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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:53001
Term: nickel sulfate
Definition: A metal sulfate having nickel(2+) as the metal ion.
Chemical ID: MESH:C029938
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3increases phosphorylationEXP 6480464CTDnickel sulfate results in increased phosphorylation of MAPK3 proteinPMID:29567110
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDnickel sulfate results in increased phosphorylation of MAPK3 proteinPMID:15588916 PMID:18495191 PMID:19101624 PMID:19135467 PMID:20600219
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTD[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased phosphorylation of MAPK3 protein; U 0126 inhibits the reaction [nickel sulfate results in increased phosphorylation of MAPK3 protein]PMID:18495191 PMID:20600219
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