Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3decreases phosphorylationEXP 6480464CTDDoxorubicin results in decreased phosphorylation of MAPK3 proteinPMID:30928397
Mapk3increases localizationEXP 6480464CTDDoxorubicin results in increased localization of MAPK3 protein modified formPMID:18775851
Mapk3increases phosphorylationEXP 6480464CTDDoxorubicin results in increased phosphorylation of MAPK3 proteinPMID:17384286 PMID:22155320 PMID:29087013 PMID:31010378 PMID:35843304
Mapk3multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Oleylethanolamide results in increased phosphorylation of MAPK3 protein]] which results in increased susceptibility to Doxorubicin; [Doxorubicin co-treated with Carvedilol] results in increased phosphorylation of MAPK3 protein; [Doxorubicin co-treated with Razoxane] results in increased phosphorylation of MAPK3 protein; Acetylcysteine inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]; diallyl trisulfide inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]; Doxorubicin results in increased activity of and results in increased localization of MAPK3 protein; Doxorubicin results in increased activity of and results in increased phosphorylation of MAPK3 protein; Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK3 protein; galangin inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]; kaempferol inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Doxorubicin results in increased localization of MAPK3 protein modified form]; U 0126 inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]PMID:15843167 PMID:16213474 PMID:16269455 PMID:16687611 PMID:17384286 PMID:18373386 PMID:18775851 PMID:22155320 PMID:29087013 PMID:35843304
Mapk3affects expressionISOMAPK3 (Homo sapiens)6480464CTDDoxorubicin affects the expression of MAPK3 proteinPMID:35218280
Mapk3affects response to substanceISOMAPK3 (Homo sapiens)6480464CTDMAPK3 protein affects the susceptibility to DoxorubicinPMID:16928833
Mapk3decreases expressionISOMAPK3 (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of MAPK3 mRNAPMID:29803840
Mapk3decreases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDDoxorubicin results in decreased phosphorylation of MAPK3 proteinPMID:23956100 PMID:25339540 PMID:25856345
Mapk3decreases phosphorylationISOMapk3 (Mus musculus)6480464CTDDoxorubicin results in decreased phosphorylation of MAPK3 proteinPMID:16109756
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDDoxorubicin results in increased phosphorylation of MAPK3 proteinPMID:15557793 PMID:17974986 PMID:18468633 PMID:18594523 PMID:31843629 PMID:33771646
Mapk3increases phosphorylationISOMapk3 (Mus musculus)6480464CTDDoxorubicin results in increased phosphorylation of MAPK3 proteinPMID:12884365 PMID:17974986 PMID:30734460
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased phosphorylation of MAPK3 protein; [Doxorubicin co-treated with dimethyl sulfone] results in increased phosphorylation of MAPK3 protein; [Quercetin co-treated with Doxorubicin] results in increased phosphorylation of MAPK3 protein; Acetaminophen inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Doxorubicin affects the phosphorylation of and affects the activity of MAPK3 protein; Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK3 protein; epigallocatechin gallate affects the reaction [Doxorubicin affects the expression of MAPK3 protein]; lercanidipine inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]; SOD2 protein affects the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]PMID:14610070 PMID:15557793 PMID:16059641 PMID:17526808 PMID:18468633 PMID:18594523 PMID:25686905 PMID:32562081 PMID:33771646 PMID:35218280
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTDCSF3 protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]; Doxorubicin promotes the reaction [AZD 6244 results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]; Doxorubicin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; EPO protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]; Genistein inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]; HGF protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]; HGF protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of MAPK3 protein]; NRG1 protein affects the reaction [Doxorubicin affects the phosphorylation of MAPK3 protein]; pifithrin promotes the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]PMID:12884365 PMID:15833803 PMID:16109756 PMID:16449733 PMID:17334414 PMID:17876044 PMID:18083897 PMID:30734460
Go Back to source page   Continue to Ontology report