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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:6736
Term: melittin
Definition: A 26-membered polypeptide consisting of Gly, Ile, Gly, Ala, Val, Leu, Lys, Val, Leu, Thr, Thr, Gly, Leu, Pro, Ala, Leu, Ile, Ser, Trp, Ile, Lys, Arg, Lys, Arg, Gln and Gln-NH2 residues joined in sequence. It is the principal active component of bee venom.
Chemical ID: MESH:D008555
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3decreases phosphorylationEXP 6480464CTDMelitten results in decreased phosphorylation of MAPK3 proteinPMID:17654254
Mapk3decreases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDMelitten results in decreased phosphorylation of MAPK3 proteinPMID:23110475
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDMelitten results in increased phosphorylation of MAPK3 proteinPMID:22613720
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTDMelitten inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Melitten inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; Melitten results in increased phosphorylation of and results in increased activity of MAPK3 proteinPMID:17579088 PMID:20082219 PMID:22926441
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTDMelitten inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK3 protein]PMID:17570326
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