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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:28885
Term: butan-1-ol
Definition: A primary alcohol that is butane in which a hydrogen of one of the methyl groups is substituted by a hydroxy group. It it produced in small amounts in humans by the gut microbes.
Chemical ID: MESH:D020001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3multiple interactionsEXP 6480464CTD1-Butanol inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; 1-Butanol inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK3 protein]]; 1-Butanol inhibits the reaction [PLD1 protein affects the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK3 protein]]; 1-Butanol inhibits the reaction [Potassium Chloride results in increased phosphorylation of MAPK3 protein]PMID:11134345 PMID:11243883 PMID:17620283 PMID:18004999
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTD1-Butanol inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 1-Butanol inhibits the reaction [C5 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 1-Butanol inhibits the reaction [C5 protein results in increased phosphorylation of MAPK3 protein]; 1-Butanol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]; 1-Butanol inhibits the reaction [VEGFA protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of MAPK3 mRNAPMID:12890486 PMID:14704231 PMID:15919668 PMID:19284563 PMID:19346296 PMID:29432896
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTD1-Butanol affects the reaction [RACK1 protein affects the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]]; 1-Butanol inhibits the reaction [C5 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 1-Butanol inhibits the reaction [C5 protein results in increased phosphorylation of MAPK3 protein]; 1-Butanol inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 1-Butanol results in decreased phosphorylation of and results in decreased activity of MAPK3 proteinPMID:12782152 PMID:15657063 PMID:19284563 PMID:19346296
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