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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:28304
Term: heparin
Definition: A highly sulfated linear glycosaminoglycan comprising complex patterns of uronic acid-(1->4)-D-glucosamine repeating subunits. Used as an injectable anticoagulant, it has the highest negative charge density of any known biological molecule.
Chemical ID: MESH:D006493
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3multiple interactionsEXP 6480464CTDHeparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAPK3 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]PMID:14966081
Mapk3increases activityISOMAPK3 (Homo sapiens)6480464CTDHeparin results in increased activity of MAPK3 proteinPMID:16556679
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTDHeparin analog inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]PMID:18057711
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTDHeparin inhibits the reaction [sodium chlorate results in decreased phosphorylation of MAPK3 protein]PMID:19937756
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