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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:15756
Term: hexadecanoic acid
Definition: A straight-chain, sixteen-carbon, saturated long-chain fatty acid.
Chemical ID: MESH:D019308
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3increases phosphorylationEXP 6480464CTDPalmitic Acid results in increased phosphorylation of MAPK3 proteinPMID:24080574 PMID:34979142
Mapk3multiple interactionsEXP 6480464CTD4-hydroxyisoleucine inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]]; 7-hydroxycoumarin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK3 protein]; acetovanillone inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK3 protein]; CYBA mutant form inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK3 protein]; Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Scopoletin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK3 protein]PMID:24080574 PMID:25109277 PMID:34979142
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDPalmitic Acid results in increased phosphorylation of MAPK3 proteinPMID:24986865
Mapk3increases phosphorylationISOMapk3 (Mus musculus)6480464CTDPalmitic Acid results in increased phosphorylation of MAPK3 proteinPMID:25614714
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTDDocosahexaenoic Acids inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK3 protein]PMID:24986865
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTDQuercetin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK3 protein]PMID:25614714
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