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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:16480
Term: nitric oxide
Definition: A nitrogen oxide which is a free radical, each molecule of which consists of one nitrogen and one oxygen atom.
Chemical ID: MESH:D009569
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3decreases expressionEXP 6480464CTDNitric Oxide results in decreased expression of MAPK3 proteinPMID:15640287
Mapk3decreases phosphorylationEXP 6480464CTDNitric Oxide results in decreased phosphorylation of MAPK3 proteinPMID:16575906
Mapk3multiple interactionsEXP 6480464CTDNitric Oxide affects the reaction [Ditiocarb results in increased phosphorylation of MAPK3 protein]; Nitric Oxide affects the reaction [NGF protein results in increased activity of MAPK3 protein]; Nitric Oxide inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]PMID:14713289 PMID:16389725 PMID:16603213
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