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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:78492
Term: diallyl trisulfide
Definition: An organic trisulfide that is trisulfane in which both of the hydrogens are replaced by allyl groups. A component of the essential oil of garlic and a major component of the traditional Chinese medicine allitridium, it exhibits antifungal, antitumour and antioxidant activity
Chemical ID: MESH:C042577
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3increases phosphorylationEXP 6480464CTDdiallyl trisulfide results in increased phosphorylation of MAPK3 proteinPMID:17263507
Mapk3multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [diallyl trisulfide results in increased phosphorylation of MAPK3 protein]; diallyl trisulfide inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]PMID:17263507 PMID:29087013
Mapk3decreases expressionISOMAPK3 (Homo sapiens)6480464CTDdiallyl trisulfide results in decreased expression of MAPK3 proteinPMID:21695758
Mapk3decreases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDdiallyl trisulfide results in decreased phosphorylation of MAPK3 proteinPMID:25205294 PMID:25927362
Mapk3increases phosphorylationISOMapk3 (Mus musculus)6480464CTDdiallyl trisulfide results in increased phosphorylation of MAPK3 proteinPMID:22137902
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [diallyl trisulfide results in increased phosphorylation of MAPK3 protein]PMID:22137902
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