Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3multiple interactionsEXP 6480464CTDepigallocatechin gallate inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MAPK3 protein]; epigallocatechin gallate results in increased phosphorylation of and results in increased activity of MAPK3 protein; MFN2 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MAPK3 protein]]PMID:15210717 PMID:28478070
Mapk3decreases expressionISOMAPK3 (Homo sapiens)6480464CTDepigallocatechin gallate results in decreased expression of MAPK3 protein modified formPMID:20346928
Mapk3increases activityISOMAPK3 (Homo sapiens)6480464CTDepigallocatechin gallate results in increased activity of MAPK3 proteinPMID:17931610
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDepigallocatechin gallate results in increased phosphorylation of MAPK3 proteinPMID:19720055
Mapk3increases phosphorylationISOMapk3 (Mus musculus)6480464CTDepigallocatechin gallate results in increased phosphorylation of MAPK3 proteinPMID:35863485
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [epigallocatechin gallate results in increased activity of MAPK3 protein]; [epigallocatechin gallate co-treated with Celecoxib] results in increased activity of MAPK3 protein; epigallocatechin gallate affects the reaction [Doxorubicin affects the expression of MAPK3 protein]; epigallocatechin gallate inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]; epigallocatechin gallate inhibits the reaction [HGF protein results in increased phosphorylation of MAPK3 protein]; epigallocatechin gallate inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein]; epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]]; epigallocatechin gallate results in increased expression of and results in increased phosphorylation of MAPK3 proteinPMID:16463383 PMID:17931610 PMID:19244381 PMID:19557821 PMID:23954321 PMID:31252129 PMID:35218280 PMID:36162953
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTDepigallocatechin gallate inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK3 protein]; epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK3 protein]; epigallocatechin gallate inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK3 protein]PMID:20450880 PMID:29402411 PMID:34740634
Go Back to source page   Continue to Ontology report