:26371374   PMID:26375174   PMID:26398857   PMID:26415098  
PMID:26435497   PMID:26467923   PMID:26491907   PMID:26514923   PMID:26549199   PMID:26617793   PMID:26636577   PMID:26658610   PMID:26742689   PMID:26754294   PMID:26827493   PMID:26923581  
PMID:27025157   PMID:27068861   PMID:27091075   PMID:27118769   PMID:27145370   PMID:27203238   PMID:27226339   PMID:27351177   PMID:27400779   PMID:27492718   PMID:27693962   PMID:27827993  
PMID:27835878   PMID:27837432   PMID:27924795   PMID:28017206   PMID:28158734   PMID:28216156   PMID:28230313   PMID:28272757   PMID:28278052   PMID:28295305   PMID:28579512   PMID:28609839  
PMID:28688765   PMID:28730748   PMID:28738742   PMID:28758954   PMID:28836382   PMID:28839270   PMID:28987634   PMID:29101749   PMID:29441602   PMID:29466698   PMID:29520716   PMID:29592783  
PMID:29742816   PMID:29845273   PMID:29901080   PMID:30138615   PMID:30430306   PMID:31032358   PMID:32105707   PMID:32782146   PMID:33107061   PMID:33881378   PMID:34204888   PMID:34316004  
PMID:35243702   PMID:36122168   PMID:36282438   PMID:36890454   PMID:37338759   PMID:38791516   PMID:39285628  


Genomics

Comparative Map Data
Mapk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,797,189 - 190,803,411 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1190,797,185 - 190,803,411 (+)EnsemblGRCr8
mRatBN7.21181,366,646 - 181,372,863 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,366,637 - 181,372,863 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1189,717,952 - 189,724,168 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01196,904,026 - 196,910,242 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,571,369 - 189,577,596 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01198,192,773 - 198,198,975 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,192,773 - 198,198,975 (+)Ensemblrn6Rnor6.0
Rnor_5.01205,172,641 - 205,178,843 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41185,935,044 - 185,941,245 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1179,022,318 - 179,028,386 (+)NCBICelera
RGSC_v3.11186,084,924 - 186,091,127 (+)NCBI
Cytogenetic Map1q36NCBI
MAPK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381630,114,105 - 30,123,220 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1630,114,105 - 30,123,506 (-)Ensemblhg38GRCh38
GRCh371630,125,426 - 30,134,541 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361630,032,927 - 30,042,131 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341630,032,927 - 30,042,039NCBI
Celera1672,661,419 - 72,670,625 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1627,786,557 - 27,795,763 (-)NCBIHuRef
CHM1_11631,341,181 - 31,350,385 (-)NCBICHM1_1
T2T-CHM13v2.01630,396,752 - 30,405,867 (-)NCBIT2T-CHM13v2.0
Mapk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,358,798 - 126,364,988 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,358,773 - 126,364,991 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm387126,759,626 - 126,765,816 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7126,759,601 - 126,765,819 (+)Ensemblmm10GRCm38
MGSCv377133,903,140 - 133,909,330 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367126,550,780 - 126,556,964 (+)NCBIMGSCv36mm8
Celera7126,607,166 - 126,613,154 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.25NCBI
Mapk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554936,869,668 - 6,879,152 (+)Ensembl
ChiLan1.0NW_0049554936,870,699 - 6,876,836 (+)NCBIChiLan1.0ChiLan1.0
MAPK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21830,864,038 - 30,873,180 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11635,352,686 - 35,361,831 (+)NCBINHGRI_mPanPan1
PanPan1.11630,489,362 - 30,498,026 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1630,489,362 - 30,498,017 (-)EnsemblpanPan2panpan1.1
MAPK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1618,109,184 - 18,115,728 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl618,109,222 - 18,114,425 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha619,687,831 - 19,694,273 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0618,245,190 - 18,251,639 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl618,245,190 - 18,251,639 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1618,044,145 - 18,050,587 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0617,959,533 - 17,965,981 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0618,275,160 - 18,281,602 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mapk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344124,287,605 - 124,292,797 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650112,384,804 - 12,392,180 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650112,342,670 - 12,390,650 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl318,291,445 - 18,299,567 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1318,291,444 - 18,299,410 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MAPK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1526,536,471 - 26,545,666 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl526,536,532 - 26,546,461 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660682,993,354 - 3,002,555 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478213,152,039 - 13,159,113 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478213,150,824 - 13,158,327 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mapk3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1275,131,760 - 75,138,057 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mapk3
24 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:125
Count of miRNA genes:73
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000026627
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1182383862191260518Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1175967553200707874Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1188241285197807511Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1183564652205813246Rat

Markers in Region
Prkm3-rs1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21181,372,667 - 181,372,836 (+)MAPPERmRatBN7.2
Rnor_6.01198,198,785 - 198,198,953NCBIRnor6.0
Rnor_5.01205,178,653 - 205,178,821UniSTSRnor5.0
RGSC_v3.41185,941,056 - 185,941,224UniSTSRGSC3.4
Celera1179,028,196 - 179,028,364UniSTS
Cytogenetic Map1q36UniSTS
BI278071  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21181,372,449 - 181,372,636 (+)MAPPERmRatBN7.2
mRatBN7.21142,352,418 - 42,352,605 (+)MAPPERmRatBN7.2
Rnor_6.01144,459,798 - 44,459,984NCBIRnor6.0
Rnor_6.01198,198,567 - 198,198,753NCBIRnor6.0
Rnor_5.01147,652,898 - 47,653,084UniSTSRnor5.0
Rnor_5.01205,178,435 - 205,178,621UniSTSRnor5.0
RGSC_v3.41185,940,838 - 185,941,024UniSTSRGSC3.4
RGSC_v3.41143,172,337 - 43,172,523UniSTSRGSC3.4
Celera1142,150,435 - 42,150,621UniSTS
Celera1179,027,978 - 179,028,164UniSTS
Cytogenetic Map11q12UniSTS
Cytogenetic Map1q36UniSTS
Mapk3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21142,352,315 - 42,353,222 (+)MAPPERmRatBN7.2
Rnor_6.01144,459,695 - 44,460,601NCBIRnor6.0
Rnor_5.01147,652,795 - 47,653,701UniSTSRnor5.0
RGSC_v3.41143,172,234 - 43,173,140UniSTSRGSC3.4
Celera1142,150,332 - 42,151,238UniSTS
Cytogenetic Map11q12UniSTS
Cytogenetic Map1q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000026688   ⟹   ENSRNOP00000026688
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1190,797,194 - 190,803,411 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087625   ⟹   ENSRNOP00000070784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1190,797,185 - 190,803,411 (+)Ensembl
mRatBN7.2 Ensembl1181,366,637 - 181,372,863 (+)Ensembl
Rnor_6.0 Ensembl1198,192,773 - 198,198,975 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000165309   ⟹   ENSRNOP00000110992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1190,797,220 - 190,803,409 (+)Ensembl
RefSeq Acc Id: NM_017347   ⟹   NP_059043
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,797,194 - 190,803,411 (+)NCBI
mRatBN7.21181,366,646 - 181,372,863 (+)NCBI
Rnor_6.01198,192,773 - 198,198,975 (+)NCBI
Rnor_5.01205,172,641 - 205,178,843 (+)NCBI
RGSC_v3.41185,935,044 - 185,941,245 (+)RGD
Celera1179,022,318 - 179,028,386 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039088525   ⟹   XP_038944453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,797,189 - 190,803,410 (+)NCBI
mRatBN7.21181,366,650 - 181,372,862 (+)NCBI
RefSeq Acc Id: NP_059043   ⟸   NM_017347
- UniProtKB: Q62686 (UniProtKB/Swiss-Prot),   Q4PIY8 (UniProtKB/Swiss-Prot),   P21708 (UniProtKB/Swiss-Prot),   Q9JJ13 (UniProtKB/Swiss-Prot),   A0A8L2R3C3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070784   ⟸   ENSRNOT00000087625
RefSeq Acc Id: XP_038944453   ⟸   XM_039088525
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R3C3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000026688   ⟸   ENSRNOT00000026688
Ensembl Acc Id: ENSRNOP00000110992   ⟸   ENSRNOT00000165309
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21708-F1-model_v2 AlphaFold P21708 1-380 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690409
Promoter ID:EPDNEW_R934
Type:multiple initiation site
Name:Mapk3_1
Description:mitogen activated protein kinase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01198,192,787 - 198,192,847EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3046 AgrOrtholog
BioCyc Gene G2FUF-57423 BioCyc
Ensembl Genes ENSRNOG00000053583 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000026688 ENTREZGENE
  ENSRNOT00000165309 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  MAP_kinase UniProtKB/Swiss-Prot
  MAP_kinase_CS UniProtKB/Swiss-Prot
  MAPK_ERK1/2 UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:50689 UniProtKB/Swiss-Prot
NCBI Gene 50689 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PharmGKB MAPK3 RGD
PhenoGen Mapk3 PhenoGen
PRINTS ERK1ERK2MAPK UniProtKB/Swiss-Prot
PROSITE MAPK UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000053583 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8L2R3C3 ENTREZGENE, UniProtKB/TrEMBL
  MK03_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4PIY8 ENTREZGENE
  Q62686 ENTREZGENE
  Q9JJ13 ENTREZGENE
UniProt Secondary Q4PIY8 UniProtKB/Swiss-Prot
  Q62686 UniProtKB/Swiss-Prot
  Q9JJ13 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Mapk3  mitogen activated protein kinase 3    protein kinase, mitogen activated 3 (extracellular-signal-regulated kinase 1, ERK1)  Name updated 1299863 APPROVED
2002-06-10 Mapk3  mitogen activated protein kinase 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains protein product has protein kinase domain, tyrosine kinase catalytic domain, serine/threonine protein kinases catalytic domain 70317
gene_domains protein product has protein kinase domain, tyrosine kinase catalytic domain, serine/threonine protein kinases catalytic domain 70572
gene_expression enzyme specific activity decreases with age 70317
gene_expression expressed in all tissues 70317
gene_function phosphorylates protein serine/threonine residues 70317
gene_pathway 17 beta estradiol activates the extracellular regulated kinase/mitogen-activated protein kinase pathway at cellular level 70572
gene_process estrogen-mediated activation of the Erk/MAP kinase pathway immediately affects NMDA receptors and long term potentiation (LTP) 70572
gene_process functions in mitogenic signaling, activation is associated with cardiomyocyte hypertrophy 70317
gene_process mediates long-term memory and long-term potentiation (LTP) 631303
gene_process translocation to the nucleus is associated with the induction of late long-term potentiation (LTP); translocation activates transcription of immediate early genes (IEGs) after plasticity-inducing stimulation of neurons 631303
gene_regulation highly responsive to extracellular proliferative stimuli 70310
gene_regulation highly responsive to extracellular proliferative stimuli 70572
gene_regulation activated by estrogen in hippocampus, downregulation by ovariectomy 70572
gene_regulation activated by Map2k1, Mek2 phosphorylation 625493
gene_regulation induced by glutamate, acetylcholine, and BDNF in neurons 631303
gene_regulation activated by Endothelin-1 (ET-1) in glomerular mesangial cells 727457
gene_regulation 24R,25-dihydroxyvitamin D3 (24R,25-(OH)2D3) increases kinase activity via phospholipase D in resting zone (RC) cells 631303
gene_regulation ouabain induces activation in cardiac myocytes 631303
gene_regulation 1-alpha,25-dihydroxyvitamin D3 (1a,25-(OH)2D3) increases the kinase activity via phospholipase C in growth zone (GC) cells of growth plate chondrocytes 631303