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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:16827
Term: corticosterone
Definition: A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.
Chemical ID: MESH:D003345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3decreases phosphorylationEXP 6480464CTDCorticosterone results in decreased phosphorylation of MAPK3 proteinPMID:29343424
Mapk3increases phosphorylationEXP 6480464CTDCorticosterone results in increased phosphorylation of MAPK3 proteinPMID:19175364
Mapk3multiple interactionsEXP 6480464CTD2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [IGF1 protein inhibits the reaction [Corticosterone results in decreased phosphorylation of MAPK3 protein]]; Curcumin inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK3 protein]; IGF1 protein inhibits the reaction [Corticosterone results in decreased phosphorylation of MAPK3 protein]PMID:19175364 PMID:29343424
Mapk3decreases activityISOMapk3 (Mus musculus)6480464CTDCorticosterone results in decreased activity of MAPK3 proteinPMID:19733225
Mapk3increases phosphorylationISOMapk3 (Mus musculus)6480464CTDCorticosterone results in increased phosphorylation of MAPK3 proteinPMID:22850435
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTD2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK3 protein]; KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK3 protein]]PMID:22850435
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