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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:28619
Term: acrylamide
Definition: A member of the class of acrylamides that results from the formal condensation of acrylic acid with ammonia.
Chemical ID: MESH:D020106
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3decreases phosphorylationEXP 6480464CTDAcrylamide results in decreased phosphorylation of MAPK3 proteinPMID:33421551 PMID:36657526
Mapk3increases expressionEXP 6480464CTDAcrylamide results in increased expression of MAPK3 protein modified formPMID:29426002
Mapk3increases phosphorylationEXP 6480464CTDAcrylamide results in increased phosphorylation of MAPK3 proteinPMID:33545342
Mapk3multiple interactionsEXP 6480464CTDacadesine inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [Acrylamide results in decreased phosphorylation of MAPK3 protein]PMID:33545342 PMID:36657526
Mapk3decreases expressionISOMAPK3 (Homo sapiens)6480464CTDAcrylamide results in decreased expression of MAPK3 mRNAPMID:32763439
Mapk3increases phosphorylationISOMapk3 (Mus musculus)6480464CTDAcrylamide results in increased phosphorylation of MAPK3 proteinPMID:25531190 PMID:31081568 PMID:36565847
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK3 protein]; [Acrylamide co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein; Acetylcysteine inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK3 protein]; Acrylamide promotes the reaction [Dietary Fats results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK3 protein]PMID:25531190 PMID:30409764 PMID:31081568
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